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1. The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis.
作者: Toby Pillinger.;Atheeshaan Arumuham.;Robert A McCutcheon.;Enrico D'Ambrosio.;Georgios Basdanis.;Marco Branco.;Richard Carr.;Valeria Finelli.;Toshi A Furukawa.;Siobhan Gee.;Adrian Heald.;Sameer Jauhar.;Zihan Ma.;Valentina Mancini.;Calum Moulton.;Georgia Salanti.;David M Taylor.;Anneka Tomlinson.;Allan H Young.;Orestis Efthimiou.;Oliver D Howes.;Andrea Cipriani.
来源: Lancet. 2025年406卷10515期2063-2077页
Antidepressants induce physiological alterations; however, the degree to which these occur in treatment with various antidepressants is unclear. We aimed to compare and rank antidepressants based on physiological side-effects by synthesising data from randomised controlled trials (RCTs).
2. Prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity: a WHO individual participant data meta-analysis.
作者: Ioannis Gallos.;Caitlin R Williams.;Malcolm J Price.;Aurelio Tobias.;Adam Devall.;John Allotey.;Fernando Althabe.;Jenny A Cresswell.;Jill Durocher.;A Metin Gülmezoglu.;Christian Haslinger.;Rodolfo C Pacagnella.;Loïc Sentilhes.;Soha Sobhy.;Idnan Yunas.;Jonathan J Deeks.;Arri Coomarasamy.;Olufemi T Oladapo.; .
来源: Lancet. 2025年406卷10514期1969-1982页
Postpartum haemorrhage (excessive bleeding after birth) is a leading cause of maternal mortality and morbidity worldwide. However, there is no global consensus on which clinical markers best define excessive bleeding or reliably predict adverse maternal outcomes. The aim of this study was to assess the prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity.
3. Parent-focused behavioural interventions for the prevention of early childhood obesity (TOPCHILD): a systematic review and individual participant data meta-analysis.
作者: Kylie E Hunter.;David Nguyen.;Sol Libesman.;Jonathan G Williams.;Mason Aberoumand.;Jannik Aagerup.;Brittany J Johnson.;Rebecca K Golley.;Angie Barba.;James X Sotiropoulos.;Nipun Shrestha.;Talia Palacios.;Samantha J Pryde.;Luke Wolfenden.;Rachael W Taylor.;Peter J Godolphin.;Karen Matvienko-Sikar.;Lee M Sanders.;Kristy P Robledo.;Vicki Brown.;Charles T Wood.;Sarah Taki.;H Shonna Yin.;Alison J Hayes.;Denise A O'Connor.;Wendy Smith.;David E Espinoza.;Lisa Askie.;Paul M Chadwick.;Chris Rissel.;Angela C Webster.;Kylie D Hesketh.;Maria Bryant.;Jessica L Thomson.;Rajalakshmi Lakshman.;Alexander G Fiks.;Christine Helle.;Cathleen Odar Stough.;Ken K Ong.;Eliana M Perrin.;Levie Karssen.;Junilla K Larsen.;Ana M Linares.;Mary Jo Messito.;Li Ming Wen.;Emily Oken.;Nina Cecilie Øverby.;Cristina Palacios.;Ian M Paul.;Finn E Rasmussen.;Elizabeth A Reifsnider.;Russell L Rothman.;Rebecca A Byrne.;Tiffany M Rybak.;Sarah-Jeanne Salvy.;Heather M Wasser.;Amanda L Thompson.;Ata Ghaderi.;Barry J Taylor.;Claudio Maffeis.;Huilan Xu.;Jennifer S Savage.;Kaumudi J Joshipura.;Kayla de la Haye.;Margrethe Røed.;Bethan Copsey.;Natalia Golova.;Rachel S Gross.;Stephanie Anzman-Frasca.;Jinan Banna.;Louise A Baur.;Anna Lene Seidler.; .
来源: Lancet. 2025年406卷10509期1235-1254页
Childhood obesity is a global public health issue, which has prompted governments to invest in prevention programmes. We aimed to investigate the effectiveness of parent-focused early childhood obesity prevention interventions globally.
4. Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis.
作者: Marco Valgimigli.;Ki Hong Choi.;Daniele Giacoppo.;Felice Gragnano.;Takeshi Kimura.;Hirotoshi Watanabe.;Hyo-Soo Kim.;Jeehoon Kang.;Kyung Woo Park.;Alf-Åge Pettersen.;Mark Woodward.;Deepak L Bhatt.;Paolo Calabrò.;Dominick J Angiolillo.;Roxana Mehran.;Young Bin Song.;Joo-Yong Hahn.
来源: Lancet. 2025年406卷10508期1091-1102页
Aspirin monotherapy is recommended indefinitely for patients with established coronary artery disease (CAD). The aim of this individual patient level meta-analysis was to provide a comprehensive evaluation of the comparative efficacy and safety of clopidogrel versus aspirin monotherapy in patients with established CAD, most of whom had undergone percutaneous coronary intervention or had acute coronary syndrome.
5. β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials.
作者: Xavier Rossello.;Eva Irene Bossano Prescott.;Anna Meta Dyrvig Kristensen.;Roberto Latini.;Valentin Fuster.;Morten Wang Fagerland.;Stuart J Pocock.;Sigrun Halvorsen.;Alberto Dominguez-Rodriguez.;Therese Lucia Friis Holmager.;Pedro Luis Sanchez.;Arnhild Bakken.;Sergio Raposeiras-Roubin.;Svend Eggert Jensen.;Takeshi Kimura.;Filippo Ottani.;Jess Lambrechtsen.;Manuel Anguita.;Neiko Ozasa.;Dan Atar.;Borja Ibanez.;John Munkhaugen.
来源: Lancet. 2025年406卷10508期1128-1137页
The effects of β-blocker therapy on clinical outcomes in patients with myocardial infarction and mildly reduced (40-49%) left ventricular ejection fraction (LVEF) are largely unknown. Four recently conducted randomised trials tested the efficacy of β blockers after a recent myocardial infarction in patients without reduced LVEF (LVEF ≥40%). However, none were individually powered to assess these effects in the subgroup of patients with mildly reduced LVEF. We aimed to assess the efficacy of β blockers in patients with myocardial infarction and mildly reduced LVEF during the index hospitalisation.
6. Blood pressure-lowering efficacy of antihypertensive drugs and their combinations: a systematic review and meta-analysis of randomised, double-blind, placebo-controlled trials.
作者: Nelson Wang.;Abdul Salam.;Rashmi Pant.;Amit Kumar.;Rupasvi Dhurjati.;Faraidoon Haghdoost.;Kota Vidyasagar.;Prachi Kaistha.;Hariprasad Esam.;Sonali R Gnanenthiran.;Raju Kanukula.;Paul K Whelton.;Brent Egan.;Aletta E Schutte.;Kazem Rahimi.;Otavio Berwanger.;Anthony Rodgers.
来源: Lancet. 2025年406卷10506期915-925页
We aimed to quantify the blood pressure-lowering efficacy of antihypertensive drugs and their combinations from the five major drug classes.
7. Safety and efficacy of steroidal mineralocorticoid receptor antagonists in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of randomised controlled trials.
作者: Lonnie Pyne.;Patrick Rossignol.;Cameron Giles.;Mats Junek.;Patrick B Mark.;Martin Gallagher.;Janak R de Zoysa.;P J Devereaux.;Michael Walsh.
来源: Lancet. 2025年406卷10505期811-820页
Mineralocorticoid receptor antagonists can prevent cardiovascular events in patients with heart failure and non-severe chronic kidney disease, but their effects in patients with kidney failure requiring dialysis are uncertain. We aimed to assess the efficacy and safety of mineralocorticoid receptor antagonists in this patient population.
8. Spironolactone in patients on chronic haemodialysis at high risk of adverse cardiovascular outcomes (ALCHEMIST): a multicentre, double-blind, randomised, placebo-controlled trial and updated meta-analysis.
作者: Patrick Rossignol.;Faiez Zannad.;Ziad Massy.;Michel Azizi.;Fatima Chorfa.;Julien Coadic.;João Pedro Ferreira.;Francisca Saraiva.;Dominique Mottier.;Francis Guillemin.;Willy Ngueyon Sime.;Sanae Bouali.;Bénédicte Rossignol.;Joëlle Nortier.;Isabelle Simon.;Christophe Robino.;Manuela Davin.;Pierre M Bataille.;François Chantrel.;Nelly Castin.;Vincent Esnault.;Isabelle Kazes.;Thierry Hannedouche.;Nassim Kamar.;Jean-Michel Achard.;Caroline Fenerol.;Carine Achard-Hottelart.;Yves Dimitrov.;Nicolas Girerd.;Delphine Maucourt-Boulch.;Luc Frimat.; .
来源: Lancet. 2025年406卷10504期705-718页
No pharmacological therapy has been shown with certainty to improve the cardiovascular prognosis in patients with kidney failure on chronic haemodialysis. We aimed to investigate the effects of the steroidal mineralocorticoid receptor antagonist spironolactone on cardiovascular outcomes in patients on haemodialysis who are at high risk of cardiovascular events.
9. Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy.
In postmenopausal women with oestrogen receptor-positive early breast cancer, 5 years of adjuvant tamoxifen substantially reduces 15-year recurrence and mortality; aromatase inhibitor treatment (AIT) is even more effective. We assess the effects of further AIT among women recurrence-free after at least 5 years of endocrine therapy.
10. Estimating the effect of maternal viral load on perinatal and postnatal HIV transmission: a systematic review and meta-analysis.
作者: Caitlin M Dugdale.;Ogochukwu Ufio.;John Giardina.;Fatma Shebl.;Elif Coskun.;Eden Pletner.;Pamela R Torola.;Duru Cosar.;Roger Shapiro.;Maria Kim.;Lynne Mofenson.;Andrea L Ciaranello.
来源: Lancet. 2025年406卷10501期349-357页
Although a growing body of evidence supports zero risk of sexual HIV transmission from a person with sustained virological suppression, known as U=U (undetectable equals untransmittable), data have been insufficient to determine whether this is also true for vertical HIV transmission. We conducted a systematic review and meta-analysis to quantify vertical transmission risk by maternal HIV viral load (mHVL) and to evaluate the applicability of U=U to perinatal and postnatal HIV transmission.
11. Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST).
作者: Hakim-Moulay Dehbi.;Urs Fischer.;Signild Åsberg.;Truman J Milling.;Stefanie Abend.;Norin Ahmed.;Mattia Branca.;Lisa A Davis.;Stefan T Engelter.;Nick Freemantle.;Thomas Gattringer.;Tatevik Ghukasyan Lakic.;Ziad Hijazi.;Martin James.;Masatoshi Koga.;Patrick Lawrence.;Robin Lemmens.;Gregory Y H Lip.;Susan Massingham.;Philip S Nash.;Amalia Ndoutoumou.;Bo Norrving.;Georgia Salanti.;Nikola Sprigg.;Götz Thomalla.;Tishok Vanniyasingam.;Per Wester.;Steven J Warach.;Jonas Oldgren.;Jesse Dawson.;David J Werring.
来源: Lancet. 2025年406卷10498期43-51页
The optimal timing of oral anticoagulation for prevention of early ischaemic stroke recurrence in people with acute ischaemic stroke and atrial fibrillation remains uncertain. We aimed to estimate the effects of starting a direct oral anticoagulant (DOAC) early (≤4 days) versus later (≥5 days) after onset of ischaemic stroke.
12. Causes of and risk factors for postpartum haemorrhage: a systematic review and meta-analysis.
作者: Idnan Yunas.;Md Asiful Islam.;Kulandaipalayam N Sindhu.;Adam J Devall.;Marcelina Podesek.;Sayeda Sadia Alam.;Shoumik Kundu.;Kristie-Marie Mammoliti.;Ashraf Aswat.;Malcolm J Price.;Javier Zamora.;Olufemi T Oladapo.;Ioannis Gallos.;Arri Coomarasamy.
来源: Lancet. 2025年405卷10488期1468-1480页
An understanding of the causes of postpartum haemorrhage is needed to provide appropriate treatment and services. Knowledge of the risk factors for postpartum haemorrhage can help address modifiable risk factors. We did a systematic review and meta-analysis to identify and quantify the various causes and risk factors for postpartum haemorrhage.
13. Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis.
作者: Raul G Nogueira.;Tudor G Jovin.;Xinfeng Liu.;Wei Hu.;Lucianne C M Langezaal.;Chuanhui Li.;Qiliang Dai.;Chunrong Tao.;Francisco J A Mont'Alverne.;Xunming Ji.;Rui Liu.;Rui Li.;Diederik W J Dippel.;Chuanjie Wu.;Wusheng Zhu.;Pengfei Xu.;Wim H van Zwam.;Longfei Wu.;Chao Zhang.;Patrik Michel.;Jian Chen.;Li Wang.;Volker Puetz.;Wenbo Zhao.;Tianlong Liu.;Heinrich J Audebert.;Zhongjun Chen.;Octavio M Pontes-Neto.;Tingyu Yi.;Timothy P Moran.;Mohamed F Doheim.;Wouter J Schonewille.; .
来源: Lancet. 2025年405卷10472期61-69页
Trials of endovascular therapy for basilar artery occlusion, including vertebral occlusion extending into the basilar artery, have shown inconsistent results. We aimed to pool data to estimate safety and efficacy and to explore the benefit across pre-specified subgroups through individual patient data meta-analysis.
14. Tranexamic acid for postpartum bleeding: a systematic review and individual patient data meta-analysis of randomised controlled trials.
作者: Katharine Ker.;Loïc Sentilhes.;Haleema Shakur-Still.;Hugo Madar.;Catherine Deneux-Tharaux.;George Saade.;Luis D Pacheco.;François-Xavier Ageron.;Raoul Mansukhani.;Eni Balogun.;Amy Brenner.;Danielle Prowse.;Monica Arribas.;Homa Ahmadzia.;Rizwana Chaudhri.;Oladapo Olayemi.;Ian Roberts.; .
来源: Lancet. 2024年404卷10463期1657-1667页
Tranexamic acid is a recommended treatment for women with a clinical diagnosis of postpartum haemorrhage, but whether it can prevent bleeding is unclear. We conducted a systematic review and individual patient data (IPD) meta-analysis of randomised controlled trials to assess the effects of tranexamic acid in women giving birth.
15. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up.
作者: Holger Thiele.;Jacob E Møller.;Jose P S Henriques.;Margriet Bogerd.;Melchior Seyfarth.;Daniel Burkhoff.;Petr Ostadal.;Richard Rokyta.;Jan Belohlavek.;Steffen Massberg.;Marcus Flather.;Matthias Hochadel.;Steffen Schneider.;Steffen Desch.;Anne Freund.;Hans Eiskjær.;Norman Mangner.;Janine Pöss.;Amin Polzin.;P Christian Schulze.;Carsten Skurk.;Uwe Zeymer.;Christian Hassager.; .
来源: Lancet. 2024年404卷10457期1019-1028页
Percutaneous active mechanical circulatory support (MCS) devices are being increasingly used in the treatment of acute myocardial infarction-related cardiogenic shock (AMICS) despite conflicting evidence regarding their effect on mortality. We aimed to ascertain the effect of early routine active percutaneous MCS versus control treatment on 6-month all-cause mortality in patients with AMICS.
16. Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis.
作者: Pardeep S Jhund.;Atefeh Talebi.;Alasdair D Henderson.;Brian L Claggett.;Muthiah Vaduganathan.;Akshay S Desai.;Carolyn S P Lam.;Bertram Pitt.;Michele Senni.;Sanjiv J Shah.;Adriaan A Voors.;Faiez Zannad.;Scott D Solomon.;John J V McMurray.
来源: Lancet. 2024年404卷10458期1119-1131页
Mineralocorticoid receptor antagonists (MRAs) reduce hospitalisations and death in patients with heart failure and reduced ejection fraction (HFrEF), but the benefit in patients with heart failure and mildly reduced ejection fraction (HFmrEF) or heart failure and preserved ejection fraction (HFpEF) is unclear. We evaluated the effect of MRAs in four trials that enrolled patients with heart failure across the range of ejection fraction.
17. De-escalation to ticagrelor monotherapy versus 12 months of dual antiplatelet therapy in patients with and without acute coronary syndromes: a systematic review and individual patient-level meta-analysis of randomised trials.
作者: Marco Valgimigli.;Sung-Jin Hong.;Felice Gragnano.;Konstantina Chalkou.;Anna Franzone.;Bruno R da Costa.;Usman Baber.;Byeong-Keuk Kim.;Yangsoo Jang.;Shao-Liang Chen.;Gregg W Stone.;Joo-Yong Hahn.;Stephan Windecker.;Michael C Gibson.;Young Bin Song.;Zhen Ge.;Pascal Vranckx.;Shamir Mehta.;Hyeon-Cheol Gwon.;Renato D Lopes.;George D Dangas.;Eùgene P McFadden.;Dominick J Angiolillo.;Sergio Leonardi.;Dik Heg.;Paolo Calabrò.;Peter Jüni.;Roxana Mehran.;Myeong-Ki Hong.; .
来源: Lancet. 2024年404卷10456期937-948页
Dual antiplatelet therapy (DAPT) for 12 months is the standard of care after coronary stenting in patients with acute coronary syndrome (ACS). The aim of this individual patient-level meta-analysis was to summarise the evidence comparing DAPT de-escalation to ticagrelor monotherapy versus continuing DAPT for 12 months after coronary drug-eluting stent implantation.
18. Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis.
作者: Yunli Zhao.;Ya Gao.;Gordon Guyatt.;Timothy M Uyeki.;Ping Liu.;Ming Liu.;Yanjiao Shen.;Xiaoyan Chen.;Shuyue Luo.;Xingsheng Li.;Rongzhong Huang.;Qiukui Hao.
来源: Lancet. 2024年404卷10454期764-772页
Antiviral post-exposure prophylaxis with neuraminidase inhibitors can reduce the incidence of influenza and the risk of symptomatic influenza, but the efficacy of the other classes of antiviral remains unclear. To support an update of WHO influenza guidelines, this systematic review and network meta-analysis evaluated antiviral drugs for post-exposure prophylaxis of influenza.
19. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials.
作者: Ya Gao.;Gordon Guyatt.;Timothy M Uyeki.;Ming Liu.;Yamin Chen.;Yunli Zhao.;Yanjiao Shen.;Jianguo Xu.;Qingyong Zheng.;Zhifan Li.;Wanyu Zhao.;Shuyue Luo.;Xiaoyan Chen.;Jinhui Tian.;Qiukui Hao.
来源: Lancet. 2024年404卷10454期753-763页
The optimal antiviral drug for treatment of severe influenza remains unclear. To support updated WHO influenza clinical guidelines, this systematic review and network meta-analysis evaluated antivirals for treatment of patients with severe influenza.
20. Rates and causes of death after release from incarceration among 1 471 526 people in eight high-income and middle-income countries: an individual participant data meta-analysis.
Formerly incarcerated people have exceptionally poor health profiles and are at increased risk of preventable mortality when compared with their general population peers. However, not enough is known about the epidemiology of mortality in this population-specifically the rates, causes, and timing of death in specific subgroups and regions-to inform the development of targeted, evidence-based responses. We aimed to document the incidence, timing, causes, and risk factors for mortality after release from incarceration.
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