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101. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
作者: Thomas A Zelniker.;Stephen D Wiviott.;Itamar Raz.;Kyungah Im.;Erica L Goodrich.;Marc P Bonaca.;Ofri Mosenzon.;Eri T Kato.;Avivit Cahn.;Remo H M Furtado.;Deepak L Bhatt.;Lawrence A Leiter.;Darren K McGuire.;John P H Wilding.;Marc S Sabatine.
来源: Lancet. 2019年393卷10166期31-39页
The magnitude of effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on specific cardiovascular and renal outcomes and whether heterogeneity is based on key baseline characteristics remains undefined.
102. Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.
作者: Peter Willeit.;Paul M Ridker.;Paul J Nestel.;John Simes.;Andrew M Tonkin.;Terje R Pedersen.;Gregory G Schwartz.;Anders G Olsson.;Helen M Colhoun.;Florian Kronenberg.;Christiane Drechsler.;Christoph Wanner.;Samia Mora.;Anastasia Lesogor.;Sotirios Tsimikas.
来源: Lancet. 2018年392卷10155期1311-1320页
Elevated lipoprotein(a) is a genetic risk factor for cardiovascular disease in general population studies. However, its contribution to risk for cardiovascular events in patients with established cardiovascular disease or on statin therapy is uncertain.
103. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.
作者: .;Nafees Ahmad.;Shama D Ahuja.;Onno W Akkerman.;Jan-Willem C Alffenaar.;Laura F Anderson.;Parvaneh Baghaei.;Didi Bang.;Pennan M Barry.;Mayara L Bastos.;Digamber Behera.;Andrea Benedetti.;Gregory P Bisson.;Martin J Boeree.;Maryline Bonnet.;Sarah K Brode.;James C M Brust.;Ying Cai.;Eric Caumes.;J Peter Cegielski.;Rosella Centis.;Pei-Chun Chan.;Edward D Chan.;Kwok-Chiu Chang.;Macarthur Charles.;Andra Cirule.;Margareth Pretti Dalcolmo.;Lia D'Ambrosio.;Gerard de Vries.;Keertan Dheda.;Aliasgar Esmail.;Jennifer Flood.;Gregory J Fox.;Mathilde Fréchet-Jachym.;Geisa Fregona.;Regina Gayoso.;Medea Gegia.;Maria Tarcela Gler.;Sue Gu.;Lorenzo Guglielmetti.;Timothy H Holtz.;Jennifer Hughes.;Petros Isaakidis.;Leah Jarlsberg.;Russell R Kempker.;Salmaan Keshavjee.;Faiz Ahmad Khan.;Maia Kipiani.;Serena P Koenig.;Won-Jung Koh.;Afranio Kritski.;Liga Kuksa.;Charlotte L Kvasnovsky.;Nakwon Kwak.;Zhiyi Lan.;Christoph Lange.;Rafael Laniado-Laborín.;Myungsun Lee.;Vaira Leimane.;Chi-Chiu Leung.;Eric Chung-Ching Leung.;Pei Zhi Li.;Phil Lowenthal.;Ethel L Maciel.;Suzanne M Marks.;Sundari Mase.;Lawrence Mbuagbaw.;Giovanni B Migliori.;Vladimir Milanov.;Ann C Miller.;Carole D Mitnick.;Chawangwa Modongo.;Erika Mohr.;Ignacio Monedero.;Payam Nahid.;Norbert Ndjeka.;Max R O'Donnell.;Nesri Padayatchi.;Domingo Palmero.;Jean William Pape.;Laura J Podewils.;Ian Reynolds.;Vija Riekstina.;Jérôme Robert.;Maria Rodriguez.;Barbara Seaworth.;Kwonjune J Seung.;Kathryn Schnippel.;Tae Sun Shim.;Rupak Singla.;Sarah E Smith.;Giovanni Sotgiu.;Ganzaya Sukhbaatar.;Payam Tabarsi.;Simon Tiberi.;Anete Trajman.;Lisa Trieu.;Zarir F Udwadia.;Tjip S van der Werf.;Nicolas Veziris.;Piret Viiklepp.;Stalz Charles Vilbrun.;Kathleen Walsh.;Janice Westenhouse.;Wing-Wai Yew.;Jae-Joon Yim.;Nicola M Zetola.;Matteo Zignol.;Dick Menzies.
来源: Lancet. 2018年392卷10150期821-834页
Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed to estimate the association of treatment success and death with the use of individual drugs, and the optimal number and duration of treatment with those drugs in patients with multidrug-resistant tuberculosis.
104. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older.
105. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis.
作者: Derek K Chu.;Lisa H-Y Kim.;Paul J Young.;Nima Zamiri.;Saleh A Almenawer.;Roman Jaeschke.;Wojciech Szczeklik.;Holger J Schünemann.;John D Neary.;Waleed Alhazzani.
来源: Lancet. 2018年391卷10131期1693-1705页
Supplemental oxygen is often administered liberally to acutely ill adults, but the credibility of the evidence for this practice is unclear. We systematically reviewed the efficacy and safety of liberal versus conservative oxygen therapy in acutely ill adults.
106. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.
作者: Andrea Cipriani.;Toshi A Furukawa.;Georgia Salanti.;Anna Chaimani.;Lauren Z Atkinson.;Yusuke Ogawa.;Stefan Leucht.;Henricus G Ruhe.;Erick H Turner.;Julian P T Higgins.;Matthias Egger.;Nozomi Takeshima.;Yu Hayasaka.;Hissei Imai.;Kiyomi Shinohara.;Aran Tajika.;John P A Ioannidis.;John R Geddes.
来源: Lancet. 2018年391卷10128期1357-1366页
Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder.
107. Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis.
作者: Siddharth Nath.;Alex Koziarz.;Jetan H Badhiwala.;Waleed Alhazzani.;Roman Jaeschke.;Sunjay Sharma.;Laura Banfield.;Ashkan Shoamanesh.;Sheila Singh.;Farshad Nassiri.;Wieslaw Oczkowski.;Emilie Belley-Côté.;Ray Truant.;Kesava Reddy.;Maureen O Meade.;Forough Farrokhyar.;Malgorzata M Bala.;Fayez Alshamsi.;Mette Krag.;Itziar Etxeandia-Ikobaltzeta.;Regina Kunz.;Osamu Nishida.;Charles Matouk.;Magdy Selim.;Andrew Rhodes.;Gregory Hawryluk.;Saleh A Almenawer.
来源: Lancet. 2018年391卷10126期1197-1204页
Atraumatic needles have been proposed to lower complication rates after lumbar puncture. However, several surveys indicate that clinical adoption of these needles remains poor. We did a systematic review and meta-analysis to compare patient outcomes after lumbar puncture with atraumatic needles and conventional needles.
108. Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis.
作者: Robert W Aldridge.;Alistair Story.;Stephen W Hwang.;Merete Nordentoft.;Serena A Luchenski.;Greg Hartwell.;Emily J Tweed.;Dan Lewer.;Srinivasa Vittal Katikireddi.;Andrew C Hayward.
来源: Lancet. 2018年391卷10117期241-250页
Inclusion health focuses on people in extremely poor health due to poverty, marginalisation, and multimorbidity. We aimed to review morbidity and mortality data on four overlapping populations who experience considerable social exclusion: homeless populations, individuals with substance use disorders, sex workers, and imprisoned individuals.
109. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.
作者: Angèle Gayet-Ageron.;David Prieto-Merino.;Katharine Ker.;Haleema Shakur.;François-Xavier Ageron.;Ian Roberts.; .
来源: Lancet. 2018年391卷10116期125-132页
Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of treatment delay on the effectiveness of antifibrinolytics.
110. Comparative efficacy and safety of reperfusion therapy with fibrinolytic agents in patients with ST-segment elevation myocardial infarction: a systematic review and network meta-analysis.
作者: Peerawat Jinatongthai.;Junporn Kongwatcharapong.;Chee Yoong Foo.;Arintaya Phrommintikul.;Surakit Nathisuwan.;Ammarin Thakkinstian.;Christopher M Reid.;Nathorn Chaiyakunapruk.
来源: Lancet. 2017年390卷10096期747-759页
Fibrinolytic therapy offers an alternative to mechanical reperfusion for ST-segment elevation myocardial infarction (STEMI) in settings where health-care resources are scarce. Comprehensive evidence comparing different agents is still unavailable. In this study, we examined the effects of various fibrinolytic drugs on clinical outcomes.
111. Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials.
作者: Alexander Jobs.;Shamir R Mehta.;Gilles Montalescot.;Eric Vicaut.;Arnoud W J Van't Hof.;Erik A Badings.;Franz-Josef Neumann.;Adnan Kastrati.;Alessandro Sciahbasi.;Paul-Georges Reuter.;Frédéric Lapostolle.;Aleksandra Milosevic.;Goran Stankovic.;Dejan Milasinovic.;Reinhard Vonthein.;Steffen Desch.;Holger Thiele.
来源: Lancet. 2017年390卷10096期737-746页
A routine invasive strategy is recommended for patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). However, optimal timing of invasive strategy is less clearly defined. Individual clinical trials were underpowered to detect a mortality benefit; we therefore did a meta-analysis to assess the effect of timing on mortality.
112. 2-year outcomes with the Absorb bioresorbable scaffold for treatment of coronary artery disease: a systematic review and meta-analysis of seven randomised trials with an individual patient data substudy.
作者: Ziad A Ali.;Patrick W Serruys.;Takeshi Kimura.;Runlin Gao.;Stephen G Ellis.;Dean J Kereiakes.;Yoshinobu Onuma.;Charles Simonton.;Zhen Zhang.;Gregg W Stone.
来源: Lancet. 2017年390卷10096期760-772页
Bioresorbable vascular scaffolds (BVS) offer the potential to improve long-term outcomes of percutaneous coronary intervention after their complete bioresorption. Randomised trials have shown non-inferiority between BVS and metallic drug-eluting stents at 1 year in composite safety and effectiveness outcomes, although some increases in rates of target vessel-related myocardial infarction and device thrombosis were identified. Outcomes of BVS following the first year after implantation are unknown. We sought to ascertain whether BVS are as safe and effective as drug-eluting stents within 2 years after implantation and between 1 and 2 years.
113. Morphological suitability for endovascular repair, non-intervention rates, and operative mortality in women and men assessed for intact abdominal aortic aneurysm repair: systematic reviews with meta-analysis.
作者: Pinar Ulug.;Michael J Sweeting.;Regula S von Allmen.;Simon G Thompson.;Janet T Powell.; .
来源: Lancet. 2017年389卷10088期2482-2491页
Prognosis for women with abdominal aortic aneurysm might be worse than the prognosis for men. We aimed to systematically quantify the differences in outcomes between men and women being assessed for repair of intact abdominal aortic aneurysm using data from study periods after the year 2000.
114. Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.
作者: Michael Böhm.;Helmut Schumacher.;Koon K Teo.;Eva M Lonn.;Felix Mahfoud.;Johannes F E Mann.;Giuseppe Mancia.;Josep Redon.;Roland E Schmieder.;Karen Sliwa.;Michael A Weber.;Bryan Williams.;Salim Yusuf.
来源: Lancet. 2017年389卷10085期2226-2237页
Studies have challenged the appropriateness of accepted blood pressure targets. We hypothesised that different levels of low blood pressure are associated with benefit for some, but harm for other outcomes.
115. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women.
作者: Silvia Stringhini.;Cristian Carmeli.;Markus Jokela.;Mauricio Avendaño.;Peter Muennig.;Florence Guida.;Fulvio Ricceri.;Angelo d'Errico.;Henrique Barros.;Murielle Bochud.;Marc Chadeau-Hyam.;Françoise Clavel-Chapelon.;Giuseppe Costa.;Cyrille Delpierre.;Silvia Fraga.;Marcel Goldberg.;Graham G Giles.;Vittorio Krogh.;Michelle Kelly-Irving.;Richard Layte.;Aurélie M Lasserre.;Michael G Marmot.;Martin Preisig.;Martin J Shipley.;Peter Vollenweider.;Marie Zins.;Ichiro Kawachi.;Andrew Steptoe.;Johan P Mackenbach.;Paolo Vineis.;Mika Kivimäki.; .
来源: Lancet. 2017年389卷10075期1229-1237页
In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk factors.
116. Differential effect of mass deworming and targeted deworming for soil-transmitted helminth control in children: a systematic review and meta-analysis.
作者: Naomi E Clarke.;Archie C A Clements.;Suhail A Doi.;Dongxu Wang.;Suzy J Campbell.;Darren Gray.;Susana V Nery.
来源: Lancet. 2017年389卷10066期287-297页
Soil-transmitted helminth infections are a major global health issue, causing substantial morbidity in the world's poorest populations. Regular delivery of anthelmintic drugs is the mainstay for global soil-transmitted helminth control. Deworming campaigns are often targeted to school-aged children, who are at high risk of soil-transmitted-helminth-associated morbidity. However, findings from modelling studies suggest that deworming campaigns should be expanded community-wide for effective control of soil-transmitted helminth transmission. We aimed to do a systematic review and meta-analysis to compare the effect of mass (community-wide) and targeted (children only) anthelmintic delivery strategies on soil-transmitted helminth prevalence in school-aged children.
117. Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials.
作者: Marc A Rodger.;Jean-Christophe Gris.;Johanna I P de Vries.;Ida Martinelli.;Évelyne Rey.;Ekkehard Schleussner.;Saskia Middeldorp.;Risto Kaaja.;Nicole J Langlois.;Timothy Ramsay.;Ranjeeta Mallick.;Shannon M Bates.;Carolien N H Abheiden.;Annalisa Perna.;David Petroff.;Paulien de Jong.;Marion E van Hoorn.;P Dick Bezemer.;Alain D Mayhew.; .
来源: Lancet. 2016年388卷10060期2629-2641页
Placenta-mediated pregnancy complications include pre-eclampsia, late pregnancy loss, placental abruption, and birth of a small-for-gestational-age (SGA) neonate. These complications are leading causes of maternal, fetal, and neonatal morbidity and mortality in high-income countries. Affected women are at high risk of recurrence in subsequent pregnancies; however, effective strategies to prevent recurrence are absent. Findings from our previous study-level meta-analysis suggested that low-molecular-weight heparin reduced the risk of recurrent placenta-mediated pregnancy complications. However, we identified significant heterogeneity in the results, possibly due to trial design or inclusion criteria. To identify which patients benefit from, and which outcomes are prevented by, low-molecular-weight heparin, we did an individual patient data meta-analysis.
118. Interventions to prevent and reduce physician burnout: a systematic review and meta-analysis.
作者: Colin P West.;Liselotte N Dyrbye.;Patricia J Erwin.;Tait D Shanafelt.
来源: Lancet. 2016年388卷10057期2272-2281页
Physician burnout has reached epidemic levels, as documented in national studies of both physicians in training and practising physicians. The consequences are negative effects on patient care, professionalism, physicians' own care and safety, and the viability of health-care systems. A more complete understanding than at present of the quality and outcomes of the literature on approaches to prevent and reduce burnout is necessary.
119. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.
作者: Global BMI Mortality Collaboration.;Emanuele Di Angelantonio.;Shilpa Bhupathiraju.;David Wormser.;Pei Gao.;Stephen Kaptoge.;Amy Berrington de Gonzalez.;Benjamin Cairns.;Rachel Huxley.;Chandra Jackson.;Grace Joshy.;Sarah Lewington.;JoAnn Manson.;Neil Murphy.;Alpa Patel.;Jonathan Samet.;Mark Woodward.;Wei Zheng.;Maigen Zhou.;Narinder Bansal.;Aurelio Barricarte.;Brian Carter.;James Cerhan.;George Smith.;Xianghua Fang.;Oscar Franco.;Jane Green.;Jim Halsey.;Janet Hildebrand.;Keum Jung.;Rosemary Korda.;Dale McLerran.;Steven Moore.;Linda O'Keeffe.;Ellie Paige.;Anna Ramond.;Gillian Reeves.;Betsy Rolland.;Carlotta Sacerdote.;Naveed Sattar.;Eleni Sofianopoulou.;June Stevens.;Michael Thun.;Hirotsugu Ueshima.;Ling Yang.;Young Yun.;Peter Willeit.;Emily Banks.;Valerie Beral.;Zhengming Chen.;Susan Gapstur.;Marc Gunter.;Patricia Hartge.;Sun Jee.;Tai-Hing Lam.;Richard Peto.;John Potter.;Walter Willett.;Simon Thompson.;John Danesh.;Frank Hu.
来源: Lancet. 2016年388卷10046期776-86页
Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant data meta-analyses of prospective studies of body-mass index (BMI), limiting confounding and reverse causality by restricting analyses to never-smokers and excluding pre-existing disease and the first 5 years of follow-up.
120. Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
作者: Andrea Cipriani.;Xinyu Zhou.;Cinzia Del Giovane.;Sarah E Hetrick.;Bin Qin.;Craig Whittington.;David Coghill.;Yuqing Zhang.;Philip Hazell.;Stefan Leucht.;Pim Cuijpers.;Juncai Pu.;David Cohen.;Arun V Ravindran.;Yiyun Liu.;Kurt D Michael.;Lining Yang.;Lanxiang Liu.;Peng Xie.
来源: Lancet. 2016年388卷10047期881-90页
Major depressive disorder is one of the most common mental disorders in children and adolescents. However, whether to use pharmacological interventions in this population and which drug should be preferred are still matters of controversy. Consequently, we aimed to compare and rank antidepressants and placebo for major depressive disorder in young people.
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