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1021. Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Italian Cooperative Study Group.
作者: C Brignola.;M Cottone.;A Pera.;S Ardizzone.;M L Scribano.;R De Franchis.;A D'Arienzo.;G D'Albasio.;D Pennestri.
来源: Gastroenterology. 1995年108卷2期345-9页
Recurrence of lesions of Crohn's disease of the ileum within 1 year after so-called curative resection was well documented by endoscopy in 73%-93% of cases. This study investigated the efficacy of mesalamine in reduction of endoscopic recurrence after surgery.
1022. Sensitization to painful distention and abnormal sensory perception in the esophagus.
The mechanism of abnormal esophageal sensory perception in patients with unexplained chest pain is unknown. The aim of this study was to test the following two hypotheses: (1) similar to cutaneous nociceptors, esophageal stretch receptors can be sensitized by a noxious chemical stimulus, and (2) patients with esophageal chest pain have sensitized receptors.
1023. Interferon alfa treatment of chronic hepatitis B: randomized trial in a predominantly homosexual male population.
作者: D K Wong.;C Yim.;C D Naylor.;E Chen.;M Sherman.;S Vas.;I R Wanless.;S Read.;H Li.;E J Heathcote.
来源: Gastroenterology. 1995年108卷1期165-71页
It has been suggested that human immunodeficiency virus (HIV) coinfection and male homosexuality predict poor response to interferon alfa therapy of chronic hepatitis B. The aim of this study was to examine the effect of HIV coinfection on the response of chronic hepatitis B virus (HBV) infection to interferon alfa therapy in a predominantly homosexual male population.
1024. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas.
作者: M Anti.;F Armelao.;G Marra.;A Percesepe.;G M Bartoli.;P Palozza.;P Parrella.;C Canetta.;N Gentiloni.;I De Vitis.
来源: Gastroenterology. 1994年107卷6期1709-18页
Fish oil supplementation can reduce cytokinetic anomalies in the flat rectal mucosa of patients with sporadic colorectal adenoma. This study attempted to identify an optimum dose for fish oil supplementation and evaluate the persistence of its effects during long-term administration.
1025. Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically ill.
作者: H Tremel.;B Kienle.;L S Weilemann.;P Stehle.;P Fürst.
来源: Gastroenterology. 1994年107卷6期1595-601页
Long-term total parenteral nutrition is accompanied with mucosal atrophy and subsequent malabsorption syndrome. Current information attests the important role of glutamine in maintaining intestinal structure and function. The aim of this study was to investigate the effect of glutamine dipeptide supplementation on small intestinal absorption capacity during critical illness.
1026. A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture. Restore Investigator Group.
作者: P M Smith.;G D Kerr.;R Cockel.;B A Ross.;C M Bate.;P Brown.;M W Dronfield.;J R Green.;W S Hislop.;A Theodossi.
来源: Gastroenterology. 1994年107卷5期1312-8页
Dilatation combined with subsequent pharmacological control of gastroesophageal reflux represents a logical but poorly documented approach to the management of benign esophageal stricture. This large trial (366 patients) aimed to assess whether omeprazole as the most effective available medication for gastroesophageal reflux disease prevents recurrent stricture formation.
1027. Omeprazole or ranitidine in long-term treatment of reflux esophagitis. The Scandinavian Clinics for United Research Group.
作者: B Hallerbäck.;P Unge.;L Carling.;B Edwin.;H Glise.;N Havu.;E Lyrenäs.;K Lundberg.
来源: Gastroenterology. 1994年107卷5期1305-11页
Patients with reflux esophagitis have rapid relapses after treatment withdrawal. This study was designed to investigate the relapse rate of symptomatic esophagitis during maintenance treatment with omeprazole or ranitidine.
1028. Effects of interferon beta on non-A, non-B acute hepatitis: a prospective, randomized, controlled-dose study. Japan Acute Hepatitis Cooperative Study Group.
Non-A, non-B acute hepatitis progresses to a higher incidence of chronicity and hepatocellular carcinoma. To avoid the development of chronic liver disease, resolution of acute hepatitis C might be most effective. The aim was to establish the effect of interferon in disturbing progression to chronicity and to determine the most appropriate treatment protocol.
1029. A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C.
作者: S Brillanti.;J Garson.;M Foli.;K Whitby.;R Deaville.;C Masci.;M Miglioli.;L Barbara.
来源: Gastroenterology. 1994年107卷3期812-7页
In chronic hepatitis C, interferon alfa (IFN-alpha) therapy fails to achieve a sustained response in approximately 75% of patients. Similarly, ribavirin induces only a transient response. The aim of this study was to evaluate whether ribavirin and IFN-alpha in combination could be effective in IFN-alpha-resistant chronic hepatitis C.
1030. Treatment of Crohn's disease by lymphocyte apheresis: a randomized controlled trial. Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives.
作者: E Lerebours.;A Bussel.;R Modigliani.;D Bastit.;C Florent.;C Rabian.;E René.;J C Soulé.
来源: Gastroenterology. 1994年107卷2期357-61页
Several uncontrolled trials suggest that lymphapheresis improves the clinical course of patients with Crohn's disease; this study was designed to assess the efficacy of lymphapheresis in preventing early relapses of Crohn's disease in patients in clinical remission after steroid treatment for an acute attack.
1031. Relaxation training reduces symptom reports and acid exposure in patients with gastroesophageal reflux disease.
作者: J McDonald-Haile.;L A Bradley.;M A Bailey.;C A Schan.;J E Richter.
来源: Gastroenterology. 1994年107卷1期61-9页
Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflux disease.
1032. A placebo-controlled trial of cyclosporine enemas for mildly to moderately active left-sided ulcerative colitis.
作者: W J Sandborn.;W J Tremaine.;K W Schroeder.;K P Batts.;G M Lawson.;B L Steiner.;J M Harrison.;A R Zinsmeister.
来源: Gastroenterology. 1994年106卷6期1429-35页
Uncontrolled studies suggest that cyclosporine administered as an enema may be of benefit for left-sided ulcerative colitis and safer than intravenous or oral administration. The efficacy and safety of cyclosporine enemas for left-sided ulcerative colitis in a placebo-controlled trial was assessed.
1033. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis.
作者: K D Lindor.;E R Dickson.;W P Baldus.;R A Jorgensen.;J Ludwig.;P A Murtaugh.;J M Harrison.;R H Wiesner.;M L Anderson.;S M Lange.
来源: Gastroenterology. 1994年106卷5期1284-90页
A double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) was conducted in 180 patients with primary biliary cirrhosis (PBC) to define the efficacy and safety of UDCA. Efficacy was assessed by time to treatment failure defined as death; liver transplantation; histological progression; development of varices, ascites, or encephalopathy; doubling of total serum bilirubin levels; progression of fatigue or pruritus; drug toxicity; or voluntary withdrawal.
1034. A 5HT3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea.
Carcinoid patients show a hypertonic colonic motor response postprandially. Ondansetron reduces postprandial colonic tone in health. It was hypothesized that ondansetron, a selective 5HT3 antagonist, corrects the colonic motor response to eating in carcinoid diarrhea.
1035. Effect of intravenous human gastrin-releasing peptide on food intake in humans.
作者: J P Gutzwiller.;J Drewe.;P Hildebrand.;L Rossi.;J Z Lauper.;C Beglinger.
来源: Gastroenterology. 1994年106卷5期1168-73页
Bombesin and gastrin-releasing peptide (GRP) are closely related peptides. Both have been proposed to serve as a satiety signal in animals.
1036. Small bowel motility following major intra-abdominal surgery: the effects of opiates and rectal cisapride.
作者: M J Benson.;J P Roberts.;D L Wingate.;J Rogers.;J J Deeks.;F D Castillo.;N S Williams.
来源: Gastroenterology. 1994年106卷4期924-36页
Human small bowel motility is altered after laparotomy. Opiate analgesia is a possible cause of these alterations, and cisapride is a potential therapy.
1037. Determinants of response to a prokinetic agent in neuropathic chronic intestinal motility disorder.
Reasons for the variable efficacy of prokinetic agents in the treatment of chronic intestinal motility disorders are unclear. The aim of this study was to assess the influence of extrinsic autonomic neuropathy and motility patterns on the symptom response to cisapride in 42 such patients.
1038. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer.
作者: G Francini.;R Petrioli.;L Lorenzini.;S Mancini.;S Armenio.;G Tanzini.;S Marsili.;A Aquino.;G Marzocca.;S Civitelli.
来源: Gastroenterology. 1994年106卷4期899-906页
Colon cancer is one of the major health problems in industrialized countries, and its incidence appears to be increasing. Surgical resectability is the most important prognostic determinant, although despite apparently curative surgery, recurrent tumors are common. Metastatic disease cannot be cured, and thus, there is a need for better adjuvant therapies.
1039. Biochemical epidemiology of colon cancer: effect of types of dietary fiber on colonic diacylglycerols in women.
In view of the potential significance of dietary fat and fiber in colon cancer and the possible indirect involvement of diacylglycerols (DAGs) in the pathogenesis of colon cancer, the effect of types of dietary fiber on fecal DAG in premenopausal women was investigated.
1040. Omeprazole versus H2-receptor antagonists in treating patients with peptic stricture and esophagitis.
作者: R D Marks.;J E Richter.;J Rizzo.;R E Koehler.;J G Spenney.;T P Mills.;G Champion.
来源: Gastroenterology. 1994年106卷4期907-15页
Although dysphagia in patients with peptic stricture is attributed to a decreased luminal diameter, coexistent esophagitis may be an equally important cause. The goals of this study were to determine whether medical healing of esophagitis in patients with stricture improves dysphagia and decreases dilatation need and to compare the efficacy and cost-effectiveness of omeprazole versus H2-receptor antagonists (H2RA).
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