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141. Health System Costs of Treating Latent Tuberculosis Infection With Four Months of Rifampin Versus Nine Months of Isoniazid in Different Settings.
作者: Mayara Lisboa Bastos.;Jonathon R Campbell.;Olivia Oxlade.;Menonli Adjobimey.;Anete Trajman.;Rovina Ruslami.;Hee Jin Kim.;Joseph Obeng Baah.;Brett G Toelle.;Richard Long.;Vernon Hoeppner.;Kevin Elwood.;Hamdan Al-Jahdali.;Lika Apriani.;Andrea Benedetti.;Kevin Schwartzman.;Dick Menzies.
来源: Ann Intern Med. 2020年173卷3期169-178页
Four months of rifampin treatment for latent tuberculosis infection is safer, has superior treatment completion rates, and is as effective as 9 months of isoniazid. However, daily medication costs are higher for a 4-month rifampin regimen than a 9-month isoniazid regimen.
142. Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Trial.
作者: Pierre Charles.;Élodie Perrodeau.;Maxime Samson.;Bernard Bonnotte.;Antoine Néel.;Christian Agard.;Antoine Huart.;Alexandre Karras.;François Lifermann.;Pascal Godmer.;Pascal Cohen.;Catherine Hanrotel-Saliou.;Nicolas Martin-Silva.;Grégory Pugnet.;François Maurier.;Jean Sibilia.;Pierre-Louis Carron.;Pierre Gobert.;Nadine Meaux-Ruault.;Thomas Le Gallou.;Stéphane Vinzio.;Jean-François Viallard.;Eric Hachulla.;Christine Vinter.;Xavier Puéchal.;Benjamin Terrier.;Philippe Ravaud.;Luc Mouthon.;Loïc Guillevin.; .
来源: Ann Intern Med. 2020年173卷3期179-187页
Biannual rituximab infusions over 18 months effectively maintain remission after a "standard" remission induction regimen for patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).
143. Effect of Acupuncture for Postprandial Distress Syndrome: A Randomized Clinical Trial.
作者: Jing-Wen Yang.;Li-Qiong Wang.;Xuan Zou.;Shi-Yan Yan.;Yu Wang.;Jing-Jie Zhao.;Jian-Feng Tu.;Jun Wang.;Guang-Xia Shi.;Hui Hu.;Wei Zhou.;Yi Du.;Cun-Zhi Liu.
来源: Ann Intern Med. 2020年172卷12期777-785页
Postprandial distress syndrome (PDS) is the most common subtype of functional dyspepsia. Acupuncture is commonly used to treat PDS, but its effect is uncertain because of the poor quality of prior studies.
144. Rifabutin-Based Triple Therapy (RHB-105) for Helicobacter pylori Eradication: A Double-Blind, Randomized, Controlled Trial.
作者: David Y Graham.;Yamil Canaan.;James Maher.;Gregory Wiener.;Kristina G Hulten.;Ira N Kalfus.
来源: Ann Intern Med. 2020年172卷12期795-802页
Although consensus supports eradication of Helicobacter pylori infections, antimicrobial resistance has substantially reduced eradication rates with most current therapies.
145. L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial.
作者: Maria de Montmollin.;Martin Feller.;Shanthi Beglinger.;Alex McConnachie.;Drahomir Aujesky.;Tinh-Hai Collet.;Ian Ford.;Jacobijn Gussekloo.;Patricia M Kearney.;Vera J C McCarthy.;Simon Mooijaart.;Rosalinde K E Poortvliet.;Terence Quinn.;David J Stott.;Torquil Watt.;Rudi Westendorp.;Nicolas Rodondi.;Douglas C Bauer.
来源: Ann Intern Med. 2020年172卷11期709-716页
L-thyroxine does not improve hypothyroid symptoms among adults with subclinical hypothyroidism (SCH). However, those with greater symptom burden before treatment may still benefit.
147. Iron Chelation in Transfusion-Dependent Patients With Low- to Intermediate-1-Risk Myelodysplastic Syndromes: A Randomized Trial.
作者: Emanuele Angelucci.;Junmin Li.;Peter Greenberg.;Depei Wu.;Ming Hou.;Efreen Horacio Montano Figueroa.;Maria Guadalupe Rodriguez.;Xunwei Dong.;Jagannath Ghosh.;Miguel Izquierdo.;Guillermo Garcia-Manero.; .
来源: Ann Intern Med. 2020年172卷8期513-522页
Iron chelation therapy (ICT) in patients with lower-risk myelodysplastic syndromes (MDS) has not been evaluated in randomized studies.
148. Effects of Interleukin-1β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial.
作者: Mounica Vallurupalli.;Jean G MacFadyen.;Robert J Glynn.;Tom Thuren.;Peter Libby.;Nancy Berliner.;Paul M Ridker.
来源: Ann Intern Med. 2020年172卷8期523-532页
Inflammatory cytokines, such as interleukin (IL)-1β, alter iron homeostasis and erythropoiesis, resulting in anemia, but whether inhibition of IL-1β can reverse these effects is unclear.
149. Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults: A Randomized Clinical Trial.
作者: Olga Pleguezuelos.;Joep Dille.;Sofie de Groen.;Fredrik Oftung.;Hubert G M Niesters.;Md Atiqul Islam.;Lisbeth Meyer Næss.;Olav Hungnes.;Nuhoda Aldarij.;Demi L Idema.;Ana Fernandez Perez.;Emma James.;Henderik W Frijlink.;Gregory Stoloff.;Paul Groeneveld.;Eelko Hak.
来源: Ann Intern Med. 2020年172卷7期453-462页
FLU-v is a broad-spectrum influenza vaccine that induces antibodies and cell-mediated immunity.
150. Adverse Effects of Low-Dose Methotrexate: A Randomized Trial.
作者: Daniel H Solomon.;Robert J Glynn.;Elizabeth W Karlson.;Fengxin Lu.;Cassandra Corrigan.;Josh Colls.;Chang Xu.;Jean MacFadyen.;Medha Barbhaiya.;Nancy Berliner.;Paul F Dellaripa.;Brendan M Everett.;Aruna D Pradhan.;Sarah P Hammond.;Meredith Murray.;Deepak A Rao.;Susan Y Ritter.;Anna Rutherford.;Jeffrey A Sparks.;Jackie Stratton.;Dong H Suh.;Sara K Tedeschi.;Kathleen M M Vanni.;Nina P Paynter.;Paul M Ridker.
来源: Ann Intern Med. 2020年172卷6期369-380页
Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis. Despite extensive clinical use for more than 30 years, few data on adverse event (AE) rates derive from randomized, placebo-controlled trials, where both causality and magnitude of risk can be inferred.
151. Poxvirus Vectored Cytomegalovirus Vaccine to Prevent Cytomegalovirus Viremia in Transplant Recipients: A Phase 2, Randomized Clinical Trial.
作者: Ibrahim Aldoss.;Corinna La Rosa.;Lindsey R Baden.;Jeffrey Longmate.;Ella J Ariza-Heredia.;Wasima N Rida.;Chetan Raj Lingaraju.;Qiao Zhou.;Joy Martinez.;Teodora Kaltcheva.;Andy Dagis.;Nicola Hardwick.;Nicolas C Issa.;Len Farol.;Auayporn Nademanee.;Monzr M Al Malki.;Stephen Forman.;Ryotaro Nakamura.;Don J Diamond.; .
来源: Ann Intern Med. 2020年172卷5期306-316页
Triplex vaccine was developed to enhance cytomegalovirus (CMV)-specific T cells and prevent CMV reactivation early after hematopoietic stem cell transplant (HCT).
152. Addition of Maraviroc Versus Placebo to Standard Antiretroviral Therapy for Initial Treatment of Advanced HIV Infection: A Randomized Trial.
作者: Yves Lévy.;Jean-Daniel Lelièvre.;Lambert Assoumou.;Esther Aznar.;Federico Pulido.;Giuseppe Tambussi.;Manuel Crespo.;Agnès Meybeck.;Jean-Michel Molina.;Constance Delaugerre.;Jacques Izopet.;Gilles Peytavin.;Fanny Cardon.;Alpha Diallo.;Rémi Lancar.;Lydie Béniguel.;Dominique Costagliola.
来源: Ann Intern Med. 2020年172卷5期297-305页
Patients diagnosed with advanced HIV infection have a poor prognosis despite initiation of combined antiretroviral therapy (c-ART).
153. Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial.
作者: Philip G Conaghan.;Michael A Bowes.;Sarah R Kingsbury.;Alan Brett.;Gwenael Guillard.;Biljana Rizoska.;Niclas Sjögren.;Philippa Graham.;Åsa Jansson.;Cecilia Wadell.;Richard Bethell.;John Öhd.
来源: Ann Intern Med. 2020年172卷2期86-95页
MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on bone and cartilage in preclinical osteoarthritis models.
154. Hospital-Level Care at Home for Acutely Ill Adults: A Randomized Controlled Trial.
作者: David M Levine.;Kei Ouchi.;Bonnie Blanchfield.;Agustina Saenz.;Kimberly Burke.;Mary Paz.;Keren Diamond.;Charles T Pu.;Jeffrey L Schnipper.
来源: Ann Intern Med. 2020年172卷2期77-85页
Substitutive hospital-level care in a patient's home may reduce cost, health care use, and readmissions while improving patient experience, although evidence from randomized controlled trials in the United States is lacking.
155. Effect of Electronic Health Record-Based Coaching on Weight Maintenance: A Randomized Trial.
作者: Molly B Conroy.;Kathleen M McTigue.;Cindy L Bryce.;Dana Tudorascu.;Bethany Barone Gibbs.;Jonathan Arnold.;Diane Comer.;Rachel Hess.;Kimberly Huber.;Laurey R Simkin-Silverman.;Gary S Fischer.
来源: Ann Intern Med. 2019年171卷11期777-784页
Weight regain after intentional loss is common. Most evidence-based weight management programs focus on short-term loss rather than long-term maintenance.
156. Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.
作者: Josep Ordi-Ros.;Luis Sáez-Comet.;Mercedes Pérez-Conesa.;Xavier Vidal.;Antoni Riera-Mestre.;Antoni Castro-Salomó.;Jordi Cuquet-Pedragosa.;Vera Ortiz-Santamaria.;Montserrat Mauri-Plana.;Cristina Solé.;Josefina Cortés-Hernández.
来源: Ann Intern Med. 2019年171卷10期685-694页
The potential role of new oral anticoagulants in antiphospholipid antibody syndrome (APS) remains uncertain.
157. Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.
作者: JoAnn E Manson.;Aaron K Aragaki.;Shari S Bassuk.;Rowan T Chlebowski.;Garnet L Anderson.;Jacques E Rossouw.;Barbara V Howard.;Cynthia A Thomson.;Marcia L Stefanick.;Andrew M Kaunitz.;Carolyn J Crandall.;Charles B Eaton.;Victor W Henderson.;Simin Liu.;Juhua Luo.;Thomas Rohan.;Aladdin H Shadyab.;Gretchen Wells.;Jean Wactawski-Wende.;Ross L Prentice.; .
来源: Ann Intern Med. 2019年171卷6期406-414页
Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown.
159. Continuous Anticoagulation and Cold Snare Polypectomy Versus Heparin Bridging and Hot Snare Polypectomy in Patients on Anticoagulants With Subcentimeter Polyps: A Randomized Controlled Trial.
作者: Yoji Takeuchi.;Katsuhiro Mabe.;Yuichi Shimodate.;Shinji Yoshii.;Shinya Yamada.;Mineo Iwatate.;Takuji Kawamura.;Kinichi Hotta.;Koji Nagaike.;Nobuaki Ikezawa.;Tomoaki Yamasaki.;Yoriaki Komeda.;Satoshi Asai.;Yasuhiro Abe.;Takuji Akamatsu.;Yuko Sakakibara.;Hisatomo Ikehara.;Yuzuru Kinjo.;Takashi Ohta.;Yoko Kitamura.;Takashi Shono.;Takuya Inoue.;Yoshio Ohda.;Nozomu Kobayashi.;Tokuma Tanuma.;Ryu Sato.;Taku Sakamoto.;Naohiko Harada.;Akiko Chino.;Hideki Ishikawa.;Masanori Nojima.;Toshio Uraoka.; .
来源: Ann Intern Med. 2019年171卷4期229-237页
Management of anticoagulants for patients undergoing polypectomy is still controversial. Cold snare polypectomy (CSP) is reported to cause less bleeding than hot snare polypectomy (HSP).
160. Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.
作者: John W Apolzan.;Elizabeth M Venditti.;Sharon L Edelstein.;William C Knowler.;Dana Dabelea.;Edward J Boyko.;Xavier Pi-Sunyer.;Rita R Kalyani.;Paul W Franks.;Preethi Srikanthan.;Kishore M Gadde.; .
来源: Ann Intern Med. 2019年170卷10期682-690页
Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.
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