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1. Interventions to Improve Adherence to Clinical Guidelines for the Management and Follow-Up of Pulmonary Nodules: A Systematic Review.
作者: Justin Aunger.;Kay Por Yip.;Kamen Dosanjh.;Katie Scandrett.;Bianca Ungureanu.;Michael Newnham.;Alice M Turner.
来源: Chest. 2025年168卷1期248-268页
Lung cancer is the leading cause of global cancer mortality. It is also the third most common cancer in the United Kingdom and the most prevalent worldwide. Pulmonary nodules can indicate early-stage lung cancer, but adherence to guidelines for radiologic surveillance is suboptimal, which affects early detection and treatment. Although interventions have been developed to improve follow-up, it remains unclear which approaches are most effective.
2. The Efficacy and Safety of Inhaled Antibiotics for the Treatment of Bronchiectasis in Adults: Updated Systematic Review and Meta-Analysis.
作者: Ricardo Cordeiro.;Hayoung Choi.;Charles S Haworth.;James D Chalmers.
来源: Chest. 2024年166卷1期61-80页
Inhaled antibiotics are recommended conditionally by international bronchiectasis guidelines for the treatment of patients with bronchiectasis, but results of individual studies are inconsistent. A previous meta-analysis demonstrated promising results regarding the efficacy and safety of inhaled antibiotics in bronchiectasis. Subsequent publications have supplemented the existing body of evidence further in this area.
3. Recurrence-Free Survival in Patients With Surgically Resected Non-Small Cell Lung Cancer: A Systematic Literature Review and Meta-Analysis.
作者: Ravi Rajaram.;Qing Huang.;Richard Z Li.;Urmila Chandran.;Yuxin Zhang.;Tony B Amos.;George W J Wright.;Nicole C Ferko.;Iftekhar Kalsekar.
来源: Chest. 2024年165卷5期1260-1270页
Standard treatment for early-stage or locoregionally advanced non-small cell lung cancer (NSCLC) includes surgical resection. Recurrence after surgery is commonly reported, but a summary estimate for postsurgical recurrence-free survival (RFS) in patients with NSCLC is lacking.
4. Accuracy of Cytologic vs Histologic Specimens for Assessment of Programmed Cell Death Ligand-1 Expression in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
作者: Pattraporn Tajarernmuang.;Felipe Aliaga.;Amr J Alwakeel.;Gamuchirai Tavaziva.;Kimberly Turner.;Dick Menzies.;Hangjun Wang.;Linda Ofiara.;Andrea Benedetti.;Anne V Gonzalez.
来源: Chest. 2024年165卷2期461-474页
Programmed cell death ligand-1 (PD-L1) expression on tumor cells, evaluated by immunohistochemistry, guides the use of immunotherapy in advanced non-small cell lung cancer (NSCLC).
5. Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?: A Systematic Review and Meta-Analysis.
作者: Aishwarya Lakshmi Vidyasagaran.;Anne Readshaw.;Melanie Boeckmann.;Alexander Jarde.;Faraz Siddiqui.;Anna-Marie Marshall.;Janita Akram.;Jonathan E Golub.;Kamran Siddiqi.;Omara Dogar.
来源: Chest. 2024年165卷1期22-47页
Associations between tobacco use and poor TB treatment outcomes are well documented. However, for important outcomes such as TB recurrence or relapse and mortality during treatment, as well as for associations with smokeless tobacco (ST), the evidence is not summarized systematically.
6. Risk Factors for Nontuberculous Mycobacterial Pulmonary Disease: A Systematic Literature Review and Meta-Analysis.
作者: Michael R Loebinger.;Jennifer K Quint.;Roald van der Laan.;Marko Obradovic.;Rajinder Chawla.;Amit Kishore.;Jakko van Ingen.
来源: Chest. 2023年164卷5期1115-1124页
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is widely underdiagnosed, and certain patient groups, such as those with underlying respiratory diseases, are at increased risk of developing the disease. Understanding patients at risk is essential to allow for prompt testing and diagnosis and appropriate management to prevent disease progression.
7. Effectiveness of Flexible Bronchoscopy Simulation-Based Training: A Systematic Review.
作者: Eveline C F Gerretsen.;Aoben Chen.;Jouke T Annema.;Marleen Groenier.;Erik H F M van der Heijden.;Walther N K A van Mook.;Frank W J M Smeenk.
来源: Chest. 2023年164卷4期952-962页
The implementation of simulation-based training (SBT) to teach flexible bronchoscopy (FB) skills to novice trainees has increased during the last decade. However, it is unknown whether SBT is effective to teach FB to novices and which instructional features contribute to training effectiveness.
8. Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis.
作者: Praleene Sivapalan.;Karen L Ellekjaer.;Marie K Jessen.;Tine S Meyhoff.;Maria Cronhjort.;Peter B Hjortrup.;Jørn Wetterslev.;Anders Granholm.;Morten H Møller.;Anders Perner.
来源: Chest. 2023年164卷4期892-912页
IV fluids are recommended for adults with sepsis. However, the optimal strategy for IV fluid management in sepsis is unknown, and clinical equipoise exists.
9. Monocyte Distribution Width as a Diagnostic Marker for Infection: A Systematic Review and Meta-analysis.
作者: Alexandra Malinovska.;Benjamin Hernried.;Andrew Lin.;Oluwakemi Badaki-Makun.;Katherine Fenstermacher.;Ann Margret Ervin.;Stephan Ehrhardt.;Scott Levin.;Jeremiah S Hinson.
来源: Chest. 2023年164卷1期101-113页
Monocyte distribution width (MDW) is an emerging biomarker for infection. It is available easily and quickly as part of the CBC count, which is performed routinely on hospital admission. The increasing availability and promising results of MDW as a biomarker in sepsis has prompted an expansion of its use to other infectious diseases.
10. Diagnostic Test Accuracy of Lung Ultrasound for Acute Chest Syndrome in Sickle Cell Disease: A Systematic Review and Meta-analysis.
作者: Mahmoud Omar.;Abdur Rahman Jabir.;Imadh Khan.;Enrico M Novelli.;Julia Z Xu.
来源: Chest. 2023年163卷6期1506-1518页
Acute chest syndrome (ACS) is a leading cause of death in patients with sickle cell disease. Lung ultrasound (LUS) is emerging as a point-of-care method to diagnose ACS, allowing for more rapid diagnosis in the ED setting and sparing patients from ionizing radiation exposure.
11. Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.
作者: Naveed Saleem.;Adarsh Kulkarni.;Timothy Arthur Chandos Snow.;Gareth Ambler.;Mervyn Singer.;Nishkantha Arulkumaran.
来源: Chest. 2023年163卷3期484-497页
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. Corticosteroids may be a beneficial adjunct in the treatment of bacterial pneumonia.
12. Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis.
作者: Daniel O Thomas-Rüddel.;Peter Schlattmann.;Mathias Pletz.;Oliver Kurzai.;Frank Bloos.
来源: Chest. 2022年161卷2期345-355页
Current guidelines recommend empirical antifungal therapy in patients with sepsis with high risk of invasive Candida infection. However, many different risk factors have been derived from multiple studies. These risk factors lack specificity, and broad application would render most ICU patients eligible for empirical antifungal therapy.
13. Systematic Review of Ozone Effects on Human Lung Function, 2013 Through 2020.
Ozone effects on lung function are particularly important to understand in the context of the air pollution-health outcomes epidemiologic literature, given the complex relationships between ozone and other air pollutants with known lung function effects.
14. Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation: A Systematic Review and Meta-analysis of Randomized Trials.
作者: Kimberley Lewis.;Joshua Piticaru.;Dipayan Chaudhuri.;John Basmaji.;Eddy Fan.;Morten Hylander Møller.;John W Devlin.;Waleed Alhazzani.
来源: Chest. 2021年159卷6期2274-2288页
Although clinical studies have evaluated dexmedetomidine as a strategy to improve noninvasive ventilation (NIV) comfort and tolerance in patients with acute respiratory failure (ARF), their results have not been summarized.
15. Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis.
作者: David Jiménez.;Aldara García-Sanchez.;Parth Rali.;Alfonso Muriel.;Behnood Bikdeli.;Pedro Ruiz-Artacho.;Raphael Le Mao.;Carmen Rodríguez.;Beverley J Hunt.;Manuel Monreal.
来源: Chest. 2021年159卷3期1182-1196页
Individual studies have reported widely variable rates for VTE and bleeding among hospitalized patients with coronavirus disease 2019 (COVID-19).
16. Impact of Corticosteroids in Coronavirus Disease 2019 Outcomes: Systematic Review and Meta-analysis.
作者: Edison J Cano.;Xavier Fonseca Fuentes.;Cristina Corsini Campioli.;John C O'Horo.;Omar Abu Saleh.;Yewande Odeyemi.;Hemang Yadav.;Zelalem Temesgen.
来源: Chest. 2021年159卷3期1019-1040页
Since its appearance in late 2019, infections caused by severe acute respiratory syndrome coronavirus 2 have created unprecedented challenges for health systems worldwide. Multiple therapeutic options have been explored, including corticosteroids. Preliminary results of corticosteroids in coronavirus disease 2019 (COVID-19) are encouraging; however, the role of corticosteroids remains controversial.
17. Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU: A Systematic Review and Meta-analysis.
The coronavirus disease 2019 (COVID-19) pandemic has placed unprecedented burden on the delivery of intensive care services worldwide.
18. Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review.
作者: Lida P Hariri.;Crystal M North.;Angela R Shih.;Rebecca A Israel.;Jason H Maley.;Julian A Villalba.;Vladimir Vinarsky.;Jonah Rubin.;Daniel A Okin.;Alyssa Sclafani.;Jehan W Alladina.;Jason W Griffith.;Michael A Gillette.;Yuval Raz.;Christopher J Richards.;Alexandra K Wong.;Amy Ly.;Yin P Hung.;Raghu R Chivukula.;Camille R Petri.;Tiara F Calhoun.;Laura N Brenner.;Kathryn A Hibbert.;Benjamin D Medoff.;C Corey Hardin.;James R Stone.;Mari Mino-Kenudson.
来源: Chest. 2021年159卷1期73-84页
Patients with severe coronavirus disease 2019 (COVID-19) have respiratory failure with hypoxemia and acute bilateral pulmonary infiltrates, consistent with ARDS. Respiratory failure in COVID-19 might represent a novel pathologic entity.
19. Acetazolamide for OSA and Central Sleep Apnea: A Comprehensive Systematic Review and Meta-Analysis.
作者: Christopher N Schmickl.;Shane A Landry.;Jeremy E Orr.;Kazuo Chin.;Kimihiko Murase.;Johan Verbraecken.;Shahrokh Javaheri.;Bradley A Edwards.;Robert L Owens.;Atul Malhotra.
来源: Chest. 2020年158卷6期2632-2645页
Therapy options for OSA and central sleep apnea (CSA) are limited, thus many patients remain untreated. Clinically, acetazolamide is sometimes used for CSA; however, given overlapping pathophysiologic properties of OSA and CSA, we hypothesized that acetazolamide is equally effective for both types. Prior reviews focused on specific subtypes of sleep apnea, study designs, and languages, thus including few studies (typically ≤3) limiting insights.
20. Evidence-Based Practices for Acute Respiratory Failure and Acute Respiratory Distress Syndrome: A Systematic Review of Reviews.
作者: Jennifer N Ervin.;Victor C Rentes.;Emily R Dibble.;Michael W Sjoding.;Theodore J Iwashyna.;Catherine L Hough.;Michelle Ng Gong.;Anne E Sales.
来源: Chest. 2020年158卷6期2381-2393页
The recent pandemic highlights the essential nature of optimizing the use of invasive mechanical ventilation (IMV) in complex critical care settings. This review of reviews maps evidence-based practices (EBPs) that are associated with better outcomes among adult patients with acute respiratory failure or ARDS on the continuum of care, from intubation to liberation.
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