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161. Exercise Hemodynamics and the Evolving Definition of Precapillary Pulmonary Hypertension.
作者: Louisa A Mounsey.;Ceanna J Kalaria.;Alyssa Kowal.;Casey Hoenstine.;Shania McGinnis.;Isabela Landsteiner.;Rajeev Malhotra.;Greg D Lewis.;Alexandra K Wong.;Alison S Witkin.;Josanna Rodriguez-Lopez.;C Corey Hardin.
来源: Chest. 2025年 162. Association of Lung Quantitative CT Scan Textures With Systemic Inflammation and Mortality in COPD.
作者: Hira A Awan.;Muhammad F A Chaudhary.;Anthony D El-Sokkary.;Eric A Hoffman.;Alejandro P Comellas.;Junfeng Guo.;Igor Z Barjaktarevic.;R Graham Barr.;Surya P Bhatt.;Sandeep Bodduluri.;Russell P Bowler.;Luis G Vargas Buonfiglio.;Christopher B Cooper.;Ashraf Fawzy.;Annette T Hastie.;Wassim W Labaki.;Fernando J Martinez.;Martha G Menchaca.;Wanda O'Neal.;Robert Paine.;Joyce D Schroeder.;Prescott G Woodruff.;Jeffrey L Curtis.;Joseph M Reinhardt.
来源: Chest. 2025年
COPD is characterized by persistent inflammation that is responsible for remodeling the bronchovascular bundles (BVBs), which may lead to poor quality of life. Quantitative CT (QCT) scan textures of the lung can capture local disease patterns of inflammation and related respiratory morbidity.
163. Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.
作者: Chao Liu.;Hui Xiong.;Xia Han.;Yanling Lv.;Decai Wang.;Jiannan Hu.;Ziling Li.;Xinyue Ma.;Yunfei Zhu.;Shuyun Xu.;Liangkai Chen.
来源: Chest. 2025年
The bidirectional relationship between frailty and COPD is documented. However, longitudinal studies examining the combined effects of genetic predisposition and preserved ratio impaired spirometry (PRISm) on frailty in COPD development are lacking.
164. XALOC-1: Clinical Remission Over 2 Years With Benralizumab in Severe Eosinophilic Asthma.
作者: Girolamo Pelaia.;David J Jackson.;Parameswaran Nair.;Benjamin Emmanuel.;Trung N Tran.;Andrew Menzies-Gow.;Michael Watt.;Sheena Kayaniyil.;Silvia Boarino.;Javier Nuevo.;Marisa Pardal.;Anat Shavit.;Vivian H Shih.;David Cohen.;Claudia Loureiro.;Alicia Padilla-Galo.
来源: Chest. 2025年168卷1期19-32页
Long-term real-world data on clinical remission in patients with severe eosinophilic asthma (SEA) receiving biologics are lacking. We describe clinical remission over 2 years in patients with SEA receiving benralizumab.
165. Forecasting the Global Economic and Health Burden of COPD From 2025 Through 2050.
作者: Elroy Boers.;Angier Allen.;Meredith Barrett.;Adam V Benjafield.;Mary B Rice.;Jadwiga A Wedzicha.;Leanne Kaye.;Heather J Zar.;Sanjeev Sinha.;Obianuju Ozoh.;Laura E Crotty Alexander.;Atul Malhotra.
来源: Chest. 2025年
Studies have reported estimates of the economic and health burden of COPD. They have been limited largely to current-day estimates or relatively short-term future projections.
166. Local Anesthetic Use in Pleural Procedures: Time to Reconsider the Guidelines?
作者: Craig A Mounsey.;Imogen R Mechie.;Dinesh N Addala.;Rhea Suribhatla.;Zara O Small.;Ella M Smith.;Robyn A E Gould.;Grace A Annetts.;Daniela Krouzkova.;Nikolaos I Kanellakis.;Najib M Rahman.
来源: Chest. 2025年 167. Clinical Impact of Tirzepatide on Patients With OSA and Obesity.
作者: Jheng-Yan Wu.;Chia-Chen Chen.;Wan Ling Tu.;Wan-Hsuan Hsu.;Ting-Hui Liu.;Ya-Wen Tsai.;Po-Yu Huang.;Min-Hsiang Chuang.;Kuo-Chuan Hung.;Tsung Yu.;Chih-Cheng Lai.
来源: Chest. 2025年
OSA is a prevalent chronic condition linked to obesity that is associated with increased risks of cardiovascular and kidney disease. Although weight loss can improve OSA outcomes, additional effective therapeutic options are needed. Tirzepatide, a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, has shown promise in promoting significant weight loss and reducing OSA severity.
168. Coronary Artery Calcification Identified on Lung Cancer Screening CT Scans: A Scoping Review.
作者: Nada Al-Antary.;Kelly A Hirko.;Andrea E Cassidy-Bushrow.;Katie R Zarins.;Mike J Simoff.;Thomas Song.;Avi Cohen.;Christine Neslund-Dudas.
来源: Chest. 2025年
Coronary artery calcification (CAC) can be a significant incidental finding on low-dose CT scans performed for lung cancer screening (LCS). CAC presence and grade hold important diagnostic and preventive value, particularly in patients without previously recognized coronary artery disease.
169. Characteristics, Prognosis, and European Society of Cardiology and European Respiratory Society Risk Stratification in Patients With Obesity and Pulmonary Arterial Hypertension.
作者: Giulio Savonitto.;Davide Barbisan.;Pietro Ameri.;Carlo Maria Lombardi.;Mauro Driussi.;Piero Gentile.;Luke Howard.;Matteo Toma.;Matteo Pagnesi.;Valentino Collini.;Carolina Bauleo.;Matteo Rugolotto.;Giovanni Santi.;Francesca Coppi.;Gianluca Pagnoni.;Pier Paolo Bocchino.;Claudia Raineri.;Alberto Giannoni.;Massimo Imazio.;Edoardo Airo.;Marco Metra.;Andrea Garascia.;Gianfranco Sinagra.;Francesco Lo Giudice.;Davide Stolfo.
来源: Chest. 2025年
The impact of obesity on pulmonary arterial hypertension (PAH) remains largely underexplored, with excess weight potentially masking symptoms and affecting the reliability of current risk stratification tools.
170. Echocardiographic Parameters and Risk Prediction in Pulmonary Arterial Hypertension: Insights From the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Network.
作者: Monica Mukherjee.;Vivek P Jani.;Ryan Osgueritchian.;Hoda Mombeini.;Aiden Abidov.;Gerald Beck.;Serpil Erzurum.;Robert P Frantz.;Paul M Hassoun.;Anna R Hemnes.;Nicholas S Hill.;Evelyn M Horn.;Jiwon Kim.;Deborah Kwon.;A Brett Larive.;Peter J Leary.;Jane A Leopold.;Stephen C Mathai.;Reena Mehra.;Margaret M Park.;Erika B Rosenzweig.;W H Wilson Tang.;Christine L Jellis.;Franz P Rischard.;Roberto Badagliacca.; .
来源: Chest. 2025年168卷2期502-519页
Echocardiographic metrics of right ventricular (RV) chamber size and function enhance prognostication, risk stratification, and measurement of therapeutic response in patients with pulmonary arterial hypertension (PAH), though the most effective metrics remain unclear.
171. Machine Listening for OSA Diagnosis: A Bayesian Meta-Analysis.
作者: Benjamin Kye Jyn Tan.;Esther Yanxin Gao.;Nicole Kye Wen Tan.;Brian Sheng Yep Yeo.;Claire Jing-Wen Tan.;Adele Chin Wei Ng.;Zhou Hao Leong.;Chu Qin Phua.;Maythad Uataya.;Liang Chye Goh.;Thun How Ong.;Leong Chai Leow.;Guang-Bin Huang.;Song Tar Toh.
来源: Chest. 2025年168卷2期520-530页
Among 1 billion patients worldwide with OSA, 90% remain undiagnosed. The main barrier to diagnosis is the overnight polysomnogram, which requires specialized equipment, skilled technicians, and inpatient beds available only in tertiary sleep centers. Recent advances in artificial intelligence (AI) have enabled OSA detection using breathing sound recordings.
172. Characterizing Sarcoidosis Patients With Obstructive Respiratory Physiology.
作者: Daniel VanDerhoef.;Nicholas Marka.;Benjamin Langworthy.;Nikhil Kapur.;Bharat Thayagarajan.;David M Perlman.;Maneesh Bhargava.
来源: Chest. 2025年
Lung involvement occurs in > 95% of sarcoidosis cases. The World Association of Sarcoidosis and Other Granulomatous Disorders Organ Assessment Instrument does not assign the likelihood of lung involvement based on pulmonary function test (PFT) results. Clinical characteristics linked to normal and abnormal physiological pattern on PFTs in sarcoidosis are incompletely understood.
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