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1. Survival outcome of VATS compared with open lobectomy for lung cancer: an individual patient data meta-analysis of randomised trials.
作者: Rosie A Harris.;Jacie Jiaqi Law.;Long Hao.;Dongrong Situ.;Finn Amundsen Dittberner.;Morten Bendixen.;Peter B Licht.;Chris A Rogers.;Eric Lim.
来源: Lancet. 2026年407卷10534期1182-1190页
Video-assisted thoracoscopic surgery (VATS) is currently the most common approach for pulmonary lobectomy in early-stage lung cancer. Reported advantages include less pain, fewer complications, faster recovery, and improved postoperative quality of life. The widespread adoption of VATS lobectomy is principally based on non-oncological benefits. Its oncological equivalence to open surgery remains assumed as no single trial has been powered for survival. To address this important question, we sought to conduct an individual patient data meta-analysis of eligible randomised trials.
2. Comparative efficacy and tolerability of antidopaminergic and muscarinic antipsychotics for acute schizophrenia: a network meta-analysis of randomised controlled trials indexed in international English and Chinese databases.
作者: Johannes Schneider-Thoma.;Yikang Zhu.;Mengchang Qin.;Yu Dong.;Shiwei Guan.;Jiaxi Wang.;Jing Tian.;Xiao Lin.;Alessandro Rodolico.;Spyridon Siafis.;Irene Bighelli.;Melanie Wehner.;Christina Veith.;Felix Krayer.;Elfriede Scheuring.;John M Davis.;Josef Priller.;Adriani Nikolakopoulou.;Georgia Salanti.;Chunbo Li.;Stefan Leucht.
来源: Lancet. 2026年407卷10531期876-891页
Antipsychotic drugs are the established treatment for acute schizophrenia but differ in receptor-binding profiles. In 2024, a new-in-class muscarinic receptor agonist (xanomeline-trospium) was licenced, acting upstream of antidopaminergic agents, and providing hope to decrease the adverse effects burden of antipsychotics. We aimed to compare the efficacy and tolerability of antipsychotics by performing network meta-analysis of randomised controlled trials (RCTs).
3. Disease burden attributable to intimate partner violence against females and sexual violence against children in 204 countries and territories, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both national and global levels.
4. The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis.
作者: Toby Pillinger.;Atheeshaan Arumuham.;Robert A McCutcheon.;Enrico D'Ambrosio.;Georgios Basdanis.;Marco Branco.;Richard Carr.;Valeria Finelli.;Toshi A Furukawa.;Siobhan Gee.;Adrian Heald.;Sameer Jauhar.;Zihan Ma.;Valentina Mancini.;Calum Moulton.;Georgia Salanti.;David M Taylor.;Anneka Tomlinson.;Allan H Young.;Orestis Efthimiou.;Oliver D Howes.;Andrea Cipriani.
来源: Lancet. 2025年406卷10515期2063-2077页
Antidepressants induce physiological alterations; however, the degree to which these occur in treatment with various antidepressants is unclear. We aimed to compare and rank antidepressants based on physiological side-effects by synthesising data from randomised controlled trials (RCTs).
5. Parent-focused behavioural interventions for the prevention of early childhood obesity (TOPCHILD): a systematic review and individual participant data meta-analysis.
作者: Kylie E Hunter.;David Nguyen.;Sol Libesman.;Jonathan G Williams.;Mason Aberoumand.;Jannik Aagerup.;Brittany J Johnson.;Rebecca K Golley.;Angie Barba.;James X Sotiropoulos.;Nipun Shrestha.;Talia Palacios.;Samantha J Pryde.;Luke Wolfenden.;Rachael W Taylor.;Peter J Godolphin.;Karen Matvienko-Sikar.;Lee M Sanders.;Kristy P Robledo.;Vicki Brown.;Charles T Wood.;Sarah Taki.;H Shonna Yin.;Alison J Hayes.;Denise A O'Connor.;Wendy Smith.;David E Espinoza.;Lisa Askie.;Paul M Chadwick.;Chris Rissel.;Angela C Webster.;Kylie D Hesketh.;Maria Bryant.;Jessica L Thomson.;Rajalakshmi Lakshman.;Alexander G Fiks.;Christine Helle.;Cathleen Odar Stough.;Ken K Ong.;Eliana M Perrin.;Levie Karssen.;Junilla K Larsen.;Ana M Linares.;Mary Jo Messito.;Li Ming Wen.;Emily Oken.;Nina Cecilie Øverby.;Cristina Palacios.;Ian M Paul.;Finn E Rasmussen.;Elizabeth A Reifsnider.;Russell L Rothman.;Rebecca A Byrne.;Tiffany M Rybak.;Sarah-Jeanne Salvy.;Heather M Wasser.;Amanda L Thompson.;Ata Ghaderi.;Barry J Taylor.;Claudio Maffeis.;Huilan Xu.;Jennifer S Savage.;Kaumudi J Joshipura.;Kayla de la Haye.;Margrethe Røed.;Bethan Copsey.;Natalia Golova.;Rachel S Gross.;Stephanie Anzman-Frasca.;Jinan Banna.;Louise A Baur.;Anna Lene Seidler.; .
来源: Lancet. 2025年406卷10509期1235-1254页
Childhood obesity is a global public health issue, which has prompted governments to invest in prevention programmes. We aimed to investigate the effectiveness of parent-focused early childhood obesity prevention interventions globally.
6. Estimating the effect of maternal viral load on perinatal and postnatal HIV transmission: a systematic review and meta-analysis.
作者: Caitlin M Dugdale.;Ogochukwu Ufio.;John Giardina.;Fatma Shebl.;Elif Coskun.;Eden Pletner.;Pamela R Torola.;Duru Cosar.;Roger Shapiro.;Maria Kim.;Lynne Mofenson.;Andrea L Ciaranello.
来源: Lancet. 2025年406卷10501期349-357页
Although a growing body of evidence supports zero risk of sexual HIV transmission from a person with sustained virological suppression, known as U=U (undetectable equals untransmittable), data have been insufficient to determine whether this is also true for vertical HIV transmission. We conducted a systematic review and meta-analysis to quantify vertical transmission risk by maternal HIV viral load (mHVL) and to evaluate the applicability of U=U to perinatal and postnatal HIV transmission.
7. Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST).
作者: Hakim-Moulay Dehbi.;Urs Fischer.;Signild Åsberg.;Truman J Milling.;Stefanie Abend.;Norin Ahmed.;Mattia Branca.;Lisa A Davis.;Stefan T Engelter.;Nick Freemantle.;Thomas Gattringer.;Tatevik Ghukasyan Lakic.;Ziad Hijazi.;Martin James.;Masatoshi Koga.;Patrick Lawrence.;Robin Lemmens.;Gregory Y H Lip.;Susan Massingham.;Philip S Nash.;Amalia Ndoutoumou.;Bo Norrving.;Georgia Salanti.;Nikola Sprigg.;Götz Thomalla.;Tishok Vanniyasingam.;Per Wester.;Steven J Warach.;Jonas Oldgren.;Jesse Dawson.;David J Werring.
来源: Lancet. 2025年406卷10498期43-51页
The optimal timing of oral anticoagulation for prevention of early ischaemic stroke recurrence in people with acute ischaemic stroke and atrial fibrillation remains uncertain. We aimed to estimate the effects of starting a direct oral anticoagulant (DOAC) early (≤4 days) versus later (≥5 days) after onset of ischaemic stroke.
8. Causes of and risk factors for postpartum haemorrhage: a systematic review and meta-analysis.
作者: Idnan Yunas.;Md Asiful Islam.;Kulandaipalayam N Sindhu.;Adam J Devall.;Marcelina Podesek.;Sayeda Sadia Alam.;Shoumik Kundu.;Kristie-Marie Mammoliti.;Ashraf Aswat.;Malcolm J Price.;Javier Zamora.;Olufemi T Oladapo.;Ioannis Gallos.;Arri Coomarasamy.
来源: Lancet. 2025年405卷10488期1468-1480页
An understanding of the causes of postpartum haemorrhage is needed to provide appropriate treatment and services. Knowledge of the risk factors for postpartum haemorrhage can help address modifiable risk factors. We did a systematic review and meta-analysis to identify and quantify the various causes and risk factors for postpartum haemorrhage.
9. Tranexamic acid for postpartum bleeding: a systematic review and individual patient data meta-analysis of randomised controlled trials.
作者: Katharine Ker.;Loïc Sentilhes.;Haleema Shakur-Still.;Hugo Madar.;Catherine Deneux-Tharaux.;George Saade.;Luis D Pacheco.;François-Xavier Ageron.;Raoul Mansukhani.;Eni Balogun.;Amy Brenner.;Danielle Prowse.;Monica Arribas.;Homa Ahmadzia.;Rizwana Chaudhri.;Oladapo Olayemi.;Ian Roberts.; .
来源: Lancet. 2024年404卷10463期1657-1667页
Tranexamic acid is a recommended treatment for women with a clinical diagnosis of postpartum haemorrhage, but whether it can prevent bleeding is unclear. We conducted a systematic review and individual patient data (IPD) meta-analysis of randomised controlled trials to assess the effects of tranexamic acid in women giving birth.
10. Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis.
作者: Yunli Zhao.;Ya Gao.;Gordon Guyatt.;Timothy M Uyeki.;Ping Liu.;Ming Liu.;Yanjiao Shen.;Xiaoyan Chen.;Shuyue Luo.;Xingsheng Li.;Rongzhong Huang.;Qiukui Hao.
来源: Lancet. 2024年404卷10454期764-772页
Antiviral post-exposure prophylaxis with neuraminidase inhibitors can reduce the incidence of influenza and the risk of symptomatic influenza, but the efficacy of the other classes of antiviral remains unclear. To support an update of WHO influenza guidelines, this systematic review and network meta-analysis evaluated antiviral drugs for post-exposure prophylaxis of influenza.
11. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials.
作者: Ya Gao.;Gordon Guyatt.;Timothy M Uyeki.;Ming Liu.;Yamin Chen.;Yunli Zhao.;Yanjiao Shen.;Jianguo Xu.;Qingyong Zheng.;Zhifan Li.;Wanyu Zhao.;Shuyue Luo.;Xiaoyan Chen.;Jinhui Tian.;Qiukui Hao.
来源: Lancet. 2024年404卷10454期753-763页
The optimal antiviral drug for treatment of severe influenza remains unclear. To support updated WHO influenza clinical guidelines, this systematic review and network meta-analysis evaluated antivirals for treatment of patients with severe influenza.
12. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data.
作者: Xin Wang.;You Li.;Ting Shi.;Louis J Bont.;Helen Y Chu.;Heather J Zar.;Bhanu Wahi-Singh.;Yiming Ma.;Bingbing Cong.;Emma Sharland.;Richard D Riley.;Jikui Deng.;Josep Figueras-Aloy.;Terho Heikkinen.;Marcus H Jones.;Johannes G Liese.;Joško Markić.;Asuncion Mejias.;Marta C Nunes.;Bernhard Resch.;Ashish Satav.;Kee Thai Yeo.;Eric A F Simões.;Harish Nair.; .; .
来源: Lancet. 2024年403卷10433期1241-1253页
Infants and young children born prematurely are at high risk of severe acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study, we aimed to assess the global disease burden of and risk factors for RSV-associated ALRI in infants and young children born before 37 weeks of gestation.
13. The risk of sexual transmission of HIV in individuals with low-level HIV viraemia: a systematic review.
The risk of sexual transmission of HIV from individuals with low-level HIV viraemia receiving antiretroviral therapy (ART) has important public health implications, especially in resource-limited settings that use alternatives to plasma-based viral load testing. This Article summarises the evidence related to sexual transmission of HIV at varying HIV viral load levels to inform messaging for people living with HIV, their partners, their health-care providers, and the wider public.
14. Effectiveness of handwashing with soap for preventing acute respiratory infections in low-income and middle-income countries: a systematic review and meta-analysis.
作者: Ian Ross.;Sarah Bick.;Philip Ayieko.;Robert Dreibelbis.;Jennyfer Wolf.;Matthew C Freeman.;Elizabeth Allen.;Michael Brauer.;Oliver Cumming.
来源: Lancet. 2023年401卷10389期1681-1690页
Acute respiratory infection (ARI) is a leading cause of morbidity and mortality globally, with 83% of ARI mortality occurring in low-income and middle-income countries (LMICs) before the COVID-19 pandemic. We aimed to estimate the effect of interventions promoting handwashing with soap on ARI in LMICs.
15. Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis.
Understanding the level and characteristics of protection from past SARS-CoV-2 infection against subsequent re-infection, symptomatic COVID-19 disease, and severe disease is essential for predicting future potential disease burden, for designing policies that restrict travel or access to venues where there is a high risk of transmission, and for informing choices about when to receive vaccine doses. We aimed to systematically synthesise studies to estimate protection from past infection by variant, and where data allow, by time since infection.
16. Food insecurity among pregnant women living in high-income countries: a systematic review.
作者: Gemma Andreae.;Stephanie Scott.;Giang Nguyen.;Zoë Bell.;Hannah Mehmood.;Letitia Sermin-Reed.;Nicola Heslehurst.
来源: Lancet. 2022年400 Suppl 1卷S17页
Food insecurity is an increasingly important public health concern in high-income countries following the 2008 global financial crash, and recently with the COVID-19 pandemic. Food insecurity has been understood as a highly gendered issue, affecting more women than men. As women have more complex nutritional needs because of their menstrual cycle, pregnancy, and breastfeeding, the nutritional impact of food insecurity is also greater for women than for men. This systematic review aims to explore pregnant women's experiences of food insecurity in high-income countries and to understand how food insecurity affects their health, wellbeing, diet, and nutrition.
17. Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis.
作者: Makoto Saito.;Rose McGready.;Halidou Tinto.;Toussaint Rouamba.;Dominic Mosha.;Stephen Rulisa.;Simon Kariuki.;Meghna Desai.;Christine Manyando.;Eric M Njunju.;Esperanca Sevene.;Anifa Vala.;Orvalho Augusto.;Christine Clerk.;Edwin Were.;Sigilbert Mrema.;William Kisinza.;Josaphat Byamugisha.;Mike Kagawa.;Jan Singlovic.;Mackensie Yore.;Anna Maria van Eijk.;Ushma Mehta.;Andy Stergachis.;Jenny Hill.;Kasia Stepniewska.;Melba Gomes.;Philippe J Guérin.;Francois Nosten.;Feiko O Ter Kuile.;Stephanie Dellicour.
来源: Lancet. 2023年401卷10371期118-130页
Malaria in the first trimester of pregnancy is associated with adverse pregnancy outcomes. Artemisinin-based combination therapies (ACTs) are a highly effective, first-line treatment for uncomplicated Plasmodium falciparum malaria, except in the first trimester of pregnancy, when quinine with clindamycin is recommended due to concerns about the potential embryotoxicity of artemisinins. We compared adverse pregnancy outcomes after artemisinin-based treatment (ABT) versus non-ABTs in the first trimester of pregnancy.
18. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.
Large trials have shown that sodium glucose co-transporter-2 (SGLT2) inhibitors reduce the risk of adverse kidney and cardiovascular outcomes in patients with heart failure or chronic kidney disease, or with type 2 diabetes and high risk of atherosclerotic cardiovascular disease. None of the trials recruiting patients with and without diabetes were designed to assess outcomes separately in patients without diabetes.
19. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis.
作者: Franco De Crescenzo.;Gian Loreto D'Alò.;Edoardo G Ostinelli.;Marco Ciabattini.;Valeria Di Franco.;Norio Watanabe.;Ayse Kurtulmus.;Anneka Tomlinson.;Zuzana Mitrova.;Francesca Foti.;Cinzia Del Giovane.;Digby J Quested.;Phil J Cowen.;Corrado Barbui.;Laura Amato.;Orestis Efthimiou.;Andrea Cipriani.
来源: Lancet. 2022年400卷10347期170-184页
Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. We aimed to estimate the comparative effectiveness of pharmacological treatments for the acute and long-term treatment of adults with insomnia disorder.
20. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis.
作者: Jennyfer Wolf.;Sydney Hubbard.;Michael Brauer.;Argaw Ambelu.;Benjamin F Arnold.;Robert Bain.;Valerie Bauza.;Joe Brown.;Bethany A Caruso.;Thomas Clasen.;John M Colford.;Matthew C Freeman.;Bruce Gordon.;Richard B Johnston.;Andrew Mertens.;Annette Prüss-Ustün.;Ian Ross.;Jeffrey Stanaway.;Jeff T Zhao.;Oliver Cumming.;Sophie Boisson.
来源: Lancet. 2022年400卷10345期48-59页
Estimates of the effectiveness of water, sanitation, and hygiene (WASH) interventions that provide high levels of service on childhood diarrhoea are scarce. We aimed to provide up-to-date estimates on the burden of disease attributable to WASH and on the effects of different types of WASH interventions on childhood diarrhoea in low-income and middle-income countries (LMICs).
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