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109. Ivermectin to Control Malaria - A Cluster-Randomized Trial.
作者: Carlos Chaccour.;Marta Maia.;Mercy Kariuki.;Paula Ruiz-Castillo.;Caroline Wanjiku.;Lydia Kasiwa.;Aurelia Brazeal.;Aina Casellas.;Mwanajuma Ngama.;Truphena Onyango.;Eldo Elobolobo.;Karisa Kazungu.;Mary Mael.;Winnie Wangari.;Khadija Nuru.;Rachel Otuko.;Almudena Sanz.;Isaac Ringera.;Allan Matano.;Starford Mitora.;Marta Ribes.;Joe Brew.;Nika Gorski.;Patricia Nicolas.;Sara Stanulovic.;Isaiah Omondi.;Joanna Furnival-Adams.;Laura Túnez.;Jamal Mbarak.;Vegovito Vegove.;Esther Yaa.;Shadrack Mramba.;Yegon Kibet.;Naomi Nyambura.;Charles Rotich.;Scholastica Wanjiru.;Musa Vura.;Faith Wanjiku.;Leslie Sam.;Lisa Collins.;Kang Xia.;Felix Hammann.;Francisco Saúte.;Matthew Rudd.;Cassidy Rist.;Caroline Jones.;Joseph Mwangangi.;N Regina Rabinovich.
来源: N Engl J Med. 2025年393卷4期362-375页
Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic drug that also kills mosquitoes feeding on treated persons, can reduce malaria transmission is unclear.
111. Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease.
作者: Robert McFarland.;Louise A Hyslop.;Catherine Feeney.;Rekha N Pillai.;Emma L Blakely.;Eilis Moody.;Matthew Prior.;Anita Devlin.;Robert W Taylor.;Mary Herbert.;Meenakshi Choudhary.;Jane A Stewart.;Douglass M Turnbull.
来源: N Engl J Med. 2025年393卷5期461-468页
Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathogenic mtDNA variants with reproductive options. A total of 22 women with pathogenic mtDNA variants have commenced or completed pronuclear transfer (and thus receipt of a mitochondrial donation), and there have been 8 live births. All 8 children were healthy at birth, with no or low levels of mtDNA heteroplasmy in blood. Hyperlipidemia and cardiac arrhythmia developed in a child whose mother had hyperlipidemia during pregnancy; both of the child's conditions responded to treatment. Infant myoclonic epilepsy developed in another child, with spontaneous remission. At the time of this report, all the children have made normal developmental progress. (Funded by the U.K. National Health Service and others.).
115. Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease.
作者: Louise A Hyslop.;Emma L Blakely.;Magomet Aushev.;Jordan Marley.;Yuko Takeda.;Angela Pyle.;Eilis Moody.;Catherine Feeney.;Jan Dutton.;Carol Shaw.;Sarah J Smith.;Kate Craig.;Charlotte L Alston.;Lisa Lister.;Karina Endacott.;Samantha Byerley.;Helen McDermott.;Kathryn Wilson.;Lynne Botham.;Beth Matthew.;Nilendran Prathalingam.;Matthew Prior.;Alison Murdoch.;Douglass M Turnbull.;Gavin Hudson.;Meenakshi Choudhary.;Robert W Taylor.;Rekha N Pillai.;Jane A Stewart.;Robert McFarland.;Mary Herbert.
来源: N Engl J Med. 2025年393卷5期438-449页
Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuclear transfer involves transplantation of nuclear genome from a fertilized egg from the affected woman to an enucleated fertilized egg donated by an unaffected woman. Thus, pronuclear transfer offers affected women the potential to have a genetically related child with a reduced risk of mtDNA disease.
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