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161. Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial.
作者: Adrian F Hernandez.;Jacob A Udell.;W Schuyler Jones.;Stefan D Anker.;Mark C Petrie.;Josephine Harrington.;Michaela Mattheus.;Svenja Seide.;Isabella Zwiener.;Offer Amir.;M Cecilia Bahit.;Johann Bauersachs.;Antoni Bayes-Genis.;Yundai Chen.;Vijay K Chopra.;Gemma A Figtree.;Junbo Ge.;Shaun G Goodman.;Nina Gotcheva.;Shinya Goto.;Tomasz Gasior.;Waheed Jamal.;James L Januzzi.;Myung Ho Jeong.;Yuri Lopatin.;Renato D Lopes.;Béla Merkely.;Puja B Parikh.;Alexander Parkhomenko.;Piotr Ponikowski.;Xavier Rossello.;Morten Schou.;Dragan Simic.;Philippe Gabriel Steg.;Joanna Szachniewicz.;Peter van der Meer.;Dragos Vinereanu.;Shelley Zieroth.;Martina Brueckmann.;Mikhail Sumin.;Deepak L Bhatt.;Javed Butler.
来源: Circulation. 2024年149卷21期1627-1638页
Empagliflozin reduces the risk of heart failure (HF) events in patients with type 2 diabetes at high cardiovascular risk, chronic kidney disease, or prevalent HF irrespective of ejection fraction. Whereas the EMPACT-MI trial (Effect of Empagliflozin on Hospitalization for Heart Failure and Mortality in Patients With Acute Myocardial Infarction) showed that empagliflozin does not reduce the risk of the composite of hospitalization for HF and all-cause death, the effect of empagliflozin on first and recurrent HF events after myocardial infarction is unknown.
162. SPECTRA Phase 2b Study: Impact of Sotatercept on Exercise Tolerance and Right Ventricular Function in Pulmonary Arterial Hypertension.
作者: Aaron B Waxman.;David M Systrom.;Solaiappan Manimaran.;Janethe de Oliveira Pena.;Jonathan Lu.;Franz P Rischard.
来源: Circ Heart Fail. 2024年17卷5期e011227页
This study aims to assess the impact of sotatercept on exercise tolerance, exercise capacity, and right ventricular function in pulmonary arterial hypertension.
163. Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial.
作者: Kristoffer Berg-Hansen.;Nigopan Gopalasingam.;Kristian Hylleberg Christensen.;Bertil Ladefoged.;Mads Jønsson Andersen.;Steen Hvitfeldt Poulsen.;Barry A Borlaug.;Roni Nielsen.;Niels Møller.;Henrik Wiggers.
来源: Circulation. 2024年149卷19期1474-1489页
Heart failure triggers a shift in myocardial metabolic substrate utilization, favoring the ketone body 3-hydroxybutyrate as energy source. We hypothesized that 14-day treatment with ketone ester (KE) would improve resting and exercise hemodynamics and exercise capacity in patients with heart failure with reduced ejection fraction.
164. Impact of Incomplete Revascularization After PCI in Left Main Disease: The EXCEL Trial.
作者: Ziad A Ali.;Javier Jas Garcia.;Keyvan Karimi Galougahi.;Jennifer Horst.;Anthony Gallo.;Doosup Shin.;Ori Ben-Yehuda.;Shmuel Chen.;Björn Redfors.;Arie Pieter Kappetein.;Joseph F Sabik.;Patrick W Serruys.;Gregg W Stone.
来源: Circ Cardiovasc Interv. 2024年17卷3期e013192页
The importance of complete revascularization after percutaneous coronary intervention (PCI) in patients with left main coronary artery disease is uncertain. We investigated the clinical impact of complete revascularization in patients with left main coronary artery disease undergoing PCI in the EXCEL trial (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization).
165. Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial.
作者: Nisha Bansal.;Ronit Katz.;Stephen Seliger.;Christopher deFilippi.;Nicholas Wettersten.;James A de Lemos.;Robert Christenson.;Anthony A Killeen.;Jarett D Berry.;Michael G Shlipak.;Joachim H Ix.
来源: Circulation. 2024年149卷12期967-969页 166. Cost-Effectiveness of Intravascular Imaging-Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial.
作者: David Hong.;Jin Lee.;Hankil Lee.;Juhee Cho.;Eliseo Guallar.;Ki Hong Choi.;Seung Hun Lee.;Doosup Shin.;Jong-Young Lee.;Seung-Jae Lee.;Sang Yeub Lee.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Young Bin Song.;Joo-Yong Hahn.;Danbee Kang.;Joo Myung Lee.; .
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷3期e010230页
Although clinical benefits of intravascular imaging-guided percutaneous coronary intervention (PCI) in patients with complex coronary artery lesions have been observed in previous trials, the cost-effectiveness of this strategy is uncertain.
167. Impact of Rapid Up-Titration of Guideline-Directed Medical Therapies on Quality of Life: Insights From the STRONG-HF Trial.
作者: Jelena Čelutkienė.;Kamilė Čerlinskaitė-Bajorė.;Gad Cotter.;Christopher Edwards.;Marianna Adamo.;Mattia Arrigo.;Marianela Barros.;Jan Biegus.;Ovidiu Chioncel.;Alain Cohen-Solal.;Albertino Damasceno.;Rafael Diaz.;Gerasimos Filippatos.;Etienne Gayat.;Antoine Kimmoun.;Valentine Léopold.;Marco Metra.;Maria Novosadova.;Matteo Pagnesi.;Peter S Pang.;Piotr Ponikowski.;Hadiza Saidu.;Karen Sliwa.;Koji Takagi.;Jozine M Ter Maaten.;Daniela Tomasoni.;Carolyn S P Lam.;Adriaan A Voors.;Alexandre Mebazaa.;Beth Davison.
来源: Circ Heart Fail. 2024年17卷4期e011221页
This analysis provides details on baseline and changes in quality of life (QoL) and its components as measured by EQ-5D-5L questionnaire, as well as association with objective outcomes, applying high-intensity heart failure (HF) care in patients with acute HF.
168. Compression-Only or Standard Cardiopulmonary Resuscitation for Trained Laypersons in Out-of-Hospital Cardiac Arrest: A Nationwide Randomized Trial in Sweden.
作者: Gabriel Riva.;Erik Boberg.;Mattias Ringh.;Martin Jonsson.;Andreas Claesson.;Anette Nord.;Sten Rubertsson.;Hans Blomberg.;Per Nordberg.;Sune Forsberg.;Mårten Rosenqvist.;Leif Svensson.;Cecilia Andréll.;Johan Herlitz.;Jacob Hollenberg.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷3期e010027页
The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest. This pilot study assesses feasibility, safety, and intermediate clinical outcomes as part of the larger TANGO2 survival trial.
169. Left Atrial Strain Predicts Subclinical Atrial Fibrillation Detected by Long-term Continuous Monitoring in Elderly High-Risk Individuals.
作者: Flemming Javier Olsen.;Søren Zöga Diederichsen.;Peter Godsk Jørgensen.;Magnus T Jensen.;Anders Dahl.;Nino Emanuel Landler.;Claus Graff.;Axel Brandes.;Derk Krieger.;Ketil Haugan.;Lars Køber.;Søren Højberg.;Jesper Hastrup Svendsen.;Tor Biering-Sørensen.
来源: Circ Cardiovasc Imaging. 2024年17卷3期e016197页
Left atrial (LA) speckle tracking provides detailed information on atrial function. Its utility for predicting subclinical atrial fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring.
170. Torsemide Versus Furosemide After Discharge in Patients Hospitalized With Heart Failure Across the Spectrum of Ejection Fraction: Findings From TRANSFORM-HF.
作者: Chris J Kapelios.;Stephen J Greene.;Robert J Mentz.;Uchechukwu Ikeaba.;Daniel Wojdyla.;Kevin J Anstrom.;Eric L Eisenstein.;Bertram Pitt.;Eric J Velazquez.;James C Fang.; .
来源: Circ Heart Fail. 2024年17卷3期e011246页
The TRANSFORM-HF trial (Torsemide Comparison With Furosemide for Management of Heart Failure) found no significant difference in all-cause mortality or hospitalization among patients randomized to a strategy of torsemide versus furosemide following a heart failure (HF) hospitalization. However, outcomes and responses to some therapies differ by left ventricular ejection fraction (LVEF). Thus, we sought to explore the effect of torsemide versus furosemide by baseline LVEF and to assess outcomes across LVEF groups.
171. Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial.
作者: Yan Yan.;Jincheng Guo.;Xiao Wang.;Guozhong Wang.;Zeyuan Fan.;Delu Yin.;Zhifang Wang.;Fuchun Zhang.;Changming Tian.;Wei Gong.;Jiamin Liu.;Jiapeng Lu.;Yongjun Li.;Changsheng Ma.;Eric Vicaut.;Gilles Montalescot.;Shaoping Nie.; .
来源: Circulation. 2024年149卷16期1258-1267页
Postprocedural anticoagulation (PPA) is frequently administered after primary percutaneous coronary intervention in ST-segment-elevation myocardial infarction, although no conclusive data support this practice.
172. Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study).
作者: Jennifer B Green.;Brendan M Everett.;Alokananda Ghosh.;Naji Younes.;Heidi Krause-Steinrauf.;Joshua Barzilay.;Cyrus Desouza.;Silvio E Inzucchi.;Yashashwi Pokharel.;David Schade.;Alexandra Scrymgeour.;Meng H Tan.;Kristina M Utzschneider.;Sunder Mudaliar.; .
来源: Circulation. 2024年149卷13期993-1003页
Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects of glucose-lowering medications on cardiovascular outcomes in individuals with type 2 diabetes and low cardiovascular risk are unclear. We investigated cardiovascular outcomes by treatment group in participants randomly assigned to insulin glargine, glimepiride, liraglutide, or sitagliptin, added to baseline metformin, in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study).
173. Long-Term Durability of High- and Very High-Power Short-Duration PVI by Invasive Remapping: The HPSD Remap Study.
作者: Nándor Szegedi.;Zoltán Salló.;Vivien Klaudia Nagy.;István Osztheimer.;István Hizoh.;Bálint Lakatos.;Melinda Boussoussou.;Gábor Orbán.;Márton Boga.;Arnold Béla Ferencz.;Ferenc Komlósi.;Patrik Tóth.;Péter Perge.;Attila Kovács.;Béla Merkely.;László Gellér.
来源: Circ Arrhythm Electrophysiol. 2024年17卷2期e012402页
High-power short-duration ablation has shown impressive efficacy and safety for pulmonary vein isolation (PVI); however, initial efficacy results with very high power short-duration ablation were discouraging. This study compared the long-term durability of PVI performed with a 90- versus 50-W power setting.
174. Conduction System Stimulation to Avoid Left Ventricle Dysfunction.
作者: Carlos E González-Matos.;Oriol Rodríguez-Queralto.;Fátima Záraket.;Jesús Jiménez.;Benjamín Casteigt.;Ermengol Vallès.
来源: Circ Arrhythm Electrophysiol. 2024年17卷2期e012473页
Right ventricular apical pacing (RVAP) can produce left ventricle dysfunction. Conduction system pacing (CSP) has been used successfully to reverse left ventricle dysfunction in patients with left bundle branch block. To date, data about CSP prevention of left ventricle dysfunction in patients with preserved left ventricular ejection fraction (LVEF) are scarce and limited mostly to nonrandomized studies. Our aim is to demonstrate that CSP can preserve normal ventricular function compared with RVAP in the setting of a high burden of ventricular pacing.
175. Single Bolus r-SAK Before Primary PCI for ST-Segment-Elevation Myocardial Infarction.
作者: Pengsheng Chen.;John W Eikelboom.;Chunyue Tan.;Wenhao Zhang.;Yi Xu.;Jianling Bai.;Jun Wang.;Tong Wang.;Xiaoxuan Gong.;Kun Liu.;Xin Chen.;Xiaoyan Wang.;Li Zhu.;Xin Zhao.;Naiquan Yang.;Jun Jiang.;Jun Pu.;Bo Zhao.;Zengguang Chen.;Baihong Li.;Guoyu Wang.;Chuan Lu.;Lianghong Ying.;Meng Jiang.;Xiaomei Zhu.;Jiazheng Ma.;Zhou Dong.;Chen Li.;Jiaxin Zong.;Fumin Zhang.;Jun Zhu.;Jun Huang.;Xiangqing Kong.;Hao Yu.;Chunjian Li.; .
来源: Circ Cardiovasc Interv. 2024年17卷2期e013455页
It is uncertain whether adjunctive thrombolysis is beneficial for patients with ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) within 120 minutes of presentation. This study was to determine whether in patients presenting with ST-segment-elevation myocardial infarction a single bolus recombinant staphylokinase (r-SAK) before timely PCI leads to improved patency of the infarct-related artery and reduces the infarct size.
176. Colchicine to Prevent Atrial Fibrillation Recurrence After Catheter Ablation: A Randomized, Placebo-Controlled Trial.
作者: Alexander P Benz.;Guy Amit.;Stuart J Connolly.;Jasrita Singh.;Juan G Acosta-Vélez.;David Conen.;Bishoy Deif.;Syamkumar Divakaramenon.;William F McIntyre.;Viwe Mtwesi.;Jason D Roberts.;Jorge A Wong.;Robin Zhao.;Jeff S Healey.; .
来源: Circ Arrhythm Electrophysiol. 2024年17卷1期e01238页
Inflammation may promote atrial fibrillation (AF) recurrence after catheter ablation. This study aimed to evaluate a short-term anti-inflammatory treatment with colchicine following ablation of AF.
177. Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery.
作者: G Chad Hughes.;Edward P Chen.;Jeffrey N Browndyke.;Wilson Y Szeto.;J Michael DiMaio.;William T Brinkman.;Jeffrey G Gaca.;James A Blumenthal.;Jorn A Karhausen.;Tiffany Bisanar.;Michael L James.;David Yanez.;Yi-Ju Li.;Joseph P Mathew.
来源: Circulation. 2024年149卷9期658-668页
Deep hypothermia has been the standard for hypothermic circulatory arrest (HCA) during aortic arch surgery. However, centers worldwide have shifted toward lesser hypothermia with antegrade cerebral perfusion. This has been supported by retrospective data, but there has yet to be a multicenter, prospective randomized study comparing deep versus moderate hypothermia during HCA.
178. Clinical Benefit of Intravascular Imaging Compared With Conventional Angiography in Left Main Coronary Artery Intervention.
作者: Woochan Kwon.;Joo Myung Lee.;Kyeong Ho Yun.;Ki Hong Choi.;Seung-Jae Lee.;Jong-Young Lee.;Sang Yeub Lee.;Sang Min Kim.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Jin-Ok Jeong.;Pil Sang Song.;Joon-Hyung Doh.;Sang-Ho Jo.;Chang-Hwan Yoon.;Min Gyu Kang.;Jin-Sin Koh.;Kwan Yong Lee.;Young-Hyo Lim.;Yun-Hyeong Cho.;Jin-Man Cho.;Woo Jin Jang.;Kook-Jin Chun.;David Hong.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Joo-Yong Hahn.;Young Bin Song.; .
来源: Circ Cardiovasc Interv. 2023年16卷12期e013359页
The RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance Versus Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention) demonstrated that intravascular imaging-guided percutaneous coronary intervention (PCI) improved clinical outcome compared with angiography-guided PCI for patients with complex coronary artery lesions. This study aims to assess whether the prognostic benefit of intravascular imaging-guided procedural optimization persists in patients undergoing PCI for left main coronary artery disease.
179. An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial.
作者: Masahiro Natsuaki.;Hirotoshi Watanabe.;Takeshi Morimoto.;Ko Yamamoto.;Yuki Obayashi.;Ryusuke Nishikawa.;Kenji Ando.;Takenori Domei.;Satoru Suwa.;Manabu Ogita.;Tsuyoshi Isawa.;Hiroyuki Takenaka.;Takashi Yamamoto.;Tetsuya Ishikawa.;Itaru Hisauchi.;Kohei Wakabayashi.;Yuko Onishi.;Kiyoshi Hibi.;Kazuya Kawai.;Ruka Yoshida.;Hiroshi Suzuki.;Gaku Nakazawa.;Takanori Kusuyama.;Itsuro Morishima.;Koh Ono.;Takeshi Kimura.
来源: Circulation. 2024年149卷8期585-600页
Bleeding rates on dual antiplatelet therapy (DAPT) within 1 month after percutaneous coronary intervention (PCI) remain high in clinical practice, particularly in patients with acute coronary syndrome or high bleeding risk. Aspirin-free strategy might result in lower bleeding early after PCI without increasing cardiovascular events, but its efficacy and safety have not yet been proven in randomized trials.
180. A Multicenter, Single-Blind, Randomized, Warfarin-Controlled Trial of Edoxaban in Patients With Chronic Thromboembolic Pulmonary Hypertension: KABUKI Trial.
作者: Kazuya Hosokawa.;Hiroko Watanabe.;Yu Taniguchi.;Nobutaka Ikeda.;Takumi Inami.;Satoshi Yasuda.;Toyoaki Murohara.;Masaru Hatano.;Yuichi Tamura.;Jun Yamashita.;Koichiro Tatsumi.;Ichizo Tsujino.;Yuko Kobayakawa.;Shiro Adachi.;Nobuhiro Yaoita.;Shun Minatsuki.;Koji Todaka.;Keiichi Fukuda.;Hiroyuki Tsutsui.;Kohtaro Abe.; .
来源: Circulation. 2024年149卷5期406-409页 |