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141. Prevalence of frailty among patients with inflammatory bowel disease and its association with clinical outcomes: a systematic review and meta-analysis.
作者: Xiangting Huang.;Mengmeng Xiao.;Benyue Jiang.;Xiuzheng Wang.;Xiaoyu Tang.;Xiao Xu.;Ying Chen.;Shixuan Wang.;Songbo Yan.;Siyi Wang.;Jiang Wang.;Pinglan Zhang.
来源: BMC Gastroenterol. 2022年22卷1期534页
Studies have reported frailty as an independent risk factor of mortality in patients with inflammatory bowel disease (IBD). However, no systematic review and meta-analysis has been conducted to determine the relationship of frailty and IBD. We aimed to investigate the prevalence of frailty in patients with IBD and the impact of frailty on the clinical prognosis of these patients.
142. Performance and comparison of artificial intelligence and human experts in the detection and classification of colonic polyps.
作者: Ming-De Li.;Ze-Rong Huang.;Quan-Yuan Shan.;Shu-Ling Chen.;Ning Zhang.;Hang-Tong Hu.;Wei Wang.
来源: BMC Gastroenterol. 2022年22卷1期517页
The main aim of this study was to analyze the performance of different artificial intelligence (AI) models in endoscopic colonic polyp detection and classification and compare them with doctors with different experience.
143. Efficacy and safety of anti-PD-1/PD-L1 therapy in the treatment of advanced colorectal cancer: a meta-analysis.
作者: Yuegang Li.;Yuwei Du.;Chi Xue.;Pei Wu.;Nan Du.;Guolian Zhu.;Huimian Xu.;Zhi Zhu.
来源: BMC Gastroenterol. 2022年22卷1期431页
Immune checkpoint inhibitors have shown promise in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) advanced colorectal cancer (CRC) immunotherapy, and many clinical trials have been conducted.
144. Clinical and Genomic Characterization of Interval Colorectal Cancer in 3 Prospective Cohorts.
作者: Keming Yang.;Yin Cao.;Carino Gurjao.;Yang Liu.;Chuan-Guo Guo.;Chun-Han Lo.;Xiaoyu Zong.;David Drew.;Connor Geraghty.;Elizabeth Prezioso.;Matt Moore.;Craig Williams.;Tom Riley.;Melissa Saul.;Shuji Ogino.;Marios Giannakis.;Adam Bass.;Robert E Schoen.;Andrew T Chan.
来源: Gastroenterology. 2022年163卷6期1522-1530.e5页
Interval colorectal cancers (CRCs), cancers diagnosed after a screening/surveillance examination in which no cancer is detected, and before the date of next recommended examination, reflect an unprecedented challenge in CRC detection and prevention. To better understand this poorly characterized CRC variant, we examined the clinical and mutational characteristics of interval CRCs in comparison with screen detected CRCs.
145. Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants.
作者: Veeral Ajmera.;Beom Kyung Kim.;Kun Yang.;Abdul M Majzoub.;Tarek Nayfeh.;Nobuharu Tamaki.;Namiki Izumi.;Atsushi Nakajima.;Ramazan Idilman.;Mesut Gumussoy.;Digdem Kuru Oz.;Ayse Erden.;Natalie E Quach.;Xin Tu.;Xinlian Zhang.;Mazen Noureddin.;Alina M Allen.;Rohit Loomba.
来源: Gastroenterology. 2022年163卷4期1079-1089.e5页
Magnetic resonance elastography (MRE) is an accurate biomarker of liver fibrosis; however, limited data characterize its association with clinical outcomes. We conducted an individual participant data pooled meta-analysis on patients with nonalcoholic fatty liver disease to evaluate the association between liver stiffness on MRE and liver-related outcomes.
146. Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening: a meta-analysis.
作者: Lixing Wang.;Yu Liu.;Duohan Zhang.;Xiaoliang Xiong.;Tingting Hao.;Lili Zhong.;Yinlong Zhao.
来源: BMC Gastroenterol. 2022年22卷1期314页
A growing body of research suggests that methylated genes can be used as early diagnostic markers for cancer. Some studies on methylated Syndecan 2 (SDC2) have shown that it has a great diagnostic ability in colorectal cancer. This meta-analysis was aimed to estimate the diagnostic performance of methylated SDC2 as a potential novel biomarker to screen for the colorectal cancer.
147. Proactive Therapeutic Drug Monitoring Versus Conventional Management for Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis.
作者: Nghia H Nguyen.;Virginia Solitano.;Sudheer K Vuyyuru.;John K MacDonald.;Silje W Syversen.;Kristin Kaasen Jørgensen.;Eileen Crowley.;Christopher Ma.;Vipul Jairath.;Siddharth Singh.
来源: Gastroenterology. 2022年163卷4期937-949.e2页
Proactive therapeutic drug monitoring (TDM) has been proposed to improve outcomes in patients with inflammatory bowel disease (IBD) treated with tumor necrosis factor (TNF)α antagonists. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing proactive TDM with conventional management in patients with IBD.
148. Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses.
作者: Yufeng Lin.;Harry Cheuk-Hay Lau.;Yali Liu.;Xing Kang.;Yiwei Wang.;Nick Lung-Ngai Ting.;Thomas Ngai-Yeung Kwong.;Jing Han.;Weixin Liu.;Changan Liu.;Junjun She.;Sunny Hei Wong.;Joseph Jao-Yiu Sung.;Jun Yu.
来源: Gastroenterology. 2022年163卷4期908-921页
The enteric mycobiota is a major component of the human gut microbiota, but its role in colorectal cancer (CRC) remains largely elusive. We conducted a meta-analysis to uncover the contribution of the fungal mycobiota to CRC.
149. Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review.
作者: Jasmine K Zia.;Adrienne Lenhart.;Pei-Lin Yang.;Margaret M Heitkemper.;Jason Baker.;Laurie Keefer.;Miguel Saps.;Callie Cuff.;Gregory Hungria.;Elizabeth J Videlock.;Lin Chang.
来源: Gastroenterology. 2022年163卷4期995-1023.e3页
Many studies have assessed risk factors of irritable bowel syndrome (IBS) and other abdominal pain-related disorders of gut-brain interaction (AP-DGBI); however, the role of these factors is unclear due to heterogeneous study designs. The aim of this systematic review was to extensively evaluate the literature and determine clinical risk and protective factors for the presence and persistence of AP-DGBI in children and adults.
150. Comparative efficacy and safety of infliximab and vedolizumab therapy in patients with inflammatory bowel disease: a systematic review and meta-analysis.
作者: Laurent Peyrin-Biroulet.;Perttu Arkkila.;Alessandro Armuzzi.;Silvio Danese.;Jordi Guardiola.;Jørgen Jahnsen.;Charles Lees.;Edouard Louis.;Milan Lukáš.;Walter Reinisch.;Xavier Roblin.;Minyoung Jang.;Han Geul Byun.;Dong-Hyeon Kim.;Sung Jeong Lee.;Raja Atreya.
来源: BMC Gastroenterol. 2022年22卷1期291页
There are limited comparative data for infliximab and vedolizumab in inflammatory bowel disease patients.
151. Long-Term Impact of Helicobacter pylori Eradication Therapy on Gastric Cancer Incidence and Mortality in Healthy Infected Individuals: A Meta-Analysis Beyond 10 Years of Follow-Up.152. The diagnostic utility of endocytoscopy for the detection of gastric cancer: a systematic review and meta-analysis.
作者: Andrew Canakis.;Shivanand Bomman.;Benjamin Twery.;Nevin Varghese.;Byung Ji.;Justin Canakis.;Eric M Goldberg.
来源: Minerva Gastroenterol (Torino). 2024年70卷2期225-230页
Endocytoscopy (ECS) is an evolving technology that utilizes ultra-high power magnification for real time cellular imaging without the need for physical biopsy. Its application for gastric cancer (GC) detection is not well evaluated at the current time, but there is potential that ECS can make a real time histopathological diagnosis to differentiate neoplastic from benign lesions. We aimed to investigate the diagnostic utility of ECS for GC detection.
153. Deep Submucosal Invasion Is Not an Independent Risk Factor for Lymph Node Metastasis in T1 Colorectal Cancer: A Meta-Analysis.
作者: Liselotte W Zwager.;Barbara A J Bastiaansen.;Nahid S M Montazeri.;Roel Hompes.;Valeria Barresi.;Katsuro Ichimasa.;Hiroshi Kawachi.;Isidro Machado.;Tadahiko Masaki.;Weiqi Sheng.;Shinji Tanaka.;Kazutomo Togashi.;Chihiro Yasue.;Paul Fockens.;Leon M G Moons.;Evelien Dekker.
来源: Gastroenterology. 2022年163卷1期174-189页
Deep submucosal invasion (DSI) is considered a key risk factor for lymph node metastasis (LNM) and important criterion to recommend surgery in T1 colorectal cancer. However, metastatic risk for DSI is shown to be low in the absence of other histologic risk factors. This meta-analysis determines the independent risk of DSI for LNM.
154. The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis.
作者: Fiona A Ross.;James H Park.;David Mansouri.;Emilie Combet.;Paul G Horgan.;Donald C McMillan.;Campbell S D Roxburgh.
来源: BMC Gastroenterol. 2022年22卷1期176页
The presence of inflammation is a key hallmark of cancer and, plays an important role in disease progression and survival in colorectal cancer (CRC). Calprotectin detected in the faeces is a sensitive measure of colonic inflammation. The role of FC as a diagnostic test that may categorise patients by risk of neoplasia is poorly defined. This systematic review and meta-analysis aims to characterise the relationship between elevations of FC and colorectal neoplasia.
155. Sleeve gastrectomy versus Roux-en-Y Gastric Bypass for remission of type 2 diabetes mellitus at 1, 3 and 5 years: a systematic review and meta-analysis.
作者: Kaneez Fatima.;Sabeeh K Farooqui.;Izma Ajaz.;Shaikh T Ali.;Nida Hashmi.;Sara Nadeem.;Sameed A Ghazi.;Shahzeb H Kaleem.;Fatima S Bozdar.;Mushk Noorani.
来源: Minerva Gastroenterol (Torino). 2022年68卷4期450-458页
Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB) are the two procedures used in the management of patient with obesity and type 2 diabetes mellitus (T2DM); however, it is still unclear which of the two is more efficient in the remission of type-2 diabetes mellitus.
156. Lack of relationship between PROX1 expression and clinicopathological parameters and prognosis in gastric cancer patients: a meta-analysis and TCGA analysis.
The relationship between PROX1 expression and clinicopathological characteristics and prognosis in patients with gastric cancer (GC) remain controversial. The aim of this study is to determine the clinicopathological and prognostic significance of PROX1 expression in patients with GC.
157. Characterization of short-chain fatty acids in patients with ulcerative colitis: a meta-analysis.
作者: Hao-Ming Xu.;Hai-Lan Zhao.;Gong-Jing Guo.;Jing Xu.;You-Lian Zhou.;Hong-Li Huang.;Yu-Qiang Nie.
来源: BMC Gastroenterol. 2022年22卷1期117页
Studies investigating the changes in short-chain fatty acids (SCFAs) in patients with ulcerative colitis (UC) have yielded inconsistent results. We performed a meta-analysis of studies that investigated the alterations in different SCFAs among UC patients to assess their role in the development of UC.
158. Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis.
Gastrointestinal symptoms have been reported in patients with COVID-19. Several clinical investigations suggested that gastrointestinal symptoms were associated with disease severity of COVID-19. However, the relevance of gastrointestinal symptoms and mortality of COVID-19 remains largely unknown. We aim to investigate the relationship between gastrointestinal symptoms and COVID-19 mortality.
159. Systematic review and meta-analysis: the advantage of endoscopic Mayo score 0 over 1 in patients with ulcerative colitis.
作者: Angelo Viscido.;Marco Valvano.;Gianpiero Stefanelli.;Annalisa Capannolo.;Chiara Castellini.;Eugenia Onori.;Antonio Ciccone.;Filippo Vernia.;Giovanni Latella.
来源: BMC Gastroenterol. 2022年22卷1期92页
Mucosal healing (MH) evaluated by endoscopy is a novel target of therapy in UC as it is associated with improved long-term outcomes. It is defined based on the Mayo endoscopic score (MES), but it is still to define whether a value of MES 0 or 1 should be the target. The purpose of this paper is to present the results of a systematic review with meta-analysis which compares long-term outcomes of patients in steroid-free clinical remission with MES 0 with those with MES 1.
160. A Systematic Review and Meta-analysis of Dietary Interventions Modulating Gut Microbiota and Cardiometabolic Diseases-Striving for New Standards in Microbiome Studies.
作者: Ilias Attaye.;Moritz V Warmbrunn.;Aureline N A F Boot.;Suze C van der Wolk.;Barbara A Hutten.;Joost G Daams.;Hilde Herrema.;Max Nieuwdorp.
来源: Gastroenterology. 2022年162卷7期1911-1932页
Cardiometabolic diseases (CMDs) have shared properties and causes. Insulin resistance is a risk factor and characteristic of CMDs and has been suggested to be modulated by plasma metabolites derived from gut microbiota (GM). Because diet is among the most important modulators of GM, we performed a systematic review of the literature to assess whether CMDs can be modulated via dietary interventions targeting the GM.
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