当前位置: 首页 >> 检索结果
141. PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations.
作者: Hyojin Park.;Sungwoon Lee.;Jessica Furtado.;Mark Robinson.;Richard J Antaya.;S Paul Oh.;Young-Kwon Hong.;Martin A Schwartz.;Lawrence H Young.;Anne Eichmann.
来源: Circulation. 2025年
Hereditary hemorrhagic telangiectasia is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function variations in activin receptor-like kinase 1 (ALK1) cause type 2 hereditary hemorrhagic telangiectasia, and Alk1 knockout mice develop AVMs, along with overactivation of vascular endothelial growth factor receptor 2/phosphoinositide 3-kinase/AKT signaling. The full spectrum of signaling alterations resulting from ALK1 variations remains unknown, and more effective and specific inhibitors to combat AVM formation in patients are needed.
142. Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort.
作者: Carolina G Downie.;Joseph J Shearer.;Kayode O Kuku.;Suzette J Bielinski.;Jorge R Kizer.;Bruce M Psaty.;Jungnam Joo.;Véronique L Roger.
来源: Circ Genom Precis Med. 2025年18卷4期e004953页
Heart failure (HF) is a heterogeneous syndrome with high mortality. The need for a new taxonomy of HF is recognized; up to now, such phenomapping efforts have primarily used clinical data. Proteomics offers potential for more precise phenotypic identification and mechanistic insights. However, few phenomapping studies have used this approach, and all have focused on targeted cardiovascular proteomics panels and a restricted HF ejection fraction group.
143. Midterm Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Recipients.
作者: Brian H Morray.;Matthew J Gillespie.;John P Cheatham.;Arash Salavitabar.;Lynn Peng.;Thomas K Jones.;Daniel S Levi.;Robert G Gray.;Jeremy Asnes.;Allison K Cabalka.;Kazuto Fujimoto.;Athar M Qureshi.;Lisa Bergersen.;Lee N Benson.;Daniel Haugan.;Doff B McElhinney.
来源: Circ Cardiovasc Interv. 2025年e015196页
The Harmony transcatheter pulmonary valve (TPV) is designed to treat severe pulmonary regurgitation in the native or surgically repaired right ventricular (RV) outflow tract. Early outcomes after TPV replacement with the Harmony valve have been positive, but longer-term data are limited.
144. Unique Role of Intracellular Perinuclear β1-Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling.
作者: Moriah Gildart Turcotte.;Anne-Maj Samuelsson.;Sofia M Possidento.;Jinliang Li.;Zhuyun Qin.;Michael S Kapiloff.;Kimberly L Dodge-Kafka.
来源: Circulation. 2025年
β-Adrenergic receptors (βARs) are prototypical G protein-coupled receptors that regulate contractility in the normal heart and pathological remodeling in disease. Canonical βAR signaling originates at the plasma membrane, but functional βARs have been localized to intracellular membranes such as the endosome, sarcoplasmic reticulum, Golgi, and nuclear envelope. The functional significance of these intracellular receptors remains unclear, including whether they regulate cellular processes distinct from those regulated by plasma membrane receptors and whether they can be independently targeted for therapeutic benefit.
146. Correction to: 2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures.
作者: Marlene S Williams.;Glenn N Levine.;Dinesh Kalra.;Anandita Agarwala.;Diana Baptiste.;Joaquin E Cigarroa.;Rebecca L Diekemper.;Marva V Foster.;Martha Gulati.;Timothy D Henry.;Dipti Itchhaporia.;Jennifer S Lawton.;L Kristin Newby.;Kelly C Rogers.;Krishan Soni.;Jacqueline E Tamis-Holland.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e000141页 147. Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early After Surgical Bioprosthetic Valve Replacement: A Randomized Clinical Trial.
作者: Chisato Izumi.;Masashi Amano.;Yusuke Yoshikawa.;Satsuki Fukushima.;Hitoshi Yaku.;Kiyoyuki Eishi.;Taichi Sakaguchi.;Nobuhisa Ohno.;Arudo Hiraoka.;Kenji Okada.;Yoshikatsu Saiki.;Takashi Miura.;Tatsuhiko Komiya.;Manabu Minami.;Haruko Yamamoto.;Katsuhiro Omae.; .
来源: Circ Cardiovasc Interv. 2025年18卷7期e015108页
Anticoagulant therapy with vitamin K antagonists is recommended in the current guidelines for 3 to 6 months following bioprosthetic valve replacement. However, in the era of direct oral anticoagulants, there is a paucity of evidence regarding the efficacy and safety of direct oral anticoagulants in this patient group.
150. Physical Activity and Incident Atrial Fibrillation in African Americans: The Jackson Heart Study.
作者: Jack Tiahnybik.;Marielle Siebert.;Daisuke Kamimura.;Wondwosen Yimer.;Yuan-I Min.;Kaustuv Bhattacharya.;James Floyd.;Yi Yang.;Susan R Heckbert.;Michael E Hall.;Adolfo Correa.;Takeki Suzuki.
来源: Circulation. 2025年152卷2期126-128页 151. The Promise and Peril of Learning Algorithms and Predictive Models in Clinical Decision Support: Be Careful What You Train For.
Continued growth in AI-enhanced clinical decision is expected. Representative populations for model training/validation are needed.
152. DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.
作者: Madeleine Carbonneau.;Yi Li.;Yishu Qu.;Yinan Zheng.;Alexis C Wood.;Mengyao Wang.;Chunyu Liu.;Tianxiao Huan.;Roby Joehanes.;Xiuqing Guo.;Jie Yao.;Kent D Taylor.;Russell P Tracy.;Peter Durda.;Yongmei Liu.;W Craig Johnson.;Wendy S Post.;Tom Blackwell.;Jerome I Rotter.;Stephen S Rich.;Susan Redline.;Myriam Fornage.;Jun Wang.;Hongyan Ning.;Lifang Hou.;Donald Lloyd-Jones.;Kendra Ferrier.;Yuan-I Min.;April P Carson.;Laura M Raffield.;Alexander Teumer.;Hans J Grabe.;Henry Völzke.;Matthias Nauck.;Marcus Dörr.;Arce Domingo-Relloso.;Amanda Fretts.;Maria Tellez-Plaza.;Shelley A Cole.;Ana Navas-Acien.;Meng Wang.;Joanne M Murabito.;Nancy L Heard-Costa.;Brenton Prescott.;Vanessa Xanthakis.;Dariush Mozaffarian.;Daniel Levy.;Jiantao Ma.
来源: Circulation. 2025年152卷7期436-449页
The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.
153. Predicting Outcomes in Pediatric Intraluminal Pulmonary Vein Stenosis Using a Comprehensive Standardized Catheterization Assessment: A Prospective Study.
作者: Ryan Callahan.;Kimberlee Gauvreau.;Mirjam Keochakian.;Jesse J Esch.;Diego Porras.;Lisa Bergersen.;Rebecca Beroukhim.;Michael Farias.;David M Harrild.;Christina M Ireland.;Neha Kwatra.;Kathy J Jenkins.
来源: Circ Cardiovasc Interv. 2025年e015002页
Pediatric intraluminal pulmonary vein stenosis (PVS) occurs in a heterogeneous patient population but is unified by its cellular composition in affected pulmonary veins. Enhanced delineation of the hemodynamic and physiological vein consequences of PVS and its impact on vein lumen, vein pressure, wall structure, vein compliance, and wall shear stress has not been studied. The objective is to assess PVS characteristics using multimodal catheterization techniques (angiography, pulmonary vein pressure, intravascular ultrasound, balloon compliance testing, and wall shear stress calculation) and determine their association with vein outcomes.
154. Quantifying Patient Preferences About Features of Nonstatin Lipid-Lowering Therapies: A Discrete Choice Experiment in the United States.
作者: Shelby D Reed.;Jessie Sutphin.;Juan Marcos Gonzalez.;Matthew J Wallace.;Judith J Stephenson.;Batul Electricwala.;Hayden B Bosworth.;Neha Pagidipati.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011804页
Despite the growing number of nonstatin lipid-lowering treatments (NS-LLTs), data are lacking on how patients value their various features and outcomes. Study objectives were to quantify patients' preferences across levels of efficacy, treatment regimens, side effects, and out-of-pocket costs of NS-LLTs and compare approaches with framing treatment efficacy.
155. Predictors of Neurodevelopmental and Mental Health Diagnoses in Congenital Heart Disease: A Danish Population-Based Cohort Study.
作者: Kimberley G Miles.;Dana B Gal.;Dóra Körmendiné Farkas.;Kristina Laugesen.;Henrik Toft Sørensen.;Nadine A Kasparian.;Nicolas L Madsen.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011944页
Over 35% of Danish children with congenital heart disease (CHD) are diagnosed with or treated for a neurodevelopmental or mental health condition. We examined child clinical, parent socioeconomic, and family health factors associated with 4 common diagnostic groups in children with CHD: developmental disorders, intellectual disability, attention-deficit/hyperactivity disorder, and anxiety and mood disorders.
156. Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study.
作者: Rémi Goupil.;Louis-Charles Desbiens.;Amel Merabtine.;Mohsen Agharazii.;François Madore.;Anand Vaidya.;Alexander A Leung.;Gregory A Kline.;Julie L V Shaw.;Tim Ramsay.;Annie-Claire Nadeau-Fredette.;Manish M Sood.;Gregory L Hundemer.
来源: Circulation. 2025年
Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting evidence suggests that milder forms of renin-independent aldosterone production (subclinical PA) are highly prevalent; however, the link between subclinical PA and MACE remains uncertain.
157. The Impact of Fontan Circulatory Failure on Heart Transplant Survival: A 20-Center Retrospective Cohort Study.
作者: Kurt R Schumacher.;David N Rosenthal.;Adriana Batazzi.;Sunkyung Yu.;Garrett Reichle.;Maria Bano.;Shriprasad R Deshpande.;Matthew O'Connor.;Humera Ahmed.;Sharon Chen.;Lydia K Wright.;Steven J Kindel.;Anna Joong.;Michelle Ploutz.;Brian Feingold.;Justin Godown.;Chad Y Mao.;Angela Lorts.;Kathleen E Simpson.;Aecha Ybarra.;Marc E Richmond.;Shahnawaz Amdani.;Jennifer Conway.;Elizabeth D Blume.;Melissa K Cousino.
来源: Circulation. 2025年152卷8期508-518页
Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality rates, including heart failure, multisystem end-organ disease, and need for heart transplant. Specific FCF morbidities have not been rigorously defined, limiting study of how FCF morbidities affect pre-heart transplant and post-heart transplant outcomes. We hypothesized that FCF-related morbidities affect survival from heart transplant waitlisting through 1 year after heart transplant.
159. Z Scores for Pediatric Echocardiography Dimensions Adjusted for Body Size, BMI, and Age.
作者: Jonathan Lauzon-Schnittka.;Virginie Plante.;Nagib Dahdah.;Steven C Greenway.;Christian Drolet.;Kenny Wong.;Andrew S Mackie.;Luc Mertens.;Tiscar Cavallé-Garrido.;Joshua Penslar.;Derek Wong.;Luis Martín Garrido-García.;Frédéric Dallaire.; .
来源: Circ Cardiovasc Imaging. 2025年18卷8期e017944页
Cardiovascular dimensions measured during pediatric echocardiograms must be normalized for body size. However, other variables may confound their interpretation, such as age and abnormal body habitus. This retrospective cross-sectional study of the Canadian Congenital and Pediatric Cardiology Research Network aimed to create Z score equations for commonly measured dimensions in pediatric 2-dimensional echocardiography that were free of residual confounding effects of body size, body mass index, and age.
160. Response by Papathanasiou to Letter Regarding Article, "Disseminated Intracardiac Thrombosis Due to Long-Standing, Asymptomatic Ventricular Fibrillation Under LVAD Support".
作者: Lara S Schlender.;Reza Wakili.;David M Leistner.;Maria Papathanasiou.
来源: Circ Heart Fail. 2025年e013260页 |