当前位置: 首页 >> 检索结果
1. Effect of Social Vulnerability on Efficacy of Bariatric Surgery Versus Medical and Lifestyle Intervention for Type 2 Diabetes: Analysis of the ARMMS-T2D Consortium of Randomized Trials.
作者: Mary Elizabeth Patti.;Bo Hu.;Sarah Kirschling.;Hanna J Wang.;Kathleen Foster.;Yael Sarig.;Donald C Simonson.;Danielle Wolfs.;David Arterburn.;Matthew J O'Brien.;Ashley H Vernon.;John M Jakicic.;Lori Laffel.;Sando Ojukwu.;Sangeeta R Kashyap.;Ali Aminian.;Philip R Schauer.;David E Cummings.;William F Gourash.;Anita Courcoulas.;John P Kirwan.
来源: Ann Intern Med. 2026年179卷3期353-361页
Social determinants of health (SDOH) can affect metabolic health.
2. Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.
作者: Eteri Machavariani.;Denise Esserman.;Kostyantyn Dumchev.;Myroslava Filippovych.;Iryna Pykalo.;Roman Ivasiy.;Lynn M Madden.;Daniel J Bromberg.;Marwan Haddad.;Olga Morozova.;David Oliveros.;Bachar Ahmad.;Sergii Dvoriak.;Frederick L Altice.
来源: Ann Intern Med. 2026年179卷2期177-186页
Opioid use disorder (OUD) drives high morbidity and mortality, but access to opioid agonist therapy (OAT) is limited in low- and middle-income countries. Integrating OAT into primary care may expand access and improve comorbidity management, although provider discomfort remains a barrier.
3. High Frequency of Chronic Urticaria Following an Investigational HIV-1 BG505 MD39.3 Trimer mRNA Vaccine in a Phase 1, Randomized, Open-Label Clinical Trial (HVTN 302).
作者: Sharon A Riddler.;Zoe Moodie.;Jesse Clark.;Catherine Yen.;Mary Allen.;Briana D Furch.;Huiyin Lu.;Shannon Grant.;Kajari Mondal.;Maija Anderson.;Janine Maenza.;Maria P Lemos.;Amanda S Woodward Davis.;Stephen R Walsh.;Magdalena E Sobieszczyk.;Ian Frank.;Paul Goepfert.;Kathryn E Stephenson.;Lindsey R Baden.;Hong-Van Tieu.;Michael C Keefer.;M Juliana McElrath.;James G Kublin.;Lawrence Corey.
来源: Ann Intern Med. 2025年178卷7期963-974页
The mRNA platform is under investigation for many vaccines, including HIV-1 vaccines.
4. The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial.
作者: Victoria A Catenacci.;Danielle M Ostendorf.;Zhaoxing Pan.;Laura K Kaizer.;Seth A Creasy.;Adnin Zaman.;Ann E Caldwell.;Jared Dahle.;Bryan Swanson.;Matthew J Breit.;Kristen Bing.;Liza T Wayland.;Shelby L Panter.;Jared J Scorsone.;Daniel H Bessesen.;Paul MacLean.;Edward L Melanson.
来源: Ann Intern Med. 2025年178卷5期634-644页
Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.
5. Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial.
作者: Gloria D Coronado.;Amanda F Petrik.;Jamie H Thompson.;Michael C Leo.;Matthew Slaughter.;Priyanka Gautom.;Syed A Hussain.;Leslie Mosso.;Jeffrey Gibbs.;Neha Yadav.;Rajasekhara R Mummadi.;Eric S Johnson.;Ricardo Jimenez.
来源: Ann Intern Med. 2025年178卷5期645-654页
Patient navigation is a recommended practice of the Guide to Community Preventive Services; little is known about whether it improves colonoscopy completion for adults who have received an abnormal stool test result.
6. The Effect of the "Safety in Dementia" Online Tool to Assist Decision Making for Caregivers of Persons With Dementia and Access to Firearms : A Randomized Trial.
作者: Marian E Betz.;Jennifer Portz.;Christopher Knoepke.;Megan L Ranney.;Stacy M Fischer.;Ryan A Peterson.;Rachel L Johnson.;Faris Omeragic.;Mirella Castaneda.;Emily Greenway.;Daniel Matlock.
来源: Ann Intern Med. 2024年177卷12期1630-1640页
Caregivers face challenges (including competing desires to prevent injury, respect autonomy, and avoid conflict) when addressing firearm access by community-dwelling persons with Alzheimer disease and related dementias (ADRD).
7. Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.
作者: Kathleen V Fitch.;Markella V Zanni.;Jennifer Manne-Goehler.;Marissa R Diggs.;Arijeet K Gattu.;Judith S Currier.;Gerald S Bloomfield.;Chiu-Bin Hsiao.;Samir K Gupta.;Judith A Aberg.;Carlos D Malvestutto.;Carl J Fichtenbaum.;Michael T Lu.;Pamela S Douglas.;Heather J Ribaudo.;Steven K Grinspoon.
来源: Ann Intern Med. 2024年177卷11期1449-1461页
REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) led to new guidelines for statin use among people with HIV (PWH) with low to moderate risk for atherosclerotic cardiovascular disease (ASCVD). Little is known about the natural history of diabetes mellitus (DM) or mechanisms contributing to statin effects on DM among this population.
8. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
作者: Gerard T Portela.;Jeffrey L Carson.;Sonja A Swanson.;John H Alexander.;Paul C Hébert.;Shaun G Goodman.;Philippe Gabriel Steg.;Marnie Bertolet.;Jordan B Strom.;Dean A Fergusson.;Tabassome Simon.;Harvey D White.;Howard A Cooper.;J Dawn Abbott.;Sunil V Rao.;Bernard R Chaitman.;Christopher B Fordyce.;Renato D Lopes.;Benoit Daneault.;Maria M Brooks.; .
来源: Ann Intern Med. 2024年177卷11期1489-1498页
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.
9. Effectiveness of Integrating Suicide Care in Primary Care : Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial.
作者: Julie Angerhofer Richards.;Maricela Cruz.;Christine Stewart.;Amy K Lee.;Taylor C Ryan.;Brian K Ahmedani.;Gregory E Simon.
来源: Ann Intern Med. 2024年177卷11期1471-1481页
Primary care encounters are common among patients at risk for suicide.
10. Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.
作者: Emily N C Manoogian.;Michael J Wilkinson.;Monica O'Neal.;Kyla Laing.;Justina Nguyen.;David Van.;Ashley Rosander.;Aryana Pazargadi.;Nikko R Gutierrez.;Jason G Fleischer.;Shahrokh Golshan.;Satchidananda Panda.;Pam R Taub.
来源: Ann Intern Med. 2024年177卷11期1462-1470页
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
11. Efficacy of a Therapeutic Pelvic Yoga Program Versus a Physical Conditioning Program on Urinary Incontinence in Women : A Randomized Trial.
作者: Alison J Huang.;Margaret Chesney.;Michael Schembri.;Harini Raghunathan.;Eric Vittinghoff.;Wendy Berry Mendes.;Sarah Pawlowsky.;Leslee L Subak.
来源: Ann Intern Med. 2024年177卷10期1339-1349页
Pelvic floor yoga has been recommended as a complementary treatment strategy for urinary incontinence (UI) in women, but evidence of its efficacy is lacking.
12. A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2.
作者: Catharine I Paules.;Jing Wang.;Kay M Tomashek.;Tyler Bonnett.;Kanal Singh.;Vincent C Marconi.;Richard T Davey.;David C Lye.;Lori E Dodd.;Otto O Yang.;Constance A Benson.;Gregory A Deye.;Sarah B Doernberg.;Noreen A Hynes.;Robert Grossberg.;Cameron R Wolfe.;Seema U Nayak.;William R Short.;Jocelyn Voell.;Gail E Potter.;Rekha R Rapaka.
来源: Ann Intern Med. 2024年177卷3期343-352页
The ACTT risk profile, which was developed from ACTT-1 (Adaptive COVID-19 Treatment Trial-1), demonstrated that hospitalized patients with COVID-19 in the high-risk quartile (characterized by low absolute lymphocyte count [ALC], high absolute neutrophil count [ANC], and low platelet count at baseline) benefited most from treatment with the antiviral remdesivir. It is unknown which patient characteristics are associated with benefit from treatment with the immunomodulator baricitinib.
13. Reducing Care Overuse in Older Patients Using Professional Norms and Accountability : A Cluster Randomized Controlled Trial.
作者: Stephen D Persell.;Lucia C Petito.;Ji Young Lee.;Daniella Meeker.;Jason N Doctor.;Noah J Goldstein.;Craig R Fox.;Theresa A Rowe.;Jeffrey A Linder.;Ryan Chmiel.;Yaw Amofa Peprah.;Tiffany Brown.
来源: Ann Intern Med. 2024年177卷3期324-334页
Effective strategies are needed to curtail overuse that may lead to harm.
14. Blood Pressure Effect of Traffic-Related Air Pollution : A Crossover Trial of In-Vehicle Filtration.
作者: Michael T Young.;Karen Jansen.;Kristen E Cosselman.;Timothy R Gould.;James A Stewart.;Timothy Larson.;Coralynn Sack.;Sverre Vedal.;Adam A Szpiro.;Joel D Kaufman.
来源: Ann Intern Med. 2023年176卷12期1586-1594页
Ambient air pollution, including traffic-related air pollution (TRAP), increases cardiovascular disease risk, possibly through vascular alterations. Limited information exists about in-vehicle TRAP exposure and vascular changes.
15. Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease.
作者: William B Feldman.;Aaron S Kesselheim.;Jerry Avorn.;Massimiliano Russo.;Shirley V Wang.
来源: Ann Intern Med. 2023年176卷8期1047-1056页
In 2019, the U.S. Food and Drug Administration (FDA) approved the first generic maintenance inhaler for asthma and chronic obstructive pulmonary disease (COPD). The inhaler, Wixela Inhub (fluticasone-salmeterol; Viatris), is a substitutable version of the dry powder inhaler Advair Diskus (fluticasone-salmeterol; GlaxoSmithKline). When approving complex generic products like inhalers, the FDA applies a special "weight-of-evidence" approach. In this case, manufacturers were required to perform a randomized controlled trial in patients with asthma but not COPD, although the product received approval for both indications.
16. Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population : A Randomized Controlled Trial.
作者: Shuhao Lin.;Sofia Cienfuegos.;Mark Ezpeleta.;Kelsey Gabel.;Vasiliki Pavlou.;Andrea Mulas.;Kaitie Chakos.;Mara McStay.;Jackie Wu.;Lisa Tussing-Humphreys.;Shaina J Alexandria.;Julienne Sanchez.;Terry Unterman.;Krista A Varady.
来源: Ann Intern Med. 2023年176卷7期885-895页
Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited.
17. Effects of Implementation of a Supervised Walking Program in Veterans Affairs Hospitals : A Stepped-Wedge, Cluster Randomized Trial.
作者: Susan N Hastings.;Karen M Stechuchak.;Ashley Choate.;Courtney Harold Van Houtven.;Kelli D Allen.;Virginia Wang.;Cathleen Colón-Emeric.;George L Jackson.;Teresa M Damush.;Cassie Meyer.;Caitlin B Kappler.;Helen Hoenig.;Nina Sperber.;Cynthia J Coffman.
来源: Ann Intern Med. 2023年176卷6期743-750页
In trials, hospital walking programs have been shown to improve functional ability after discharge, but little evidence exists about their effectiveness under routine practice conditions.
18. Population-Wide Screening for Chronic Kidney Disease : A Cost-Effectiveness Analysis.
作者: Marika M Cusick.;Rebecca L Tisdale.;Glenn M Chertow.;Douglas K Owens.;Jeremy D Goldhaber-Fiebert.
来源: Ann Intern Med. 2023年176卷6期788-797页
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have the potential to alter the natural history of chronic kidney disease (CKD), and they should be included in cost-effectiveness analyses of screening for CKD.
19. Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 : A Randomized Platform Trial.
作者: Gilmar Reis.;Eduardo Augusto Dos Santos Moreira Silva.;Daniela Carla Medeiros Silva.;Lehana Thabane.;Vitoria Helena de Souza Campos.;Thiago Santiago Ferreira.;Castilho Vitor Quirino Dos Santos.;Ana Maria Ribeiro Nogueira.;Ana Paula Figueiredo Guimaraes Almeida.;Leonardo Cançado Monteiro Savassi.;Adhemar Dias de Figueiredo Neto.;Carina Bitarães.;Aline Cruz Milagres.;Eduardo Diniz Callegari.;Maria Izabel Campos Simplicio.;Luciene Barra Ribeiro.;Rosemary Oliveira.;Ofir Harari.;Lindsay A Wilson.;Jamie I Forrest.;Hinda Ruton.;Sheila Sprague.;Paula McKay.;Christina M Guo.;Gordon H Guyatt.;Craig R Rayner.;David R Boulware.;Nicole Ezer.;Todd C Lee.;Emily Gibson McDonald.;Mona Bafadhel.;Christopher Butler.;Josue Rodrigues Silva.;Mark Dybul.;Edward J Mills.; .
来源: Ann Intern Med. 2023年176卷5期667-675页
Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19.
20. Safety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19.
作者: Teresa H Evering.;Kara W Chew.;Mark J Giganti.;Carlee Moser.;Mauricio Pinilla.;David Alain Wohl.;Judith S Currier.;Joseph J Eron.;Arzhang Cyrus Javan.;Rachel Bender Ignacio.;David Margolis.;Qing Zhu.;Ji Ma.;Lijie Zhong.;Li Yan.;Ulises D'Andrea Nores.;Keila Hoover.;Bharat Mocherla.;Manish C Choudhary.;Rinki Deo.;Justin Ritz.;William A Fischer.;Courtney V Fletcher.;Jonathan Z Li.;Michael D Hughes.;Davey Smith.;Eric S Daar.; .
来源: Ann Intern Med. 2023年176卷5期658-666页
Development of safe and effective SARS-CoV-2 therapeutics is a high priority. Amubarvimab and romlusevimab are noncompeting anti-SARS-CoV-2 monoclonal antibodies with an extended half-life.
|