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169. Italian version of the General Medication Adherence Scale (GMAS): translation, adaptation, and validation.
作者: Daniele Napolitano.;Alessandra Bronzino.;Alessio Lo Cascio.;Gabriele Rumi.;Elena Sblendorio.;Nicoletta Orgiana.;Mattia Bozzetti.;Simone Amato.;Francesco Germini.;Eleonora Ribaudi.;Laura Turchini.;Nicolò Lentini.;Roberta Pastorino.;Vincenzina Mora.;Valentin Calvez.;Antonio Gasbarrini.;Franco Scaldaferri.
来源: Minerva Gastroenterol (Torino). 2025年
Medication adherence, defined as the extent to which a patient's behaviour aligns with medical recommendations, is crucial in managing chronic diseases. Despite its importance, global adherence rates are suboptimal, with non-adherence leading to poor clinical outcomes and increased healthcare costs. The General Medication Adherence Scale (GMAS) is a self-report tool widely used to assess adherence across cultural contexts. However, no validated Italian version exists. This study aimed to translate and validate the GMAS in Italian, ensuring its reliability and cultural relevance for Italian patients with chronic conditions.
170. Heterogeneity of treatment preferences in the absence of guideline recommendations - a case vignette study in colorectal cancer tumor boards in Germany, Austria and Switzerland.
作者: Johannes Soff.;Stefan Rolf Benz.;Christoph Kowalski.;Judith Hansinger.;Michael Gerken.;Daniel Maier.;Soo-Zin Kim-Wanner.;Jacqueline Witzmann.;Anke Reinacher-Schick.;Christian Peter Pox.;Kees Kleihues-van Tol.;Bianca Franke.;Olaf Schoffer.;Jochen Schmitt.;Monika Klinkhammer-Schalke.;Vinzenz Völkel.; .
来源: BMC Gastroenterol. 2025年25卷1期700页
For the treatment of colorectal cancer, the S3-Guideline of the German Guideline Program in Oncology supports clinical decision-making. Centers certified by the German Cancer Society are required to implement the guideline recommendations as comprehensively as possible. When guidelines provide insufficient or ambiguous evidence, heterogeneity of treatment preferences is likely to emerge across individual centers. The aim of this study is to describe the preferences of the centers' tumor boards for treatment decisions when clear, evidence-based guideline recommendations are lacking.
171. MMP11 predicts colorectal cancer outcomes and its inhibitor RXP03 exerts anti-tumor effects via apoptosis activation.
MMP11 exhibits significant overexpression in various cancers; however, its role in colorectal cancer (CRC) remains poorly understood. This study aimed to investigate the relationship between MMP11 and the prognosis of colorectal cancer and to evaluate the therapeutic potential of an MMP11 inhibitor.
172. Small bowel diverticular disease: are we clinically aware?
作者: Yujen Tseng.;Jiayinaer Bolatihan.;Xiao Li.;Jiajing Yu.;Dou Wang.;Yuqin Jin.;Lili Ma.;Zhongguang Luo.
来源: BMC Gastroenterol. 2025年25卷1期701页
Small bowel diverticulum (SBD) is an outpouching of the small intestinal wall and is often neglected in clinical practice due to its undiscerning location. Majority of SBD can be asymptomatic but can also be associated with life-threatening complications. We hereby performed a clinical analysis to investigate the characteristics associated with SBD.
173. Effect of AI-assisted diagnosis on adenomas of different sizes: a meta-analysis with evidence from RCTs and trial sequential analysis.
作者: Dengchao Wang.;Youyun Shi.;Jinshan Liu.;Anyin Wang.;Yong Cheng.
来源: BMC Gastroenterol. 2025年25卷1期698页
The application of Artificial Intelligence (AI)-assisted techniques in adenoma detection during colonoscopy has increased. However, the effectiveness of AI in improving adenoma detection rates (ADR) and reducing adenoma miss rates (AMR) across varying adenoma sizes has yet to be thoroughly assessed.
174. The diagnostic value of serum cysteine protease inhibitor (CST4) in colorectal cancer: a preliminary study.
CST4 is associated with various cancers but its diagnostic value in colorectal cancer (CRC) has not been clearly established. This study aims to further validate the diagnostic value of CST4 in colorectal cancer using random forest models in machine learning based on existing research.
175. The effect of a plant- and dairy-based protein diet on serum levels of inflammatory and oxidative stress biomarkers in patients with liver cirrhosis: a randomized controlled trial.
作者: Banafshe Khalese Ranjbar.;Mahdiyeh Taghizadeh.;Soraiya Ebrahimpour-Koujan.;Mir Saeed Yekaninejad.;Amir Anushiravani.;Mehdi Saberifiroozi.;Somayyeh Asghari.
来源: BMC Gastroenterol. 2025年25卷1期695页
Previous studies have confirmed that plant and dairy proteins help with hepatic encephalopathy; yet, the impact on oxidative stress and inflammation in liver cirrhosis remains unexplored. This is the first interventional clinical trial investigating the impact of a plant and dairy protein diet on oxidative stress and inflammatory biomarkers in cirrhotic patients.
176. Partial Splenic embolization combined with endoscopic variceal ligation in variceal rebleeding prevention among liver cirrhosis patients complicated with hypersplenism, thrombocytopenia, and esophagogastric variceal hemorrhage: a prospective observational study.
作者: Bin Yue.;Di Yang.;Zhongqiao Lu.;Shiyou Zhao.;Zhenhong Tang.
来源: BMC Gastroenterol. 2025年25卷1期696页
Patients with liver cirrhosis often suffer from complications such as splenomegaly, thrombocytopenia, and esophagogastric variceal hemorrhage, necessitating effective preventive measures. This study aimed to investigate the outcome of partial splenic embolization (PSE) combined with endoscopic variceal ligation (EVL) in variceal rebleeding prevention among liver cirrhosis patients complicated with hypersplenism, thrombocytopenia, and esophagogastric variceal hemorrhage.
177. Global prevalence of metabolic dysfunction-associated fatty liver disease in children and adolescents with overweight and obesity: a systematic review and meta-analysis.
作者: Shuangzhen Jia.;Xiaolin Ye.;Tianwei Wu.;Zhaoxia Wang.;Jie Wu.
来源: BMC Gastroenterol. 2025年25卷1期691页
The prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) among children and adolescents with overweight and/or obesity is rising globally, reflecting increasing obesity rates and metabolic syndrome. This study aims to provide a comprehensive global estimate of MAFLD prevalence in this population.
178. Association between daily calcium intake and the prevalence of chronic diarrhea: an analysis of NHANES 2005-2010 data.
Chronic diarrhea significantly affects quality of life, yet the potential role of calcium intake in its prevention remains underexplored. This study aims to investigate the association between daily calcium intake and chronic diarrhea using data from the 2005 to 2010 National Health and Nutrition Examination Survey (NHANES).
179. Association of serum osmolality with metabolic dysfunction-associated steatotic liver disease in adults.
Hydration status is linked to metabolic syndrome, hypertension, and obesity in adults, and dehydration is associated with metabolic dysfunction-associated steatotic liver disease (MASLD) in children. However, the relationship between serum osmolality (OSM) and MASLD odds in adults remains unclear.
180. Glutamine prevents diarrhea in colorectal cancer patients undergoing chemotherapy or chemoradiotherapy: a meta-analysis.
作者: Lijuan Chen.;Duo Wang.;Chang Meng.;Hongshuo Sun.;Ruolin Li.;Guobin Miao.;Peng Liu.
来源: BMC Gastroenterol. 2025年25卷1期697页
To assess the efficacy of glutamine in preventing diarrhea associated with chemotherapy or chemoradiotherapy in colorectal cancer.
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