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1821. Intravenous methoxy polyethylene glycol-epoetin beta for haemoglobin control in patients with chronic kidney disease who are on dialysis: a randomised non-inferiority trial (MAXIMA).
作者: Nathan W Levin.;Steven Fishbane.;Francisco Valdés Cañedo.;Steven Zeig.;George M Nassar.;John E Moran.;Giuseppe Villa.;Ulrich Beyer.;Delphine Oguey.; .
来源: Lancet. 2007年370卷9596期1415-21页
Conventional treatment with epoetin to manage anaemia in chronic kidney disease needs frequent administrations, changes of dose, and close monitoring of haemoglobin concentrations. We aimed to compare the effectiveness of methoxy polyethylene glycol-epoetin beta, given intravenously at 2-week or 4-week intervals, with epoetin treatment one to three times per week for haemoglobin control in haemodialysis patients.
1823. Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial.
作者: John J Aponte.;Pedro Aide.;Montse Renom.;Inacio Mandomando.;Quique Bassat.;Jahit Sacarlal.;M Nelia Manaca.;Sarah Lafuente.;Arnoldo Barbosa.;Amanda Leach.;Marc Lievens.;Johan Vekemans.;Betuel Sigauque.;Marie-Claude Dubois.;Marie-Ange Demoitié.;Marla Sillman.;Barbara Savarese.;John G McNeil.;Eusebio Macete.;W Ripley Ballou.;Joe Cohen.;Pedro L Alonso.
来源: Lancet. 2007年370卷9598期1543-51页
Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa.
1825. Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based, cluster randomised, placebo-controlled trial.
作者: James M Tielsch.;Subarna K Khatry.;Rebecca J Stoltzfus.;Joanne Katz.;Steven C LeClerq.;Ramesh Adhikari.;Luke C Mullany.;Robert Black.;Shardaram Shresta.
来源: Lancet. 2007年370卷9594期1230-9页
Zinc supplementation can reduce subsequent morbidity in children recovering from diarrhoea and respiratory illness in developing countries. However, whether routine supplementation would decrease morbidity and mortality in populations with zinc deficiency is unclear. We assessed the effect of daily zinc supplementation on children in southern Nepal.
1826. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial.
作者: Thierry Facon.;Jean Yves Mary.;Cyrille Hulin.;Lotfi Benboubker.;Michel Attal.;Brigitte Pegourie.;Marc Renaud.;Jean Luc Harousseau.;Gaëlle Guillerm.;Carine Chaleteix.;Mamoun Dib.;Laurent Voillat.;Hervé Maisonneuve.;Jacques Troncy.;Véronique Dorvaux.;Mathieu Monconduit.;Claude Martin.;Philippe Casassus.;Jérôme Jaubert.;Henry Jardel.;Chantal Doyen.;Brigitte Kolb.;Bruno Anglaret.;Bernard Grosbois.;Ibrahim Yakoub-Agha.;Claire Mathiot.;Hervé Avet-Loiseau.; .
来源: Lancet. 2007年370卷9594期1209-18页
In multiple myeloma, combination chemotherapy with melphalan plus prednisone is still regarded as the standard of care in elderly patients. We assessed whether the addition of thalidomide to this combination, or reduced-intensity stem cell transplantation, would improve survival.
1828. Human papillomavirus DNA testing for the detection of cervical intraepithelial neoplasia grade 3 and cancer: 5-year follow-up of a randomised controlled implementation trial.
作者: N W J Bulkmans.;J Berkhof.;L Rozendaal.;F J van Kemenade.;A J P Boeke.;S Bulk.;F J Voorhorst.;R H M Verheijen.;K van Groningen.;M E Boon.;W Ruitinga.;M van Ballegooijen.;P J F Snijders.;C J L M Meijer.
来源: Lancet. 2007年370卷9601期1764-72页
Tests for the DNA of high-risk types of human papillomavirus (HPV) have a higher sensitivity for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) than does cytological testing, but the necessity of such testing in cervical screening has been debated. Our aim was to determine whether the effectiveness of cervical screening improves when HPV DNA testing is implemented.
1830. The effectiveness of supported employment for people with severe mental illness: a randomised controlled trial.
作者: Tom Burns.;Jocelyn Catty.;Thomas Becker.;Robert E Drake.;Angelo Fioritti.;Martin Knapp.;Christoph Lauber.;Wulf Rössler.;Toma Tomov.;Jooske van Busschbach.;Sarah White.;Durk Wiersma.; .
来源: Lancet. 2007年370卷9593期1146-52页
The value of the individual placement and support (IPS) programme in helping people with severe mental illness gain open employment is unknown in Europe. Our aim was to assess the effectiveness of IPS, and to examine whether its effect is modified by local labour markets and welfare systems.
1833. Effect of expanded insecticide-treated bednet coverage on child survival in rural Kenya: a longitudinal study.
作者: Greg W Fegan.;Abdisalan M Noor.;Willis S Akhwale.;Simon Cousens.;Robert W Snow.
来源: Lancet. 2007年370卷9592期1035-9页
The potential of insecticide-treated bednets (ITNs) to contribute to child survival has been well documented in randomised controlled trials. ITN coverage has increased rapidly in Kenya from 7% in 2004 to 67% in 2006. We aimed to assess the extent to which this investment has led to improvements in child survival.
1835. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial.
作者: Bengt I Eriksson.;Ola E Dahl.;Nadia Rosencher.;Andreas A Kurth.;C Niek van Dijk.;Simon P Frostick.;Martin H Prins.;Rohan Hettiarachchi.;Stefan Hantel.;Janet Schnee.;Harry R Büller.; .
来源: Lancet. 2007年370卷9591期949-56页
After hip replacement surgery, prophylaxis following discharge from hospital is recommended to reduce the risk of venous thromboembolism. Our aim was to assess the oral, direct thrombin inhibitor dabigatran etexilate for such prophylaxis.
1836. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial.
作者: Donna McCann.;Angelina Barrett.;Alison Cooper.;Debbie Crumpler.;Lindy Dalen.;Kate Grimshaw.;Elizabeth Kitchin.;Kris Lok.;Lucy Porteous.;Emily Prince.;Edmund Sonuga-Barke.;John O Warner.;Jim Stevenson.
来源: Lancet. 2007年370卷9598期1560-7页
We undertook a randomised, double-blinded, placebo-controlled, crossover trial to test whether intake of artificial food colour and additives (AFCA) affected childhood behaviour.
1837. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.
作者: Anushka Patel.; .;S MacMahon.;J Chalmers.;B Neal.;M Woodward.;L Billot.;S Harrap.;N Poulter.;M Marre.;M Cooper.;P Glasziou.;D E Grobbee.;P Hamet.;S Heller.;L S Liu.;G Mancia.;C E Mogensen.;C Y Pan.;A Rodgers.;B Williams.
来源: Lancet. 2007年370卷9590期829-40页
Blood pressure is an important determinant of the risks of macrovascular and microvascular complications of type 2 diabetes, and guidelines recommend intensive lowering of blood pressure for diabetic patients with hypertension. We assessed the effects of the routine administration of an angiotensin converting enzyme (ACE) inhibitor-diuretic combination on serious vascular events in patients with diabetes, irrespective of initial blood pressure levels or the use of other blood pressure lowering drugs.
1839. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial.
作者: Djillali Annane.;Philippe Vignon.;Alain Renault.;Pierre-Edouard Bollaert.;Claire Charpentier.;Claude Martin.;Gilles Troché.;Jean-Damien Ricard.;Gérard Nitenberg.;Laurent Papazian.;Elie Azoulay.;Eric Bellissant.; .
来源: Lancet. 2007年370卷9588期676-84页
International guidelines for management of septic shock recommend that dopamine or norepinephrine are preferable to epinephrine. However, no large comparative trial has yet been done. We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone in septic shock.
1840. Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial.
作者: Isabel Leroux-Roels.;Astrid Borkowski.;Thomas Vanwolleghem.;Mamadou Dramé.;Frédéric Clement.;Eliane Hons.;Jeanne-Marie Devaster.;Geert Leroux-Roels.
来源: Lancet. 2007年370卷9587期580-9页
Antigen sparing is regarded as crucial for pandemic vaccine development because worldwide influenza vaccine production capacity is limited. Adjuvantation is an important antigen-sparing strategy. We assessed the safety and immunogenicity of a recombinant H5N1 split-virion vaccine formulated with a proprietary adjuvant system and investigated whether it can induce cross-reactive immunity.
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