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101. Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
作者: Christiane Jungen.;H Sophia Chen.;Adrianus P Wijnmaalen.;Petra Dibbets-Schneider.;Augusto Meretta.;Sebastiaan R Piers.;Yoshitaka Kimura.;Alexander F A Androulakis.;Rob J van der Geest.;Lioe-Fee de Geus-Oei.;Bart J A Mertens.;Arthur J H A Scholte.;Hildo J Lamb.;Monique R M Jongbloed.;Katja Zeppenfeld.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013150页
In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown.
102. Very Long-Term Follow-Up of Pulmonary Vein Isolation Using Cryoballoon for Catheter Ablation for Atrial Fibrillation: An 8-Year Multicenter Experience.
作者: Marco Schiavone.;Giulio Molon.;Paolo Pieragnoli.;Giuseppe Arena.;Saverio Iacopino.;Giovanni Battista Perego.;Enrico Chieffo.;Emanuele Bertaglia.;Giuseppe Stabile.;Massimiliano Manfrin.;Roberto Verlato.;Umberto Startari.;Roberto Rordorf.;Massimiliano Marini.;Gaetano Fassini.;Alessandro Costa.;Chiara Bartoli.;Jacopo Colella.;Giulia Girardengo.;Cinzia Dossena.;Francesco Rivezzi.;Assunta Iuliano.;Enrico Baldi.;Claudio Tondo.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013645页
Cryoballoon pulmonary vein isolation has become an established treatment for atrial fibrillation (AF). However, data on long-term outcomes beyond 5 years are scarce. This prospective analysis aimed to evaluate the long-term outcome after cryoballoon pulmonary vein isolation.
103. Incidence of Pacing-Induced Cardiomyopathy Among Patients With Leadless Versus Transvenous Ventricular Pacemakers.
作者: Favour E Markson.;Temidayo A Abe.;David S Frankel.;Robert D Schaller.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013800页
Frequent nonphysiological ventricular pacing and resultant pacing-induced cardiomyopathy are well characterized in transvenous pacemakers (TVP). The incidence of pacing-induced cardiomyopathy in leadless pacemakers (LP) is less understood, particularly compared with TVP.
104. 2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.
作者: Zachary T Yoneda.;Matthew O'Neill.;Diane M Crawford.;Mingfang Ao.;Lili Sun.;Majd A El-Harasis.;Lisa Pitchford.;John A Rathmacher.;Jay Montgomery.;Sharon T Shen.;Juan Carlos Estrada.;Pablo J Saavedra.;Christopher R Ellis.;Travis Richardson.;Arvindh Kangasundram.;George H Crossley.;Wendall S Akers.;Fei Ye.;Dan M Roden.;Gregory F Michaud.;M Benjamin Shoemaker.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013378页
Inflammation is a common mechanism for atrial fibrillation (AF). 2-Hydroxybenzylamine (2-HOBA) is a novel therapeutic that scavenges isolevuglandins-a downstream mediator of inflammation and oxidative stress. 2-HOBA is safe and reduces AF in mice, prompting a first-in-human pilot clinical trial.
105. Reported Incidence of Atrial Fibrillation Varies by Ethnicity and Presentation in the Multi-Ethnic Study of Atherosclerosis.
作者: Benjamin Y Hsieh.;Ting-Wei Ernie Liao.;David T Linker.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013620页
Atrial fibrillation (AF) is a common cardiac arrhythmia. Its detection rates vary significantly across ethnic groups, impacting epidemiological and clinical outcomes. We aim to explore ethnic differences in self-reported versus hospital-reported AF using the MESA (Multi-Ethnic Study of Atherosclerosis).
106. Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial.
作者: Sheri J Hartman.;Andrea Z LaCroix.;Dorothy D Sears.;Loki Natarajan.;Rong W Zablocki.;Ruohui Chen.;Jeffrey S Patterson.;Lindsay Dillon.;James F Sallis.;Simon Schenk.;David W Dunstan.;Neville Owen.;Dori E Rosenberg.
来源: Circulation. 2025年152卷8期492-504页
Public health and clinical guidelines identify the importance of sedentary behaviors for cardiovascular diseases, particularly among postmenopausal women. The goal of this trial was to compare the behavioral and physiological impacts of 2 distinct approaches to changing sedentary behaviors.
107. Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.
作者: Qutuba G Karwi.;Liyan Zhang.;Keshav Gopal.;Cory S Wagg.;Kim L Ho.;Qiuyu Sun.;Sai Panidarapu.;Kaya Persad.;Betüol Altuany.;Shaden Damen.;Ezra Ketema.;Jody Levasseur.;Thomas Pulinilkunnil.;John R Ussher.;Jason R B Dyck.;Gary D Lopaschuk.
来源: Circ Heart Fail. 2025年18卷9期e012012页
Elevated levels of cardiac branched-chain amino acids (BCAAs) and their metabolites, namely branched-chain keto acids (BCKAs), contribute to the development of insulin resistance, contractile dysfunction, and adverse remodeling in the failing heart. However, there is still confusion about whether BCAA or BCKA mediate these detrimental effects in the failing heart.
108. Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction.
作者: Jinxi Wang.;Daniela Sarahi Yang Bennett.;Emma J Echard.;Biyi Chen.;Grace Ciampa.;Weiyang Zhao.;Qian Shi.;Jin-Young Yoon.;Robert M Weiss.;Chad E Grueter.;Duane D Hall.;Barry London.;Long-Sheng Song.
来源: Circulation. 2025年152卷10期699-716页
Calcium (Ca2+) homeostasis in cardiac fibroblasts (CFs) plays a critical role in myocardial repair and remodeling after injury. JPH2 (junctophilin-2; human JPH2 or mouse Jph2) is a structural protein known to regulate intracellular Ca2+ signaling and excitation-contraction coupling in cardiomyocytes. However, the role of JPH2 in CF biology remains unexplored.
109. Device-Measured Sleep Characteristics, Daily Step Count, and Cardiometabolic Health Markers: Findings From the Prospective Physical Activity, Sitting, and Sleep (ProPASS) Consortium.
作者: Wenxin Bian.;Matthew N Ahmadi.;Raaj Kishore Biswas.;Joanna M Blodgett.;Andrew J Atkin.;Hsiu-Wen Chan.;Borja Del Pozo Cruz.;Kristin Suorsa.;Esmée A Bakker.;Richard M Pulsford.;Gregore I Mielke.;Peter J Johansson.;Pasan Hettiarachchi.;Nicholas A Koemel.;Dick H J Thijssen.;Sari Stenholm.;Gita D Mishra.;Armando Teixeira-Pinto.;Vegar Rangul.;Lauren B Sherar.;Ulf Ekelund.;Alun D Hughes.;I-Min Lee.;Peter A Cistulli.;Andreas Holtermann.;Annemarie Koster.;Mark Hamer.;Emmanuel Stamatakis.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011873页
Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep patterns (regularity and duration) with cardiometabolic biomarkers in adults.
110. Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant.
作者: Justin L Grodin.;Anand Gupta.;Ishan Rison.;Julia Kozlitina.;Lorena Saelices-Gomez.;Saket Girotra.;Amil M Shah.;Lori R Roth.;Jan M Griffin.;Mark H Drazner.;W H Wilson Tang.;Mathew S Maurer.;James A de Lemos.
来源: Circ Genom Precis Med. 2025年18卷4期e004911页
To better define the importance of the amyloidogenic p.V142I TTR allele across the life span of a carrier, we leveraged data from All of Us to provide a generalizable assessment of the population-level burden of cardiovascular risk and estimate the age at disease onset.
111. Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension.
作者: Tijana Tuhy.;Julie C Coursen.;Tammy Graves.;Michael Patatanian.;Christopher Cherry.;Shannon E Niedermeyer.;Sarah L Khan.;Darin T Rosen.;Michael P Croglio.;Mohab Elnashar.;Todd M Kolb.;Stephen C Mathai.;Rachel L Damico.;Paul M Hassoun.;Larissa A Shimoda.;Karthik Suresh.;Micheala A Aldred.;Catherine E Simpson.
来源: Circ Genom Precis Med. 2025年18卷4期e004936页
Pulmonary arterial hypertension (PAH) involves progressive cellular and molecular change within the pulmonary vasculature, leading to increased vascular resistance. Current therapies targeting nitric oxide, endothelin, and prostacyclin pathways yield variable treatment responses. Patients with systemic sclerosis-associated PAH (SSc-PAH) often experience worse outcomes than those with idiopathic PAH (IPAH). We hypothesized that distinct and overlapping gene expression patterns in SSc-PAH versus IPAH lung tissues could inform the investigation of precision-targeted therapies.
112. Association of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease.
作者: Salomeh Keyhani.;Beth E Cohen.;Marzieh Vali.;Katherine J Hoggatt.;Dawn M Bravata.;Peter C Austin.;Emily Lum.;Deborah Hasin.;Carl Grunfeld.;Michael G Shlipak.
来源: Circulation. 2025年152卷6期352-365页
Whether cannabis is a risk factor for cardiovascular events is unknown. We examined the association between smoking cannabis and cardiovascular events in a cohort of older veterans (66 to 68 years of age) with coronary artery disease.
113. VEGFA Stop-Gained Variant Deteriorates Cardiac Remodeling in Myocardial Infarction.
作者: Zhongxiang Chen.;Diqi Zhu.;Kaa Seng Lai.;Yiwei Chen.;Yuqing Hu.;Yabo Fang.;Zihang Yan.;Beibei Hu.;Zhen Zhang.;Min Zhang.;Fen Li.
来源: Circ Genom Precis Med. 2025年18卷4期e004879页
A sustained dosage of VEGFA (vascular endothelial growth factor A) is crucial for angiogenesis in both homeostasis and cardiovascular diseases. Start codon CUG-initiated alternative translation is a conserved mechanism for producing mature VEGFA. Genetic surveys have identified stop-gained variants predicted to prematurely terminate CUG-initiated translation without affecting start codon ATG-initiated translation. However, the impacts of these variants on the vasculature in steady-state and disease conditions remain unknown.
114. Ventricular Arrhythmia and Cardiac Fibrosis in Endurance Experienced Athletes (VENTOUX).
作者: Wasim Javed.;Ioannis Botis.;Ze Min Goh.;Mubien Shabi.;Benjamin Brown.;Raluca Tomoaia.;Maryum Farooq.;Eylem Levelt.;Lee Graham.;John Gierula.;Peter Kellman.;John P Greenwood.;Sven Plein.;Peter P Swoboda.
来源: Circ Cardiovasc Imaging. 2025年18卷8期e018470页
Sudden cardiac death due to primary arrhythmia is a leading cause of mortality in athletes, predominantly affecting older male athletes. Myocardial fibrosis is strongly associated with arrhythmogenesis in nonischemic cardiomyopathy, but its clinical significance in asymptomatic endurance athletes is unknown. We aimed to investigate whether myocardial fibrosis on cardiovascular magnetic resonance in asymptomatic veteran male athletes was associated with incident ventricular arrhythmia on long-term implantable loop recorder.
115. Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.
作者: Cameron Beeche.;Bingxin Zhao.;Hamed Tavolinejad.;Bianca Pourmussa.;Joonghyun Kim.;Jeffrey Duda.;James Gee.;Walter R Witschey.; .;Julio A Chirinos.
来源: Circulation. 2025年152卷11期748-761页
Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular outcomes; others experience early vascular aging, linked to adverse cardiovascular outcomes. The aorta is the artery that exhibits the most prominent age-related changes; however, the biological mechanisms underlying aortic aging, its genetic architecture, and its relationship with cardiovascular structure, function, and disease states remain poorly understood.
116. Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction.
作者: Maicon Landim-Vieira.;Robin M Perelli.;Michelle Rodriguez-Garcia.;Vivek P Jani.;Ronnie C Chastain.;Joshua H Lamar.;Ellen Mines.;Gwimoon Seo.;Aurelia Araujo Fernandes.;Bjorn Knollmann.;Michael P Carboni.;Stephen P Chelko.;Vitold E Galkin.;P Bryant Chase.;Jose Renato Pinto.;Andrew P Landstrom.
来源: Circ Genom Precis Med. 2025年18卷4期e004720页
Dilated cardiomyopathy (DCM) is a heart muscle disease in which the left ventricle is enlarged, resulting in systolic dysfunction. Pathogenic variants in genes encoding proteins involved in cardiac contractility, cytoskeleton structure, and Ca2+ handling have been associated with DCM. TNNC1 (cTnC [cardiac troponin C]) variants are implicated in DCM, hypertrophic, and restrictive cardiomyopathies. Unlike other sarcomere genes, most reports of TNNC1 variants lack segregation or pedigree data, partly because the majority of the variants described, to date, have been reported as de novo. Therefore, a critical need is warranted to further understand the mechanisms by which TNNC1 variants could impact myofilament function, especially in response to PKA (protein kinase A)-mediated phosphorylation as this posttranslational modification modulates sarcomere function in response to β-adrenergic stimulation.
117. Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network Single Ventricle Reconstruction Trial.
作者: Thomas A Miller.;Binu Sharma.;Russell Gongwer.;Felicia L Trachtenberg.;Jane W Newburger.;Caren S Goldberg.;Kathryn E Gustafson.;J William Gaynor.;Jodie K Votava-Smith.;Linda M Lambert.;Renee Sananes.;Mary C Kral.;Rocky Tsang.;Kimberley P Heinrich.;James Cnota.;Amee Shah.;Dawn Ilardi.; .
来源: Circulation. 2025年
Neurodevelopmental and functional impairments are among the most consequential morbidities for survivors of hypoplastic left heart syndrome after staged single ventricle surgical palliation. The SVRIII trial (Long-Term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type) enrolled adolescents, who were randomized to different surgical shunt types at the time of Norwood procedure as neonates, for multifaceted in-person evaluation. This study reports their neurodevelopmental outcomes.
118. Long-Term Follow-Up in Severe Mitral Stenosis With Low Transmitral Diastolic Pressure Gradient: From MASTER Registry.
作者: Iksung Cho.;Dae-Young Kim.;Jinseob Kim.;Ha Jeong Lim.;Jiwon Seo.;Kyu Kim.;Seo-Yeon Gwak.;Hyun-Jung Lee.;Hee Jeong Lee.;Kyu-Yong Ko.;Chi Young Shim.;Jong-Won Ha.;Seonhwa Lee.;In-Cheol Kim.;Kang-Un Choi.;Jang-Won Son.;Joo Hee Park.;Geu-Ru Hong.;Jagat Narula.
来源: Circ Cardiovasc Imaging. 2025年18卷9期e018124页
Long-term follow-up studies in severe mitral stenosis (MS) with low transmitral mean diastolic pressure gradient (MDPG) are not available. We evaluated the prognostic implications of severe MS with low MDPG in our MASTER (Multicenter Mitral Stenosis with Rheumatic Etiology) registry.
119. Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes.
作者: Sam Straw.;Oliver I Brown.;Charlotte A Cole.;Judith E Lowry.;Marcella Conning-Rowland.;Stephe Kamalathasan.;Sushma Datla.;Maria F Paton.;Ruth Burgess.;Michael Drozd.;Thomas A Slater.;Samuel D Relton.;Eylem Levelt.;Klaus K Witte.;Mark T Kearney.;Richard M Cubbon.;John Gierula.
来源: Circ Cardiovasc Imaging. 2025年18卷9期e018370页
Left ventricular ejection fraction (LVEF) is an essential tool for heart failure (HF) assessment but is limited by load dependence. Additional tools are needed to risk-stratify normal LVEF populations. We aimed to assess the prognostic value of systolic blood pressure-indexed left ventricular end-systolic volume ratio, or cardiac contractility index (CCI).
120. PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations.
作者: Hyojin Park.;Sungwoon Lee.;Jessica Furtado.;Mark Robinson.;Richard J Antaya.;S Paul Oh.;Young-Kwon Hong.;Martin A Schwartz.;Lawrence H Young.;Anne Eichmann.
来源: Circulation. 2025年152卷9期599-615页
Hereditary hemorrhagic telangiectasia is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function variations in activin receptor-like kinase 1 (ALK1) cause type 2 hereditary hemorrhagic telangiectasia, and Alk1 knockout mice develop AVMs, along with overactivation of vascular endothelial growth factor receptor 2/phosphoinositide 3-kinase/AKT signaling. The full spectrum of signaling alterations resulting from ALK1 variations remains unknown, and more effective and specific inhibitors to combat AVM formation in patients are needed.
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