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161. Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers.
作者: Suk Yee Lam.;Michiel C Mommersteeg.;Bingting Yu.;Linda Broer.;Manon C W Spaander.;Fabian Frost.;Stefan Weiss.;Henry Völzke.;Markus M Lerch.;Ben Schöttker.;Yan Zhang.;Hannah Stocker.;Hermann Brenner.;Daniel Levy.;Shih-Jen Hwang.;Alexis C Wood.;Stephen S Rich.;Jerome I Rotter.;Kent D Taylor.;Russell P Tracy.;Edmond K Kabagambe.;Marcis Leja.;Janis Klovins.;Raitis Peculis.;Dace Rudzite.;Liene Nikitina-Zake.;Girts Skenders.;Vita Rovite.;André Uitterlinden.;Ernst J Kuipers.;Gwenny M Fuhler.;Georg Homuth.;Maikel P Peppelenbosch.
来源: Gastroenterology. 2022年162卷6期1705-1715页
A genome-wide significant association between anti-Helicobacter pylori (H pylori) IgG titers and Toll-like receptor (TLR1/6/10) locus on 4p14 was demonstrated for individuals of European ancestry, but not uniformly replicated. We re-investigated this association in an updated genome-wide association study (GWAS) meta-analysis for populations with low gastric cancer incidence, address potential causes of cohort heterogeneity, and explore functional implications of genetic variation at the TLR1/6/10 locus.
162. A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease.
作者: Jonathan Gan.;Scarlet Nazarian.;Julian Teare.;Ara Darzi.;Hutan Ashrafian.;Alex J Thompson.
来源: BMC Gastroenterol. 2022年22卷1期16页
A widely used method in assessing small bowel permeability is the lactulose:mannitol test, where the lactulose:mannitol ratio (LMR) is measured. However, there is discrepancy in how the test is conducted and in the values of LMR obtained across studies. This meta-analysis aims to determine LMR in healthy subjects, coeliac and Crohn's disease.
163. Clinical and Endoscopic Characteristics Associated With Post-Endoscopy Upper Gastrointestinal Cancers: A Systematic Review and Meta-analysis.
作者: Leo Alexandre.;Theo Tsilegeridis-Legeris.;Stephen Lam.
来源: Gastroenterology. 2022年162卷4期1123-1135页
Ten percent of patients with an upper gastrointestinal cancer will have received an esophagogastroduodenoscopy (EGD) within 3 years before diagnosis, termed post-endoscopy upper gastrointestinal cancers (PEUGIC). We aimed to determine the characteristics of PEUGIC, and compare these with detected cancers.
164. Association of HSD17B13 rs72613567: TA allelic variant with liver disease: review and meta-analysis.
作者: Shan Tang.;Jing Zhang.;Ting-Ting Mei.;Wen-Yan Zhang.;Su-Jun Zheng.;Hai-Bin Yu.
来源: BMC Gastroenterol. 2021年21卷1期490页
To assess the association of HSD17B13 rs72613567:TA allelic variant with liver disease, we performed the current review and meta-analysis.
165. Helicobacter pylori infection is associated with reduced risk of Barrett's esophagus: a meta-analysis and systematic review.
Helicobacter pylori (Hp) is a class I carcinogen in gastric carcinogenesis, but its role in Barrett's esophagus (BE) is unknown. Therefore, we aimed to explore the possible relationship.
166. Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis.
作者: Ankit Chhoda.;Ziga Vodusek.;Kapil Wattamwar.;Eric Mukherjee.;Craig Gunderson.;Alyssa Grimshaw.;Anup Sharma.;Nita Ahuja.;Fay Kastrinos.;James J Farrell.
来源: Gastroenterology. 2022年162卷3期786-798页
Identification and resection of successful targets, that is, T1 N0M0 pancreatic ductal adenocarcinoma (PDAC) and high-grade precursors during surveillance of high-risk individuals (HRIs) confers improved survival. Late-stage PDACs refer to T2-4 N0M0 and nodal or distant metastatic PDAC stages diagnosed during the follow-up phase of HRI surveillance. This study aimed to quantify late-stage PDACs during HRI surveillance and identify associated clinicoradiologic factors.
167. Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis.
Heat shock protein 70 (HSP70) has been associated with the clinicopathological characteristics and prognosis of many cancers types, implying that it is a potential cancer biomarker. However, no consensus has been reached regarding its clinicopathological and prognostic significance in patients with gastric cancer. To address this gap, we performed a systematic review and meta-analysis.
168. Efficacy of Biologic Drugs in Short-Duration Versus Long-Duration Inflammatory Bowel Disease: A Systematic Review and an Individual-Patient Data Meta-Analysis of Randomized Controlled Trials.
作者: Shomron Ben-Horin.;Lena Novack.;Ren Mao.;Jing Guo.;Yue Zhao.;Ruslan Sergienko.;Jian Zhang.;Taku Kobayashi.;Toshifumi Hibi.;Yehuda Chowers.;Laurent Peyrin-Biroulet.;Jean Frederic Colombel.;Gilaad G Kaplan.;Min-Hu Chen.
来源: Gastroenterology. 2022年162卷2期482-494页
Starting biologic treatment early in the course of inflammatory bowel disease (IBD) may be associated with higher efficacy, especially in Crohn's disease (CD).
169. Serologic Response to Coronavirus Disease 2019 (COVID-19) Vaccination in Patients With Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-analysis.
Patients with immune-mediated inflammatory diseases (IMIDs) have an increased risk of coronavirus disease 2019 (COVID-19), primarily attributed to the use of immunosuppressive drugs such as glucocorticoids, which may attenuate the response to vaccines. This meta-analysis assessed the serologic response to COVID-19 vaccination in patients with IMIDs.
171. AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis.
作者: Robert S O'Shea.;Perica Davitkov.;Cynthia W Ko.;Anita Rajasekhar.;Grace L Su.;Shahnaz Sultan.;Alina M Allen.;Yngve Falck-Ytter.
来源: Gastroenterology. 2021年161卷5期1615-1627.e1页 172. Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis.
作者: Jordan P Iannuzzi.;James A King.;Jessica Hope Leong.;Joshua Quan.;Joseph W Windsor.;Divine Tanyingoh.;Stephanie Coward.;Nauzer Forbes.;Steven J Heitman.;Abdel-Aziz Shaheen.;Mark Swain.;Michael Buie.;Fox E Underwood.;Gilaad G Kaplan.
来源: Gastroenterology. 2022年162卷1期122-134页
Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing temporal trends of acute pancreatitis incidence globally.
173. The association between irritable bowel syndrome and ischemic colitis: a systematic review and meta-analysis.
作者: Wasit Wongtrakul.;Nipith Charoenngam.;Patompong Ungprasert.
来源: Minerva Gastroenterol (Torino). 2022年68卷4期470-474页
Studies have suggested an association between ischemic colitis and irritable bowel syndrome (IBS) although the results were inconsistent. This systematic review and meta-analysis were performed to comprehensively examine the association between IBS and ischemic colitis by identifying all available cohort and case-control studies and combining their effect estimates together.
174. Efficiency of complete omentectomy in patients with resectable gastric cancer: a meta‑analysis and systematic review.
作者: Akao Zhu.;Guang Yin.;Xinchun Liu.;Wencheng Kong.;Yu Zhang.;Yuqiang Shan.;Rongchao Ying.;Jian Zhang.;Chunhua Zhou.
来源: BMC Gastroenterol. 2021年21卷1期346页
We performed a meta-analysis to investigate the efficacy of complete omentectomy (CO) in patients undergoing radical gastrectomy for gastric cancer.
175. Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
作者: Brigida Barberio.;Davide Massimi.;Nora Cazzagon.;Fabiana Zingone.;Alexander C Ford.;Edoardo V Savarino.
来源: Gastroenterology. 2021年161卷6期1865-1877页
Although the association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) is well recognized, uncertainties remain about the magnitude of this problem. We conducted a systematic review and meta-analysis assessing prevalence of PSC in IBD to investigate whether type of IBD, how presence of PSC was defined, sex, disease extent or location, time period, or geographic location influenced prevalence.
176. Host Genetic Determinants Associated With Helicobacter pylori Eradication Treatment Failure: A Systematic Review and Meta-analysis.
作者: Shailja C Shah.;Adam Tepler.;Cecilia P Chung.;Giovanni Suarez.;Richard M Peek.;Adriana Hung.;Christianne Roumie.;Neeraj Narula.
来源: Gastroenterology. 2021年161卷5期1443-1459页
Helicobacter pylori infects approximately 50% of individuals worldwide. Successful H pylori eradication is associated with reduced risk of gastric cancer and peptic ulcer disease, among other conditions. We hypothesized that host genetic determinants, especially those affecting gastric pH, might contribute to eradication therapy failure, particularly when treatment adherence and antibiotic susceptibility are confirmed. We aimed to conduct a meta-analysis of host genetic variants associated with H pylori eradication failure.
177. Systematic review and meta-analysis: real-world data rates of deep remission with anti-TNFα in inflammatory bowel disease.
Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; however, real-world data (RWD) can provide information complementary to RCTs, specifically regarding treatment duration. In this systematic review with meta-analysis, we use real-world data (RWD) to determine rates of DR in IBD treated with anti-TNFα.
178. Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis.
作者: Tian Fang.;Tingting Liang.;Yizhuo Wang.;Haitao Wu.;Shuhan Liu.;Linying Xie.;Jiaying Liang.;Chang Wang.;Yehui Tan.
来源: BMC Gastroenterol. 2021年21卷1期297页
Approximately 5.0-24.2% of colorectal cancers (CRCs) have inactivating mutations in SMAD4, making it one of the frequently mutated genes in CRC. We thus carried out a comprehensive system review and meta-analysis investigating the prognostic significance and clinicopathological features of SMAD4 gene mutation in CRC patients.
179. Hepatitis B virus infection and risk of gastric cancer: a systematic review and meta-analysis.
作者: Wasit Wongtrakul.;Nipith Charoenngam.;Ben Ponvilawan.;Pongprueth Rujirachun.;Phuuwadith Wattanachayakul.;Thitiphan Srikulmontri.;Nutchaphon Hong.;Pavarist Rai.;Patompong Ungprasert.
来源: Minerva Gastroenterol (Torino). 2023年69卷4期546-552页
Hepatitis B virus (HBV) infection is a well-established risk factor for hepatocellular carcinoma. Recent studies have also suggested a higher risk of several extrahepatic cancers in patients with chronic HBV infection, including gastric cancer, even though the results are somewhat inconsistent. The current study was conducted to comprehensively investigate whether patients with HBV infection are at a higher risk of incident gastric cancer compared with individuals without HBV infection using systematic review and meta-analysis technique.
180. Evidence-Based Management of Hepatocellular Carcinoma: Systematic Review and Meta-analysis of Randomized Controlled Trials (2002-2020).
作者: Philipp K Haber.;Marc Puigvehí.;Florian Castet.;Vennis Lourdusamy.;Robert Montal.;Parissa Tabrizian.;Michael Buckstein.;Edward Kim.;Augusto Villanueva.;Myron Schwartz.;Josep M Llovet.
来源: Gastroenterology. 2021年161卷3期879-898页
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a rapidly changing landscape of treatments. In the past 20 years, numerous randomized controlled trials (RCTs) have aimed at improving outcomes across disease stages. We aimed to analyze the current evidence and identify potential factors influencing response to therapies.
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