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1201. In type 2 diabetes, the effectiveness and side effects of GLP-1 RAs vary.
Yao H, Zhang A, Li D, et al. Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis. BMJ. 2024;384:e076410. 38286487.
1202. SCCM issued recommendations for corticosteroid use in acutely ill adults with sepsis, ARDS, or CAP.
Chaudhuri D, Nei AM, Rochwerg B, et al. 2024 focused update: guidelines on use of corticosteroids in sepsis, acute respiratory distress syndrome, and community-acquired pneumonia. Crit Care Med. 2024;52:e219-e233. 38240492.
1204. The Safety of Outpatient Health Care : Review of Electronic Health Records.
作者: David M Levine.;Ania Syrowatka.;Hojjat Salmasian.;David M Shahian.;Stuart Lipsitz.;Jonathan P Zebrowski.;Laura C Myers.;Merranda S Logan.;Christopher G Roy.;Christine Iannaccone.;Michelle L Frits.;Lynn A Volk.;Sevan Dulgarian.;Mary G Amato.;Heba H Edrees.;Luke Sato.;Patricia Folcarelli.;Jonathan S Einbinder.;Mark E Reynolds.;Elizabeth Mort.;David W Bates.
来源: Ann Intern Med. 2024年177卷6期738-748页
Despite considerable emphasis on delivering safe care, substantial patient harm occurs. Although most care occurs in the outpatient setting, knowledge of outpatient adverse events (AEs) remains limited.
1205. In patients with type 2 diabetes and recent MI, colchicine reduced a composite CV outcome at 23 mo.
Roubille F, Bouabdallaoui N, Kouz S, et al. Low-dose colchicine in patients with type 2 diabetes and recent myocardial infarction in the COLchicine Cardiovascular Outcomes Trial (COLCOT). Diabetes Care. 2024;47:467-470. 38181203.
1206. Update Alert: Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.1207. In HFpEF with obesity, semaglutide improved health status and weight loss at 52 wk, regardless of initial health status.
Kosiborod MN, Verma S, Borlaug BA, et al; STEP-HFpEF Trial Committees and Investigators. Effects of semaglutide on symptoms, function, and quality of life in patients with heart failure with preserved ejection fraction and obesity: a prespecified analysis of the STEP-HFpEF trial. Circulation. 2024;149:204-216. 37952180.
1208. In older patients with AF and frailty, switching from VKA to NOAC therapy increased a composite of major or CRNM bleeding at 12 mo.
Joosten LP, van Doorn S, van de Ven PM, et al. Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial. Circulation. 2024;149:279-289. 37634130.
1209. In AF, CHA2DS2-VASc 1 subgroups did not differ for predicting risk for arterial thromboembolism at 1 y.
Østergaard L, Olesen JB, Petersen JK, et al. Arterial thromboembolism in patients with atrial fibrillation and CHA2DS2-VASc 1: a nationwide study. Circulation. 2024;149:764-773. 38152890.
1210. Reversal of Intestinal Failure With Teduglutide in PERCC1-Associated Enteropathy: A Case Report.
作者: Emily Stenke.;Cara Dunne.;Anthea Bryce-Smyth.;Michelle Hurley.;Ben Pode-Shakked.;Yair Anikster.;Tricia Tan.;Anna Kowalka.;Paul Bech.;Billy Bourke.
来源: Ann Intern Med. 2024年177卷8期1141-1144页 1211. In community-acquired pneumonia, adding oral clarithromycin to standard care increased early clinical response.
Giamarellos-Bourboulis EJ, Siampanos A, Bolanou A, et al. Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2024;12:294-304. 38184008.
1212. New use of thiazide diuretics vs. nonthiazide antihypertensive drugs was linked to hyponatremia over 2 y.
Andersson NW, Wohlfahrt J, Feenstra B, et al. Cumulative incidence of thiazide-induced hyponatremia: a population-based cohort study. Ann Intern Med. 2024;177:1-11. 38109740.
1213. Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians (Version 1, Update Alert).
作者: Amir Qaseem.;Lauri A Hicks.;Itziar Etxeandia-Ikobaltzeta.;Tatyana A Shamliyan.;Thomas G Cooney.; .;Ethan Balk.;J. Thomas Cross.;Nick Fitterman.;Jennifer S. Lin.;Michael Maroto.;Matthew C. Miller.;Adam J. Obley.;Douglas K. Owens.;Paul G. Shekelle.;Jeffrey A. Tice.;Janice E. Tufte.;Jennifer Yost.
来源: Ann Intern Med. 2024年177卷6期eL230113页 1214. In mild ischemic stroke or high-risk TIA, DAPT started ≤72 h after onset reduced new stroke and increased bleeding at 90 d.
Gao Y, Chen W, Pan Y, et al; INSPIRES Investigators. Dual antiplatelet treatment up to 72 hours after ischemic stroke. N Engl J Med. 2023;389:2413-2424. 38157499.
1216. The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis.
作者: Renata Iskander.;Hannah Moyer.;Dean Fergusson.;Sean McGrath.;Andrea Benedetti.;Jonathan Kimmelman.
来源: Ann Intern Med. 2024年177卷6期759-767页
Many patients participate in cancer trials to access new therapies. The extent to which new treatments produce clinical benefit for trial participants is unclear.
1218. The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV.
作者: Jordan E Lake.;Douglas W Kitch.;Amy Kantor.;Raja Muthupillai.;Karin L Klingman.;Christina Vernon.;Pablo F Belaunzaran-Zamudio.;Carl J Fichtenbaum.;Sonya Heath.;Hugo Perazzo.;Kathleen Corey.;Todd T Brown.;Alan Landay.;Fred Sattler.;Kristine M Erlandson.
来源: Ann Intern Med. 2024年177卷6期835-838页 1219. Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease.
作者: Fu-Shun Yen.;Chii-Min Hwu.;Jia-Sin Liu.;Yi-Ling Wu.;Keong Chong.;Chih-Cheng Hsu.
来源: Ann Intern Med. 2024年177卷6期693-700页
No studies have reported the long-term outcomes of initiating sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with estimated glomerular filtration rates less than 20 mL/min/1.73 m2 to predialysis.
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