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101. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
作者: Marie Truyens.;Triana Lobatón.;Marc Ferrante.;Peter Bossuyt.;Séverine Vermeire.;Lieven Pouillon.;Pieter Dewint.;Anneline Cremer.;Harald Peeters.;Guy Lambrecht.;Edouard Louis.;Jean-François Rahier.;Olivier Dewit.;Vinciane Muls.;Tom Holvoet.;Liv Vandermeulen.;Anneleen Peeters.;Gerard Bryan Gonzales.;Simon Bos.;Debby Laukens.;Martine De Vos.
来源: Gastroenterology. 2022年163卷5期1294-1305.e3页
Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD), and only limited treatment options are available. Based on the hypothetical link between low serum tryptophan concentrations and fatigue, we determined the effect of 5-hydroxytryptophan supplementation on fatigue in patients with inactive IBD.
102. Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge.
作者: Joseph A Murray.;Jack A Syage.;Tsung-Teh Wu.;Matthew A Dickason.;Ana G Ramos.;Carol Van Dyke.;Irina Horwath.;Philip T Lavin.;Markku Mäki.;Isabel Hujoel.;Konstantinos A Papadakis.;Adam C Bledsoe.;Chaitan Khosla.;Jennifer A Sealey-Voyksner.; .
来源: Gastroenterology. 2022年163卷6期1510-1521.e6页
Gluten ingestion in patients with celiac disease can lead to gastrointestinal symptoms and small intestinal mucosal injury.
103. Alterations of liver enzymes and lipid profile in response to exhaustive eccentric exercise: vitamin D supplementation trial in overweight females with non-alcoholic fatty liver disease.
Eccentric exhaustive exercise (EEE) training has been known as a promising training modality to enhance performance and stimulate adaptation in healthy individuals or patients that might also cause abnormal liver enzymes and lipid profiles. Vitamin D (Vit D) supplementation is believed to improve the condition of Non-Alcoholic Fatty Liver Disease (NAFLD) patients. However, there is limited evidence on the effect of Vit D supplementation on the EEE-induced alterations. This study aimed to investigate the effect of short-term supplementation of Vit D on the liver enzymes and lipid profile alterations following EEE in overweight women with NAFLD.
104. Multicenter Randomized Controlled Trial of Surveillance Versus Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia: The SURVENT Trial: Study Rationale, Methodology, Innovation, and Implications.
作者: Sachin Wani.;Rhonda F Souza.;Valerie L Durkalski.;Jose Serrano.;Frank Hamilton.;Nicholas J Shaheen.; .
来源: Gastroenterology. 2022年163卷3期556-562.e4页 105. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial.
作者: William D Chey.;Francis Mégraud.;Loren Laine.;Luis J López.;Barbara J Hunt.;Colin W Howden.
来源: Gastroenterology. 2022年163卷3期608-619页
Novel, effective treatments for Helicobacter pylori infection are needed. This study evaluated the efficacy of vonoprazan, a potassium-competitive acid blocker, vs standard treatment on H pylori eradication in the United States and Europe.
106. Metabolome Changes With Diet-Induced Remission in Pediatric Crohn's Disease.
作者: Mohammed Ghiboub.;Susanne Penny.;Charlotte M Verburgt.;Rotem Sigall Boneh.;Eytan Wine.;Alejandro Cohen.;Katherine A Dunn.;Devanand M Pinto.;Marc A Benninga.;Wouter J de Jonge.;Arie Levine.;Johan E Van Limbergen.
来源: Gastroenterology. 2022年163卷4期922-936.e15页
The Crohn's disease (CD) exclusion diet (CDED) plus partial enteral nutrition (PEN) and exclusive enteral nutrition (EEN) both induce remission in pediatric CD. CDED+PEN is better tolerated and able to sustain remission. We characterized the changes in fecal metabolites induced by CDED+PEN and EEN and their relationship with remission.
107. Computer-Aided Detection Improves Adenomas per Colonoscopy for Screening and Surveillance Colonoscopy: A Randomized Trial.
作者: Aasma Shaukat.;David R Lichtenstein.;Samuel C Somers.;Daniel C Chung.;David G Perdue.;Murali Gopal.;Daniel R Colucci.;Sloane A Phillips.;Nicholas A Marka.;Timothy R Church.;William R Brugge.; .
来源: Gastroenterology. 2022年163卷3期732-741页
Colonoscopy for colorectal cancer screening is endoscopist dependent, and colonoscopy quality improvement programs aim to improve efficacy. This study evaluated the clinical benefit and safety of using a computer-aided detection (CADe) device in colonoscopy procedures.
108. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial.
作者: Anke M Onnekink.;Lotte Boxhoorn.;Hester C Timmerhuis.;Simon T Bac.;Marc G Besselink.;Marja A Boermeester.;Thomas L Bollen.;Koop Bosscha.;Stefan A W Bouwense.;Marco J Bruno.;Sandra van Brunschot.;Vincent C Cappendijk.;Esther C J Consten.;Cornelis H Dejong.;Marcel G W Dijkgraaf.;Casper H J van Eijck.;Willemien G Erkelens.;Harry van Goor.;Janneke van Grinsven.;Jan-Willem Haveman.;Jeanin E van Hooft.;Jeroen M Jansen.;Krijn P van Lienden.;Maarten A C Meijssen.;Vincent B Nieuwenhuijs.;Jan-Werner Poley.;Rutger Quispel.;Rogier J de Ridder.;Tessa E H Römkens.;Hjalmar C van Santvoort.;Joris J Scheepers.;Matthijs P Schwartz.;Tom Seerden.;Marcel B W Spanier.;Jan Willem A Straathof.;Robin Timmer.;Niels G Venneman.;Robert C Verdonk.;Frank P Vleggaar.;Roy L van Wanrooij.;Ben J M Witteman.;Paul Fockens.;Rogier P Voermans.; .
来源: Gastroenterology. 2022年163卷3期712-722.e14页
Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical Step-Up Approach in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that the endoscopic step-up approach might be preferred over the surgical step-up approach in patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both step-up approaches after a period of at least 5 years.
109. Safety and efficacy of topical drug-free cream in subjects with hemorrhoidal disease: a randomized, double blind, clinical trial.
作者: Alessandro Sturiale.;Lisa Fralleone.;Danilo Cafaro.;Gaetano Gallo.;Luigi Brusciano.;Felipe Celedon Porzio.;Sreedhara Venkataratnaiah Setty.;Gabriele Naldini.
来源: Minerva Gastroenterol (Torino). 2022年68卷4期407-414页
Hemorrhoidal disease (HD) is one of the most common anorectal benign disorder affecting millions of people around the world. Grade I-II HD are generally treated with a conservative approach with topical products such as creams and ointments considered a safe and effective option to treat mild symptoms. The aim of the present study was to assess the safety and efficacy of a topical medical device (Lenoid™; International Health Science [IHS] - Biofarma Group, Mereto di Tomba, Udine, Italy) in patients affected by symptomatic HD.
110. Effect of Helicobacter pylori Eradication on Gastric Cancer Prevention: Updated Report From a Randomized Controlled Trial With 26.5 Years of Follow-up.
作者: Lingjun Yan.;Ying Chen.;Fa Chen.;Tao Tao.;Zhijian Hu.;Junzhuo Wang.;Jianwang You.;Benjamin C Y Wong.;Jianshun Chen.;Weimin Ye.
来源: Gastroenterology. 2022年163卷1期154-162.e3页
Helicobacter pylori infection is considered as the most important risk factor in the pathogenesis of gastric cancer. This study aims to evaluate the long-term effects of H pylori eradication treatment on the incidence and mortality of gastric cancer among a high-risk population.
111. Comparison of the outcomes between sorafenib and lenvatinib as the first-line systemic treatment for HBV-associated hepatocellular carcinoma: a propensity score matching analysis.
作者: Na Ryung Choi.;Ju Yeon Kim.;Ji Hoon Hong.;Moon Haeng Hur.;Heejin Cho.;Min Kyung Park.;Jihye Kim.;Yun Bin Lee.;Eun Ju Cho.;Jeong-Hoon Lee.;Su Jong Yu.;Jung-Hwan Yoon.;Yoon Jun Kim.
来源: BMC Gastroenterol. 2022年22卷1期135页
In a randomized controlled trial, lenvatinib was non-inferior to sorafenib in overall survival (OS) of patients with unresectable hepatocellular carcinoma (uHCC). This study aimed to compare the effects of sorafenib and lenvatinib as first-line systemic therapy against uHCC with real-world data in chronic hepatitis B patients.
112. Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia.
作者: Michael B Wallace.;Prateek Sharma.;Pradeep Bhandari.;James East.;Giulio Antonelli.;Roberto Lorenzetti.;Micheal Vieth.;Ilaria Speranza.;Marco Spadaccini.;Madhav Desai.;Frank J Lukens.;Genci Babameto.;Daisy Batista.;Davinder Singh.;William Palmer.;Francisco Ramirez.;Rebecca Palmer.;Tisha Lunsford.;Kevin Ruff.;Elizabeth Bird-Liebermann.;Victor Ciofoaia.;Sophie Arndtz.;David Cangemi.;Kirsty Puddick.;Gregory Derfus.;Amitpal S Johal.;Mohammed Barawi.;Luigi Longo.;Luigi Moro.;Alessandro Repici.;Cesare Hassan.
来源: Gastroenterology. 2022年163卷1期295-304.e5页
Artificial intelligence (AI) may detect colorectal polyps that have been missed due to perceptual pitfalls. By reducing such miss rate, AI may increase the detection of colorectal neoplasia leading to a higher degree of colorectal cancer (CRC) prevention.
113. A novel duodenal-release formulation of caraway oil and L-menthol is a safe, effective and well tolerated therapy for functional dyspepsia.
作者: Brian E Lacy.;William D Chey.;Michael S Epstein.;Syed M Shah.;Patrick Corsino.;Linda R Zeitzoff.;Brooks D Cash.
来源: BMC Gastroenterol. 2022年22卷1期105页
A randomized, placebo-controlled clinical trial (FDREST) of a novel formulation of caraway oil and L-menthol (COLM-SST) demonstrated symptom relief in patients with functional dyspepsia (FD). Two follow-up studies were conducted to evaluate patient satisfaction, self-regulated dosing, and long-term safety data: FDACT, Functional Dyspepsia Adherence and Compliance Trial, and FDSU36, Functional Dyspepsia Safety Update at 36 months.
114. Investigating the effect of quadruple therapy with Saccharomyces boulardii or Lactobacillus reuteri strain (DSMZ 17648) supplements on eradication of Helicobacter pylori and treatments adverse effects: a double-blind placebo-controlled randomized clinical trial.
作者: Nooshin Naghibzadeh.;Fatemeh Salmani.;Samira Nomiri.;Tahmine Tavakoli.
来源: BMC Gastroenterol. 2022年22卷1期107页
The goal of this study was to investigate the effects of treatment with Saccharomyces boulardii and Lactobacillus reuteri on the eradication of Helicobacter pylori and Adverse effects (AEs) of the treatment.
115. Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes.
作者: Christina Stene.;Andrada Röme.;Ingrid Palmquist.;Caroline Linninge.;Göran Molin.;Siv Ahrné.;Louis Banka Johnson.;Bengt Jeppsson.
来源: BMC Gastroenterol. 2022年22卷1期100页
Oral administration of health-promoting bacteria is increasingly used in clinical practise. These bacteria have anti-inflammatory characteristics and modulate the immune system without major reported side effects. The mechanisms of action are not yet fully defined. Our aim was to study systemic effects of probiotics by measurements of leukocytes as well as local effects on rectal mucosal biopsies after adding a standardized inflammatory stimulus in vitro.
116. Impact of a procalcitonin-based algorithm on the quality of management of patients with uncomplicated adhesion-related small bowel obstruction assessed by a textbook outcome: a multicenter cluster-randomized open-label controlled trial.
作者: Charles Sabbagh.;Francois Mauvais.;Jean-Jacques Tuech.;Christophe Tresallet.;Pablo Ortega-Debalon.;Muriel Mathonnet.;Jeremie H Lefevre.;Zaher Lakkis.;David Fuks.;Fabrice Muscari.;Bernard Dron.;Philippe Couderc.;Arnaud Alves.;Jean-Marc Regimbeau.
来源: BMC Gastroenterol. 2022年22卷1期90页
Acute adhesion-related small bowel obstruction (ASBO) is a common digestive emergency, accounting for 1 to 3% of all digestive emergencies. The efficacy of conservative management in this setting is a subject of debate, as it may delay the decision to perform surgery and increase the frequency of bowel resection (e.g., in the presence of bowel necrosis) or, in contrast, prompt an excessive number of unnecessary laparotomies. Thus, the decision to perform surgery is difficult. We propose that the introduction of the procalcitonin (PCT)-based algorithm improves the quality of the management of patients with ASBO by aiding the decision of whether or not to perform surgery.
117. Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.
作者: Julián Panés.;Jean-Frederic Colombel.;Geert R D'Haens.;Stefan Schreiber.;Remo Panaccione.;Laurent Peyrin-Biroulet.;Edward V Loftus.;Silvio Danese.;Satoshi Tanida.;Yusuke Okuyama.;Edouard Louis.;Alessandro Armuzzi.;Marc Ferrante.;Harald Vogelsang.;Toshifumi Hibi.;Mamoru Watanabe.;Jessica Lefebvre.;Tricia Finney-Hayward.;Yuri Sanchez Gonzalez.;Thao T Doan.;Nael M Mostafa.;Kimitoshi Ikeda.;Wangang Xie.;Bidan Huang.;Joel Petersson.;Jasmina Kalabic.;Anne M Robinson.;William J Sandborn.
来源: Gastroenterology. 2022年162卷7期1891-1910页
SERENE UC (Study of a Novel Approach to Induction and Maintenance Dosing With Adalimumab in Patients With Moderate to Severe Ulcerative Colitis) evaluated the efficacy of higher adalimumab induction and maintenance dose regimens in patients with ulcerative colitis.
118. Effect of a 12-week home-based exercise training program on aerobic capacity, muscle mass, liver and spleen stiffness, and quality of life in cirrhotic patients: a randomized controlled clinical trial.
作者: Pavapol Sirisunhirun.;Wimolrak Bandidniyamanon.;Yonworanat Jrerattakon.;Kobkun Muangsomboon.;Pornpoj Pramyothin.;Supot Nimanong.;Tawesak Tanwandee.;Phunchai Charatcharoenwitthaya.;Siwaporn Chainuvati.;Watcharasak Chotiyaputta.
来源: BMC Gastroenterol. 2022年22卷1期66页
Physical inactivity and sarcopenia are two important predictors associated with increased morbidity and mortality in patients with cirrhosis. At present, the benefit of a home-based exercise training program is not well established in cirrhotic patients. The main objective of this study was to evaluate the effect of a 12-week home-based exercise training program on aerobic capacity in cirrhotic patients.
119. Endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy versus open appendectomy for acute appendicitis: a pilot study.
作者: Zhemin Shen.;Peilong Sun.;Miao Jiang.;Zili Zhen.;Jingtian Liu.;Mu Ye.;Weida Huang.
来源: BMC Gastroenterol. 2022年22卷1期63页
An increasing number of studies have shown the merits of endoscopic retrograde appendicitis therapy (ERAT) in diagnosing and treating acute uncomplicated appendicitis. However, no related prospective controlled studies have been reported yet. Our aim is to assess the feasibility and safety of ERAT in the treatment of acute uncomplicated appendicitis.
120. Guselkumab for the Treatment of Crohn's Disease: Induction Results From the Phase 2 GALAXI-1 Study.
作者: William J Sandborn.;Geert R D'Haens.;Walter Reinisch.;Julián Panés.;Daphne Chan.;Susana Gonzalez.;Kathleen Weisel.;Matthew Germinaro.;Mary Ellen Frustaci.;Zijiang Yang.;Omoniyi J Adedokun.;Chenglong Han.;Remo Panaccione.;Tadakazu Hisamatsu.;Silvio Danese.;David T Rubin.;Bruce E Sands.;Anita Afzali.;Jane M Andrews.;Brian G Feagan.; .
来源: Gastroenterology. 2022年162卷6期1650-1664.e8页
Guselkumab, a selective p19 interleukin-23 antagonist, is approved for the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and safety of guselkumab in patients with moderately to severely active Crohn's disease with inadequate response or intolerance to conventional or biologic therapy.
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