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108. Pediatric Bronchiectasis Action Management Plan to Improve Clinical Outcomes: A Randomized Controlled Trial.
作者: Kobi L Schutz.;A B Chang.;L A Versteegh.;S T Yerkovich.;P S Morris.;P Laird.;A Schultz.;J M Marchant.;G B McCallum.
来源: Chest. 2025年
Managing bronchiectasis exacerbations is a priority for patients, parents, and caregivers of children with bronchiectasis. However, evidence-based strategies among the pediatric population remain limited.
109. How Using Different Oximeters May Affect Clinical Decision-Making: A Method Comparison Study in Patients Receiving CPAP or Noninvasive Ventilation.
Nocturnal pulsed oxygen saturation (SpO2) monitoring is recommended for detecting residual sleep-disordered breathing, including nocturnal hypoventilation, in patients treated by noninvasive ventilation (NIV) or CPAP. It is a general assumption that different pulse oximetry devices will provide similar results. However, this may not be correct.
110. Novel Hypoglossal Stimulation Markedly Improves Airflow and Airway Collapsibility in OSA.
作者: Amal M Osman.;A Simon Carney.;Eng H Ooi.;Himani Joshi.;Barbara Toson.;Carolin Tran.;Anna L Hudson.;Phuc Nguyen.;Nick Gelekis.;Peter R Eastwood.;Peter Catcheside.;Danny J Eckert.
来源: Chest. 2025年
Hypoglossal nerve stimulation (HNS) to treat OSA currently requires placement of a cuff or so-called saddle electrode around or adjacent to the hypoglossal nerve or nerves. Limitations for this therapy include cost, invasiveness, and variable efficacy.
111. Digital Respiratory Technologies Across the Lifespan: An Overview of Opportunities and Challenges From Children to Older Adults.
Digital health technologies (DHTs), such as mobile health technologies, wearables, telehealth, and telemonitoring, are used increasingly in health care. This is particularly true for respiratory conditions such as asthma, cystic fibrosis, TB, interstitial lung disease, and COPD because DHTs can support diagnosis, self-management, and ongoing care. However, respiratory conditions change across an individual's lifespan in both their presentation and management priorities for the clinician and patient. This creates new challenges and opportunities for using DHTs. Adopting an all-of-life approach is key when considering DHT use within each life stage and across the lifespan.
112. Sepsis-Induced Cardiomyopathy: Mechanism, Prevalence, Assessment, Prognosis, and Management.
作者: Ryota Sato.;Filippo Sanfilippo.;Michael Lanspa.;Abhijit Duggal.;Siddharth Dugar.
来源: Chest. 2025年
Sepsis-induced cardiomyopathy (SICM) is a heterogeneous cardiovascular dysfunction associated with sepsis and septic shock. Although traditionally defined by reversible left ventricular (LV) systolic dysfunction, recent evidence has revealed a broader spectrum, including LV diastolic dysfunction, hyperdynamic LV systolic states, and right ventricular (RV) injury, occurring independently or in combination. Despite their prognostic significance, these phenotypes remain underrecognized and understudied.
113. Implementing a Precision Medicine Thoracic Service Using In-House Reflex Testing in a Large Academic-Community Practice.
作者: Debora S Bruno.;Matthew M Mirsky.;Andrea L Donner.;Shelby R Kopp.;Mehul Jani.;Wadad Mneimneh.;Jennifer M Yoest.;Seunghee P Margevicius.;John Shanahan.;Pingfu Fu.;Melinda L Hsu.;Qian Wang.;Lauren S Chiec.;Giselle A Dutcher.;Sean Cho.;Afshin Dowlati.;Johnie Rose.;Navid Sadri.
来源: Chest. 2025年
Broad genomic testing is necessary to treat patients with stage IV non-small cell lung cancer (NSCLC). This article describes a NSCLC precision medicine service at an academic-community practice and provides model-based estimates of the impact of a similar intervention.
114. The Dose-Response of Inhaled Corticosteroids in Combination Inhaled Corticosteroid/Long Acting Beta2-Agonist Maintenance Therapy for Asthma: A Systematic Review and Meta-Analysis.
作者: Jonathan H Noble.;Samantha Warhurst.;Ryan Cullen.;Ross Sayers.;Francesca Lynch.;Joseph Kulathinal.;Mark Weatherall.;Richard W Beasley.
来源: Chest. 2025年
High doses of a maintenance inhaled corticosteroids (ICSs) in asthma may achieve only modest additional clinical benefit beyond low-to-medium doses and are associated with an increased risk of adverse systemic effects. The ICS dose-response relationship when administered as maintenance combination ICS/long-acting beta2-agonist (LABA) therapy is uncertain.
115. Comparison of Underlying Risk of Lung Cancer Developing and Death Resulting in Screened Populations.
作者: M Patricia Rivera.;Thad Benefield.;Danielle D Durham.;Jennifer L Lund.;Daniel S Reuland.;Li C Cheung.;Lindsay M Lane.;Hormuzd A Katki.;Louise M Henderson.
来源: Chest. 2025年
Trial participants typically are healthier than the general population. Differences in underlying characteristics between the population undergoing lung cancer screening (LCS) and LCS trial participants may alter the benefits of LCS.
117. OSA in Women: Associations With Reproductive Aging and Screening Challenges.
作者: Galit Levi Dunietz.;Ronald D Chervin.;Riva Tauman.;Sigal Shaklai.;Abdulghani Sankari.
来源: Chest. 2025年
OSA is a common, chronic sleep disorder affecting up to 49% of men and 23% of women, yet it remains highly underdiagnosed. Sex-specific prevalence and OSA phenotype suggests that affected women are comparatively more likely to experience certain symptoms, such as insomnia and mood disturbances, and less likely to have loud snoring and observed apneas. Sex differences in symptom presentation may contribute to OSA underdiagnosis in women because traditional diagnostic criteria and clinical assessments often prioritize symptoms more common in men. This review highlights reproductive aging as an overlooked risk factor for OSA, independent of aging, and describes resultant barriers and inequities in OSA screening.
118. An Inventory of Clinical Sarcoidosis Status in the United States.
作者: Kerry M Hena.;Briana Barkes.;Fabian Heinrich.;Rebecca Kogan.;Rachel K Strykowski.;Ogugua Ndili Obi.;Marc A Judson.;Lisa A Maier.;Karen C Patterson.; .
来源: Chest. 2025年
The landscape of sarcoidosis in the United States is unclear, which makes it difficult to optimize the allocation of health care resources, clinical care programs, and research activities for sites that specialize in sarcoidosis.
119. The Consistency of Hypercapnic Respiratory Failure Case Definitions in Electronic Health Record Data.
作者: Brian W Locke.;W Wayne Richards.;Ramkiran Gouripeddi.;Jeanette P Brown.;Joseph Finkelstein.;Krishna M Sundar.;Ithan D Peltan.;Samuel M Brown.
来源: Chest. 2025年
Several studies suggest a high prevalence and disease burden associated with hypercapnic respiratory failure of any cause in emergency department (ED) and inpatient settings. However, these studies use different case definitions. The consistency and validity of these case definitions have not been assessed.
120. Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT).
作者: David J Gagnon.;Kristin M Burkholder.;Alexandra J Weissman.;Richard R Riker.;Sergey Ryzhov.;Teresa L May.;John DiPalazzo.;Joanne T deKay.;Lacey Knudsen.;Meagan W Moore.;Nicholas A Pozzessere.;Mary Weatherbee.;Muriel Kelly.;Adane S Nigatu.;Joseph L Sevigny.;Stephen Simpson.;W Kelley Thomas.;Clifton W Callaway.;Bram J Geller.;Douglas B Sawyer.;David B Seder.
来源: Chest. 2025年
Antibiotic prophylaxis following out-of-hospital cardiac arrest (OHCA) reduces early-onset pneumonia. However, it has an uncertain impact on mortality and noninfectious outcomes, with ongoing concerns about the subsequent development of antibiotic resistance.
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