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1. The Efficacy and Safety of Inhaled Antibiotics for the Treatment of Bronchiectasis in Adults: Updated Systematic Review and Meta-Analysis.
作者: Ricardo Cordeiro.;Hayoung Choi.;Charles S Haworth.;James D Chalmers.
来源: Chest. 2024年166卷1期61-80页
Inhaled antibiotics are recommended conditionally by international bronchiectasis guidelines for the treatment of patients with bronchiectasis, but results of individual studies are inconsistent. A previous meta-analysis demonstrated promising results regarding the efficacy and safety of inhaled antibiotics in bronchiectasis. Subsequent publications have supplemented the existing body of evidence further in this area.
2. Recurrence-Free Survival in Patients With Surgically Resected Non-Small Cell Lung Cancer: A Systematic Literature Review and Meta-Analysis.
作者: Ravi Rajaram.;Qing Huang.;Richard Z Li.;Urmila Chandran.;Yuxin Zhang.;Tony B Amos.;George W J Wright.;Nicole C Ferko.;Iftekhar Kalsekar.
来源: Chest. 2024年165卷5期1260-1270页
Standard treatment for early-stage or locoregionally advanced non-small cell lung cancer (NSCLC) includes surgical resection. Recurrence after surgery is commonly reported, but a summary estimate for postsurgical recurrence-free survival (RFS) in patients with NSCLC is lacking.
3. Accuracy of Cytologic vs Histologic Specimens for Assessment of Programmed Cell Death Ligand-1 Expression in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
作者: Pattraporn Tajarernmuang.;Felipe Aliaga.;Amr J Alwakeel.;Gamuchirai Tavaziva.;Kimberly Turner.;Dick Menzies.;Hangjun Wang.;Linda Ofiara.;Andrea Benedetti.;Anne V Gonzalez.
来源: Chest. 2024年165卷2期461-474页
Programmed cell death ligand-1 (PD-L1) expression on tumor cells, evaluated by immunohistochemistry, guides the use of immunotherapy in advanced non-small cell lung cancer (NSCLC).
4. Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?: A Systematic Review and Meta-Analysis.
作者: Aishwarya Lakshmi Vidyasagaran.;Anne Readshaw.;Melanie Boeckmann.;Alexander Jarde.;Faraz Siddiqui.;Anna-Marie Marshall.;Janita Akram.;Jonathan E Golub.;Kamran Siddiqi.;Omara Dogar.
来源: Chest. 2024年165卷1期22-47页
Associations between tobacco use and poor TB treatment outcomes are well documented. However, for important outcomes such as TB recurrence or relapse and mortality during treatment, as well as for associations with smokeless tobacco (ST), the evidence is not summarized systematically.
5. Risk Factors for Nontuberculous Mycobacterial Pulmonary Disease: A Systematic Literature Review and Meta-Analysis.
作者: Michael R Loebinger.;Jennifer K Quint.;Roald van der Laan.;Marko Obradovic.;Rajinder Chawla.;Amit Kishore.;Jakko van Ingen.
来源: Chest. 2023年164卷5期1115-1124页
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is widely underdiagnosed, and certain patient groups, such as those with underlying respiratory diseases, are at increased risk of developing the disease. Understanding patients at risk is essential to allow for prompt testing and diagnosis and appropriate management to prevent disease progression.
6. Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis.
作者: Praleene Sivapalan.;Karen L Ellekjaer.;Marie K Jessen.;Tine S Meyhoff.;Maria Cronhjort.;Peter B Hjortrup.;Jørn Wetterslev.;Anders Granholm.;Morten H Møller.;Anders Perner.
来源: Chest. 2023年164卷4期892-912页
IV fluids are recommended for adults with sepsis. However, the optimal strategy for IV fluid management in sepsis is unknown, and clinical equipoise exists.
7. Monocyte Distribution Width as a Diagnostic Marker for Infection: A Systematic Review and Meta-analysis.
作者: Alexandra Malinovska.;Benjamin Hernried.;Andrew Lin.;Oluwakemi Badaki-Makun.;Katherine Fenstermacher.;Ann Margret Ervin.;Stephan Ehrhardt.;Scott Levin.;Jeremiah S Hinson.
来源: Chest. 2023年164卷1期101-113页
Monocyte distribution width (MDW) is an emerging biomarker for infection. It is available easily and quickly as part of the CBC count, which is performed routinely on hospital admission. The increasing availability and promising results of MDW as a biomarker in sepsis has prompted an expansion of its use to other infectious diseases.
8. Guided Bronchoscopy for the Evaluation of Pulmonary Lesions: An Updated Meta-analysis.
作者: Tejaswi R Nadig.;Nina Thomas.;Paul J Nietert.;Jessica Lozier.;Nichole T Tanner.;Jessica S Wang Memoli.;Nicholas J Pastis.;Gerard A Silvestri.
来源: Chest. 2023年163卷6期1589-1598页
Guided bronchoscopy is increasingly used to diagnose peripheral pulmonary lesions (PPLs). A meta-analysis published in 2012 demonstrated a pooled diagnostic yield of 70%; however, recent publications have documented yields as low as 40% and as high as 90%.
9. Diagnostic Test Accuracy of Lung Ultrasound for Acute Chest Syndrome in Sickle Cell Disease: A Systematic Review and Meta-analysis.
作者: Mahmoud Omar.;Abdur Rahman Jabir.;Imadh Khan.;Enrico M Novelli.;Julia Z Xu.
来源: Chest. 2023年163卷6期1506-1518页
Acute chest syndrome (ACS) is a leading cause of death in patients with sickle cell disease. Lung ultrasound (LUS) is emerging as a point-of-care method to diagnose ACS, allowing for more rapid diagnosis in the ED setting and sparing patients from ionizing radiation exposure.
10. Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.
作者: Naveed Saleem.;Adarsh Kulkarni.;Timothy Arthur Chandos Snow.;Gareth Ambler.;Mervyn Singer.;Nishkantha Arulkumaran.
来源: Chest. 2023年163卷3期484-497页
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. Corticosteroids may be a beneficial adjunct in the treatment of bacterial pneumonia.
11. BMI and Treatment Response in Patients With Pulmonary Arterial Hypertension: A Meta-analysis.
作者: Breanne E McCarthy.;Robyn L McClelland.;Dina H Appleby.;Jude S Moutchia.;Jasleen K Minhas.;Jeff Min.;Jeremy A Mazurek.;K Akaya Smith.;Jason S Fritz.;Steven C Pugliese.;Ryan J Urbanowicz.;John H Holmes.;Harold I Palevsky.;Steven M Kawut.;Nadine Al-Naamani.
来源: Chest. 2022年162卷2期436-447页
Obesity is increasingly prevalent in pulmonary arterial hypertension (PAH) but is associated with improved survival, creating an "obesity paradox" in PAH. It is unknown if the improved outcomes could be attributable to obese patients deriving a greater benefit from PAH therapies.
12. Thromboprophylaxis in Patients With COVID-19: A Brief Update to the CHEST Guideline and Expert Panel Report.
作者: Lisa K Moores.;Tobias Tritschler.;Shari Brosnahan.;Marc Carrier.;Jacob F Collen.;Kevin Doerschug.;Aaron B Holley.;Jonathan Iaccarino.;David Jimenez.;Gregoire LeGal.;Parth Rali.;Philip Wells.
来源: Chest. 2022年162卷1期213-225页
Patients hospitalized with COVID-19 often exhibit markers of a hypercoagulable state and have an increased incidence of VTE. In response, CHEST issued rapid clinical guidance regarding prevention of VTE. Over the past 18 months the quality of the evidence has improved. We thus sought to incorporate this evidence and update our recommendations as necessary.
13. Genetic Associations and Architecture of Asthma-COPD Overlap.
作者: Catherine John.;Anna L Guyatt.;Nick Shrine.;Richard Packer.;Thorunn A Olafsdottir.;Jiangyuan Liu.;Lystra P Hayden.;Su H Chu.;Jukka T Koskela.;Jian'an Luan.;Xingnan Li.;Natalie Terzikhan.;Hanfei Xu.;Traci M Bartz.;Hans Petersen.;Shuguang Leng.;Steven A Belinsky.;Aivaras Cepelis.;Ana I Hernández Cordero.;Ma'en Obeidat.;Gudmar Thorleifsson.;Deborah A Meyers.;Eugene R Bleecker.;Lori C Sakoda.;Carlos Iribarren.;Yohannes Tesfaigzi.;Sina A Gharib.;Josée Dupuis.;Guy Brusselle.;Lies Lahousse.;Victor E Ortega.;Ingileif Jonsdottir.;Don D Sin.;Yohan Bossé.;Maarten van den Berge.;David Nickle.;Jennifer K Quint.;Ian Sayers.;Ian P Hall.;Claudia Langenberg.;Samuli Ripatti.;Tarja Laitinen.;Ann C Wu.;Jessica Lasky-Su.;Per Bakke.;Amund Gulsvik.;Craig P Hersh.;Caroline Hayward.;Arnulf Langhammer.;Ben Brumpton.;Kari Stefansson.;Michael H Cho.;Louise V Wain.;Martin D Tobin.
来源: Chest. 2022年161卷5期1155-1166页
Some people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone.
14. Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis.
作者: Daniel O Thomas-Rüddel.;Peter Schlattmann.;Mathias Pletz.;Oliver Kurzai.;Frank Bloos.
来源: Chest. 2022年161卷2期345-355页
Current guidelines recommend empirical antifungal therapy in patients with sepsis with high risk of invasive Candida infection. However, many different risk factors have been derived from multiple studies. These risk factors lack specificity, and broad application would render most ICU patients eligible for empirical antifungal therapy.
15. Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation: A Systematic Review and Meta-analysis of Randomized Trials.
作者: Kimberley Lewis.;Joshua Piticaru.;Dipayan Chaudhuri.;John Basmaji.;Eddy Fan.;Morten Hylander Møller.;John W Devlin.;Waleed Alhazzani.
来源: Chest. 2021年159卷6期2274-2288页
Although clinical studies have evaluated dexmedetomidine as a strategy to improve noninvasive ventilation (NIV) comfort and tolerance in patients with acute respiratory failure (ARF), their results have not been summarized.
16. Impact of Right Ventricular Dysfunction on Short-term and Long-term Mortality in Sepsis: A Meta-analysis of 1,373 Patients.
作者: Saraschandra Vallabhajosyula.;Aditi Shankar.;Rahul Vojjini.;Wisit Cheungpasitporn.;Pranathi R Sundaragiri.;Hilary M DuBrock.;Hiroshi Sekiguchi.;Robert P Frantz.;Hector R Cajigas.;Garvan C Kane.;Jae K Oh.
来源: Chest. 2021年159卷6期2254-2263页
Right ventricular (RV) dysfunction in sepsis and septic shock has been infrequently studied and has uncertain prognostic significance.
17. Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis.
作者: David Jiménez.;Aldara García-Sanchez.;Parth Rali.;Alfonso Muriel.;Behnood Bikdeli.;Pedro Ruiz-Artacho.;Raphael Le Mao.;Carmen Rodríguez.;Beverley J Hunt.;Manuel Monreal.
来源: Chest. 2021年159卷3期1182-1196页
Individual studies have reported widely variable rates for VTE and bleeding among hospitalized patients with coronavirus disease 2019 (COVID-19).
18. Impact of Corticosteroids in Coronavirus Disease 2019 Outcomes: Systematic Review and Meta-analysis.
作者: Edison J Cano.;Xavier Fonseca Fuentes.;Cristina Corsini Campioli.;John C O'Horo.;Omar Abu Saleh.;Yewande Odeyemi.;Hemang Yadav.;Zelalem Temesgen.
来源: Chest. 2021年159卷3期1019-1040页
Since its appearance in late 2019, infections caused by severe acute respiratory syndrome coronavirus 2 have created unprecedented challenges for health systems worldwide. Multiple therapeutic options have been explored, including corticosteroids. Preliminary results of corticosteroids in coronavirus disease 2019 (COVID-19) are encouraging; however, the role of corticosteroids remains controversial.
19. Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU: A Systematic Review and Meta-analysis.
The coronavirus disease 2019 (COVID-19) pandemic has placed unprecedented burden on the delivery of intensive care services worldwide.
20. Acetazolamide for OSA and Central Sleep Apnea: A Comprehensive Systematic Review and Meta-Analysis.
作者: Christopher N Schmickl.;Shane A Landry.;Jeremy E Orr.;Kazuo Chin.;Kimihiko Murase.;Johan Verbraecken.;Shahrokh Javaheri.;Bradley A Edwards.;Robert L Owens.;Atul Malhotra.
来源: Chest. 2020年158卷6期2632-2645页
Therapy options for OSA and central sleep apnea (CSA) are limited, thus many patients remain untreated. Clinically, acetazolamide is sometimes used for CSA; however, given overlapping pathophysiologic properties of OSA and CSA, we hypothesized that acetazolamide is equally effective for both types. Prior reviews focused on specific subtypes of sleep apnea, study designs, and languages, thus including few studies (typically ≤3) limiting insights.
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