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1361. Small bowel motility following major intra-abdominal surgery: the effects of opiates and rectal cisapride.
作者: M J Benson.;J P Roberts.;D L Wingate.;J Rogers.;J J Deeks.;F D Castillo.;N S Williams.
来源: Gastroenterology. 1994年106卷4期924-36页
Human small bowel motility is altered after laparotomy. Opiate analgesia is a possible cause of these alterations, and cisapride is a potential therapy.
1362. Determinants of response to a prokinetic agent in neuropathic chronic intestinal motility disorder.
Reasons for the variable efficacy of prokinetic agents in the treatment of chronic intestinal motility disorders are unclear. The aim of this study was to assess the influence of extrinsic autonomic neuropathy and motility patterns on the symptom response to cisapride in 42 such patients.
1363. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer.
作者: G Francini.;R Petrioli.;L Lorenzini.;S Mancini.;S Armenio.;G Tanzini.;S Marsili.;A Aquino.;G Marzocca.;S Civitelli.
来源: Gastroenterology. 1994年106卷4期899-906页
Colon cancer is one of the major health problems in industrialized countries, and its incidence appears to be increasing. Surgical resectability is the most important prognostic determinant, although despite apparently curative surgery, recurrent tumors are common. Metastatic disease cannot be cured, and thus, there is a need for better adjuvant therapies.
1364. Biochemical epidemiology of colon cancer: effect of types of dietary fiber on colonic diacylglycerols in women.
In view of the potential significance of dietary fat and fiber in colon cancer and the possible indirect involvement of diacylglycerols (DAGs) in the pathogenesis of colon cancer, the effect of types of dietary fiber on fecal DAG in premenopausal women was investigated.
1365. Omeprazole versus H2-receptor antagonists in treating patients with peptic stricture and esophagitis.
作者: R D Marks.;J E Richter.;J Rizzo.;R E Koehler.;J G Spenney.;T P Mills.;G Champion.
来源: Gastroenterology. 1994年106卷4期907-15页
Although dysphagia in patients with peptic stricture is attributed to a decreased luminal diameter, coexistent esophagitis may be an equally important cause. The goals of this study were to determine whether medical healing of esophagitis in patients with stricture improves dysphagia and decreases dilatation need and to compare the efficacy and cost-effectiveness of omeprazole versus H2-receptor antagonists (H2RA).
1366. A new, effective, and safe therapeutic option using proton irradiation for hepatocellular carcinoma.
作者: Y Matsuzaki.;T Osuga.;Y Saito.;Y Chuganji.;N Tanaka.;J Shoda.;H Tsuji.;H Tsujii.
来源: Gastroenterology. 1994年106卷4期1032-41页
Conventional radiation is almost useless for hepatocellular carcinoma (HCC) because of the severe adverse effects of the irradiation to the accompanying liver cirrhosis. In contrast, the proton beam has Bragg peak, which limits distribution of the beam. The aim of this study was to prove the usefulness of proton irradiation for HCC.
1368. Effects of duodenal distention on fasting and postprandial antropyloroduodenal motility in humans.
作者: M Edelbroek.;M Horowitz.;J Dent.;W M Sun.;C Malbert.;A Smout.;L Akkermans.
来源: Gastroenterology. 1994年106卷3期583-92页
Mechanoreceptors in the proximal small intestine may play an important role in the regulation of gastric emptying. Balloon distention of the duodenum causes fundic relaxation. The purpose of the present study was to determine the effect of stimulation of duodenal mechanoreceptors on both fasting and postprandial antropyloroduodenal motility in humans.
1369. Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis. Le Groupe Français pour l'Etude du Traitement des Hépatites Chroniques NANB/C.
Because the effects of interferon in the presence and absence of cirrhosis are still debated in chronic active hepatitis type non-A, non-B, C (NANB/C), the aim of this study was to determine to what extent the presence of cirrhosis influences the response to interferon.
1370. A double-blind controlled trial of oral-pulse methotrexate therapy in the treatment of primary sclerosing cholangitis.
Primary sclerosing cholangitis (PSC) is a progressive disease with no accepted effective treatment. Because methotrexate was associated with clinical and histological improvement in two men with PSC, we conducted a prospective trial of methotrexate in PSC.
1371. Quality of life: a valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease. Canadian Crohn's Relapse Prevention Trial Study Group.
作者: E J Irvine.;B Feagan.;J Rochon.;A Archambault.;R N Fedorak.;A Groll.;D Kinnear.;F Saibil.;J W McDonald.
来源: Gastroenterology. 1994年106卷2期287-96页
Quality of life (QOL), a subjective index of health perception and function, embraces physical, social, and emotional performance but has not had a prominent role in clinical trials of inflammatory bowel disease (IBD). To test the robustness of the Inflammatory Bowel Disease Questionnaire (IBDQ), a disease-specific QOL index, this study assessed its validity, reliability, and responsiveness during a multicenter trial.
1372. Do continuous infusions of omeprazole and ranitidine retain their effect with prolonged dosing?
Prolonged infusions of H2-antagonists are commonly used in intensive care units, although little is known about their antisecretory efficacy beyond the initial 24 hours of dosing. The aim of this study was to assess the antisecretory effects of infusions of ranitidine and omeprazole for a period of 72 hours.
1373. Updating prognosis in primary biliary cirrhosis using a time-dependent Cox regression model. PBC1 and PBC2 trial groups.
作者: E Christensen.;D G Altman.;J Neuberger.;B L De Stavola.;N Tygstrup.;R Williams.
来源: Gastroenterology. 1993年105卷6期1865-76页
The precision of current prognostic models in primary biliary cirrhosis (PBC) is rather low, partly because they are based on data from just one time during the course of the disease. The aim of this study was to design a new, more precise prognostic model by incorporating follow-up data in the development of the model.
1374. Primary digestive tract lymphoma: a prospective multicentric study of 91 patients. Groupe d'Etude des Lymphomes Digestifs.
作者: A Ruskoné-Fourmestraux.;P Aegerter.;A Delmer.;N Brousse.;A Galian.;J C Rambaud.
来源: Gastroenterology. 1993年105卷6期1662-71页
The optimal management of primary gastrointestinal lymphoma including the use of surgery remains unsettled. This prospective study aimed to determine the prognostic factors of primary gastrointestinal lymphoma and to evaluate a therapeutic strategy based on surgical tumor reduction, followed by chemotherapy adapted to the histological type of tumor and tumor removal or nonremoval.
1375. Propranolol versus sclerotherapy in preventing variceal rebleeding: a randomized controlled trial.
作者: J Terés.;J Bosch.;J M Bordas.;J C Garcia Pagán.;F Feu.;I Cirera.;J Rodés.
来源: Gastroenterology. 1993年105卷5期1508-14页
Sclerotherapy has been widely recommended as initial treatment for prevention of variceal rebleeding. The present study was aimed at comparing the efficacy of endoscopic sclerotherapy and long-term administration of propranolol in the prevention of rebleeding and long-term survival in patients who had bled from varices.
1376. Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects.
作者: H P Bartram.;A Gostner.;W Scheppach.;B S Reddy.;C V Rao.;G Dusel.;F Richter.;A Richter.;H Kasper.
来源: Gastroenterology. 1993年105卷5期1317-22页
Experimental studies have indicated dietary fish oil as a protective agent in colon carcinogenesis. Prostaglandins have been suggested to be involved in this process. In the present study, the effects of fish oil on rectal cell proliferation (i.e., intermediate biomarker of cancer risk), mucosal membrane fatty acids, and prostaglandin E2 (PGE2) release were investigated in 12 healthy volunteers.
1378. An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma.
作者: J R Pisegna.;G G Slimak.;J L Doppman.;D B Strader.;D C Metz.;R V Benya.;M Orbuch.;V A Fishbeyn.;D L Fraker.;J A Norton.
来源: Gastroenterology. 1993年105卷4期1179-83页
Metastatic gastrinoma is becoming increasingly recognized in patients with Zollinger-Ellison Syndrome. The mean 5-year survival of these patients is < 20%. Chemotherapeutic regimens are of limited benefit. The aim of this study was to evaluate the use of interferon in these patients because a preliminary report suggested it might be effective.
1379. Evaluation of liquid yeast-derived sucrase enzyme replacement in patients with sucrase-isomaltase deficiency.
作者: W R Treem.;N Ahsan.;B Sullivan.;T Rossi.;R Holmes.;J Fitzgerald.;R Proujansky.;J Hyams.
来源: Gastroenterology. 1993年105卷4期1061-8页
No enzyme replacement therapy exists for patients with congenital sucrase-isomaltase deficiency (CSID). A by-product of the manufacture of baker's yeast is a liquid preparation containing high sucrase activity. The aim of the present study was to investigate the activity and stability of this preparation and its effect on breath hydrogen excretion and gastrointestinal symptoms after sucrose ingestion in 14 patients with CSID.
1380. Oral 5-aminosalicylic acid for inflammatory bowel disease in pregnancy: safety and clinical course.
Oral 5-aminosalicylic acid (5-ASA) has proven an effective maintenance therapy of ulcerative colitis and may also be useful in Crohn's disease, but its safety in pregnancy has not been established. The present study therefore examined the course and outcome of pregnancies in patients with inflammatory bowel disease who continued to take oral 5-ASA.
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