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103. Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer.
作者: Amy E Turriff.;Christina M Annunziata.;Ashkan A Malayeri.;Bernadette Redd.;Miroslava Pavelova.;Ian S Goldlust.;Padma Sheila Rajagopal.;Jielu Lin.;Diana W Bianchi.
来源: N Engl J Med. 2024年391卷22期2123-2132页
Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers that can identify pregnant persons who are most likely to have cancer and to determine the best approach for follow-up.
104. Transmission as a Key Driver of Resistance to the New Tuberculosis Drugs.
作者: Galo A Goig.;Chloé Loiseau.;Nino Maghradze.;Kakha Mchedlishvili.;Teona Avaliani.;Daniela Brites.;Sonia Borrell.;Rusudan Aspindzelashvili.;Zaza Avaliani.;Maia Kipiani.;Nestani Tukvadze.;Levan Jugheli.;Sebastien Gagneux.
来源: N Engl J Med. 2025年392卷1期97-99页 105. Long-Distance Spread of a Highly Drug-Resistant Epidemic Cholera Strain.
作者: Caroline Rouard.;Louis Collet.;Elisabeth Njamkepo.;Claire Jenkins.;Rosalie Sacheli.;Thierry Benoit-Cattin.;Julie Figoni.;François-Xavier Weill.
来源: N Engl J Med. 2024年391卷23期2271-2273页 106. Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A.
作者: Alok Srivastava.;Aby Abraham.;Fouzia Aboobacker.;Gurbind Singh.;Tulasi Geevar.;Uday Kulkarni.;Sushil Selvarajan.;Anu Korula.;Rutvi Gautam Dave.;Mohana Shankar.;Abraham S Singh.;Anbu Jeba.;Navien Kumaar.;Christopher Benjamin.;Kavitha M Lakshmi.;Vivi Miriam Srivastava.;Ramachandran V Shaji.;Sukesh C Nair.;Harrison C Brown.;Gabriela Denning.;Pete Lollar.;Christopher B Doering.;Trent Spencer.
来源: N Engl J Med. 2025年392卷5期450-457页
Severe hemophilia A is managed with factor VIII replacement or hemostatic products that stop or prevent bleeding. Data on gene therapy with hematopoietic stem-cell (HSC)-based expression of factor VIII for the treatment of severe hemophilia A are lacking.
107. Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children.
作者: Sumit Gupta.;Rachel E Rau.;John A Kairalla.;Karen R Rabin.;Cindy Wang.;Anne L Angiolillo.;Sarah Alexander.;Andrew J Carroll.;Susan Conway.;Lia Gore.;Ilan Kirsch.;Holly R Kubaney.;Amanda M Li.;Jennifer L McNeer.;Olga Militano.;Tamara P Miller.;Yvonne Moyer.;Maureen M O'Brien.;Maki Okada.;Shalini C Reshmi.;Mary Shago.;Elizabeth Wagner.;Naomi Winick.;Brent L Wood.;Tara Haworth-Wright.;Faraz Zaman.;Gerhard Zugmaier.;Sue Zupanec.;Meenakshi Devidas.;Stephen P Hunger.;David T Teachey.;Elizabeth A Raetz.;Mignon L Loh.
来源: N Engl J Med. 2025年392卷9期875-891页
B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common childhood cancer. Despite a high overall cure rate, relapsed B-cell ALL remains a leading cause of cancer-related death among children. The addition of the bispecific T-cell engager molecule blinatumomab (an anti-CD19 and anti-CD3 single-chain molecule) to therapy for newly diagnosed standard-risk (as defined by the National Cancer Institute) B-cell ALL in children may improve outcomes.
108. Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia.
作者: Claire Roddie.;Karamjeet S Sandhu.;Eleni Tholouli.;Aaron C Logan.;Paul Shaughnessy.;Pere Barba.;Armin Ghobadi.;Manuel Guerreiro.;Deborah Yallop.;Mehrdad Abedi.;Jeremy M Pantin.;Jean A Yared.;Amer M Beitinjaneh.;Sridhar Chaganti.;Katharine Hodby.;Tobias Menne.;Martha L Arellano.;Ram Malladi.;Bijal D Shah.;Luke Mountjoy.;Kristen M O'Dwyer.;Karl S Peggs.;Pierre Lao-Sirieix.;Yiyun Zhang.;Wolfram Brugger.;Edgar Braendle.;Martin Pule.;Michael R Bishop.;Daniel J DeAngelo.;Jae H Park.;Elias Jabbour.
来源: N Engl J Med. 2024年391卷23期2219-2230页
Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve persistence.
109. Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam.
作者: Lay-Myint Yoshida.;Michiko Toizumi.;Hien Anh Thi Nguyen.;Billy J Quilty.;Le Thuy Lien.;Le Huy Hoang.;Chihiro Iwasaki.;Mizuki Takegata.;Noriko Kitamura.;Monica L Nation.;Jason Hinds.;Kevin van Zandvoort.;Belinda D Ortika.;Eileen M Dunne.;Catherine Satzke.;Hung Thai Do.;Kim Mulholland.;Stefan Flasche.;Duc-Anh Dang.
来源: N Engl J Med. 2024年391卷21期1992-2002页
After pneumococcal disease and colonization have been controlled through vaccination campaigns, a reduced pneumococcal conjugate vaccine (PCV) schedule may be sufficient to sustain that control at reduced costs.
110. Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.
作者: Seth P Lerner.;Catherine Tangen.;Robert S Svatek.;Siamak Daneshmand.;Kamal S Pohar.;Eila Skinner.;Anne Schuckman.;Arthur I Sagalowsky.;Norm D Smith.;Ashish M Kamat.;Wassim Kassouf.;Melissa Plets.;Rick Bangs.;Theresa M Koppie.;Ajjai Alva.;Francisco G La Rosa.;Sumanta K Pal.;Adam S Kibel.;Daniel J Canter.;Ian M Thompson.; .
来源: N Engl J Med. 2024年391卷13期1206-1216页
Whether extended lymphadenectomy is associated with improved disease-free and overall survival, as compared with standard lymphadenectomy, among patients with localized muscle-invasive bladder cancer undergoing radical cystectomy is unclear.
113. Susceptibility to Vaccine-Preventable Infections in Asylum Seekers.
作者: Christian Olivo-Freites.;Patricia Miguez-Arosemena.;Cristina Olivo-Freites.;Deborah Edelman.;Kayla Leschly.;Jayme Leschly.;Louise C Ivers.;Amir M Mohareb.
来源: N Engl J Med. 2024年391卷20期1959-1960页 114. Colchicine in Acute Myocardial Infarction.
作者: Sanjit S Jolly.;Marc-André d'Entremont.;Shun Fu Lee.;Rajibul Mian.;Jessica Tyrwhitt.;Sasko Kedev.;Gilles Montalescot.;Jan H Cornel.;Goran Stanković.;Raul Moreno.;Robert F Storey.;Timothy D Henry.;Shamir R Mehta.;Matthias Bossard.;Petr Kala.;Jamie Layland.;Biljana Zafirovska.;P J Devereaux.;John Eikelboom.;John A Cairns.;Binita Shah.;Tej Sheth.;Sanjib K Sharma.;Wadea Tarhuni.;David Conen.;Sarah Tawadros.;Shahar Lavi.;Salim Yusuf.; .
来源: N Engl J Med. 2025年392卷7期633-642页
Inflammation is associated with adverse cardiovascular events. Data from recent trials suggest that colchicine reduces the risk of cardiovascular events.
115. Routine Spironolactone in Acute Myocardial Infarction.
作者: Sanjit S Jolly.;Marc-André d'Entremont.;Bertram Pitt.;Shun Fu Lee.;Rajibul Mian.;Jessica Tyrwhitt.;Sasko Kedev.;Gilles Montalescot.;Jan H Cornel.;Goran Stanković.;Raul Moreno.;Robert F Storey.;Timothy D Henry.;Shamir R Mehta.;Matthias Bossard.;Petr Kala.;Ravinay Bhindi.;Biljana Zafirovska.;P J Devereaux.;John Eikelboom.;John A Cairns.;Madhu K Natarajan.;J D Schwalm.;Sanjib K Sharma.;Wadea Tarhuni.;David Conen.;Sarah Tawadros.;Shahar Lavi.;Valon Asani.;Dragan Topic.;Warren J Cantor.;Olivier F Bertrand.;Ali Pourdjabbar.;Salim Yusuf.; .; .
来源: N Engl J Med. 2025年392卷7期643-652页
Mineralocorticoid receptor antagonists have been shown to reduce mortality in patients after myocardial infarction with congestive heart failure. Whether routine use of spironolactone is beneficial after myocardial infarction is uncertain.
118. Simple Strategies to Reduce Cardiac Strain in Older Adults in Extreme Heat.
作者: Georgia K Chaseling.;Nicole T Vargas.;Lily Hospers.;Hadiatou Barry.;Amy Harwood.;Connor Graham.;Audrey-Ann Bartlett.;Amélie Debray.;Grant Lynch.;Anthony Capon.;Craig G Crandall.;Maria Fiatarone Singh.;Yorgi Mavros.;Peng Bi.;Anil Nigam.;Malorie Chabot-Blanchet.;Daniel Gagnon.;Ollie Jay.
来源: N Engl J Med. 2024年391卷18期1754-1756页 119. A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest.
作者: Keith Couper.;Chen Ji.;Charles D Deakin.;Rachael T Fothergill.;Jerry P Nolan.;John B Long.;James M Mason.;Felix Michelet.;Chloe Norman.;Henry Nwankwo.;Tom Quinn.;Anne-Marie Slowther.;Michael A Smyth.;Kath R Starr.;Alison Walker.;Sara Wood.;Steve Bell.;Gemma Bradley.;Martina Brown.;Shona Brown.;Emma Burrow.;Karl Charlton.;Andrew Claxton Dip.;Victoria Dra'gon.;Christine Evans.;Jakob Falloon.;Theresa Foster.;Justin Kearney.;Nigel Lang.;Matthew Limmer.;Adam Mellett-Smith.;Joshua Miller.;Carla Mills.;Ria Osborne.;Nigel Rees.;Robert E S Spaight.;Gemma L Squires.;Belinda Tibbetts.;Michelle Waddington.;Gregory A Whitley.;Jason V Wiles.;Julia Williams.;Sarah Wiltshire.;Adam Wright.;Ranjit Lall.;Gavin D Perkins.; .
来源: N Engl J Med. 2025年392卷4期336-348页
In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug administration than an intravenous route; however, its effect on clinical outcomes is uncertain.
120. Ten-Year Outcomes after Bariatric Surgery in Adolescents.
作者: Justin R Ryder.;Todd M Jenkins.;Changchun Xie.;Anita P Courcoulas.;Carroll M Harmon.;Michael A Helmrath.;Stephanie Sisley.;Marc P Michalsky.;Mary Brandt.;Thomas H Inge.
来源: N Engl J Med. 2024年391卷17期1656-1658页 |