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141. Effect of Normobaric Hypoxia on Exercise Performance in Pulmonary Hypertension: Randomized Trial.
作者: Simon R Schneider.;Laura C Mayer.;Mona Lichtblau.;Charlotte Berlier.;Esther I Schwarz.;Stéphanie Saxer.;Michael Furian.;Konrad E Bloch.;Silvia Ulrich.
来源: Chest. 2021年159卷2期757-771页
Many patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension (PH) wish to travel to altitude or by airplane, but their risk of hypoxia-related adverse health effects is insufficiently explored.
142. Effect of Early Balanced Crystalloids Before ICU Admission on Sepsis Outcomes.
作者: Karen E Jackson.;Li Wang.;Jonathan D Casey.;Gordon R Bernard.;Wesley H Self.;Todd W Rice.;Matthew W Semler.; .
来源: Chest. 2021年159卷2期585-595页
Studies suggest that using balanced crystalloids (lactated Ringer's solution or Plasma-Lyte A) rather than saline (0.9% sodium chloride) may improve outcomes for patients with sepsis in the ED and ICU.
143. Survivors of Intensive Care With Type 2 Diabetes and the Effect of Shared-Care Follow-Up Clinics: The SWEET-AS Randomized Controlled Pilot Study.
作者: Yasmine Ali Abdelhamid.;Liza K Phillips.;Mary G White.;Jeffrey Presneill.;Michael Horowitz.;Adam M Deane.
来源: Chest. 2021年159卷1期174-185页
Follow-up clinics after ICU admission have demonstrated limited benefit. However, existing trials have evaluated heterogeneous cohorts and used physicians who had limited training in outpatient care.
144. Development of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors.
作者: Marc Moss.;S David White.;Heather Warner.;Daniel Dvorkin.;Daniel Fink.;Stephanie Gomez-Taborda.;Carrie Higgins.;Gintas P Krisciunas.;Joseph E Levitt.;Jeffrey McKeehan.;Edel McNally.;Alix Rubio.;Rebecca Scheel.;Jonathan M Siner.;Rosemary Vojnik.;Susan E Langmore.
来源: Chest. 2020年158卷5期1923-1933页
The bedside swallowing evaluation (BSE) is an assessment of swallowing function and airway safety during swallowing. After extubation, the BSE often is used to identify the risk of aspiration in acute respiratory failure (ARF) survivors.
145. A Randomized Trial of Initiation of Chronic Noninvasive Mechanical Ventilation at Home vs In-Hospital in Patients With Neuromuscular Disease and Thoracic Cage Disorder: The Dutch Homerun Trial.
作者: Ries J M van den Biggelaar.;Anda Hazenberg.;Nicolle A M Cobben.;Michael A Gaytant.;Karin M Vermeulen.;Peter J Wijkstra.
来源: Chest. 2020年158卷6期2493-2501页
There is an increasing demand for home mechanical ventilation (HMV) in patients with chronic respiratory insufficiency. At present, noninvasive ventilation is exclusively initiated in a clinical setting at all four centers for HMV in the Netherlands. In addition to its high societal costs and patient discomfort, commencing HMV is often delayed because of a lack of hospital bed capacity.
146. Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk: Post Hoc Analyses of the SAVE Study.
作者: Dominik Linz.;Kelly A Loffler.;Prashanthan Sanders.;Peter Catcheside.;Craig S Anderson.;Danni Zheng.;WeiWei Quan.;Mary Barnes.;Susan Redline.;R Doug McEvoy.;Mathias Baumert.; .
来源: Chest. 2020年158卷6期2621-2631页
Traditional methods for the quantification of OSA severity may not encapsulate potential relationships between hypoxemia in OSA and cardiovascular risk.
147. Self-reported Snoring Patterns Predict Stroke Events in High-Risk Patients With OSA: Post Hoc Analyses of the SAVE Study.
作者: Jingwei Li.;R Doug McEvoy.;Danni Zheng.;Kelly A Loffler.;Xia Wang.;Susan Redline.;Richard J Woodman.;Craig S Anderson.
来源: Chest. 2020年158卷5期2146-2154页
The relation of snoring to risks of stroke and other major cardiovascular (CV) events is uncertain.
148. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.
作者: Matthieu Jabaudon.;Jules Audard.;Bruno Pereira.;Samir Jaber.;Jean-Yves Lefrant.;Raiko Blondonnet.;Thomas Godet.;Emmanuel Futier.;Céline Lambert.;Jean-Etienne Bazin.;Julie A Bastarache.;Jean-Michel Constantin.;Lorraine B Ware.; .
来源: Chest. 2020年158卷6期2394-2403页
The Radiographic Assessment of Lung Edema (RALE) score is associated with the severity of ARDS, and treatments targeted at reducing pulmonary edema such as conservative fluid management cause a reduction in RALE score over time.
149. Impact of a Multimodal Telemonitoring Intervention on CPAP Adherence in Symptomatic OSA and Low Cardiovascular Risk: A Randomized Controlled Trial.
作者: Renaud Tamisier.;Erika Treptow.;Marie Joyeux-Faure.;Patrick Levy.;Marc Sapene.;Meriem Benmerad.;Sebastien Bailly.;Yves Grillet.;Bruno Stach.;Jean-François Muir.;Hervé Pegliasco.;Jean-Louis Pépin.; .
来源: Chest. 2020年158卷5期2136-2145页
One of the major challenges in treating OSA is to achieve adequate CPAP adherence. Telemonitoring has the potential to provide individualized management and early recognition of problems during treatment.
150. Deterioration of Nighttime Respiratory Mechanics in COPD: Impact of Bronchodilator Therapy.
作者: Nicolle J Domnik.;Matthew D James.;Robin E Scheeren.;Grace A Ayoo.;Sarah M Taylor.;Amanda T Di Luch.;Kathryn M Milne.;Sandra G Vincent.;Devin B Phillips.;Amany F Elbehairy.;Sophie J Crinion.;Helen S Driver.;J Alberto Neder.;Denis E O'Donnell.
来源: Chest. 2021年159卷1期116-127页
COPD is associated with nighttime respiratory symptoms, poor sleep quality, and increased risk of nocturnal death. Overnight deterioration of inspiratory capacity (IC) and FEV1 have been documented previously. However, the precise nature of this deterioration and mechanisms by which evening bronchodilation may mitigate this occurrence have not been studied.
151. Evidence for Expanding Invasive Mediastinal Staging for Peripheral T1 Lung Tumors.
作者: Emily A DuComb.;Benjamin A Tonelli.;Ya Tuo.;Bernard F Cole.;Vitor Mori.;Jason H T Bates.;George R Washko.;Raúl San José Estépar.;C Matthew Kinsey.
来源: Chest. 2020年158卷5期2192-2199页
Guidelines recommend invasive mediastinal staging for patients with non-small cell lung cancer and a "central" tumor. However, there is no consensus definition for central location. As such, the decision to perform invasive staging largely remains on an empirical foundation.
152. Intensity of Renal Replacement Therapy and Duration of Mechanical Ventilation: Secondary Analysis of the Acute Renal Failure Trial Network Study.
作者: Shilpa Sharma.;Yvelynne P Kelly.;Paul M Palevsky.;Sushrut S Waikar.
来源: Chest. 2020年158卷4期1473-1481页
Randomized clinical trials have failed to show benefit from increasing intensity of renal replacement therapy (RRT) for acute kidney injury, but continue to be frequently used. In addition, intensive RRT is associated with an increase in adverse events potentially secondary to small solute losses, such as phosphate. We hypothesized that, compared with less-intensive RRT, intensive RRT would lead to longer duration of mechanical ventilation.
153. Pressure-Support Ventilation vs T-Piece During Spontaneous Breathing Trials Before Extubation Among Patients at High Risk of Extubation Failure: A Post-Hoc Analysis of a Clinical Trial.
作者: Arnaud W Thille.;Rémi Coudroy.;Mai-Anh Nay.;Arnaud Gacouin.;Alexandre Demoule.;Romain Sonneville.;François Beloncle.;Christophe Girault.;Laurence Dangers.;Alexandre Lautrette.;Quentin Levrat.;Anahita Rouzé.;Emmanuel Vivier.;Jean-Baptiste Lascarrou.;Jean-Damien Ricard.;Keyvan Razazi.;Guillaume Barberet.;Christine Lebert.;Stephan Ehrmann.;Alexandre Massri.;Jeremy Bourenne.;Gael Pradel.;Pierre Bailly.;Nicolas Terzi.;Jean Dellamonica.;Guillaume Lacave.;René Robert.;Stéphanie Ragot.;Jean-Pierre Frat.; .
来源: Chest. 2020年158卷4期1446-1455页
Spontaneous breathing trial (SBT) using a T-piece remains the most frequently performed trial before extubation in ICUs.
154. Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial.
作者: Ivor S Douglas.;Philip M Alapat.;Keith A Corl.;Matthew C Exline.;Lui G Forni.;Andre L Holder.;David A Kaufman.;Akram Khan.;Mitchell M Levy.;Gregory S Martin.;Jennifer A Sahatjian.;Eric Seeley.;Wesley H Self.;Jeremy A Weingarten.;Mark Williams.;Douglas M Hansell.
来源: Chest. 2020年158卷4期1431-1445页
Fluid and vasopressor management in septic shock remains controversial. In this randomized controlled trial, we evaluated the efficacy of dynamic measures (stroke volume change during passive leg raise) to guide resuscitation and improve patient outcome.
155. Long-term Noninvasive Ventilation in Obesity Hypoventilation Syndrome Without Severe OSA: The Pickwick Randomized Controlled Trial.
作者: Juan F Masa.;Iván Benítez.;Maria Á Sánchez-Quiroga.;Francisco J Gomez de Terreros.;Jaime Corral.;Auxiliadora Romero.;Candela Caballero-Eraso.;Maria L Alonso-Álvarez.;Estrella Ordax-Carbajo.;Teresa Gomez-Garcia.;Mónica González.;Soledad López-Martín.;José M Marin.;Sergi Martí.;Trinidad Díaz-Cambriles.;Eusebi Chiner.;Carlos Egea.;Javier Barca.;Francisco J Vázquez-Polo.;Miguel A Negrín.;María Martel-Escobar.;Ferrán Barbé.;Babak Mokhlesi.; .
来源: Chest. 2020年158卷3期1176-1186页
Noninvasive ventilation (NIV) is an effective form of treatment in obesity hypoventilation syndrome (OHS) with severe OSA. However, there is paucity of evidence in patients with OHS without severe OSA phenotype.
156. Pneumonia and Exposure to Household Air Pollution in Children Under the Age of 5 Years in Rural Malawi: Findings From the Cooking and Pneumonia Study.
作者: Kevin Mortimer.;Maia Lesosky.;Sean Semple.;Jullita Malava.;Cynthia Katundu.;Amelia Crampin.;Duolao Wang.;William Weston.;Dan Pope.;Deborah Havens.;Stephen B Gordon.;John Balmes.
来源: Chest. 2020年158卷2期501-511页
Exposure to household air pollution is associated with an increased risk of pneumonia in children in low- and middle-income countries; however, exposure-response data are limited, and there are uncertainties around the extent to which biomass-fueled cookstoves can reduce these exposures.
157. Re-evaluation of the Uplift Clinical Trial Using Age-Appropriate Spirometric Criteria.
作者: Carlos A Vaz Fragoso.;Linda S Leo-Summers.;Thomas M Gill.;Gail J McAvay.
来源: Chest. 2020年158卷2期539-549页
The clinical trial of tiotropium in COPD, UPLIFT, enrolled adults with a mean age of 65 years and moderate-to-severe airflow obstruction, based on criteria from the Global Initiative for Chronic Obstructive Lung Disease (GOLD). For the UPLIFT cohort, however, GOLD-based criteria are not age-appropriate.
158. Effect of Venlafaxine on Apnea-Hypopnea Index in Patients With Sleep Apnea: A Randomized, Double-Blind Crossover Study.
作者: Christopher N Schmickl.;Yanru Li.;Jeremy E Orr.;Rachel Jen.;Scott A Sands.;Bradley A Edwards.;Pamela DeYoung.;Robert L Owens.;Atul Malhotra.
来源: Chest. 2020年158卷2期765-775页
One of the key mechanisms underlying OSA is reduced pharyngeal muscle tone during sleep. Data suggest that pharmacologic augmentation of central serotonergic/adrenergic tone increases pharyngeal muscle tone.
159. Association of Guideline-Recommended COPD Inhaler Regimens With Mortality, Respiratory Exacerbations, and Quality of Life: A Secondary Analysis of the Long-Term Oxygen Treatment Trial.
作者: Thomas Keller.;Laura J Spece.;Lucas M Donovan.;Edmunds Udris.;Scott S Coggeshall.;Matthew Griffith.;Alexander D Bryant.;Richard Casaburi.;J Allen Cooper.;Gerard J Criner.;Philip T Diaz.;Anne L Fuhlbrigge.;Steven E Gay.;Richard E Kanner.;Fernando J Martinez.;Ralph J Panos.;David Shade.;Alice Sternberg.;Thomas Stibolt.;James K Stoller.;James Tonascia.;Robert Wise.;Roger D Yusen.;David H Au.;Laura C Feemster.
来源: Chest. 2020年158卷2期529-538页
Although inhaled therapy reduces exacerbations among patients with COPD, the effectiveness of providing inhaled treatment per risk stratification models remains unclear.
160. Effect of Intermittent or Continuous Feed on Muscle Wasting in Critical Illness: A Phase 2 Clinical Trial.
作者: Angela S McNelly.;Danielle E Bear.;Bronwen A Connolly.;Gill Arbane.;Laura Allum.;Azhar Tarbhai.;Jackie A Cooper.;Philip A Hopkins.;Matthew P Wise.;David Brealey.;Kieron Rooney.;Jason Cupitt.;Bryan Carr.;Kiran Koelfat.;Steven Olde Damink.;Philip J Atherton.;Nicholas Hart.;Hugh E Montgomery.;Zudin A Puthucheary.
来源: Chest. 2020年158卷1期183-194页
Acute skeletal muscle wasting in critical illness is associated with excess morbidity and mortality. Continuous feeding may suppress muscle protein synthesis as a result of the muscle-full effect, unlike intermittent feeding, which may ameliorate it.
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