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141. HCN4 Mutation Causing Familial Inappropriate Sinus Tachycardia Leads to a Conformational Change Mimicking cAMP Binding and Induces Constitutive Channel Activity.
作者: Sara L Bober.;Qiuju Li.;David Ros-Pardo.;Trent Faultless.;Íñigo Marcos-Alcalde.;Paulino Gómez-Puertas.;Michael H Gollob.
来源: Circ Arrhythm Electrophysiol. 2025年e013899页
Inappropriate sinus tachycardia (IST) is an arrhythmia characterized by rapid sinus rates of over 100 bpm at rest. The mechanisms underlying this often-debilitating condition are not fully understood. The differential diagnosis for this persistent observation is broad, including medication side effects or serendipitous use of chronotropic stimulating drugs. Genetic causes of IST are seldom considered. Only 2 mutations have been linked to this condition, both of which affect the gene encoding HCN4 channels, which play an important role in generating pacemaker activity of the SA node.
142. Lysosomal Ca2+ Release Through TRPML1 Governs Ventricular Arrhythmia After Myocardial Infarction.
作者: An Xie.;Gyeoung-Jin Kang.;Hong Liu.;Eun Ji Kim.;Feng Feng.;Dobromir Dobrev.;Samuel C Dudley.
来源: Circ Arrhythm Electrophysiol. 2025年e013964页
In nonischemic cardiomyopathy, mitochondrial Ca2+ handling is involved in arrhythmogenesis by modulating diastolic sarcoplasmic reticulum (SR) Ca2+ release. Recently, it has been reported that lysosomal Ca2+ release can trigger an SR Ca2+ release. We investigated whether lysosomal Ca2+ flux through the TRPML1 (transient receptor potential mucolipin 1) channel could contribute to ischemic cardiomyopathy-related arrhythmia by causing diastolic SR Ca2+ release.
145. Letter by Liu et al Regarding Article, "Risk of Incident Atrial Fibrillation in Women With a History of Hypertensive Disorders of Pregnancy: A Population-Based Retrospective Cohort Study".147. Response by Johnston et al to Letters Regarding Article, "Risk of Incident Atrial Fibrillation in Women With a History of Hypertensive Disorders of Pregnancy: A Population-Based Retrospective Cohort Study".148. Letter by Fauchier et al Regarding Article, "Risk of Incident Atrial Fibrillation in Women With a History of Hypertensive Disorders of Pregnancy: A Population-Based Retrospective Cohort Study".153. Long-Term Outcomes After Fontan Conversion Operation: A Comparative Analysis Based on Type of Fontan Connection.
作者: Amr Moustafa.;Zeyad Kholeif.;William R Miranda.;Heidi M Connolly.;Elizabeth H Stephens.;Joseph A Dearani.;Alexander C Egbe.
来源: Circ Heart Fail. 2025年e012990页
Fontan conversion (FC) is associated with a lower risk of atrial arrhythmias and thromboembolism, but it is unknown whether FC improves long-term survival. The purpose of this study was to assess the impact of FC on transplant-free survival.
154. Outcomes of Ventricular Tachycardia Catheter Ablation in Pediatric Arrhythmogenic Right Ventricular Cardiomyopathy.
作者: Salah H Alahwany.;Shunsuke Uetake.;Juan Jiménez-Jáimez.;Eva Cabrera-Borrego.;Aarti Dalal.;Prince J Kannankeril.;M Benjamin Shoemaker.;Daisuke Togashi.;Yumi Katsume.;Travis D Richardson.;Arvindh Kanagasundram.;William G Stevenson.;Harikrishna Tandri.
来源: Circ Arrhythm Electrophysiol. 2025年e014075页
Radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in arrhythmogenic right ventricular cardiomyopathy is safe and reduces ventricular arrhythmia burden. Previous studies included adult patients, and data on pediatric patients are scarce. The objective of our study was to report on the safety and efficacy of RFCA in pediatric arrhythmogenic right ventricular cardiomyopathy.
155. Transcatheter Closure of Patent Foramen Ovale With a Novel Biodegradable Device: A Prospective, Multicenter, Randomized Controlled Clinical Trial.
作者: Fengwen Zhang.;Jie Dong.;Peijian Wei.;Weiyi Fang.;Hao Hu.;Xiangqing Kong.;Ming Bai.;Jiahua Pan.;Zhiling Luo.;Ping Zhang.;Baiming Qu.;Jinpeng Hu.;Yaoxing Lu.;Chuangshi Wang.;Shouzheng Wang.;Xiangbin Pan.
来源: Circulation. 2025年
Novel biodegradable patent foramen ovale (PFO) closure devices offer a promising therapeutic option. The efficacy and safety of the novel biodegradable devices compared with nitinol devices have not yet been investigated in a randomized clinical trial.
156. Relations of AI-Vascular Age Estimated From a Peripheral Pressure Waveform With Incident Atrial Fibrillation: The Framingham Heart Study.
作者: Timothy J Korzinski.;Celestin Hategeka.;Brenton R Prescott.;David Hamel-Sellman.;Vanessa Xanthakis.;Leroy L Cooper.;Naomi M Hamburg.;Connie W Tsao.;Honghuang Lin.;Ramachandran S Vasan.;Gary F Mitchell.;Emelia J Benjamin.
来源: Circ Arrhythm Electrophysiol. 2025年e014383页 157. High-Voltage Focal Pulsed Field Ablation to Treat Scar-Related Ventricular Tachycardia: The First-in-Human VCAS Trial.
作者: Vivek Y Reddy.;Jacob S Koruth.;Petr Peichl.;Jan Petru.;Moritoshi Funasako.;Jan Skoda.;Keita Watanabe.;Moritz Nies.;Josef Kautzner.;Petr Neuzil.
来源: Circulation. 2025年
Unlike the tremendous progress made in atrial fibrillation ablation, the greatest unmet clinical need is for innovative ablation treatments for scar-related ventricular tachycardia (VT) - particularly given the thick, often fibrotic tissue characteristic of the scarred substrate. A focal pulsed field ablation (PFA) catheter with a novel waveform was designed: high-voltage to provide tissue penetration, and low-energy (using short duration pulses) to avoid tissue overheating. We present the outcomes of VCAS, a first-in-human study of this PFA catheter to ablate scar-related VT.
158. Diastolic Blood Pressure and Cognitive Function in Adults With Achieved Systolic Blood Pressure Below 130 mm Hg: Insights From the SPRINT-MIND Trial.
作者: Ruixue Yang.;Zhou Fang.;Daman Yang.;Lei Zhang.;Qiaoxi Yang.;Qianhui Ling.;Xilan Dong.;Miaomiao Zhuang.;Tianchen Guo.;Sifei Chen.;Yufei Ji.;Jun Cai.
来源: Circ Cardiovasc Qual Outcomes. 2025年e011902页
The potential J-shaped relationship whereby lower diastolic blood pressure (DBP) is associated with a higher risk of adverse cognitive outcomes has raised concerns regarding intensive systolic blood pressure (SBP) lowering. However, the current guidelines advocate a stricter SBP target of <130 mm Hg, with no clear consensus on a DBP target, especially with respect to brain health. The present study aimed to determine the relationship between treated DBP and cognitive function, as well as cerebral perfusion and structure, in adults who achieved an SBP <130 mm Hg.
160. Multicenter Pivotal Trial of the Minima Stent for Vascular Stenosis in Infants and Young Children.
作者: Patrick M Sullivan.;Evan M Zahn.;Shyam Sathanandam.;Brian Morray.;Shabana Shahanavaz.;Arash Salavitabar.;Aimee K Armstrong.;Diego Porras.;Darren P Berman.
来源: Circ Cardiovasc Interv. 2025年e015618页
The Minima Stent System is the first stent designed, tested, and Food and Drug Administration-approved for use in neonates, infants, and children. Our objective was to evaluate the safety and efficacy of Minima implantation for pulmonary artery stenosis (PAS) and coarctation of the aorta (CoA).
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