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101. Residual Confounding in Health Plan Performance Assessments: Evidence From Randomization in Medicaid.
作者: Jacob Wallace.;J Michael McWilliams.;Anthony Lollo.;Janet Eaton.;Chima D Ndumele.
来源: Ann Intern Med. 2022年175卷3期314-324页
Risk adjustment is used widely in payment systems and performance assessments, but the extent to which it distinguishes plan or provider effects from confounding due to patient differences is typically unknown.
102. Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
作者: .;Jens D Lundgren.;Birgit Grund.;Christina E Barkauskas.;Thomas L Holland.;Robert L Gottlieb.;Uriel Sandkovsky.;Samuel M Brown.;Kirk U Knowlton.;Wesley H Self.;D Clark Files.;Mamta K Jain.;Thomas Benfield.;Michael E Bowdish.;Bradley G Leshnower.;Jason V Baker.;Jens-Ulrik Jensen.;Edward M Gardner.;Adit A Ginde.;Estelle S Harris.;Isik S Johansen.;Norman Markowitz.;Michael A Matthay.;Lars Østergaard.;Christina C Chang.;Anna L Goodman.;Weizhong Chang.;Robin L Dewar.;Norman P Gerry.;Elizabeth S Higgs.;Helene Highbarger.;Daniel D Murray.;Thomas A Murray.;Ven Natarajan.;Roger Paredes.;Mahesh K B Parmar.;Andrew N Phillips.;Cavan Reilly.;Adam W Rupert.;Shweta Sharma.;Kathryn Shaw-Saliba.;Brad T Sherman.;Marc Teitelbaum.;Deborah Wentworth.;Huyen Cao.;Paul Klekotka.;Abdel G Babiker.;Victoria J Davey.;Annetine C Gelijns.;Virginia L Kan.;Mark N Polizzotto.;B Taylor Thompson.;H Clifford Lane.;James D Neaton.
来源: Ann Intern Med. 2022年175卷2期234-243页
In a randomized, placebo-controlled, clinical trial, bamlanivimab, a SARS-CoV-2-neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients with COVID-19 based on an early futility assessment.
103. Comparison of a Hemostatic Powder and Standard Treatment in the Control of Active Bleeding From Upper Nonvariceal Lesions : A Multicenter, Noninferiority, Randomized Trial.
作者: James Y W Lau.;Rapat Pittayanon.;Andrew Kwek.;Raymond S Tang.;Heyson Chan.;Rungsun Rerknimitr.;June Lee.;Tiing Leong Ang.;Bing-Yee Suen.;Yuan-Yuan Yu.;Francis K L Chan.;Joseph J Y Sung.
来源: Ann Intern Med. 2022年175卷2期171-178页
The effectiveness of the hemostatic powder TC-325 as a single endoscopic treatment for acute nonvariceal upper gastrointestinal bleeding is uncertain.
104. Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis : A Randomized Trial.
作者: Kim L Bennell.;Belinda J Lawford.;Catherine Keating.;Courtney Brown.;Jessica Kasza.;Dave Mackenzie.;Ben Metcalf.;Alexander J Kimp.;Thorlene Egerton.;Libby Spiers.;Joseph Proietto.;Priya Sumithran.;Anthony Harris.;Jonathan G Quicke.;Rana S Hinman.
来源: Ann Intern Med. 2022年175卷2期198-209页
Scalable knee osteoarthritis programs are needed to deliver recommended education, exercise, and weight loss interventions.
105. Gastric Bypass Versus Sleeve Gastrectomy in Type 2 Diabetes: Effects on Hepatic Steatosis and Fibrosis : A Randomized Controlled Trial.
作者: Kathrine Aglen Seeberg.;Heidi Borgeraas.;Dag Hofsø.;Milada Cvancarova Småstuen.;Nils Petter Kvan.;John Olav Grimnes.;Morten Lindberg.;Farhat Fatima.;Lars Thomas Seeberg.;Rune Sandbu.;Jøran Hjelmesæth.;Jens Kristoffer Hertel.
来源: Ann Intern Med. 2022年175卷1期74-83页
Weight loss improves fatty liver disease. No randomized trial has compared the effects of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on liver fat content and fibrosis.
106. Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine : Secondary Analysis of a Randomized Trial.
作者: Deepali Kumar.;Victor H Ferreira.;Victoria G Hall.;Queenie Hu.;Reuben Samson.;Terrance Ku.;Matthew Ierullo.;Beata Majchrzak-Kita.;George Tomlinson.;Anne-Claude Gingras.;Atul Humar.
来源: Ann Intern Med. 2022年175卷2期226-233页
COVID-19 is more severe in transplant recipients. Variants of concern have supplanted wild-type virus. In transplant recipients, data are limited on 2-dose or 3-dose vaccine immunogenicity against variant viruses.
107. Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial.
作者: Carlo Senore.;Emilia Riggi.;Paola Armaroli.;Luigina Bonelli.;Stefania Sciallero.;Marco Zappa.;Arrigo Arrigoni.;Claudia Casella.;Cristiano Crosta.;Fabio Falcini.;Franco Ferrero.;Mario Fracchia.;Orietta Giuliani.;Mauro Risio.;Antonio G Russo.;Carmen Beatriz Visioli.;Stefano Rosso.;Nereo Segnan.; .
来源: Ann Intern Med. 2022年175卷1期36-45页
Recent reports showed that the protective effect of flexible sigmoidoscopy (FS) screening was maintained up to17 years, although differences were reported by sex.
108. A Primary Care-Based Cognitive Behavioral Therapy Intervention for Long-Term Opioid Users With Chronic Pain : A Randomized Pragmatic Trial.
作者: Lynn DeBar.;Meghan Mayhew.;Lindsay Benes.;Allison Bonifay.;Richard A Deyo.;Charles R Elder.;Francis J Keefe.;Michael C Leo.;Carmit McMullen.;Ashli Owen-Smith.;David H Smith.;Connie M Trinacty.;William M Vollmer.
来源: Ann Intern Med. 2022年175卷1期46-55页
Chronic pain is common, disabling, and costly. Few clinical trials have examined cognitive behavioral therapy (CBT) interventions embedded in primary care settings to improve chronic pain among those receiving long-term opioid therapy.
109. Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa : An Unblinded Randomized Controlled Trial.
作者: Mark J Siedner.;Mahomed-Yunus S Moosa.;Suzanne McCluskey.;Rebecca F Gilbert.;Selvan Pillay.;Isaac Aturinda.;Kevin Ard.;Winnie Muyindike.;Nicholas Musinguzi.;Godfrey Masette.;Melendhran Pillay.;Pravikrishnen Moodley.;Jaysingh Brijkumar.;Tamlyn Rautenberg.;Gavin George.;Rajesh T Gandhi.;Brent A Johnson.;Henry Sunpath.;Mwebesa B Bwana.;Vincent C Marconi.
来源: Ann Intern Med. 2021年174卷12期1683-1692页
Virologic failure in HIV predicts the development of drug resistance and mortality. Genotypic resistance testing (GRT), which is the standard of care after virologic failure in high-income settings, is rarely implemented in sub-Saharan Africa.
110. Effectiveness of Belimumab After Rituximab in Systemic Lupus Erythematosus : A Randomized Controlled Trial.
作者: Muhammad Shipa.;Andrew Embleton-Thirsk.;Mariea Parvaz.;Liliana Ribeiro Santos.;Patrick Muller.;Kashfia Chowdhury.;David A Isenberg.;Caroline J Doré.;Caroline Gordon.;Michael R Ehrenstein.; .
来源: Ann Intern Med. 2021年174卷12期1647-1657页
B-cell depletion with rituximab is commonly used for patients with systemic lupus erythematosus (SLE) that is refractory to conventional therapy, but it yields variable responses. We hypothesized that high B-cell activating factor (BAFF) levels after rituximab can cause disease flares, thereby limiting its effectiveness.
111. The Safety and Immunologic Effectiveness of the Live Varicella-Zoster Vaccine in Patients Receiving Tumor Necrosis Factor Inhibitor Therapy : A Randomized Controlled Trial.
作者: Jeffrey R Curtis.;Stacey S Cofield.;S Louis Bridges.;John Bassler.;Atul Deodhar.;Theresa L Ford.;Joseph Huffstutter.;Allen Jankeel.;Alan Kivitz.;Shaila Kamal.;Stephen Lindsey.;Ilhem Messaoudi.;Norma Mendoza.;Kaleb Michaud.;Ted R Mikuls.;David Ridley.;William Shergy.;Sarah A R Siegel.;Kevin L Winthrop.
来源: Ann Intern Med. 2021年174卷11期1510-1518页
The safety and effectiveness of live virus vaccines, such as the varicella-zoster vaccine, are unknown in patients with inflammatory diseases receiving immunomodulatory therapy such as tumor necrosis factor inhibitors (TNFis).
112. Effect of the STAMP (Sharing and Talking About My Preferences) Intervention on Completing Multiple Advance Care Planning Activities in Ambulatory Care : A Cluster Randomized Controlled Trial.
作者: Terri R Fried.;Andrea L Paiva.;Colleen A Redding.;Lynne Iannone.;John R O'Leary.;Maria Zenoni.;Megan M Risi.;Slawomir Mejnartowicz.;Joseph S Rossi.
来源: Ann Intern Med. 2021年174卷11期1519-1527页
Interventions with the potential for broad reach in ambulatory settings are necessary to achieve a life course approach to advance care planning.
113. Annual Tuberculosis Preventive Therapy for Persons With HIV Infection : A Randomized Trial.
作者: Gavin Churchyard.;Vicky Cárdenas.;Violet Chihota.;Kathy Mngadi.;Modulakgotla Sebe.;William Brumskine.;Neil Martinson.;Getnet Yimer.;Shu-Hua Wang.;Alberto L Garcia-Basteiro.;Dinis Nguenha.;LeeAnne Masilela.;Zainab Waggie.;Susan van den Hof.;Salome Charalambous.;Frank Cobelens.;Richard E Chaisson.;Alison D Grant.;Katherine L Fielding.; .
来源: Ann Intern Med. 2021年174卷10期1367-1376页
Tuberculosis preventive therapy for persons with HIV infection is effective, but its durability is uncertain.
114. Efficacy of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome : A Randomized Trial.
作者: Yuanjie Sun.;Yan Liu.;Baoyan Liu.;Kehua Zhou.;Zenghui Yue.;Wei Zhang.;Wenbin Fu.;Jun Yang.;Ning Li.;Liyun He.;Zhiwei Zang.;Tongsheng Su.;Jianqiao Fang.;Yulong Ding.;Zongshi Qin.;Hujie Song.;Hui Hu.;Hong Zhao.;Qian Mo.;Jing Zhou.;Jiani Wu.;Xiaoxu Liu.;Weiming Wang.;Ran Pang.;Huan Chen.;Xinlu Wang.;Zhishun Liu.
来源: Ann Intern Med. 2021年174卷10期1357-1366页
Acupuncture has promising effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), but high-quality evidence is scarce.
115. Midodrine for the Prevention of Vasovagal Syncope : A Randomized Clinical Trial.
作者: Robert Sheldon.;Peter Faris.;Anthony Tang.;Felix Ayala-Paredes.;Juan Guzman.;Manlio Marquez.;Carlos A Morillo.;Andrew D Krahn.;Teresa Kus.;Debbie Ritchie.;Shahana Safdar.;Connor Maxey.;Satish R Raj.; .
来源: Ann Intern Med. 2021年174卷10期1349-1356页
Recurrent vasovagal syncope is common, responds poorly to treatment, and causes physical trauma and poor quality of life. Midodrine prevents hypotension and syncope during tilt tests in patients with vasovagal syncope.
116. Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial.
作者: Andreas Barratt-Due.;Inge Christoffer Olsen.;Katerina Nezvalova-Henriksen.;Trine Kåsine.;Fridtjof Lund-Johansen.;Hedda Hoel.;Aleksander Rygh Holten.;Anders Tveita.;Alexander Mathiessen.;Mette Haugli.;Ragnhild Eiken.;Anders Benjamin Kildal.;Åse Berg.;Asgeir Johannessen.;Lars Heggelund.;Tuva Børresdatter Dahl.;Karoline Hansen Skåra.;Pawel Mielnik.;Lan Ai Kieu Le.;Lars Thoresen.;Gernot Ernst.;Dag Arne Lihaug Hoff.;Hilde Skudal.;Bård Reiakvam Kittang.;Roy Bjørkholt Olsen.;Birgitte Tholin.;Carl Magnus Ystrøm.;Nina Vibeche Skei.;Trung Tran.;Susanne Dudman.;Jan Terje Andersen.;Raisa Hannula.;Olav Dalgard.;Ane-Kristine Finbråten.;Kristian Tonby.;Bjorn Blomberg.;Saad Aballi.;Cathrine Fladeby.;Anne Steffensen.;Fredrik Müller.;Anne Ma Dyrhol-Riise.;Marius Trøseid.;Pål Aukrust.; .
来源: Ann Intern Med. 2021年174卷9期1261-1269页
New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known.
117. Effect of Bedside Compared With Outside the Room Patient Case Presentation on Patients' Knowledge About Their Medical Care : A Randomized, Controlled, Multicenter Trial.
作者: Christoph Becker.;Martina Gamp.;Philipp Schuetz.;Katharina Beck.;Alessia Vincent.;Seraina Hochstrasser.;Kerstin Metzger.;Madlaina Widmer.;Emanuel Thommen.;Beat Mueller.;Christoph A Fux.;Jörg D Leuppi.;Rainer Schaefert.;Wolf Langewitz.;Marten Trendelenburg.;Tobias Breidthardt.;Jens Eckstein.;Michael Osthoff.;Stefano Bassetti.;Sabina Hunziker.; .
来源: Ann Intern Med. 2021年174卷9期1282-1292页
Although bedside case presentation contributes to patient-centered care through active patient participation in medical discussions, the complexity of medical information and jargon-induced confusion may cause misunderstandings and patient discomfort.
118. Effect of Sotagliflozin on Total Hospitalizations in Patients With Type 2 Diabetes and Worsening Heart Failure : A Randomized Trial.
作者: Michael Szarek.;Deepak L Bhatt.;Ph Gabriel Steg.;Christopher P Cannon.;Lawrence A Leiter.;Darren K McGuire.;Julia B Lewis.;Matthew C Riddle.;Adriaan A Voors.;Marco Metra.;Lars H Lund.;Michel Komajda.;Jeffrey M Testani.;Christopher S Wilcox.;Piotr Ponikowski.;Renato D Lopes.;Phillip Banks.;Eshetu Tesfaye.;Justin A Ezekowitz.;Subodh Verma.;Bertram Pitt.; .
来源: Ann Intern Med. 2021年174卷8期1065-1072页
In the SOLOIST-WHF (Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure) trial, sotagliflozin, a sodium-glucose cotransporter-1 and sodium-glucose cotransporter-2 inhibitor, reduced total occurrences of cardiovascular deaths, hospitalizations for heart failure, and urgent visits for heart failure relative to placebo by 33%.
119. Effects of Tai Chi or Conventional Exercise on Central Obesity in Middle-Aged and Older Adults : A Three-Group Randomized Controlled Trial.
作者: Parco M Siu.;Angus P Yu.;Edwin C Chin.;Doris S Yu.;Stanley S Hui.;Jean Woo.;Daniel Y Fong.;Gao X Wei.;Michael R Irwin.
来源: Ann Intern Med. 2021年174卷8期1050-1057页
Central obesity is a major manifestation of metabolic syndrome, which is a common health problem in middle-aged and older adults.
120. Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? : A Randomized Trial.
作者: Sasha Shepperd.;Chris Butler.;Andrea Cradduck-Bamford.;Graham Ellis.;Alastair Gray.;Anthony Hemsley.;Pradeep Khanna.;Peter Langhorne.;Sam Mort.;Scott Ramsay.;Rebekah Schiff.;David J Stott.;Angela Wilkinson.;Ly-Mee Yu.;John Young.
来源: Ann Intern Med. 2021年174卷7期889-898页
Delivering hospital-level care with comprehensive geriatric assessment (CGA) in the home is one approach to deal with the increased demand for bed-based hospital care, but clinical effectiveness is uncertain.
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