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1. The Prevalence and Characteristics of Difficult Patient Encounters : A Systematic Review and Meta-analysis.
作者: Jeffrey L Jackson.;Akira Kuriyama.;Jeff Whittle.;Anthony Davis-Maxwell.;Michelle Thompson.;Mary G Murphy.;Suma Gondi.;Kristen Brennan.;Cory Ganshert.;Kathlyn E Fletcher.
来源: Ann Intern Med. 2026年179卷3期382-393页
Patients are sometimes experienced as difficult by their providers.
2. Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome : A Systematic Review and Meta-analysis.
作者: Michael C Ferraro.;Neil E O'Connell.;Andreas Goebel.;Ruaraidh Hill.;Ffion Curtis.;Jack Wilkinson.;Jacqueline R Center.;Sylvia M Gustin.;Aidan G Cashin.;James H McAuley.
来源: Ann Intern Med. 2026年179卷2期256-269页
Clinical guidelines recommend bisphosphonates for complex regional pain syndrome (CRPS) despite limited evidence of efficacy.
3. Risk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists : A Systematic Review and Meta-analysis.
作者: Albert Ko.;Yu-Cheng Chang.;Furkan Bahar.;Tsu Hsien Wang.;Nutchapon Xanthavanij.;Chun-Chiao Yu.;Rebecca Jen-Ling Hsieh.;Xin Ya See.;Shao-Wei Lo.;Junmin Song.;Yuan Ping Hsia.;Cho-Hung Chiang.;Xiaocao Xu.;Shuwen Lin.;Cho-Han Chiang.
来源: Ann Intern Med. 2026年179卷2期216-229页
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used for type 2 diabetes mellitus (T2DM) and overweight or obesity, but their association with cancer is unclear.
4. Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome : A Systematic Review and Meta-analysis.
作者: Alice Soumare.;Thomas Kapfer.;Thomas Botrel.;Leslie Adda.;Maxime Renaux.;Pierre-Louis Blot.;Jean-Michel Constantin.;Arthur James.;Rayan Braïk.
来源: Ann Intern Med. 2026年179卷1期67-80页
The benefit-risk profile of systemic corticosteroids in non-COVID-19 pneumonia and acute respiratory distress syndrome (ARDS) remains debated.
5. Efficacy of Individual-Level Interventions to Mitigate the Risk for Burnout Among Health Care Professionals : A Systematic Review and Meta-analysis of Randomized Controlled Trials.
作者: George Collett.;Jaya Gupta.;Abubaker Eltayeb.;Ania Korszun.;Linda Sharples.;Kenneth Rice.;Ajay K Gupta.
来源: Ann Intern Med. 2026年179卷1期51-66页
There is limited evidence of the strategies to mitigate burnout among all health care professionals (HCPs).
6. Effectiveness of Psychological Therapies for Depression During the Perinatal Period : A Systematic Review and Meta-analysis.
作者: Elyse Couch.;Htun Ja Mai.;Ghid Kanaan.;Eduardo L Caputo.;Olivia Lewis.;Michael L Zahradnik.;Margaret Howard.;Lauren Connell Bohlen.;Kristin Konnyu.;Ethan M Balk.
来源: Ann Intern Med. 2025年178卷12期1752-1762页
Perinatal depression can have a deleterious impact on mothers and infants.
7. Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis.
作者: Hiddo J L Heerspink.;Morgan E Grams.;Yingying Sang.;Shoshana H Ballew.;Josef Coresh.;Aditya Surapaneni.;Natalia Alencar de Pinho.;Nigel J Brunskill.;Alexander R Chang.;Elizabeth Ciemins.;Laura M Dember.;Keiko Kabasawa.;Lindsey Kornowske.;Adeera Levin.;Rupert Major.;Patrick B Mark.;Eric McArthur.;James Medcalf.;Marie Metzger.;Girish N Nadkarni.;David M J Naimark.;Cassianne Robinson-Cohen.;Keiichi Sumida.;Robin W M Vernooij.;Ron T Gansevoort.;Bengt Fellström.;Steven Chadban.; .
来源: Ann Intern Med. 2026年179卷1期32-41页
Urinary albumin-creatinine ratio (UACR) and urinary protein-creatinine ratio (UPCR) are both used in clinical practice to diagnose and monitor chronic kidney disease (CKD). Which measure exhibits stronger associations with clinical outcomes and whether this varies by patient characteristics are unknown.
8. Agreement Between Different Types of Blood Pressure Monitoring : A Systematic Review and Network Meta-analysis.
作者: Jiunn-Tyng Yeh.;Chi-Jung Huang.;Chun-Wei Lee.;Yu-Jen Chen.;Shao-Li Huang.;Wei-Ting Wang.;Yu-Kang Tu.;Tzu-Jung Chiu.;Chern-En Chiang.;Chen-Huan Chen.;Hao-Min Cheng.
来源: Ann Intern Med. 2025年178卷10期1441-1450页
Accurate blood pressure measurement (BPM) is essential for managing hypertension, but previous studies have not systematically compared different monitoring methods across varying BP levels. To address this gap, a comprehensive analysis using network meta-analysis (NMA) and meta-regression was done to evaluate their agreement and clinical implications.
9. The Effect of Weight Loss Before In Vitro Fertilization on Reproductive Outcomes in Women With Obesity : A Systematic Review and Meta-analysis.
作者: Moscho Michalopoulou.;Susan Ann Jebb.;Alice Hobson.;Shen Chuen Khaw.;Richard Stevens.;Pedro Melo.;Stella Jane Pierce Haffner.;Kathryn Sheridan Clay.;Sarah Mounsey.;Ingrid Granne.;Lee Lim.;Tim Child.;Nerys Marie Astbury.
来源: Ann Intern Med. 2025年178卷9期1298-1313页
It is unclear whether weight loss before in vitro fertilization (IVF) improves reproductive outcomes in women with obesity.
10. Catheter and Surgical Ablation for Atrial Fibrillation : A Systematic Review and Meta-analysis.
作者: Bryce Montané.;Shiyang Zhang.;Jonathan D Wolfe.;Sabrina Prime.;Chongliang Luo.;Daniel H Cooper.;Michelle Doering.;Carina Blomstrom-Lundqvist.;Samer A M Nashef.;Pavel Osmancik.;Jason G Andrade.;Emanuele Bertaglia.;Ratika Parkash.;Daniel B Mark.;Jens C Nielsen.;Linda D Sharples.;Brian F Gage.
来源: Ann Intern Med. 2025年178卷8期1138-1149页
Ablation of atrial fibrillation can restore normal heart rhythm, but its effect on clinical outcomes is uncertain.
11. Moderate- to Long-Term Effect of Dietary Interventions for Depression and Anxiety : A Systematic Review and Meta-analysis.
作者: Eman Abukmail.;Neeraj Koloth Pradeep.;Samantha Ahmed.;Loai Albarqouni.
来源: Ann Intern Med. 2025年178卷7期987-999页
Dietary interventions are a potential alternative treatment of depression and anxiety.
12. Pharmacologic Treatment of Acute Attacks of Episodic Migraine: A Systematic Review and Network Meta-analysis for the American College of Physicians.
作者: Gerald Gartlehner.;Andreea Dobrescu.;Gernot Wagner.;Andrea Chapman.;Emma Persad.;Claus Nowak.;Irma Klerings.;Camilla Neubauer.;Johanna Feyertag.;Arianna Gadinger.;Kylie Thaler.
来源: Ann Intern Med. 2025年178卷4期507-524页
Migraine is common, affecting 15% of Americans.
13. De-escalating Dual Antiplatelet Therapy to Ticagrelor Monotherapy in Acute Coronary Syndrome : A Systematic Review and Individual Patient Data Meta-analysis of Randomized Clinical Trials.
作者: Yong-Joon Lee.;Xiaofei Gao.;Sang-Hyup Lee.;Jing Kan.;Jun-Jie Zhang.;Seung-Jun Lee.;Sung-Jin Hong.;Chul-Min Ahn.;Jung-Sun Kim.;Byeong-Keuk Kim.;Young-Guk Ko.;Donghoon Choi.;Yangsoo Jang.;Gregg W Stone.;Shao-Liang Chen.;Myeong-Ki Hong.
来源: Ann Intern Med. 2025年178卷4期533-542页
The role of transitioning from short dual antiplatelet therapy (DAPT) to potent P2Y12 inhibitor monotherapy in patients with acute coronary syndrome (ACS) undergoing drug-eluting stent (DES) implantation remains inconclusive.
14. Bleeding Risks With Non-Vitamin K Oral Anticoagulants Versus Single Antiplatelet Therapy : A Systematic Review and Meta-analysis of Randomized Trials.
作者: Michael Ke Wang.;Geethan Baskaran.;Ghazal Razeghi.;Richard Ma.;Louis S Park.;Manasi Tannu.;P J Devereaux.;William F McIntyre.;Jeff S Healey.;Ashkan Shoamanesh.;David Conen.
来源: Ann Intern Med. 2025年178卷3期360-368页
In several settings, therapeutic-dose non-vitamin K oral anticoagulants (NOACs) are superior to aspirin for the prevention of arterial and venous thromboembolism.
15. Comparative Effectiveness of Pharmacologic Treatments for the Prevention of Episodic Migraine Headache: A Systematic Review and Network Meta-analysis for the American College of Physicians.
作者: Johanna A A Damen.;Bada Yang.;Demy L Idema.;Robin W M Vernooij.;Linde Huis In 't Veld.;Mike Kusters.;Rene Spijker.;Kim van der Braak.;Pauline Heus.;Kevin Jenniskens.;Lotty Hooft.
来源: Ann Intern Med. 2025年178卷3期369-380页
Various treatments for preventing episodic migraine are available.
16. Effectiveness of Synchronous Postdischarge Contacts on Health Care Use and Patient Satisfaction : A Systematic Review and Meta-analysis.
作者: Joel C Boggan.;Spoorthi Sankineni.;Paul A Dennis.;Dazhe Chen.;Tina Wong Sledge.;David Halpern.;Sharron Rushton.;John W Williams.;Tatyana Der.;Amir Alishahi Tabriz.;Adelaide M Gordon.;Morgan Jacobs.;Nathan A Boucher.;Maria Colandrea.;Anastasia-Stefania Alexopoulos.;Joanne Roman Jones.;Nina Leflore-Lloyd.;Sarah Cantrell.;Karen M Goldstein.;Jennifer M Gierisch.
来源: Ann Intern Med. 2025年178卷2期229-240页
Postdischarge contacts (PDCs) after hospitalization are common practice, but their effectiveness in reducing use of acute care after discharge remains unclear.
17. Anticoagulation Among Patients Hospitalized for COVID-19 : A Systematic Review and Prospective Meta-analysis.
作者: .;Claire L Vale.;Peter J Godolphin.;David J Fisher.;Julian P T Higgins.;Alexandra McAleenan.;Francesca Spiga.;Tobias Tritschler.;Pedro Gabriel Melo de Barros E Silva.;David D Berg.;Jeffrey S Berger.;Lindsay R Berry.;Behnood Bikdeli.;Marc Blondon.;Erin A Bohula.;Marco Cattaneo.;Riccardo Colombo.;Valeria Coluccio.;Maria T DeSancho.;Michael E Farkouh.;Valentin Fuster.;Massimo Girardis.;Judith S Hochman.;Thomas P Jensen.;Vivekanand Jha.;Peter Jüni.;Ajay J Kirtane.;Patrick Lawler.;Grégoire Le Gal.;Ramon Lecumberri.;Steven R Lentz.;Renato D Lopes.;Elizabeth Lorenzi.;Marco Marietta.;Carlos Henrique Miranda.;Nuccia Morici.;Susan C Morpeth.;David A Morrow.;Zoe K McQuilten.;Nuria Muñoz-Rivas.;Matthew D Neal.;Suman Pant.;Sahil A Parikh.;Usha Perepu.;Parham Sadeghipour.;Sanjum Sethi.;Michelle Sholzberg.;Alex C Spyropoulos.;Gregg W Stone.;Azita Hajhossein Talasaz.;Steven Tong.;James Totterdell.;Balasubramanian Venkatesh.;Maddalena Alessandra Wu.;Ryan Zarychanski.;Stephane Zuily.;Julie Viry.;Jamie Rylance.;Neill K J Adhikari.;Janet V Diaz.;John C Marshall.;Jonathan A C Sterne.;Srinivas Murthy.
来源: Ann Intern Med. 2025年178卷1期59-69页
Reported results of clinical trials assessing higher-dose anticoagulation in patients hospitalized for COVID-19 have been inconsistent.
18. Artificial Intelligence-Assisted Colonoscopy for Polyp Detection : A Systematic Review and Meta-analysis.
作者: Saeed Soleymanjahi.;Jack Huebner.;Lina Elmansy.;Niroop Rajashekar.;Nando Lüdtke.;Rumzah Paracha.;Rachel Thompson.;Alyssa A Grimshaw.;Farid Foroutan.;Shahnaz Sultan.;Dennis L Shung.
来源: Ann Intern Med. 2024年177卷12期1652-1663页
Randomized clinical trials (RCTs) of computer-aided detection (CADe) system-enhanced colonoscopy compared with conventional colonoscopy suggest increased adenoma detection rate (ADR) and decreased adenoma miss rate (AMR), but the effect on detection of advanced colorectal neoplasia (ACN) is unclear.
19. Effect of Weight Loss Interventions on the Symptomatic Burden and Biomarkers of Polycystic Ovary Syndrome : A Systematic Review of Randomized Controlled Trials.
作者: Jadine Scragg.;Alice Hobson.;Lia Willis.;Kathryn S Taylor.;Sharon Dixon.;Susan A Jebb.
来源: Ann Intern Med. 2024年177卷12期1664-1674页
Polycystic ovary syndrome (PCOS) is common in women of reproductive age and is associated with obesity. Clinical guidelines recommend weight loss, but the impact on the clinical manifestations of PCOS is unclear.
20. Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease : A Systematic Review and Retrospective Individual Participant-Level Meta-analysis of Clinical Trials.
作者: Elaine Ku.;Lesley A Inker.;Hocine Tighiouart.;Charles E McCulloch.;Ogechi M Adingwupu.;Tom Greene.;Raymond O Estacio.;Mark Woodward.;Dick de Zeeuw.;Julia B Lewis.;Thierry Hannedouche.;Tazeen H Jafar.;Enyu Imai.;Giuseppe Remuzzi.;Hiddo J L Heerspink.;Fan Fan Hou.;Robert D Toto.;Philip K Li.;Mark J Sarnak.
来源: Ann Intern Med. 2024年177卷7期953-963页
In patients with advanced chronic kidney disease (CKD), the effects of initiating treatment with an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin-receptor blocker (ARB) on the risk for kidney failure with replacement therapy (KFRT) and death remain unclear.
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