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121. Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma after curative resection.
The prevention of recurrence for patients with hepatocellular carcinoma after curative resection is still a great challenge in clinical practice. There are numerous studies that trying to search for favorable strategies to decrease the recurrence and prolong life span for these patients, whereas no consensus is reached till now. Herein, we aim to compare the efficacy between different reported treatments by network meta-analysis(NMA).
122. Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study.
作者: Yu Huang.;Qiang Chen.;Yating Liu.;Ruoxi Tian.;Xu Yin.;Yaoguang Hao.;Yang Yang.;Jian Yang.;Zongxuan Li.;Suyang Yu.;Hongyan Li.;Guiying Wang.
来源: BMC Gastroenterol. 2023年23卷1期294页
A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk.
123. Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis.
The incidence of HBV-negative and HCV-negative hepatocellular carcinoma (NBNC-HCC) is significantly increasing. However, their clinicopathologic features and prognosis remain elucidated. Our study aimed to compare the clinicopathologic characteristics and survival outcomes of NBNC-HCC with hepatitis virus-related HCC.
124. Selective COX-2 inhibitors do not increase gastrointestinal reactions after colorectal cancer surgery: a systematic review and meta-analysis.
作者: Ting Hu.;Cheng-Jiang Liu.;Xiaoming Yin.;WenJuan Tang.;LanFang Yin.;Hui Bai.;FangFang Liu.;Dan Wang.;YiLei Li.
来源: BMC Gastroenterol. 2023年23卷1期281页
The effectiveness of selective COX-2 inhibitors in preventing colorectal cancer recurrence has been demonstrated, however it is unknown how safe and successful they will be over the long term. As a result, we looked at the efficacy, safety, and consequences of adding COX-2 inhibitors to the treatment plan afterward.
125. Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
作者: Vivek C Goodoory.;Mais Khasawneh.;Christopher J Black.;Eamonn M M Quigley.;Paul Moayyedi.;Alexander C Ford.
来源: Gastroenterology. 2023年165卷5期1206-1218页
Some probiotics may be beneficial in irritable bowel syndrome (IBS), but differences in species and strains used, as well as endpoints reported, have hampered attempts to make specific recommendations as to which should be preferred. We updated our previous meta-analysis examining this issue.
126. Efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride citrate in the treatment of constipation in China: a systematic review and meta-analysis.
To analyze the efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride citrate for the treatment of constipation.
127. Comparison of metal versus plastic stent for preoperative biliary drainage in patients with pancreatic cancer undergoing neoadjuvant therapy: a meta-analysis and systematic review.
This study was performed to compare a metal stent (MS) and plastic stent (PS) in terms of efficacy and complications during neoadjuvant therapy (NAT) and the perioperative period.
128. Comparison of different second line treatments for metastatic pancreatic cancer: a systematic review and network meta-analysis.
作者: Fausto Petrelli.;Alessandro Parisi.;Gianluca Tomasello.;Emanuele Mini.;Marcella Arru.;Alessandro Russo.;Ornella Garrone.;Shelize Khakoo.;Raffaele Ardito.;Michele Ghidini.
来源: BMC Gastroenterol. 2023年23卷1期212页
In metastatic pancreatic ductal adenocarcinoma (mPDAC), first line treatment options usually include combination regimens of folinic acid, 5-fluorouracil (5-FU), irinotecan, and oxaliplatin (FOLFIRINOX or mFOLFIRINOX) or gemcitabine based regimens such as in combination with albumin-bound paclitaxel (GEM + nab-PTX). After progression, multiple regimens including NALIRI + 5-FU and folinic acid, FOLFIRINOX, 5-FU-based oxaliplatin doublets (OFF, FOLFOX, or XELOX), or 5-FU-based monotherapy (FL, capecitabine, or S-1) are considered appropriate by major guidelines. This network meta-analysis (NMA) aimed to compare the efficacy of different treatment strategies tested as second-line regimens for patients with mPDAC after first-line gemcitabine-based systemic treatment.
129. Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer.
作者: Suhail Yousuf.;Mengjie Qiu.;Lena Voith von Voithenberg.;Johannes Hulkkonen.;Igor Macinkovic.;Axel R Schulz.;Domenic Hartmann.;Florian Mueller.;Margarete Mijatovic.;David Ibberson.;Karam T AlHalabi.;Jenny Hetzer.;Simon Anders.;Bernhard Brüne.;Henrik E Mei.;Charles D Imbusch.;Benedikt Brors.;Mathias Heikenwälder.;Matthias M Gaida.;Markus W Büchler.;Andreas Weigert.;Thilo Hackert.;Susanne Roth.
来源: Gastroenterology. 2023年165卷4期891-908.e14页
As pancreatic ductal adenocarcinoma (PDAC) continues to be recalcitrant to therapeutic interventions, including poor response to immunotherapy, albeit effective in other solid malignancies, a more nuanced understanding of the immune microenvironment in PDAC is urgently needed. We aimed to unveil a detailed view of the immune micromilieu in PDAC using a spatially resolved multimodal single-cell approach.
130. Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on esophageal motility: a systematic review.
作者: Arman Shafiee.;Razman Arabzadeh Bahri.;Mohammad Mobin Teymouri Athar.;Fatemeh Afsharrezaei.;Mostafa Gholami.
来源: BMC Gastroenterol. 2023年23卷1期170页
Esophageal motility disorders are a group of disorders associated with dysfunctional swallowing resulting from impaired neuromuscular coordination. Phosphodiesterase 5 (PDE-5) inhibitors induce smooth relaxation and are proposed as a treatment option for esophageal motility disorders such as achalasia.
132. A systematic review and meta-analysis: the therapeutic and preventive effect of Lactobacillus reuteri DSM 17,938 addition in children with diarrhea.
To summarize the effect of adding Lactobacillus reuteri in the treatment plan for diarrheal disease in children, and analyze the potential of probiotics in preventing the occurrence of diarrheal disease.
133. Efficacy and safety comparison of neoadjuvant chemotherapy followed by surgery and upfront surgery for treating intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.
Currently, surgical resection is the most commonly performed and effective treatment for intrahepatic cholangiocarcinoma (ICC) worldwide. However, the prognosis of ICC is unsatisfactory. This study aimed to compare the efficacy and safety of neoadjuvant chemotherapy followed by surgery and upfront surgery in treating intrahepatic cholangiocarcinoma (ICC). The study also intends to explore whether chemotherapy should be introduced before surgery and which populations should be considered for neoadjuvant chemotherapy.
134. Thiols as a marker of inflammatory bowel disease activity: a systematic review.
作者: Rebeca Araujo Passos.;Priscila Ribas Farias Costa.;Claudia Feio da Maia Lima.;George Mariane Soares Santana.;Victor David.;Geisa de Jesus Santos.;Cyrla Zaltman.;Marcia Soares-Mota.;Raquel Rocha.
来源: BMC Gastroenterol. 2023年23卷1期94页
Evidence indicates that inflammation in Inflammatory Bowel Disease (IBD) is associated with increased systemic levels of reactive oxygen species. Systemic oxidative stress has been associated with reduced levels of plasma thiols. Less invasive tests capable of reflecting and predicting IBD activity are increasingly sought after. We sought to systematically review the evidence inherent in serum thiol levels as a marker of Crohn's Disease and Ulcerative Colitis activity (PROSPERO: CRD42021255521).
135. Whether the Golgi protein 73 could be a diagnostic serological marker in hepatocellular carcinoma: a meta analysis.
作者: Xu Zhang.;Li-Na Wu.;Xiao-Qing Li.;Xia Luo.;Shui-Wei Liu.;Le Zhang.;Shah Nawaz.;Li-Na Ma.;Xiang-Chun Ding.
来源: BMC Gastroenterol. 2023年23卷1期85页
The Value of Golgi protein 73 (GP73) in the diagnosis of Hepatocellular carcinoma (HCC) remains controversial, especially in its differentiation between HCC and cirrhosis. Besides, some papers showed that GP73 levels are correlated with liver fibrosis. This study conducts a meta-analysis to evaluate the value of GP73 in diagnosing HCC and differential diagnosing HCC from liver cirrhosis.
136. Effectiveness of eradication therapy for Helicobacter pylori infection in Africa: a systematic review and meta-analysis.
作者: Sintayehu Fekadu.;Hizkel Engiso.;Sisay Seyfe.;Hisashi Iizasa.;Ashebir Godebo.;Serawit Deyno.;Hironori Yoshiyama.
来源: BMC Gastroenterol. 2023年23卷1期55页
The effectiveness of Helicobacter pylori (H. pylori) eradication depends on the treatment protocol. This study investigates the H. pylori eradication rate in Africa using the best available evidence from databases.
137. The relationship between the use of metformin and the risk of pancreatic cancer in patients with diabetes: a systematic review and meta-analysis.
We aim to evaluate the relationship between the use of metformin and the risk of pancreatic cancer in type 2 diabetes patients.
138. Frequency, outcomes, and need for intervention in stricturing gastrointestinal tuberculosis: a systematic review and meta-analysis.
作者: Anuraag Jena.;Ritin Mohindra.;Kirtan Rana.;Pardhu B Neelam.;Dhuni Chand Thakur.;Harjeet Singh.;Pankaj Gupta.;Vikas Suri.;Vishal Sharma.
来源: BMC Gastroenterol. 2023年23卷1期46页
Gastrointestinal strictures impact clinical presentation in abdominal tuberculosis and are associated with significant morbidity.
139. Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis.
作者: Jérôme Bourgault.;Erik Abner.;Hasanga D Manikpurage.;Natàlia Pujol-Gualdo.;Triin Laisk.; .;Émilie Gobeil.;Eloi Gagnon.;Arnaud Girard.;Patricia L Mitchell.;Sébastien Thériault.;Tõnu Esko.;Patrick Mathieu.;Benoit J Arsenault.
来源: Gastroenterology. 2023年164卷6期953-965.e3页
Acute pancreatitis (AP) is a complex disease and the leading cause of gastrointestinal disease-related hospital admissions. Few therapeutic options exist for AP prevention. Blood proteins with causal evidence may represent promising drug targets, but few have been causally linked with AP. Our objective was to identify blood proteins linked with AP by combining genome-wide association meta-analysis and proteome-wide Mendelian randomization (MR) studies.
140. Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis.
作者: Maria Rosa Ingrosso.;Michael Camilleri.;Jan Tack.;Gianluca Ianiro.;Christopher J Black.;Alexander C Ford.
来源: Gastroenterology. 2023年164卷4期642-654页
Although there have been multiple drugs tested in gastroparesis, their relative efficacy and safety are unknown. We evaluated this in a network meta-analysis of randomized controlled trials (RCTs).
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