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1. Prospective randomized, placebo-controlled study: role of branched-chain amino acids infusion as adjunct therapy post-liver surgery for patients in the intensive care unit.
Several animal studies have shown that Branched-chain amino acids (BCAAs) may prevent acute liver injury, although its effects in humans are as yet undetermined. Thus the purpose of this study is to evaluate the impact of intravenous BCAAs infusion on liver profile post-liver surgery in the intensive care unit (ICU).
2. The disease course in microscopic colitis may be influenced by hormonal factors.
作者: Klas Sjöberg.;Lina Vigren.;Marie-Rose Mellander.;Izabella Janczewska.;Hans Strid.;Elisabeth Hultgren Hörnquist.;Andreas Münch.
来源: BMC Gastroenterol. 2025年25卷1期438页
Microscopic colitis (MC) is characterized by non-bloody, watery diarrhea predominantly in elderly women. Known risk factors are smoking, medication with NSAIDs, PPIs or SSRIs, while data on hormonal factors is sparse. The aim of the present study was to investigate whether hormonal factors that disrupt the sex hormonal balance could have an impact on the disease course in MC.
3. Treatment sequences, outcomes, healthcare utilization, and costs in patients with inflammatory bowel diseases requiring advanced treatment-real world comparative effectiveness from German claims data.
作者: Axel Dignass.;Niels Teich.;Stephan Kaiser.;Juliane Sünwoldt.;Christina Dünweber.;Ines Weinhold.;Julia Borchert.;Robert Kudernatsch.
来源: BMC Gastroenterol. 2025年25卷1期436页
There is limited data on inflammatory bowel disease advanced therapy sequences. Therefore, we examined real-world advanced therapy sequences to compare persistence, healthcare use and costs in first-line advanced therapy.
4. ZBTB10 as a potential prognosis biomarker and correlates with the tumor immune microenvironment in stomach adenocarcinoma.
作者: Yingdi Jiang.;Fuhua Han.;Lu Dai.;Shali Qiu.;Yanjie Zhou.;Ke Wang.;Jiang Lin.
来源: BMC Gastroenterol. 2025年25卷1期435页
ZBTB10 is a member of the zinc finger and bric-a-brac/tramtrack/broad (ZBTB) domain-containing protein family, reported to be associated with tumorigenesis and progression. However, its specific roles in oncogenesis, prognosis, and immune infiltration in stomach adenocarcinoma (STAD) remain to be elucidated.
5. Prognostic value of platelet-to-lymphocyte ratio in hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.
作者: Qingtian Zhou.;Zewen Jiang.;Tingting Ye.;Li Yu.;Qinglian Wang.;Pin Lin.;Yanfeng Shao.
来源: BMC Gastroenterol. 2025年25卷1期437页
The prognostic significance of the Platelet-to-Lymphocyte Ratio (PLR) in patients with hepatocellular carcinoma (HCC) undergoing treatment with immune checkpoint inhibitors (ICIs) remains uncertain. A systematic review and meta-analysis was conducted to assess the prognostic value of PLR in HCC patients receiving ICIs.
6. Comprehensive evaluation of clinical phenotypes and pathogenic features in late-onset monogenic inflammatory bowel disease: a comparative study with infantile-onset cases.
作者: Haoying Liu.;Yinxian Shen.;Jiaxin Xu.;Shangzhan Huang.;TingTing Qin.;Qi Zhou.;Jiazhi Liao.;Fang Xiao.
来源: BMC Gastroenterol. 2025年25卷1期432页
Monogenic inflammatory bowel disease (mIBD) in patients with onset after the age of 16 has been increasingly recognized, but these reports are sporadic and lack a systematic overview, leaving the clinical and genetic characteristics poorly understood. This study aimed to characterize these late-onset mIBD (LO-mIBD), using an infantile-onset population as a control.
7. Expression of kinetochore component NDC80 promotes esophageal squamous cell carcinoma cells proliferation and migration.
作者: Youwu Shi.;Jing Sun.;Feng Du.;Zhiwei Sun.;Ying Yang.;Jing Yu.;Yanjie Xiao.;Xiaoyu Sun.;Wen Zhang.;Hongkun Zheng.;Xiaodong Zhang.;Jun Jia.
来源: BMC Gastroenterol. 2025年25卷1期433页
NDC80, a crucial component of the kinetochore, plays a pivotal role in regulating cell mitosis. Recent studies reported that NDC80 regulates the proliferation of cancer cells and may be related to poor prognosis in cancer. However, the biological function and mechanism of NDC80 in esophageal squamous cell carcinoma (ESCC) have not yet been elucidated. In this study, we analyzed the expression and mutation of NDC80 in ESCC tissue and assessed its impact on ESCC cells in vitro.
8. A study on the timing of small-bowel capsule endoscopy and its impact on the detection rate of bleeding sources.
作者: Daisuke Kametaka.;Masaya Iwamuro.;Toshihiro Inokuchi.;Seiji Kawano.;Sakiko Hiraoka.;Motoyuki Otsuka.
来源: BMC Gastroenterol. 2025年25卷1期434页
Small-bowel capsule endoscopy (SBCE) is an essential diagnostic tool for obscure gastrointestinal bleeding, particularly for identifying bleeding sources in the small intestine. The timing of SBCE is thought to affect its diagnostic yield; however, the optimal timing remains unknown.
10. The potential value of serum pepsinogen and gastrin-17 for the diagnosis of chronic atrophic gastritis at different stages of severity: a clinical diagnostic study.
作者: Tianyi Zhang.;Xuyun Zhou.;Xiangxiang Meng.;Jianxin Li.;Sujun Hou.;Junmei Wang.;Mengmeng Yin.;Long Cao.;Baitian Wang.
来源: BMC Gastroenterol. 2025年25卷1期428页
Pepsinogen (PG) and gastrin-17 (G-17) are crucial in the gastric digestive processes. This study aimed to assess the diagnostic value of the serum PG and G-17 in identifying chronic atrophic gastritis (CAG) at different stages of severity under varying Helicobacter pylori (H. pylori) infection statuses.
11. Feasibility, effectiveness, and safety of simultaneous side-by-side deployment of uncovered self-expandable metal stents for malignant hilar biliary obstruction: a retrospective single-center study.
作者: Chengcheng Christine Zhang.;Marcus Kantowski.;Cyrill Wehling.;Patrick Michl.;Ronald Koschny.;Peter Sauer.
来源: BMC Gastroenterol. 2025年25卷1期431页
Malignant hilar biliary obstruction is associated with a poor prognosis, making biliary drainage important for improving the quality of life. Endoscopic simultaneous side-by-side deployment of uncovered self-expandable metal stents is a novel approach. However, reliable clinical data on this method are limited. This retrospective, single-center study aimed to evaluate the feasibility, effectiveness, and safety of simultaneous side-by-side deployment of self-expandable metal stents for malignant hilar biliary obstruction.
12. Quantitative literature analysis on efficacy and safety of balloon-occluded transarterial chemoembolization for hepatocellular carcinoma.
作者: Wei Fan Sui.;Yu Xin Duan.;Ze Feng Cai.;Jian Yun Li.;Jian Hua Fu.
来源: BMC Gastroenterol. 2025年25卷1期430页
To analyze the efficacy and safety of balloon-occluded transarterial chemoembolization (B-TACE) of hepatocellular carcinoma (HCC).
13. A risk prediction model for nausea and vomiting after TACE: a cross-sectional study.
It was found that 33.8-52.5% of patients experienced nausea and vomiting after Transcatheter Arterial Chemoembolization (TACE) for liver cancer, based on prior literature. But there are no models that predict this risk. In this study, we investigated the factors associated with nausea and vomiting after TACE and developed a predictive model to predict these adverse events.
14. Predictive accuracy of fecal calprotectin in assessing clinical activity and disease severity in patients with Ulcerative Colitis and Crohn's disease.
作者: Ankit V Jain.;Sandeep Gopal.;Anurag J Shetty.;Suresh Shenoy.;B V Tantry.;B Unnikrishnan.;Ramesh Holla.;Rishit Anand.
来源: BMC Gastroenterol. 2025年25卷1期429页
Inflammatory bowel disease (IBD) is an idiopathic disorder characterized by repeated relapses and remissions. Endoscopy, the gold standard for diagnosis and monitoring of these patients is time consuming, expensive, and invasive. Hence, faecal calprotectin (FCP) has been suggested as marker to determine the degree of intestinal inflammation and predict relapse in IBD.
15. Comparative serum imidazole propionate profiling in colorectal adenoma and cancer by UPLC-MS/MS.
作者: Jie Lv.;Qianqian Chen.;Lu Yang.;Jing Guan.;Sheng Wang.;Gen Gui.;Zhaoyun Yang.;Xu Wang.;Bin Sun.
来源: BMC Gastroenterol. 2025年25卷1期426页
The incidence of colorectal cancer (CRC) is increasing with colorectal adenomas recognized as key precancerous lesions. Emerging evidence suggests that Imidazole propionate (ImP), a metabolite of gut microbiota, is elevated in patients, indicating a potential role in tumorigenesis of CRC.
16. Global, regional, and national burden of inflammatory bowel disease in persons aged 60-89 years from 1992 to 2021.
作者: Zhou Zhang.;Na Du.;Chun-Mei Xu.;Wei Chen.; Ting-Ting-Chen.;Yu Xiao.
来源: BMC Gastroenterol. 2025年25卷1期425页
The global burden of inflammatory bowel disease (IBD) is increasing, but detailed data on older adults remain scarce.
17. Trends in incidence and mortality of early-onset gastrointestinal cancers: a comprehensive study.
Early-Onset Gastrointestinal Cancers concerns tumors in people under 50. Accumulating evidence suggests a significant increase in the burden of colorectal cancer in young adults. We investigated the global burden and spatiotemporal trends of the 6 major gastrointestinal (GI) cancers, including colon and rectum cancer (CRC), esophageal cancer (EC), gallbladder and biliary tract cancer (GBTC), liver cancer (LC), pancreatic cancer (PC), and stomach cancer (SC). in young adults, based on cancer-specific incidence and mortality.
18. Development and validation of a nomogram for predicting early recurrence in patients undergoing different courses of postoperative adjuvant transarterial chemoembolisation.
作者: Hongkun Tan.;Yuyan Xu.;Cheng Zhang.;Kaihang Zhong.;Yaohong Wen.;Chunming Wang.;Zhoubin Feng.;Jianan Feng.;Shunjun Fu.;Guolin He.;Lei Cai.;Mingxin Pan.
来源: BMC Gastroenterol. 2025年25卷1期422页
Hepatocellular carcinoma (HCC) is associated with a high rate of postoperative recurrence. Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) is effective in preventing recurrence. However, the effect of different courses of PA-TACE on tumor prognosis remains unclear. As such, this study aimed to develop and validate a nomogram that incorporates different courses of PA-TACE to predict early tumor recurrence.
19. Status of short videos as health information sources for chronic pancreatitis in China: a cross-sectional study.
Chronic pancreatitis is a chronic inflammatory disease of the pancreatic tissue caused by genetic or environmental factors; it has a complex etiology and is difficult to diagnose and treat clinically, severely affecting the physical and mental health of patients. Currently, the treatment of chronic pancreatitis often relies on lifelong self-health management by patients. However, the quality of videos related to chronic pancreatitis on short video platforms remains to be determined, and these videos may contain erroneous information that patients cannot recognize. This study aims to assess the quality of information in short videos related to chronic pancreatitis on the Chinese platforms TikTok and Bilibili.
20. Cholesterol-modified prognostic nutritional index as an independent prognostic biomarker in primary biliary cholangitis patients.
作者: Huiling Zhu.;Mengyao Zheng.;Wenbin Li.;Yaqin Huang.;Lili Zhang.;Wenting Yang.;Jinhui Yang.
来源: BMC Gastroenterol. 2025年25卷1期421页
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by inflammation of the interlobular bile ducts, often associated with malabsorption of fat-soluble vitamins and osteoporosis. Thus, evaluating the nutritional status of patients with PBC and implementing appropriate interventions are significant. But CPNI in determining the nutritional status and forecasting survival outcome among patients with PBC remains unclear.
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