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122. Endobronchial Ultrasound Staging of Operable Non-small Cell Lung Cancer: Do Triple-Normal Lymph Nodes Require Routine Biopsy?
作者: Danielle A Hylton.;Biniam Kidane.;Jonathan Spicer.;Simon Turner.;Isabella Churchill.;Kerrie Sullivan.;Christian J Finley.;Yaron Shargall.;John Agzarian.;Andrew J E Seely.;Kazuhiro Yasufuku.;Waël C Hanna.; .
来源: Chest. 2021年159卷6期2470-2476页
Staging guidelines for lung cancer recommend endobronchial ultrasound (EBUS) and systematic biopsy of at least three mediastinal lymph node (LN) stations for accurate staging. A four-point ultrasonographic score (Canada Lymph Node Score [CLNS]) was developed to determine the probability of malignancy in each LN. A LN with a CLNS of < 2 is considered low probability for malignancy. We hypothesized that, in patients with cN0 non-small cell lung cancer, LNs with CLNS of < 2 may not require routine biopsy because they represent true node-negative disease.
123. Phase II Investigation of the Efficacy of Antimycobacterial Therapy in Chronic Pulmonary Sarcoidosis.
作者: Wonder P Drake.;Daniel A Culver.;Robert P Baughman.;Marc A Judson.;Elliott D Crouser.;W Ennis James.;Gregory D Ayers.;Tan Ding.;Kenny Abel.;Abena Green.;Amy Kerrigan.;Ahmed Sesay.;Gordon R Bernard.
来源: Chest. 2021年159卷5期1902-1912页
A Phase I, single-center investigation found that 8 weeks of antimycobacterial therapy improved sarcoidosis FVC. Safety and efficacy assessments have not been performed in a multicenter cohort.
124. Effect of CPAP Therapy on Kidney Function in Patients With Chronic Kidney Disease: A Pilot Randomized Controlled Trial.
作者: Alex N Rimke.;Sofia B Ahmed.;Tanvir C Turin.;Sachin R Pendharkar.;Jill K Raneri.;Emma J Lynch.;Patrick J Hanly.
来源: Chest. 2021年159卷5期2008-2019页
OSA is common in chronic kidney disease (CKD) and may accelerate a decline in kidney function. It is not clear whether treatment of OSA with CPAP improves kidney function.
125. Effects of Low-Load/High-Repetition Resistance Training on Exercise Capacity, Health Status, and Limb Muscle Adaptation in Patients With Severe COPD: A Randomized Controlled Trial.
作者: Andre Nyberg.;Mickael Martin.;Didier Saey.;Nadia Milad.;Dany Patoine.;Mathieu C Morissette.;Dominique Auger.;Per Stål.;Francois Maltais.
来源: Chest. 2021年159卷5期1821-1832页
Training volume is paramount in the magnitude of physiological adaptations following resistance training. However, patients with severe COPD are limited by dyspnea during traditional two-limb low-load/high-repetition resistance training (LLHR-RT), resulting in suboptimal training volumes. During a single exercise session, single-limb LLHR-RT decreases the ventilatory load and enables higher localized training volumes compared with two-limb LLHR-RT.
126. Low Tidal Volume Mechanical Ventilation Against No Ventilation During Cardiopulmonary Bypass in Heart Surgery (MECANO): A Randomized Controlled Trial.
作者: Lee S Nguyen.;Philippe Estagnasie.;Messaouda Merzoug.;Alain Brusset.;Jean-Dominique Law Koune.;Stephane Aubert.;Thierry Waldmann.;Cecile Naudin.;Jean-Michel Grinda.;Hadrien Gibert.;Pierre Squara.
来源: Chest. 2021年159卷5期1843-1853页
Postoperative pulmonary complications are common after cardiac surgery and have been related to lung collapse during cardiopulmonary bypass (CPB). No consensus exists regarding the effects of maintaining mechanical ventilation during CPB to decrease these complications.
127. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial.
作者: Tommaso Mauri.;Giuseppe Foti.;Carla Fornari.;Giacomo Grasselli.;Riccardo Pinciroli.;Federica Lovisari.;Daniela Tubiolo.;Carlo Alberto Volta.;Savino Spadaro.;Roberto Rona.;Egle Rondelli.;Paolo Navalesi.;Eugenio Garofalo.;Rihard Knafelj.;Vojka Gorjup.;Riccardo Colombo.;Andrea Cortegiani.;Jian-Xin Zhou.;Rocco D'Andrea.;Italo Calamai.;Ánxela Vidal González.;Oriol Roca.;Domenico Luca Grieco.;Tomas Jovaisa.;Dimitrios Bampalis.;Tobias Becher.;Denise Battaglini.;Huiqing Ge.;Mariana Luz.;Jean-Michel Constantin.;Marco Ranieri.;Claude Guerin.;Jordi Mancebo.;Paolo Pelosi.;Roberto Fumagalli.;Laurent Brochard.;Antonio Pesenti.; .
来源: Chest. 2021年159卷4期1426-1436页
Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant.
128. Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP: A Randomized Trial.
作者: Jean-Louis Pépin.;Ognian Georgiev.;Rumen Tiholov.;Valérie Attali.;Johan Verbraecken.;Bertien Buyse.;Markku Partinen.;Ingo Fietze.;Georgi Belev.;Dejan Dokic.;Renaud Tamisier.;Patrick Lévy.;Isabelle Lecomte.;Jeanne-Marie Lecomte.;Jean-Charles Schwartz.;Yves Dauvilliers.; .
来源: Chest. 2021年159卷4期1598-1609页
Excessive daytime sleepiness (EDS) in individuals with OSA syndrome persisting despite good adherence to CPAP is a disabling condition. Pitolisant is a selective histamine H3-receptor antagonist with wake-promoting effects.
129. Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple-Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With COPD: A Post Hoc Analysis of the Informing the Pathway of COPD Treatment Trial.
作者: Nicola A Hanania.;David M Mannino.;Gerard J Criner.;Mark T Dransfield.;MeiLan K Han.;C Elaine Jones.;Sally Kilbride.;David A Lomas.;Neil Martin.;Fernando J Martinez.;Dave Singh.;Robert A Wise.;David M G Halpin.;Robson Lima.;David A Lipson.
来源: Chest. 2021年159卷3期985-995页
In the Informing the Pathway of COPD Treatment (IMPACT) trial, single-inhaler triple-therapy fluticasone furoate (FF), umeclidinium (UMEC), and vilanterol (VI) reduced moderate/severe exacerbation rates vs FF/VI and UMEC/VI in patients with symptomatic COPD and a history of exacerbations, with a similar safety profile.
130. Randomized Controlled Trial of a Novel Communication Device Assessed During Noninvasive Ventilation Therapy.
作者: An-Kwok Ian Wong.;Patricia C Cheung.;James Zhang.;George Cotsonis.;Michael Kutner.;Peter C Gay.;Nancy A Collop.
来源: Chest. 2021年159卷4期1531-1539页
Noninvasive ventilation (NIV), a form of positive airway pressure (PAP) therapy, is the standard of care for various forms of acute respiratory failure (ARF). Communication impairment is a side effect of NIV, impedes patient care, contributes to distress and intolerance, and potentially increases intubation rates. This study aimed to evaluate communication impairment during CPAP therapy and demonstrate communication device improvement with a standardized protocol.
131. A Behavior Change Intervention Aimed at Increasing Physical Activity Improves Clinical Control in Adults With Asthma: A Randomized Controlled Trial.
作者: Patricia D Freitas.;Natalia F P Passos.;Regina M Carvalho-Pinto.;Milton A Martins.;Vinicius Cavalheri.;Kylie Hill.;Rafael Stelmach.;Celso R F Carvalho.
来源: Chest. 2021年159卷1期46-57页
Higher levels of physical activity have been associated with better asthma clinical control.
132. Effect of Normobaric Hypoxia on Exercise Performance in Pulmonary Hypertension: Randomized Trial.
作者: Simon R Schneider.;Laura C Mayer.;Mona Lichtblau.;Charlotte Berlier.;Esther I Schwarz.;Stéphanie Saxer.;Michael Furian.;Konrad E Bloch.;Silvia Ulrich.
来源: Chest. 2021年159卷2期757-771页
Many patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension (PH) wish to travel to altitude or by airplane, but their risk of hypoxia-related adverse health effects is insufficiently explored.
133. Effect of Early Balanced Crystalloids Before ICU Admission on Sepsis Outcomes.
作者: Karen E Jackson.;Li Wang.;Jonathan D Casey.;Gordon R Bernard.;Wesley H Self.;Todd W Rice.;Matthew W Semler.; .
来源: Chest. 2021年159卷2期585-595页
Studies suggest that using balanced crystalloids (lactated Ringer's solution or Plasma-Lyte A) rather than saline (0.9% sodium chloride) may improve outcomes for patients with sepsis in the ED and ICU.
134. Survivors of Intensive Care With Type 2 Diabetes and the Effect of Shared-Care Follow-Up Clinics: The SWEET-AS Randomized Controlled Pilot Study.
作者: Yasmine Ali Abdelhamid.;Liza K Phillips.;Mary G White.;Jeffrey Presneill.;Michael Horowitz.;Adam M Deane.
来源: Chest. 2021年159卷1期174-185页
Follow-up clinics after ICU admission have demonstrated limited benefit. However, existing trials have evaluated heterogeneous cohorts and used physicians who had limited training in outpatient care.
135. Development of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors.
作者: Marc Moss.;S David White.;Heather Warner.;Daniel Dvorkin.;Daniel Fink.;Stephanie Gomez-Taborda.;Carrie Higgins.;Gintas P Krisciunas.;Joseph E Levitt.;Jeffrey McKeehan.;Edel McNally.;Alix Rubio.;Rebecca Scheel.;Jonathan M Siner.;Rosemary Vojnik.;Susan E Langmore.
来源: Chest. 2020年158卷5期1923-1933页
The bedside swallowing evaluation (BSE) is an assessment of swallowing function and airway safety during swallowing. After extubation, the BSE often is used to identify the risk of aspiration in acute respiratory failure (ARF) survivors.
136. A Randomized Trial of Initiation of Chronic Noninvasive Mechanical Ventilation at Home vs In-Hospital in Patients With Neuromuscular Disease and Thoracic Cage Disorder: The Dutch Homerun Trial.
作者: Ries J M van den Biggelaar.;Anda Hazenberg.;Nicolle A M Cobben.;Michael A Gaytant.;Karin M Vermeulen.;Peter J Wijkstra.
来源: Chest. 2020年158卷6期2493-2501页
There is an increasing demand for home mechanical ventilation (HMV) in patients with chronic respiratory insufficiency. At present, noninvasive ventilation is exclusively initiated in a clinical setting at all four centers for HMV in the Netherlands. In addition to its high societal costs and patient discomfort, commencing HMV is often delayed because of a lack of hospital bed capacity.
137. Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk: Post Hoc Analyses of the SAVE Study.
作者: Dominik Linz.;Kelly A Loffler.;Prashanthan Sanders.;Peter Catcheside.;Craig S Anderson.;Danni Zheng.;WeiWei Quan.;Mary Barnes.;Susan Redline.;R Doug McEvoy.;Mathias Baumert.; .
来源: Chest. 2020年158卷6期2621-2631页
Traditional methods for the quantification of OSA severity may not encapsulate potential relationships between hypoxemia in OSA and cardiovascular risk.
138. Self-reported Snoring Patterns Predict Stroke Events in High-Risk Patients With OSA: Post Hoc Analyses of the SAVE Study.
作者: Jingwei Li.;R Doug McEvoy.;Danni Zheng.;Kelly A Loffler.;Xia Wang.;Susan Redline.;Richard J Woodman.;Craig S Anderson.
来源: Chest. 2020年158卷5期2146-2154页
The relation of snoring to risks of stroke and other major cardiovascular (CV) events is uncertain.
139. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.
作者: Matthieu Jabaudon.;Jules Audard.;Bruno Pereira.;Samir Jaber.;Jean-Yves Lefrant.;Raiko Blondonnet.;Thomas Godet.;Emmanuel Futier.;Céline Lambert.;Jean-Etienne Bazin.;Julie A Bastarache.;Jean-Michel Constantin.;Lorraine B Ware.; .
来源: Chest. 2020年158卷6期2394-2403页
The Radiographic Assessment of Lung Edema (RALE) score is associated with the severity of ARDS, and treatments targeted at reducing pulmonary edema such as conservative fluid management cause a reduction in RALE score over time.
140. Impact of a Multimodal Telemonitoring Intervention on CPAP Adherence in Symptomatic OSA and Low Cardiovascular Risk: A Randomized Controlled Trial.
作者: Renaud Tamisier.;Erika Treptow.;Marie Joyeux-Faure.;Patrick Levy.;Marc Sapene.;Meriem Benmerad.;Sebastien Bailly.;Yves Grillet.;Bruno Stach.;Jean-François Muir.;Hervé Pegliasco.;Jean-Louis Pépin.; .
来源: Chest. 2020年158卷5期2136-2145页
One of the major challenges in treating OSA is to achieve adequate CPAP adherence. Telemonitoring has the potential to provide individualized management and early recognition of problems during treatment.
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