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1281. Methotrexate in chronic active ulcerative colitis: a double-blind, randomized, Israeli multicenter trial.
作者: R Oren.;N Arber.;S Odes.;M Moshkowitz.;D Keter.;I Pomeranz.;Y Ron.;I Reisfeld.;E Broide.;A Lavy.;A Fich.;R Eliakim.;J Patz.;E Bardan.;Y Villa.;T Gilat.
来源: Gastroenterology. 1996年110卷5期1416-21页
Uncontrolled studies have suggested that methotrexate may be effective in patients with active ulcerative colitis. The aim of this study was to evaluate the effectiveness of oral methotrexate in chronic steroid-dependent ulcerative colitis in a randomized, double-blind multicenter trial.
1282. Botulinum toxin for achalasia: long-term outcome and predictors of response.
作者: P J Pasricha.;R Rai.;W J Ravich.;T R Hendrix.;A N Kalloo.
来源: Gastroenterology. 1996年110卷5期1410-5页
Botulinum toxin injection into the lower esophageal sphincter of patients with achalasia results in effective short-term relief of symptoms. The aims of this study were to examine the long-term outcome of these patients and to determine the predictors of response to this therapy.
1283. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid.
The combination of duodenal lipid and gastric distention induces meal-like fullness followed by nausea in healthy subjects. The aim of this study was to assess the role of cholecystokinin (CCK) A receptors in these changes using a CCK-A antagonist loxiglumide.
1284. Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
作者: E Villa.;A Dugani.;A M Rebecchi.;A Vignoli.;A Grottola.;P Buttafoco.;L Losi.;M Perini.;P Trande.;A Merighi.;R Lerose.;F Manenti.
来源: Gastroenterology. 1996年110卷5期1346-53页
The gold standard for screening for colorectal carcinoma is colonoscopy. The aim of this study was to compare endoscopic results with those obtained using the noninvasive screening test of K-ras determination in the stool in a large population of patients undergoing colonoscopy.
1285. High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: implications for colon cancer screening.
作者: A M Axelrad.;D E Fleischer.;A J Geller.;C C Nguyen.;J H Lewis.;F H Al-Kawas.;M I Avigan.;E A Montgomery.;S B Benjamin.
来源: Gastroenterology. 1996年110卷4期1253-8页
A visual, nonbiopsy technique that could reliably determine the histology of diminutive colorectal polyps could greatly reduce the cost of colon cancer screening. This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine dye to diagnosis diminutive colorectal polyps.
1286. Ursodeoxycholic acid reduces protein levels and nucleation-promoting activity in human gallbladder bile.
作者: K J Van Erpecum.;P Portincasa.;E Eckhardt.;P M Go.;G P VanBerge-Henegouwen.;A K Groen.
来源: Gastroenterology. 1996年110卷4期1225-37页
Ursodeoxycholic acid prevents gallstone formation in selected patients. The aim of this study was to examine whether decreased concentration and nucleation-promoting activity of various proteins contribute to this beneficial effect.
1287. Transjugular intrahepatic portosystemic shunt versus sclerotherapy in the elective treatment of variceal hemorrhage.
作者: J Cabrera.;M Maynar.;R Granados.;E Gorriz.;R Reyes.;J M Pulido-Duque.;J L Rodriguez SanRoman.;C Guerra.;D Kravetz.
来源: Gastroenterology. 1996年110卷3期832-9页
Uncontrolled studies suggest that placement of a transjugular intrahepatic portosystemic shunt (TIPS) could be useful in the treatment of variceal bleeding. The aim of this study was to evaluate the efficacy and safety of TIPS in the elective treatment of hemorrhage from esophageal varices in a randomized controlled study that compared the effects of TIPS with those of endoscopic sclerotherapy (ES).
1288. Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer.
作者: J Labenz.;B Tillenburg.;U Peitz.;J P Idström.;E F Verdú.;M Stolte.;G Börsch.;A L Blum.
来源: Gastroenterology. 1996年110卷3期725-32页
Omeprazole is less effective in healthy subjects than in patients with duodenal ulcers. The aim of this study was to determine whether Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcers.
1289. Mesalamine in Crohn's disease with steroid-induced remission: effect on steroid withdrawal and remission maintenance, Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives.
作者: R Modigliani.;J F Colombel.;J L Dupas.;M Dapoigny.;V Costil.;M Veyrac.;B Duclos.;J C Soulé.;J P Gendre.;J P Galmiche.;O Danne.;G Cadiot.;H Lamouliatte.;J Belaïche.;J Y Mary.
来源: Gastroenterology. 1996年110卷3期688-93页
Steroid dependence and early relapse are frequent after a prednisolone-induces remission in Crohn's disease. The aim of this trial was to test whether mesalamine started at the onset of steroid tapering increases the rate of weaning from prednisolone and reduces the relapse rate after prednisolone cessation.
1290. Magnetic resonance cholangiography: comparison with endoscopic retrograde cholangiopancreatography.
作者: J A Soto.;M A Barish.;E K Yucel.;D Siegenberg.;J T Ferrucci.;R Chuttani.
来源: Gastroenterology. 1996年110卷2期589-97页
Magnetic resonance cholangiography (MRC) is a noninvasive diagnostic modality capable of producing high-quality images of the biliary tree. The purpose of this study was to determine in a prospective, blinded fashion the sensitivity and specificity of three-dimensional fast spin-echo (3D FSE) MRC for the evaluation of biliary tract abnormalities.
1291. Role of intraduodenal proteases in plasma cholecystokinin and pancreaticobiliary responses to protein and amino acids.
作者: P W Thimister.;W P Hopman.;C E Sloots.;G Rosenbusch.;H L Willems.;F J Trijbels.;J B Jansen.
来源: Gastroenterology. 1996年110卷2期567-75页
The role of small intestinal proteolytic activity in the regulation of upper gastrointestinal function in humans is poorly understood. The aim of this study was to determine the importance of proteolytic activity for protein- or amino acid-induced cholecystokinin release and pancreaticobiliary secretion.
1292. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices.
Combining endoscopic sclerotherapy with ligation has been proposed to hasten variceal eradication. A randomized trial was performed comparing combination ligation plus sclerotherapy with ligation alone in patients with major bleeding from esophageal varices.
1293. Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration.
作者: S Khulusi.;S Badve.;P Patel.;R Lloyd.;J M Marrero.;C Finlayson.;M A Mendall.;T C Northfield.
来源: Gastroenterology. 1996年110卷2期452-8页
The pathogenesis of gastric metaplasia (GM) in the duodenum is unclear. The aim of this investigation was to study the effect on the extent of GM of ulcer healing, Helicobacter pylori eradication, and acid suppression singly and in combination. The relationship between GM and gastroduodenal inflammation and H. pylori infection density was also studied.
1294. Intracolonic injection of glycerol: a model for abdominal pain in irritable bowel syndrome?
作者: D Louvel.;M Delvaux.;G Staumont.;F Camman.;J Fioramonti.;L Bueno.;J Frexinos.
来源: Gastroenterology. 1996年110卷2期351-61页
Abdominal pain is the main symptom in patients with irritable bowel syndrome (IBS). Glycerol is an irritant of colonic mucosa. The aim of this study was to evaluate the effects of an intraluminal injection of glycerol on colonic motility and tone in patients with IBS and their modulation by drugs.
1295. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans.
作者: T Kanda.;H Fujii.;T Tani.;H Murakami.;T Suda.;Y Sakai.;T Ono.;K Hatakeyama.
来源: Gastroenterology. 1996年110卷2期339-43页
Acute ischemic diseases of the small bowel are lethal emergencies with no reliable diagnostic biochemical tests available. Experimental studies have suggested rat intestinal fatty acid-binding protein (I-FABP) as a serum marker reflecting bowel ischemia; the present study evaluates the human homologue (human I-FABP) as a serum marker for the diagnosis of acute ischemic diseases of the bowel.
1296. Oral budesonide as maintenance treatment for Crohn's disease: a placebo-controlled, dose-ranging study. Canadian Inflammatory Bowel Disease Study Group.
作者: G R Greenberg.;B G Feagan.;F Martin.;L R Sutherland.;A B Thomson.;C N Williams.;L G Nilsson.;T Persson.
来源: Gastroenterology. 1996年110卷1期45-51页
Budesonide is a corticosteroid with high topical anti-inflammatory activity and low systemic activity due to rapid hepatic metabolism. The efficacy and safety of an oral controlled-release preparation of budesonide for maintenance of remission was evaluated in patients with ileal or ileocecal Crohn's disease.
1297. An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease.
作者: W J Sandborn.;E C Van O.;B J Zins.;W J Tremaine.;D C Mays.;J J Lipsky.
来源: Gastroenterology. 1995年109卷6期1808-17页
Azathioprine, an effective therapy for Crohn's disease, is limited by a prolonged time to response. The aim of this study was to determine the safety and utility of a loading dose of azathioprine to decrease the time to response in patients with Crohn's disease.
1298. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon.
Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation.
1300. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula.
作者: K J Kelly.;A J Lazenby.;P C Rowe.;J H Yardley.;J A Perman.;H A Sampson.
来源: Gastroenterology. 1995年109卷5期1503-12页
Treatment for gastroesophageal reflux may be ineffective in patients with an eosinophilic infiltration of the esophagus. The aim of this study was to investigate whether unremitting symptoms of gastroesophageal reflux and biopsy abnormalities of the esophagus may be associated with the ingestion of certain foods.
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