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1381. Fat-induced ileal brake in humans: a dose-dependent phenomenon correlated to the plasma levels of peptide YY.
作者: L Pironi.;V Stanghellini.;M Miglioli.;R Corinaldesi.;R De Giorgio.;E Ruggeri.;C Tosetti.;G Poggioli.;A M Morselli Labate.;N Monetti.
来源: Gastroenterology. 1993年105卷3期733-9页
Upper gastrointestinal motility is regulated by the presence of nutrients in the distal gut. The present study evaluated whether lipid-induced ileal brake on gastric emptying (1) can be elicited by low fat concentrations; (2) is a dose-dependent phenomenon; and (3) is related to gastrointestinal peptide release.
1382. Diurnal secretory patterns and tolerance during individually titrated infusions of ranitidine.
Gastric acid secretion in humans shows chronobiological patterns that modify the efficacy of antisecretory agents. The ability of individually titrated ranitidine infusions to overcome circadian patterns of gastric acidity and tolerance during prolonged dosing was assessed.
1383. Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B.
作者: M R Brunetto.;M Giarin.;G Saracco.;F Oliveri.;P Calvo.;G Capra.;A Randone.;M L Abate.;P Manzini.;M Capalbo.
来源: Gastroenterology. 1993年105卷3期845-50页
Anti-hepatitis e antigen-positive chronic hepatitis B is a progressive liver disease associated with precore mutant hepatitis B virus (HBV) and poor response to interferon. Therefore, precore mutant HBV may behave as an interferon-resistant virus. The relations between the prevalences of wild-type and precore mutant HBVs in baseline viremias and response to interferon were analyzed.
1384. A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C.
作者: S Kakumu.;K Yoshioka.;T Wakita.;T Ishikawa.;M Takayanagi.;Y Higashi.
来源: Gastroenterology. 1993年105卷2期507-12页
Chronic hepatitis C is a common and often progressive liver disease for which interferon alfa therapy widely spreads, but the beneficial response is frequently transient. Ribavirin is a nucleoside analog with a broad spectrum of antiviral action, and we investigated the efficacy of it in patients with chronic active hepatitis C.
1385. Tin protoporphyrin prolongs the biochemical remission produced by heme arginate in acute hepatic porphyria.
作者: S B Dover.;M R Moore.;E J Fitzsimmons.;A Graham.;K E McColl.
来源: Gastroenterology. 1993年105卷2期500-6页
In acute porphyria, repletion of intrahepatic heme, with exogenously administered heme, suppresses the overproduction of delta-aminolaevulinic acid (ALA) and porphobilinogen (PBG). The effect of reducing heme breakdown has been assessed by administering tin protoporphyrin, a competitive inhibitor of heme oxygenase.
1386. Change in serum hyaluronan: a simple index of short-term drug-induced changes in hepatic sinusoidal perfusion.
作者: P R Gibson.;J R Fraser.;J C Colman.;P A Jones.;G Jennings.;F J Dudley.
来源: Gastroenterology. 1993年105卷2期470-4页
Hyaluronan is an endogenous polysaccharide whose clearance from the plasma is predominantly by liver sinusoidal cells and is sinusoidal flow dependent. This study was designed to determine if a change in serum hyaluronan might reliably reflect short-term drug-induced changes in sinusoidal perfusion.
1387. Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease.
作者: K Ewe.;A G Press.;C C Singe.;M Stufler.;B Ueberschaer.;G Hommel.;K H Meyer zum Büschenfelde.
来源: Gastroenterology. 1993年105卷2期367-72页
The role of azathioprine (AZA) in the treatment of active Crohn's disease (CD) is still controversial. This study examined whether AZA combined with standard prednisolone therapy improved the therapeutic outcome compared with monotherapy with prednisolone.
1389. Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis.
作者: R J Sokol.;N Butler-Simon.;C Conner.;J E Heubi.;F R Sinatra.;F J Suchy.;M B Heyman.;J Perrault.;R J Rothbaum.;J Levy.
来源: Gastroenterology. 1993年104卷6期1727-35页
Malabsorption and deficiency of vitamin E causing neurological degeneration are common consequences of chronic childhood cholestatic liver disease. The objective of this study was to determine the long-term efficacy and safety of d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in correcting vitamin E deficiency in children with chronic cholestasis who were unresponsive to other forms of oral vitamin E.
1390. Hepatitis C RNA in liver of chronic hepatitis C patients before and after interferon alfa treatment.
作者: L A Balart.;R Perrillo.;J Roddenberry.;F Regenstein.;K S Shim.;Y S Shieh.;B Taylor.;S Dash.;M A Gerber.
来源: Gastroenterology. 1993年104卷5期1472-7页
Successful treatment of chronic hepatitis C with interferon alfa is frequently followed by relapse. Because loss of hepatitis C viral RNA (HCV-RNA) in serum is not predictive of sustained response, the loss of HCV-RNA in liver as a predictor of sustained response was investigated.
1391. Isosorbide-5-mononitrate versus propranolol in the prevention of first bleeding in cirrhosis.
作者: M Angelico.;L Carli.;C Piat.;S Gentile.;V Rinaldi.;E Bologna.;L Capocaccia.
来源: Gastroenterology. 1993年104卷5期1460-5页
Hemodynamic studies have shown the efficacy of nitrates in reducing portal pressure in cirrhosis. We therefore studied the efficacy of isosorbide-5-mononitrate vs. propranolol in the prevention of first bleeding within a prospective controlled trial.
1392. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study.
作者: M S Khuroo.;M Y Dar.;G N Yattoo.;S A Zargar.;G Javaid.;B A Khan.;M I Boda.
来源: Gastroenterology. 1993年104卷5期1452-9页
Recently, drug treatment and percutaneous drainage have been used successfully when treating hepatic hydatid cysts. Until now, there is no published study comparing the relative safety and efficacy of these two forms of treatment.
1393. Mesalamine capsules for the treatment of active Crohn's disease: results of a 16-week trial. Pentasa Crohn's Disease Study Group.
作者: J W Singleton.;S B Hanauer.;G L Gitnick.;M A Peppercorn.;M G Robinson.;L D Wruble.;E L Krawitt.
来源: Gastroenterology. 1993年104卷5期1293-301页
Mesalamine is released from sulfasalazine in the colon and benefits colonic Crohn's disease. The mesalamine used in this study releases the drug throughout the small bowel and colon. Therefore, this study was designed to detect benefit for Crohn's disease involving the small bowel alone or both the colon and small bowel.
1394. A somatostatin analogue inhibits afferent pathways mediating perception of rectal distention.
Octreotide, a somatostatin analogue, has antinociceptive activity in several models. We studied whether octreotide modifies perception of rectal distention in healthy volunteers and examined its mechanism of action.
1397. Gabexate mesilate in human acute pancreatitis. German Pancreatitis Study Group.
作者: M Büchler.;P Malfertheiner.;W Uhl.;J Schölmerich.;F Stöckmann.;G Adler.;W Gaus.;K Rolle.;H G Beger.
来源: Gastroenterology. 1993年104卷4期1165-70页
A multicenter controlled study was performed to evaluate the effect of high doses of the low molecular weight protease inhibitor gabexate mesilate on mortality and complications associated with moderate and severe acute pancreatitis.
1398. Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B.
作者: J H Hoofnagle.;A M Di Bisceglie.;J G Waggoner.;Y Park.
来源: Gastroenterology. 1993年104卷4期1116-21页
The prognosis of advanced cirrhosis due to chronic hepatitis B is poor, and results of therapies, including liver transplantation, have been unsatisfactory. Little is known about the effectiveness of interferon alfa in patients with cirrhosis.
1399. Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein.
Fiber and water-holding agents are used for the treatment of constipation. In what may appear to be a paradox, they are sometimes also used for the treatment of diarrhea; it has been proposed that they sequester water from liquid stools and/or increase the ratio of fecal solids to fecal water and thereby improve stool consistency. The purpose of the present study was to test the validity of this hypothesis in normal subjects in whom secretory diarrhea was induced by phenolphthalein.
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