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1001. Oral budesonide as maintenance treatment for Crohn's disease: a placebo-controlled, dose-ranging study. Canadian Inflammatory Bowel Disease Study Group.
作者: G R Greenberg.;B G Feagan.;F Martin.;L R Sutherland.;A B Thomson.;C N Williams.;L G Nilsson.;T Persson.
来源: Gastroenterology. 1996年110卷1期45-51页
Budesonide is a corticosteroid with high topical anti-inflammatory activity and low systemic activity due to rapid hepatic metabolism. The efficacy and safety of an oral controlled-release preparation of budesonide for maintenance of remission was evaluated in patients with ileal or ileocecal Crohn's disease.
1002. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon.
Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation.
1003. Continuous prazosin administration in cirrhotic patients: effects on portal hemodynamics and on liver and renal function.
作者: A Albillos.;J L Lledó.;I Rossi.;M Pérez-Páramo.;M J Tabuenca.;R Bañares.;J Iborra.;A Garrido.;P Escartín.;J Bosch.
来源: Gastroenterology. 1995年109卷4期1257-65页
Hepatic vascular resistance is influenced by alpha-adrenergic tone. The aim of this study was to investigate the effects of continuous blockade of alpha-adrenoceptors with prazosin on hemodynamics, liver function, and renal function and whether the association of propranolol or furosemide enhances the portal pressure lowering effect of prazosin.
1004. The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis.
作者: P J Pasricha.;A Bedi.;K O'Connor.;A Rashid.;A J Akhtar.;M L Zahurak.;S Piantadosi.;S R Hamilton.;F M Giardiello.
来源: Gastroenterology. 1995年109卷3期994-8页
The mechanism by which sulindac causes regression of adenomas in patients with familial adenomatous polyposis (FAP) is unclear. Conflicting data on the drug's effects on colorectal epithelial proliferation have been reported. An alternative mechanism, and one not previously studied, is via induction of colorectal epithelial cell apoptosis (programmed cell death). This hypothesis was tested by studying the effects of sulindac on colorectal epithelial proliferation and apoptosis in patients with FAP.
1005. Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients.
作者: A Castells.;J Bruix.;C Brú.;C Ayuso.;M Roca.;L Boix.;R Vilana.;J Rodés.
来源: Gastroenterology. 1995年109卷3期917-22页
The progression of hepatocellular carcinoma may be influenced by estrogens. This has offered the rationale for evaluating the therapeutic usefulness of estrogen-receptor blockers; it is being debated whether long-term tamoxifen administration improves survival in patients with this neoplasm. The aim of this study was to assess the efficacy of tamoxifen administration in the treatment of hepatocellular carcinoma.
1006. European trial of cyclosporine in chronic active Crohn's disease: a 12-month study. The European Study Group.
作者: E F Stange.;R Modigliani.;A S Peña.;A J Wood.;G Feutren.;P R Smith.
来源: Gastroenterology. 1995年109卷3期774-82页
The role of cyclosporine in Crohn's disease is controversial. This study aimed to delineate the long-term effect of cyclosporine in chronic active Crohn's disease.
1009. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease.
作者: R S McLeod.;B G Wolff.;A H Steinhart.;P W Carryer.;K O'Rourke.;D F Andrews.;J E Blair.;J R Cangemi.;Z Cohen.;J B Cullen.
来源: Gastroenterology. 1995年109卷2期404-13页
Recurrence of Crohn's disease frequently occurs after surgery. A randomized controlled trial was performed to determine if mesalamine is effective in decreasing the risk of recurrent Crohn's disease after surgical resection is performed.
1010. Erythromycin enhances fasting and postprandial proximal gastric tone in humans.
作者: S Bruley des Varannes.;V Parys.;A Ropert.;J A Chayvialle.;C Rozé.;J P Galmiche.
来源: Gastroenterology. 1995年109卷1期32-9页
Low doses of erythromycin induce antral contractions and accelerate gastric emptying. However, the effect of erythromycin on the proximal stomach remains unknown. The aim of this study was to assess the effect and mechanism(s) of action of erythromycin on proximal gastric tone in humans.
1011. Photodynamic therapy for obstructing esophageal cancer: light dosimetry and randomized comparison with Nd:YAG laser therapy.
Light dosimetry analysis to achieve predictable tumor necrosis has not been performed for photodynamic therapy (PDT) in the gastrointestinal tract. We evaluated dihematoporphyrin ethers for sensitizing esophageal carcinomas to 630 nm light and compared PDT with neodymium:yttrium-aluminum-garnet (Nd:YAG) laser therapy in a randomized trial.
1012. Lack of benefit of escalating dosage of interferon alfa in patients with chronic hepatitis C.
作者: P Marcellin.;M Pouteau.;M Martinot-Peignoux.;F Degos.;V Duchatelle.;N Boyer.;C Lemonnier.;C Degott.;S Erlinger.;J P Benhamou.
来源: Gastroenterology. 1995年109卷1期156-65页
In patients with chronic hepatitis C treated with interferon alfa, sustained normalization of alanine aminotransferase was observed in about 20%, and no predictive factor of response could be clearly identified. The aims of this study were to assess the efficacy of an escalating dose of interferon and to determine the predictive factors of response.
1013. Multicenter trial of octreotide in patients with refractory acquired immunodeficiency syndrome-associated diarrhea.
作者: D M Simon.;J P Cello.;J Valenzuela.;R Levy.;G Dickerson.;R Goodgame.;M Brown.;K Lyche.;W J Fessel.;J Grendell.
来源: Gastroenterology. 1995年108卷6期1753-60页
Diarrhea is a significant problem in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine octreotide effectiveness in refractory AIDS-associated diarrhea.
1014. A placebo-controlled trial of primary biliary cirrhosis treatment with colchicine and ursodeoxycholic acid.
作者: M Vuoristo.;M Färkkilä.;A L Karvonen.;R Leino.;J Lehtola.;J Mäkinen.;J Mattila.;C Friman.;K Seppälä.;J Tuominen.
来源: Gastroenterology. 1995年108卷5期1470-8页
Ursodeoxycholic acid (UDCA) and colchicine have beneficial effects in primary biliary cirrhosis (PBC). The efficacy of colchicine and UDCA in PBC was compared in a 2-year placebo-controlled study (n = 90).
1015. Double-blind trial of omeprazole and amoxicillin to cure Helicobacter pylori infection in patients with duodenal ulcers.
作者: E Bayerdörffer.;S Miehlke.;G A Mannes.;A Sommer.;W Höchter.;J Weingart.;W Heldwein.;H Klann.;T Simon.;W Schmitt.
来源: Gastroenterology. 1995年108卷5期1412-7页
Anti-Helicobacter pylori treatment with combinations of omeprazole and amoxicillin is a promising treatment option. The aim of this study was to investigate whether a daily omeprazole dose of 120 mg combined with amoxicillin would cure H. pylori infection at a rate comparable with that achieved with "triple therapy."
1016. Colchicine treatment of primary sclerosing cholangitis.
作者: R Olsson.;U Broomé.;A Danielsson.;I Hägerstrand.;G Järnerot.;L Lööf.;H Prytz.;B O Rydén.;S Wallerstedt.
来源: Gastroenterology. 1995年108卷4期1199-203页
There is no medical treatment of documented benefit in primary sclerosing cholangitis (PSC). Colchicine has been observed to reduce mortality in primary biliary cirrhosis in one study. The aim of this study was to examine the effect of colchicine in PSC.
1017. Effect of sulindac on sporadic colonic polyps.
作者: J Ladenheim.;G Garcia.;D Titzer.;H Herzenberg.;P Lavori.;R Edson.;M B Omary.
来源: Gastroenterology. 1995年108卷4期1083-7页
We sought to determine in a double-blinded, placebo-controlled study if the nonsteroidal anti-inflammatory drug sulindac causes regression of sporadic colonic polyps. The impetus for this study is the profound regressive effect of sulindac on polyps in familial adenomatous polyposis.
1018. Effect of three laxatives and a cation exchange resin on fecal sodium and potassium excretion.
作者: M Emmett.;R E Hootkins.;K D Fine.;C A Santa Ana.;J L Porter.;J S Fordtran.
来源: Gastroenterology. 1995年108卷3期752-60页
The treatment of hyperkalemia in patients with renal insufficiency often includes the ingestion of sorbitol and a cation exchange resin. Sorbitol alone may be used to remove sodium and water from overloaded patients. The efficacy of these regimens has never been compared with other laxative or laxative-resin combinations. The aim of the study was to compare the relative effect of three laxatives with different mechanisms of action, alone and in combination with resin, on fecal sodium and potassium excretion.
1019. Conscious sedation for gastroscopy: patient tolerance and cardiorespiratory parameters.
作者: F Froehlich.;W Schwizer.;J Thorens.;M Köhler.;J J Gonvers.;M Fried.
来源: Gastroenterology. 1995年108卷3期697-704页
Most patients receive conscious sedation for gastroscopy. However, the benefit of the most often used combination of low-dose intravenous midazolam and topical lidocaine on patient tolerance remains poorly defined and has not been shown to outweigh cardiorespiratory risks. To respond to these issues, a randomized, double-blind, placebo-controlled prospective study was performed.
1020. Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome.
Experimental studies have shown gut hypersensitivity in irritable bowel syndrome. The aim of this study was to determine whether heightened perception of gut distention in irritable bowel syndrome is related to either decreased gut compliance, altered mechanosensitive afferents, or nonspecific sensory dysfunction.
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