103. Alcohol Use and COVID-19 Outcomes.
作者: Aaron P Turner.;Scott V Adams.;Eric Hawkins.;Vincent S Fan.;Reyhaneh Nikzad.;John R Kundzins.;Kristina Crothers.
来源: Chest. 2025年
There is increasing recognition that health behaviors may contribute to outcomes following COVID-19, but information on the role of alcohol use is limited.
104. Anti-Ro52 Seropositive Interstitial Lung Disease Is Associated With a Higher Risk of Disease Progression and Mortality.
作者: Ryosuke Imai.;Rene S Bermea.;Sophia H Zhao.;Sydney B Montesi.;Anjali Singh.;Bess M Flashner.;Andrew J Synn.;Julia K Munchel.;Mary B Rice.;Alyssa Soskis.;Barry S Shea.;Robert W Hallowell.
来源: Chest. 2025年
Identifying biomarkers is vital for interstitial lung disease (ILD) management and prognostication. Although anti-Ro52 antibodies frequently are detected in autoimmune diseases, their significance in ILD remains unclear.
105. The Performance of the Surrogate Informed Consent Process for Critical Care Research: A Multi-Modal Study of Investigators, Coordinators, Surrogates, and Patients.
作者: Chloe Glaros.;Caroline K Tietbohl.;Kristen A Torres.;Rafaela Avallone Mantelli.;D Clark Files.;Matthew F Mart.;Michael A Matthay.;Karen E A Burns.;Daniel D Matlock.;Matthew Wynia.;Marc Moss.
来源: Chest. 2025年
Although surrogates are often required to participate in the informed consent process for critical care research, how to best engage surrogates in this process remains unclear.
106. Hospitalization Trends and Risk Factors in Rheumatoid Arthritis-Related Interstitial Lung Disease: An Observational Study From Ontario, Canada.
Rheumatoid arthritis-related interstitial lung disease (RA-ILD) represents an important disease manifestation of rheumatoid arthritis. A scarcity of population-level information on hospitalization rates in RA-ILD exists.
107. Longitudinal Pulmonary Arterial Pressure Trajectories Inform Clinical Outcome in Kidney Transplantation Patients.
作者: Katarina Zeder.;Suman Kundu.;Edward D Siew.;Jeffrey S Annis.;Laurel Y Lee.;Jonah Garry.;Kelly A Birdwell.;Matthew S Freiberg.;Gabor Kovacs.;Evan L Brittain.;Bradley A Maron.
来源: Chest. 2025年
Pulmonary hypertension (PH) is a high-risk finding in end-stage kidney disease (ESKD) and is independently associated with increased mortality.
108. Pulmonary Rehabilitation Referral Practice Patterns Across Lung Transplantation Centers in the United States: A Multi-Center Survey-Based Study.
作者: Juan D Deleija.;Sadia Z Shah.;Jamie Felzer.;Xin Tan.;Chris Garvey.;Thomas W DeCato.;Kelly Pennington.;Sameep Sehgal.;Cassie Kennedy.;Anupam Kumar.
来源: Chest. 2025年
Functional status and frailty are important considerations in lung transplantation (LT) candidacy because of the potential impact on outcomes after LT. Once listed, waitlist duration can be unpredictable, and preservation of functional capacity is critical to prevent deterioration in conditioning. Pulmonary rehabilitation (PR) has been deemed to be a cornerstone of management of chronic lung disease; its role is often emphasized in lung transplantation.
109. Ultrathin Bronchoscopy With Radial Endobronchial Ultrasound and Rapid On-Site Evaluation for the Diagnosis of Peripheral Pulmonary Lesions: A Multicenter Randomized Controlled Factorial Trial.
作者: Erik Vakil.;Marc Fortin.;Anne V Gonzalez.;Laïla Samy.;Alex C Chee.;Elaine Dumoulin.;Marie Dvorakova.;Christopher A Hergott.;Moosa Khalil.;Noël Lampron.;Paul MacEachern.;Simon Martel.;Benjamin Shieh.;Mathieu Simon.;Thibaud Soumagne.;Tatjana Terzic.;Alain Tremblay.
来源: Chest. 2025年
The routine use of CT imaging and lung cancer screening has increased the incidence of peripheral pulmonary lesions (PPLs). Sampling may be needed for some nodules. Many new technologies are available to improve the diagnostic performance of bronchoscopy for the sampling of PPLs, but few comparative trials exist. The objective of this study was to compare the diagnostic performance of bronchoscopy with radial endobronchial ultrasound (rEBUS) using an ultrathin bronchoscope (BF-MP190F; Olympus) with a non-ultrathin bronchoscope and to compare the diagnostic performance of bronchoscopy with and without rapid on-site evaluation (ROSE).
110. To Make a Self: Exploring and Supporting Professional Identity Formation and Resilience of Intensivists Through Humanities.
Becoming a clinician requires not only the accumulation of medical knowledge but also the development of a professional identity. The humanities may illuminate how professional and personal experiences shape identity, support meaning-making, and foster resilience through reflection and creative expression.
111. Selecting an Inhaled Delivery System in COPD.
Challenges facing health care professionals (HCPs) in selecting an inhaled medication delivery system for patients with COPD include (1) numerous maintenance medications and combinations; (2) at least 22 different handheld inhaler devices; (3) management recommendations focusing mainly on classes of medications; (4) lack of knowledge about available medications/combinations, delivery systems, and guidelines/expert recommendations for treating patients with COPD; (5) in some countries, contracts between health insurance and pharmaceutical companies limit which medications or devices are covered. In this article, we address 3 considerations for HCPs related to treating patients with COPD: selecting an inhaled delivery system; assessing whether the inhaled medication device has provided symptomatic benefit; and providing educational materials for patients on how to use their prescribed medication device correctly. Four patient cases are presented to illustrate these clinical aspects. The main patient factors for selecting an inhaled delivery system include cognitive function, manual dexterity, and inhalation ability. Continuity of the type of handheld inhaler can be beneficial if the patient is using it correctly. To assess the efficacy of the inhaled medication-device at follow-up, HCPs can ask the patient, "Does your current treatment help your breathing?" If the response is Yes, it is appropriate to continue the therapy and to also review inhaler technique; if the response is No, then the next step is to assess the patient's inhaler technique as well as adherence. If the patient demonstrates or describes good technique, is adherent, and does not report subjective benefit, it is reasonable to change the medication or the device.
112. Tezepelumab in Patients With Eosinophilic Granulomatosis With Polyangiitis After Suboptimal Response to Anti-IL5/5R Therapy.
作者: Alexandra M Nanzer.;Jessica Gates.;Faizan Haris.;Grainne d'Ancona.;Claire Hopkins.;Michelle Fernando.;Tevfik F Ismail.;Jaideep Dhariwal.;David J Jackson.
来源: Chest. 2025年 113. Sputum Cellularity and MRI Ventilation Defects in Severe Asthma.
作者: Hana Serajeddini.;Ashutosh Thakar.;Melanie Kjarsgaard.;Chynna Huang.;Nandhitha Ragunayakam.;Ekamdeep Sandhu.;Carmen Venegas Garrido.;Yonni Friedlander.;Norm Konyer.;Kayla Zhang.;Nadia Suray Tan.;Katherine Radford.;Manali Mukherjee.;Parameswaran Nair.;Sarah Svenningsen.
来源: Chest. 2025年
Airway inflammation is a hallmark feature of asthma characterized by elevated eosinophils and/or neutrophils. Eosinophils in sputum can contribute to ventilation defects. The functional consequence of other types of cellularity on ventilation is unknown.
114. Diagnosing Pulmonary Embolism During Pregnancy.
作者: Meriem Hammache.;Camille Simard.;Sandrine Hamel.;Suzie Ouellet.;Gisèle Jolicoeur.;Karen Wou.;Kate Sellen.;Ramy El-Jalbout.;Jayson Potts.;Ghada Bourjeily.;Maral Koolian.;Vicky Tagalakis.;Leslie Skeith.;Grégoire Le Gal.;Isabelle Malhamé.
来源: Chest. 2025年
Pulmonary embolism (PE) is one of the leading causes of pregnancy-related deaths in high-income countries. Maternal mortality from PE has been attributed to delayed recognition and investigations. The diagnosis of PE may be challenging, as its early signs and symptoms may overlap with physiological changes of pregnancy. As such, promptly ruling out suspected PE using diagnostic testing is of paramount importance. This narrative review provides a contemporary overview of risk assessment tools, diagnostic modalities, counseling needs, and existing best practice guidance for the diagnosis of PE in pregnancy.
115. Prediction Pathway for Severe Asthma Exacerbations: A Bayesian Network Analysis.
作者: Chandra Prakash Yadav.;Atlanta Chakraborty.;David B Price.;Laura Huey Mien Lim.;Yah Ru Juang.;Richard Beasley.;Mohsen Sadatsafavi.;Christer Janson.;Mariko Koh Siyue.;Eileen Wang.;Michael E Wechsler.;David J Jackson.;John Busby.;Liam G Heaney.;Paul E Pfeffer.;Bassam Mahboub.;Diahn-Warng Perng.;Borja G Cosio.;Luis Perez-de-Llano.;Riyad Al-Lehebi.;Désirée Larenas-Linnemann.;Mona S Al-Ahmad.;Chin Kook Rhee.;Takashi Iwanaga.;Enrico Heffler.;Giorgio Walter Canonica.;Richard W Costello.;Nikolaos G Papadopoulos.;Andriana I Papaioannou.;Celeste M Porsbjerg.;Carlos A Torres-Duque.;George C Christoff.;Todor A Popov.;Mark Hew.;Matthew J Peters.;Peter G Gibson.;Jorge Máspero.;Celine Bergeron.;Saraid Cerda.;Elvia Angelica Contreras.;Wenjia Chen.
来源: Chest. 2025年168卷2期301-316页
Accurate risk prediction of exacerbations is pivotal in severe asthma management. Multiple risk factors are at play, but the pathway of risk prediction remains unclear.
116. Discriminative Accuracy of the Simplified Spirometry for Identifying Spirometry-Defined COPD in the Community.
作者: Fan Wu.;Gaoying Tang.;Zhishan Deng.;Qi Wan.;Kunning Zhou.;Heshen Tian.;Binwei Hao.;Cuiqiong Dai.;Zihui Wang.;Siqi Zou.;Xiulin Liao.;Si Huang.;Qiaorui Zhou.;Yuyan Hou.;Jincong Gan.;Huixian Lin.;Xianliang Zeng.;Lifei Lu.;Suyin Huang.;Changli Yang.;Shengtang Chen.;Yongqing Huang.;Shuqing Yu.;Yumin Zhou.;Pixin Ran.
来源: Chest. 2025年
The low spirometry testing rate for screening of COPD is partly attributed to complex procedures, stringent quality control requirements, and long examination times. Simplifying the spirometry protocol may increase the feasibility of COPD screening in community settings.
117. Association Between a Recalled Positive Airway Pressure Device and Obstructive Lung Disease: A Province-Based Study.
作者: Tetyana Kendzerska.;Robert Talarico.;Marcus Povitz.;Kenneth Blades.;Constance Mackenzie.;Andrea S Gershon.;Najib T Ayas.;Marta Kaminska.;Mark Fenton.;Kerry A McBrien.;Steven Hawken.;Diana Ratycz.;Robert L Owens.;Sachin R Pendharkar.
来源: Chest. 2025年
Limited real-world data exist on the health impacts of the Philips Respironics recall for positive airway pressure (PAP) devices.
118. Best Practices for Right Heart Catheterization in the Diagnosis of Pulmonary Hypertension.
作者: Yuri Matusov.;Nicholas A Kolaitis.;Dael Geft.;Jacqueline DesJardin.;Christopher Barnett.;Antoine Hage.;Teresa De Marco.;Michael I Lewis.
来源: Chest. 2025年
Right heart catheterization is the gold standard for the diagnosis of pulmonary hypertension. There are variations in practice and several pitfalls introducing errors in diagnosis that can significantly affect treatment. Errors in assessing the correct pulmonary artery wedge pressure can significantly affect accurate classification of patients with pulmonary hypertension and lead to potentially deleterious treatment decisions. This review focuses on best practices in right heart catheterization performance, emphasizing practical and pathophysiological principles to obtain the most accurate result, as well as advanced applications in pulmonary hypertension.
119. Health and Utilization Burden of OSA Among US Active-Duty Military Personnel.
作者: Emerson M Wickwire.;Vincent F Capaldi.;Jeph Herrin.;Benoit Stryckman.;Connie Thomas.;Scott G Williams.;J Kent Werner.;Wendy Funk.;Thomas Nassif.;Jennifer S Albrecht.
来源: Chest. 2025年
Despite the significant health and economic burden associated with OSA among civilians, little is known about this burden among active-duty military personnel.
120. Proteomic Analysis of Nasopharyngeal Aspirate Biomarkers for Prematurity-Related Bronchopulmonary Dysplasia.
作者: Fernando Garrido-Muñoz.;Alejandro Fernández-Vega.;Rebeca Gregorio-Hernández.;Marta Padín-Fontán.;Mónica de Las Heras-Martín.;Marta Teresa-Palacio.;Paula Alonso-Quintela.;Alberto Trujillo-Fagundo.;Alba Pérez-Pérez.;Marcelino Pumarada-Prieto.;Jon Montero-Gato.;Victoria Aldecoa-Bilbao.;Ignacio Oulego-Erroz.;Mario Sánchez-Fernández.;Almudena Alonso-Ojembarrena.
来源: Chest. 2025年
The high incidence of bronchopulmonary dysplasia (BPD) continues to be a problem among extremely low-gestational-age neonates (ELGANs). Recent improvements in next-generation proteomics have provided opportunities to obtain new perspectives on the early detection of BPD. In this study, our main objectives were to study the proteomes of patients by collecting nasopharyngeal aspirate (NPA) samples and evaluate the differences between ELGANs with and without BPD at 1 week of life.
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