当前位置: 首页 >> 检索结果
1001. Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease : A Post Hoc Analysis of DAPA-CKD.
作者: Meir Schechter.;Niels Jongs.;Glenn M Chertow.;Ofri Mosenzon.;John J V McMurray.;Ricardo Correa-Rotter.;Peter Rossing.;Anna Maria Langkilde.;C David Sjöström.;Robert D Toto.;David C Wheeler.;Hiddo J L Heerspink.
来源: Ann Intern Med. 2023年176卷1期59-66页
Acute hospitalizations are common in patients with chronic kidney disease (CKD) and often lead to decreases in health-related quality of life and increased care costs.
1002. In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality.
Tasoudis PT, Kyriakoulis IG, Sagris D, et al. Clopidogrel monotherapy versus aspirin monotherapy in patients with established cardiovascular disease: systematic review and meta-analysis. Thromb Haemost. 2022;122:1879-87. 35577054.
1003. Living, Rapid Reviews in a Rapidly Evolving World.
In their article, Holmer and colleagues reported the final update of a living review that examined the duration of IgG antibody response, the role of previous SARS-CoV-2 infection to prevent reinfection, and the role of antibodies in protection from reinfection. The editorialist discusses the challenge of living reviews as new evidence emerges and the relevant clinical questions evolve.
1004. Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers : A Randomized Trial.
作者: Mark Loeb.;Amy Bartholomew.;Madiha Hashmi.;Wadea Tarhuni.;Mohamed Hassany.;Ilan Youngster.;Ranjani Somayaji.;Oscar Larios.;Joseph Kim.;Bayan Missaghi.;Joseph V Vayalumkal.;Dominik Mertz.;Zain Chagla.;Maureen Cividino.;Karim Ali.;Sarah Mansour.;Lana A Castellucci.;Charles Frenette.;Leighanne Parkes.;Mark Downing.;Matthew Muller.;Verne Glavin.;Jennifer Newton.;Ravi Hookoom.;Jerome A Leis.;James Kinross.;Stephanie Smith.;Sayem Borhan.;Pardeep Singh.;Eleanor Pullenayegum.;John Conly.
来源: Ann Intern Med. 2022年175卷12期1629-1638页
It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators.
1005. Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial.
作者: Gail E Potter.;Tyler Bonnett.;Kevin Rubenstein.;David A Lindholm.;Rekha R Rapaka.;Sarah B Doernberg.;David C Lye.;Richard A Mularski.;Noreen A Hynes.;Susan Kline.;Catharine I Paules.;Cameron R Wolfe.;Maria G Frank.;Nadine G Rouphael.;Gregory A Deye.;Daniel A Sweeney.;Rhonda E Colombo.;Richard T Davey.;Aneesh K Mehta.;Jennifer A Whitaker.;Jose G Castro.;Alpesh N Amin.;Christopher J Colombo.;Corri B Levine.;Mamta K Jain.;Ryan C Maves.;Vincent C Marconi.;Robert Grossberg.;Sameh Hozayen.;Timothy H Burgess.;Robert L Atmar.;Anuradha Ganesan.;Carlos A Gomez.;Constance A Benson.;Diego Lopez de Castilla.;Neera Ahuja.;Sarah L George.;Seema U Nayak.;Stuart H Cohen.;Tahaniyat Lalani.;William R Short.;Nathaniel Erdmann.;Kay M Tomashek.;Pablo Tebas.
来源: Ann Intern Med. 2022年175卷12期1716-1727页
The COVID-19 standard of care (SOC) evolved rapidly during 2020 and 2021, but its cumulative effect over time is unclear.
1006. Outpatient Treatment of Confirmed COVID-19: Living, Rapid Practice Points From the American College of Physicians (Version 1).
作者: Amir Qaseem.;Jennifer Yost.;Matthew C Miller.;Rebecca Andrews.;Janet A Jokela.;Mary Ann Forciea.;George M Abraham.;Linda L Humphrey.; .;Rachael A Lee.;Mark P Tschanz.;Itziar Etxeandia-Ikobaltzeta.;Curtis Harrod.;Tatyana Shamliyan.;Karla Umana.
来源: Ann Intern Med. 2023年176卷1期115-124页
Strategies to manage COVID-19 in the outpatient setting continue to evolve as new data emerge on SARS-CoV-2 variants and the availability of newer treatments. The Scientific Medical Policy Committee (SMPC) of the American College of Physicians (ACP) developed these living, rapid practice points to summarize the best available evidence on the treatment of adults with confirmed COVID-19 in an outpatient setting. These practice points do not evaluate COVID-19 treatments in the inpatient setting or adjunctive COVID-19 treatments in the outpatient setting.
1007. Major Update 2: Antibody Response and Risk for Reinfection After SARS-CoV-2 Infection-Final Update of a Living, Rapid Review.
作者: Haley K Holmer.;Katherine Mackey.;Celia V Fiordalisi.;Mark Helfand.
来源: Ann Intern Med. 2023年176卷1期85-91页
The durability of the antibody response after SARS-CoV-2 infection and the role of antibodies in protection against reinfection are unclear.
1008. Ongoing Need for Clinical Trials and Contemporary End Points for Outpatient COVID-19.
The American College of Physicians presents recommendations for the outpatient treatment of COVID-19 based on Sommer and colleagues' systematic review. The editorialists commend the authors of the recommendations and review for trying to summarize the rapidly evolving literature into clear practice points and discuss the challenges of continually updating reviews and associated recommendations as new evidence emerges and relevant outcomes evolve.
1009. Comparative Effectiveness of Mask Type in Preventing SARS-CoV-2 in Health Care Workers: Uncertainty Persists.
Two and a half years after the emergence of the COVID-19 pandemic, Loeb and colleagues reported the first randomized trial of N95 respirators versus medical masks in health care workers. The editorialist discusses the findings and highlights remaining areas of uncertainty about optimal mask type.
1010. Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Review for the American College of Physicians.
作者: Isolde Sommer.;Andreea Dobrescu.;Dominic Ledinger.;Isabel Moser.;Kylie Thaler.;Emma Persad.;Martin Fangmeyer.;Robert Emprechtinger.;Irma Klerings.;Gerald Gartlehner.
来源: Ann Intern Med. 2023年176卷1期92-104页
Clinicians and patients want to know the benefits and harms of outpatient treatment options for SARS-CoV-2 infection.
1011. Participant Recruitment From Low- and Middle-Income Countries for Pivotal Trials of Drugs Approved by the U.S. Food and Drug Administration : A Cross-Sectional Analysis.
作者: Fareed A Awan.;Andrew B Becker.;Yuetong Wang.;Jonathan Kimmelman.
来源: Ann Intern Med. 2022年175卷12期1675-1684页
Many participants in clinical trials supporting U.S. Food and Drug Administration (FDA) drug approvals are recruited from outside the United States, including from low- and middle-income countries (LMICs). Where participants are recruited for pivotal trials has implications for ethical research conduct and generalizability.
1012. Health Care During Incarceration: A Policy Position Paper From the American College of Physicians.
作者: Newton E Kendig.;Renee Butkus.;Suja Mathew.;David Hilden.; .
来源: Ann Intern Med. 2022年175卷12期1742-1745页
The American College of Physicians (ACP) has a long-standing commitment to improving the health of all Americans and opposes any form of discrimination in the delivery of health care services. ACP is committed to working toward fully understanding and supporting the unique needs of the incarcerated population and eliminating health disparities for these persons. In this position paper, ACP offers recommendations to policymakers and administrators to improve the health and well-being of persons incarcerated in adult correctional facilities.
1013. Monoclonal Antibodies for Treatment of SARS-CoV-2 Infection During Pregnancy : A Cohort Study.
作者: Erin K McCreary.;Lara Lemon.;Christina Megli.;Amber Oakes.;Christopher W Seymour.; .
来源: Ann Intern Med. 2022年175卷12期1707-1715页
Monoclonal antibody (mAb) treatment decreases hospitalization and death in high-risk outpatients with mild to moderate COVID-19. However, no studies have evaluated adverse events and effectiveness of mAbs in pregnant persons compared with no mAb treatment.
1014. Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis: A Randomized Controlled Trial.
作者: Andrew J Goldberg.;Kashfia Chowdhury.;Ekaterina Bordea.;Iva Hauptmannova.;James Blackstone.;Deirdre Brooking.;Elizabeth L Deane.;Stephen Bendall.;Andrew Bing.;Chris Blundell.;Sunil Dhar.;Andrew Molloy.;Steve Milner.;Mike Karski.;Steve Hepple.;Malik Siddique.;David T Loveday.;Viren Mishra.;Paul Cooke.;Paul Halliwell.;David Townshend.;Simon S Skene.;Caroline J Doré.; .;Rick Brown.;Michael Butler.;Carolyn Chadwick.;Tim Clough.;Nick Cullen.;Mark Davies.;Howard Davies.;Bill Harries.;Michael Khoo.;Nilesh Makwana.;An Murty.;Ali Najefi.;Paul O'Donnell.;Martin Raglan.;Rhys Thomas.;Paulo Torres.;Matthew Welck.;Ian Winson.;Razi Zaidi.
来源: Ann Intern Med. 2022年175卷12期1648-1657页
End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF).
1015. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial.
作者: Michael Camilleri.;Thyagarajan Subramanian.;Fernando Pagan.;Stuart Isaacson.;Ramon Gil.;Robert A Hauser.;Mary Feldman.;Mark Goldstein.;Rajeev Kumar.;Daniel Truong.;Nisha Chhabria.;Benjamin L Walter.;Jonathan Eskenazi.;Robert Riesenberg.;Daniel Burdick.;Winona Tse.;Eric Molho.;Bradley Robottom.;Perminder Bhatia.;Srinath Kadimi.;Kevin Klos.;David Shprecher.;Otto Marquez-Mendoza.;Gonzalo Hidalgo.;Stephen Grill.;George Li.;Howard Mandell.;Mary Hughes.;Sharisse Stephenson.;Joel Vandersluis.;Michael Pfeffer.;Andrew Duker.;Vikram Shivkumar.;William Kinney.;James MacDougall.;Michael Zasloff.;Denise Barbut.
来源: Ann Intern Med. 2022年175卷12期1666-1674页
Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with PD.
1016. Contact Tracing and Exposure Investigation in Response to the First Case of Monkeypox Virus Infection in the United States During the 2022 Global Monkeypox Outbreak.
作者: Erica S Shenoy.;Sharon B Wright.;Deborah N Barbeau.;Lisa A Foster.;Aleah D King.;Patrick S Gordon.;Preeti Mehrotra.;Dana E Pepe.;Daniel A Caroff.;Lindsey R Kim.;Shannon E McGrath.;Amy Courtney.;Meredith Fahy.;David C Hooper.;Kaitlin Macdonald.;Eileen F Searle.;Jennifer A Shearer.;Kimon C Zachary.;Lindsay Bouton.;Melissa Cumming.;Brandi Hopkins.;Juliana Jacoboski.;Erin Mann.;Matthew Osborne.;Carley Perez.;Jordan Schultz.;Sarah Scotland.;Elizabeth Traphagen.;Lawrence C Madoff.;Catherine M Brown.
来源: Ann Intern Med. 2022年175卷12期1639-1647页
In May 2022, the first case of monkeypox virus (MPXV) infection in the United States in the current global outbreak was identified. As part of the public health and health care facility response, a contact tracing and exposure investigation was done.
1017. Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations : A Randomized, Multicenter Trial.
作者: Jeff S Healey.;Andrew D Krahn.;Jamil Bashir.;Guy Amit.;François Philippon.;William F McIntyre.;Bernice Tsang.;Jacqueline Joza.;Derek V Exner.;David H Birnie.;Mouhannad Sadek.;Darryl P Leong.;Markus Sikkel.;Victoria Korley.;John L Sapp.;Jean-Francois Roux.;Shun Fu Lee.;Gloria Wong.;Angie Djuric.;Danna Spears.;Sandra Carroll.;Eugene Crystal.;Tom Hruczkowski.;Stuart J Connolly.;Blandine Mondesert.; .
来源: Ann Intern Med. 2022年175卷12期1658-1665页
Implantable cardioverter defibrillators (ICDs) improve survival in patients at risk for cardiac arrest, but are associated with intravascular lead-related complications. The subcutaneous ICD (S-ICD), with no intravascular components, was developed to minimize lead-related complications.
1018. Preoperative Evaluation for Noncardiac Surgery.
The previous In the Clinic that addressed preoperative evaluation for noncardiac surgery was published in December 2016. This update reaffirms much of the information in the previous version and provides new information that has accumulated since then. The goal of preoperative assessment is to identify the risk for postoperative complications so health care teams can more fully understand how to implement strategies to mitigate risks before and after the operation.
1019. Characteristics of High-Need, High-Cost Patients : A "Best-Fit" Framework Synthesis.
作者: Nancy D Berkman.;Eva Chang.;Julie Seibert.;Rania Ali.
来源: Ann Intern Med. 2022年175卷12期1728-1741页
Accurately identifying high-need, high-cost (HNHC) patients to reduce their preventable or modifiable health care use for their chronic conditions is a priority and a challenge for U.S. policymakers, health care delivery systems, and payers.
1020. Recommendations for pharmacologic management of IBS with constipation.
Chang L, Sultan S, Lembo A, et al. AGA clinical practice guideline on the pharmacological management of irritable bowel syndrome with constipation. Gastroenterology. 2022;163:118-36. 35738724.
|