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1. Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial.
作者: Edward T Qian.;Ryan M Brown.;Karen E Jackson.;Li Wang.;Joanna L Stollings.;Robert E Freundlich.;Jonathan P Wanderer.;Edward D Siew.;Gordon R Bernard.;Wesley H Self.;Jonathan D Casey.;Todd W Rice.;Matthew W Semler.; .
来源: Chest. 2025年168卷2期336-345页
Balanced crystalloid solutions may improve clinical outcomes compared with saline for some critically ill adults, but it is unclear whether differences in composition between balanced crystalloid solutions affect outcomes.
2. Effect of Dupilumab on Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS.
作者: Surya P Bhatt.;Klaus F Rabe.;Nicola A Hanania.;Claus F Vogelmeier.;Mona Bafadhel.;Stephanie A Christenson.;Alberto Papi.;Dave Singh.;Elizabeth Laws.;Paula Dakin.;Jennifer Maloney.;Xin Lu.;Deborah Bauer.;Ashish Bansal.;Raolat M Abdulai.;Lacey B Robinson.
来源: Chest. 2025年168卷1期56-66页
Patient-reported outcomes should be considered alongside clinical assessments to guide therapy for COPD.
3. Prolonged Mechanical Ventilation in Critically Ill Patients: Six-Month Mortality, Care Pathways, and Quality of Life.
作者: Nicolas Paul.;Elena Ribet Buse.;Julius J Grunow.;Stefan J Schaller.;Claudia D Spies.;Andreas Edel.;Björn Weiss.
来源: Chest. 2025年168卷1期106-118页
There is limited knowledge about long-term mortality, care pathways, and health-related quality of life (HrQoL) among patients in the ICU receiving prolonged mechanical ventilation (PMV).
4. Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest: A Secondary Analysis of the Direct vs Video Laryngoscope Trial.
作者: Amelia L Muhs.;Kevin P Seitz.;Edward T Qian.;Brant Imhoff.;Li Wang.;Matthew E Prekker.;Brian E Driver.;Stacy A Trent.;Daniel Resnick-Ault.;Steven G Schauer.;Adit A Ginde.;Derek W Russell.;Sheetal Gandotra.;David B Page.;John P Gaillard.;Lane M Smith.;Andrew J Latimer.;Steven H Mitchell.;Nicholas J Johnson.;Shekhar A Ghamande.;Heath D White.;Kevin W Gibbs.;Jessica A Palakshappa.;Derek J Vonderhaar.;David R Janz.;Micah R Whitson.;Christopher R Barnes.;Alon Dagan.;Ari Moskowitz.;Vijay Krishnamoorthy.;James T Herbert.;Michael D April.;Aaron M Joffe.;Jeremy P Walco.;Christopher G Hughes.;Kipp Shipley.;Amelia W Maiga.;Bradley D Lloyd.;Stephanie C DeMasi.;Wesley H Self.;Todd W Rice.;Matthew W Semler.;Jonathan D Casey.; .
来源: Chest. 2025年167卷5期1408-1415页
Airway management is a critical component of the care of patients experiencing cardiac arrest, but data from randomized trials on the use of video vs direct laryngoscopy for intubation in the setting of cardiac arrest are limited. Current American Heart Association guidelines recommend placement of an endotracheal tube either during CPR or shortly after return of spontaneous circulation, but do not provide guidance around intubation methods, including the choice of laryngoscope.
5. Effect of Famotidine on Outcomes in Pulmonary Arterial Hypertension: A Randomized Controlled Trial.
作者: Peter J Leary.;Samuel G Rayner.;Kelley R H Branch.;Laurie Hogl.;Nancy M Liston.;Lia M Barros.;Jessi Prout.;Stephanie Nolley.;Jonathan Buber.;David D Ralph.;Jeffrey L Probstfield.
来源: Chest. 2025年168卷1期189-199页
Adaptation of the right ventricle is a key determinant of outcomes in pulmonary arterial hypertension (PAH). Despite a compelling rationale to develop targeted therapies for the right ventricle in PAH, no such treatments exist. H2-receptor antagonism is a potential myocardial-focused paradigm in heart failure.
6. Treatment With Oral or Inhaled Treprostinil in Patients With Pulmonary Arterial Hypertension and Cardiovascular Comorbidities.
作者: R James White.;Karim El-Kersh.;Stephan Rosenkranz.;Veronica Franco.;Carmine Dario Vizza.;Roberto Badagliacca.;Joanna Pepke-Zaba.;Jean Elwing.;Rahul G Argula.;Shelley Shapiro.;Hyoshin Kim.;Scott Seaman.;Eric Shen.;Manisit Das.;Meredith Broderick.;Vallerie McLaughlin.
来源: Chest. 2025年167卷6期1746-1758页
An increasing number of patients with pulmonary arterial hypertension (PAH) have cardiovascular comorbidities. However, the effects of comorbidities on responses to PAH treatment are not well understood.
7. Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived Indices: The Lactel Randomized Multicenter Study.
作者: Pierre-Grégoire Guinot.;Corentin Evezard.;Maxime Nguyen.;Sebastien Pili-Floury.;Vivien Berthoud.;Guillaume Besch.;Belaid Bouhemad.; .
来源: Chest. 2025年167卷4期1068-1078页
Acute circulatory failure is critical in patients in the ICU. Indices derived from oxygen and CO2 metabolism (CO2-O2-derived indices) including the central venous-to-arterial CO2 difference and central venous-to-arterial CO2 difference/arteriovenous oxygen content ratio are markers for global metabolic demand and tissue hypoxia.
8. Results of the Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-Controlled Study (SHARP): A Randomized Placebo-Controlled Double-Blind Repeated-Measures Crossover Phase IV Clinical Trial of the Effect of the Wake-Promoting Agent Solriamfetol on Cognitive Function in OSA With Excessive Daytime Sleepiness and Cognitive Impairment.
作者: Hans P A Van Dongen.;Eileen B Leary.;Christopher Drake.;Richard Bogan.;Judith Jaeger.;Russell Rosenberg.;Caroline Streicher.;Herriot Tabuteau.
来源: Chest. 2025年167卷3期863-875页
OSA causes episodes of fragmented sleep and intermittent hypoxia and leads to excessive daytime sleepiness (EDS). Deficits in cognitive function are a troublesome symptom in patients with OSA and EDS.
9. A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity: A Randomized Controlled Study.
作者: Varun Sharma.;Helen Clare Ricketts.;Louise McCombie.;Naomi Brosnahan.;Luisa Crawford.;Lesley Slaughter.;Anna Goodfellow.;Femke Steffensen.;Rekha Chaudhuri.;Michael E J Lean.;Douglas C Cowan.
来源: Chest. 2025年167卷1期42-53页
Obesity-associated asthma results in increased morbidity and mortality. We report 1-year asthma outcomes with a weight management regimen, the Counterweight-Plus Programme (CWP), compared with usual care (UC) in a single-center, randomized controlled trial in patients with difficult-to-treat asthma and obesity.
10. Lower or Higher Oxygenation Targets in Patients With COVID-19 in the ICU: A Secondary Bayesian Analysis of the Handling Oxygenation Targets in COVID-19 Trial.
作者: Frederik Mølgaard Nielsen.;Thomas Lass Klitgaard.;Anders Granholm.;Theis Lange.;Anders Perner.;Olav Lilleholt Schjørring.;Bodil Steen Rasmussen.
来源: Chest. 2025年167卷3期757-767页
In the Handling Oxygenation Targets in COVID-19 (HOT-COVID) trial, a Pao2 target of 60 mm Hg compared with 90 mm Hg resulted in more days alive without life support at 90 days in adults in the ICU with COVID-19 and hypoxemia. The trial was stopped after enrolling 726 of 780 planned patients because of slow recruitment. Herein, we present the preplanned Bayesian analysis of the HOT-COVID trial.
11. Effect of Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine on Exacerbation Rate and Risk in Patients With Moderate to Severe COPD.
作者: Frank C Sciurba.;Stephanie A Christenson.;Tara Rheault.;Thomas Bengtsson.;Kathleen Rickard.;Igor Z Barjaktarevic.
来源: Chest. 2025年167卷2期425-435页
Exacerbations in COPD can be life-threatening and can lead to irreversible declines in lung function and quality of life. Medications that reduce exacerbation burden are an unmet need, because exacerbations put patients at risk of more exacerbations and decrease quality of life. Ensifentrine is a first-in-class selective dual inhibitor of phosphodiesterase 3 and 4 with demonstrated nonsteroidal antiinflammatory activity and bronchodilatory effects.
12. The Responsiveness of Exercise Tests in COPD: A Randomized Controlled Trial.
作者: Theresa C Harvey-Dunstan.;Molly M Baldwin.;Ruth Tal-Singer.;Matthew Allinder.;Michael I Polkey.;Alan Hamilton.;Matthew Richardson.;Sarah A Edwards.;Michael C Steiner.;Mike D Morgan.;Sally J Singh.; .
来源: Chest. 2025年167卷1期98-111页
COPD is characterized by reduced exercise tolerance, and improving physical performance is an important therapeutic goal. A variety of exercise tests are commonly used to assess exercise tolerance, including laboratory and field-based tests. The responsiveness of these various tests to common COPD interventions is yet to be compared, but the results may inform test selection in clinical and research settings.
13. Decídetexto: Mobile Cessation Support for Latino Adults Who Smoke: A Randomized Clinical Trial.
作者: Francisco Cartujano-Barrera.;Lisa Sanderson Cox.;Delwyn Catley.;Xueya Cai.;Francisco J Diaz.;Evelyn Arana-Chicas.;Arlette Chávez-Iñiguez.;Chinwe Ogedegbe.;Kristi D Graves.;M Patricia Rivera.;Arturo Ponce.;Edward F Ellerbeck.;Ana Paula Cupertino.
来源: Chest. 2025年167卷2期619-629页
Latino adults experience multiple barriers to health care access and treatment that result in tobacco-related disparities. Mobile interventions have the potential to deliver smoking cessation treatment among Latino adults, who show the highest use rates of mobile technologies.
14. Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD: A Post Hoc Analysis From the FLAME Trial.
作者: Alexander G Mathioudakis.;Sebastian Bate.;Pradeesh Sivapalan.;Jens-Ulrik Stæhr Jensen.;Dave Singh.;Jørgen Vestbo.
来源: Chest. 2024年166卷5期987-997页
The varied treatment response to inhaled corticosteroids (ICS) in patients with COPD and the associated increased risk of pneumonia necessitate a personalized ICS therapeutic approach. This is informed by blood eosinophil count (BEC), which predicts ICS treatment response. However, BEC appears to change in response to ICS treatment.
15. Effect of Azithromycin on Asthma Remission in Adults With Persistent Uncontrolled Asthma: A Secondary Analysis of a Randomized, Double-Anonymized, Placebo-Controlled Trial.
作者: Dennis Thomas.;Vanessa M McDonald.;Sean Stevens.;Melissa Baraket.;Sandra Hodge.;Alan James.;Christine Jenkins.;Guy B Marks.;Matthew Peters.;Paul N Reynolds.;John W Upham.;Ian A Yang.;Peter G Gibson.
来源: Chest. 2024年166卷2期262-270页
Asthma remission is a potential treatment goal.
16. Noninvasive Electromagnetic Phrenic Nerve Stimulation in Critically Ill Patients: A Feasibility Study.
作者: Alessandro Panelli.;Aline M Grimm.;Sven Krause.;Michael A Verfuß.;Bernhard Ulm.;Julius J Grunow.;Hermann G Bartels.;Niklas M Carbon.;Thomas Niederhauser.;Steffen Weber-Carstens.;Laurent Brochard.;Stefan J Schaller.
来源: Chest. 2024年166卷3期502-510页
Electromagnetic stimulation of the phrenic nerve induces diaphragm contractions, but no coils for clinical use have been available. We recently demonstrated the feasibility of ventilation using bilateral transcutaneous noninvasive electromagnetic phrenic nerve stimulation (NEPNS) before surgery in lung-healthy patients with healthy weight in a dose-dependent manner.
17. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma.
作者: Cendrine Godet.;Anne-Laure Brun.;Francis Couturaud.;François Laurent.;Jean-Pierre Frat.;Sylvain Marchand-Adam.;Frédéric Gagnadoux.;Elodie Blanchard.;Camille Taillé.;Bruno Philippe.;Sandrine Hirschi.;Claire Andréjak.;Arnaud Bourdin.;Cécile Chenivesse.;Stéphane Dominique.;Gilles Mangiapan.;Marlène Murris-Espin.;Frédéric Rivière.;Gilles Garcia.;François-Xavier Blanc.;François Goupil.;Anne Bergeron.;Thomas Flament.;Pascaline Priou.;Hervé Mal.;Joe de Keizer.;Stéphanie Ragot.;Jacques Cadranel.; .
来源: Chest. 2024年165卷6期1307-1318页
One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
18. High vs Low PEEP in Patients With ARDS Exhibiting Intense Inspiratory Effort During Assisted Ventilation: A Randomized Crossover Trial.
作者: Giuseppe Bello.;Valentina Giammatteo.;Alessandra Bisanti.;Luca Delle Cese.;Tommaso Rosà.;Luca S Menga.;Luca Montini.;Teresa Michi.;Giorgia Spinazzola.;Gennaro De Pascale.;Mariano Alberto Pennisi.;Roberta Ribeiro De Santis Santiago.;Lorenzo Berra.;Massimo Antonelli.;Domenico Luca Grieco.
来源: Chest. 2024年165卷6期1392-1405页
Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory effort (ΔPes), which is the major determinant of self-inflicted lung injury.
19. Comparison of Pirfenidone and Nintedanib: Post Hoc Analysis of the CleanUP-IPF Study.
作者: John S Kim.;Susan Murray.;Eric Yow.;Kevin J Anstrom.;Hyun J Kim.;Kevin R Flaherty.;Fernando J Martinez.;Imre Noth.
来源: Chest. 2024年165卷5期1163-1173页
Antifibrotics are effective in slowing FVC decline in idiopathic pulmonary fibrosis (IPF). However, whether antifibrotic type is differentially associated with FVC decline remains inconclusive.
20. Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial: Effect on 3-Month Symptoms and Quality of Life.
作者: Yonatan Y Greenstein.;Kinsley Hubel.;Joshua Froess.;Stephen R Wisniewski.;Vidya Venugopal.;Yu-Hsuan Lai.;Jeff S Berger.;Steven Y Chang.;Christos Colovos.;Faraaz Shah.;Lucy Z Kornblith.;Patrick R Lawler.;Manila Gaddh.;Raquel Morillo Guerrero.;William Nkemdirim.;Renato D Lopes.;Harmony R Reynolds.;Jose Seijas Amigo.;Lana Wahid.;Ajani Zahra.;Ewan C Goligher.;Ryan Zarychanski.;Eric Leifer.;David T Huang.;Matthew D Neal.;Judith S Hochman.;Mary Cushman.;Michelle N Gong.
来源: Chest. 2024年165卷4期785-799页
Therapeutic-dose heparin decreased days requiring organ support in noncritically ill patients hospitalized for COVID-19, but its impact on persistent symptoms or quality of life (QOL) is unclear.
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