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983. Primary biliary cholangitis and SARS-CoV-2 infection: incidence, susceptibility and outcomes.
作者: Javier Ampuero.;Ana Lucena.;Manuel Hernández-Guerra.;Isabel Moreno-Moraleda.;Juan Arenas.;Isabel Conde.;Laura Muñoz.;Lidia Canillas.;Edgar Fernandez.;Raisa Quiñones.;Miguel Angel Simon.;Elena Gómez-Dominguez.;Maria Luisa Gutierrez.;Conrado Fernandez-Rodriguez.;Maria Jose Domper-Arnal.;Francisco Jorquera.;Maria Luisa Garcia-Buey.;Montserrat Garcia-Retortillo.;Rosa Morillas.;Marina Berenguer.;Marta Casado.;Dalia Morales-Arraez.;José Manuel Sousa.;Esther Molina.
来源: Gut. 2021年 984. Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis.
作者: Moritz Leppkes.;Aylin Lindemann.;Stefanie Gößwein.;Susanne Paulus.;Dominik Roth.;Anne Hartung.;Eva Liebing.;Sebastian Zundler.;Miguel Gonzalez-Acera.;Jay V Patankar.;Fabrizio Mascia.;Kristina Scheibe.;Markus Hoffmann.;Stefan Uderhardt.;Christine Schauer.;Sebastian Foersch.;Clemens Neufert.;Michael Vieth.;Georg Schett.;Raja Atreya.;Anja A Kühl.;Andre Bleich.;Christoph Becker.;Martin Herrmann.;Markus F Neurath.
来源: Gut. 2022年71卷12期2414-2429页
Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive.
988. Estimating the environmental impact of disposable endoscopic equipment and endoscopes.
作者: Sathvik Namburar.;Daniel von Renteln.;John Damianos.;Lisa Bradish.;Jeanne Barrett.;Andres Aguilera-Fish.;Benoit Cushman-Roisin.;Heiko Pohl.
来源: Gut. 2022年71卷7期1326-1331页
Procedure-intense specialties, such as surgery or endoscopy, are a major contributor to the impact of the healthcare sector on the environment. We aimed to measure the amount of waste generated during endoscopic procedures and to understand the impact on waste of changing from reusable to single use endoscopes in the USA.
989. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
作者: Tianyun Long.;Nazia Abbasi.;Juan E Hernandez.;Yuxin Li.;Ibrahim M Sayed.;Shengyun Ma.;Attilio Iemolo.;Brian A Yee.;Gene W Yeo.;Francesca Telese.;Pradipta Ghosh.;Soumita Das.;Wendy Jia Men Huang.
来源: Gut. 2022年71卷9期1790-1802页
Tuft cells residing in the intestinal epithelium have diverse functions. In the small intestine, they provide protection against inflammation, combat against helminth and protist infections, and serve as entry portals for enteroviruses. In the colon, they had been implicated in tumourigenesis. Commitment of intestinal progenitor cells to the tuft cell lineage requires Rho GTPase Cell Division Cycle 42 (CDC42), a Rho GTPase that acts downstream of the epidermal growth factor receptor and wingless-related integration site signalling cascades, and the master transcription factor POU class 2 homeobox 3 (POU2F3). This study investigates how this pathway is regulated by the DEAD box containing RNA binding protein DDX5 in vivo.
990. Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria.
作者: A Raquel Esteves.;Mário F Munoz-Pinto.;Daniela Nunes-Costa.;Emanuel Candeias.;Diana F Silva.;João D Magalhães.;A Raquel Pereira-Santos.;I Luisa Ferreira.;Susana Alarico.;Igor Tiago.;Nuno Empadinhas.;Sandra Morais Cardoso.
来源: Gut. 2023年72卷1期73-89页
Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities.
992. Chinese Consensus Report on Family-Based Helicobacter pylori Infection Control and Management (2021 Edition).
作者: Song-Ze Ding.;Yi-Qi Du.;Hong Lu.;Wei-Hong Wang.;Hong Cheng.;Shi-Yao Chen.;Min-Hu Chen.;Wei-Chang Chen.;Ye Chen.;Jing-Yuan Fang.;Heng-Jun Gao.;Ming-Zhou Guo.;Ying Han.;Xiao-Hua Hou.;Fu-Lian Hu.;Bo Jiang.;Hai-Xing Jiang.;Chun-Hui Lan.;Jing-Nan Li.;Yan Li.;Yan-Qing Li.;Jie Liu.;You-Ming Li.;Bin Lyu.;You-Yong Lu.;Ying-Lei Miao.;Yong-Zhan Nie.;Jia-Ming Qian.;Jian-Qiu Sheng.;Cheng-Wei Tang.;Fen Wang.;Hua-Hong Wang.;Jiang-Bin Wang.;Jing-Tong Wang.;Jun-Ping Wang.;Xue-Hong Wang.;Kai-Chun Wu.;Xing-Zhou Xia.;Wei-Fen Xie.;Yong Xie.;Jian-Ming Xu.;Chang-Qing Yang.;Gui-Bin Yang.;Yuan Yuan.;Zhi-Rong Zeng.;Bing-Yong Zhang.;Gui-Ying Zhang.;Guo-Xin Zhang.;Jian-Zhong Zhang.;Zhen-Yu Zhang.;Peng-Yuan Zheng.;Yin Zhu.;Xiu-Li Zuo.;Li-Ya Zhou.;Nong-Hua Lyu.;Yun-Sheng Yang.;Zhao-Shen Li.; .
来源: Gut. 2022年71卷2期238-253页
Helicobacter pylori infection is mostly a family-based infectious disease. To facilitate its prevention and management, a national consensus meeting was held to review current evidence and propose strategies for population-wide and family-based H. pylori infection control and management to reduce the related disease burden.
993. International variation in oesophageal and gastric cancer survival 2012-2014: differences by histological subtype and stage at diagnosis (an ICBP SURVMARK-2 population-based study).
作者: Melina Arnold.;Eileen Morgan.;Aude Bardot.;Mark J Rutherford.;Jacques Ferlay.;Alana Little.;Bjorn Møller.;Oliver Bucher.;Prithwish De.;Ryan R Woods.;Nathalie Saint-Jacques.;Anna T Gavin.;Gerda Engholm.;Michael P Achiam.;Geoff Porter.;Paul M Walsh.;Sally Vernon.;Serena Kozie.;Agnihotram V Ramanakumar.;Charlotte Lynch.;Samantha Harrison.;Neil Merrett.;Dianne L O'Connell.;Tom Mala.;Mark Elwood.;John Zalcberg.;Dyfed W Huws.;David Ransom.;Freddie Bray.;Isabelle Soerjomataram.
来源: Gut. 2022年71卷8期1532-1543页
To provide the first international comparison of oesophageal and gastric cancer survival by stage at diagnosis and histological subtype across high-income countries with similar access to healthcare.
994. Risk of adverse events and reported clinical relapse after COVID-19 vaccination in patients with IBD.
作者: Rosanna Cannatelli.;Francesca Ferretti.;Stefania Carmagnola.;Irene Maria Bambina Bergna.;Maria Camilla Monico.;Giovanni Maconi.;Sandro Ardizzone.
来源: Gut. 2022年71卷9期1926-1928页 995. Antibody response to the BNT162b2 SARS-CoV-2 vaccine in paediatric patients with inflammatory bowel disease treated with anti-TNF therapy.
作者: Zahra Jama Shire.;Frederic Reicherz.;Sally Lawrence.;Harjeev Sudan.;Liam Golding.;Abdelilah Majdoubi.;Paul N Levett.;Pascal M Lavoie.;Kevan Jacobson.
来源: Gut. 2022年71卷9期1922-1924页 996. Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet.
作者: Kevin Vervier.;Stephen Moss.;Nitin Kumar.;Anne Adoum.;Meg Barne.;Hilary Browne.;Arthur Kaser.;Christopher J Kiely.;B Anne Neville.;Nina Powell.;Tim Raine.;Mark D Stares.;Ana Zhu.;Juan De La Revilla Negro.;Trevor D Lawley.;Miles Parkes.
来源: Gut. 2022年71卷9期1821-1830页
Reducing FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) can be clinically beneficial in IBS but the mechanism is incompletely understood. We aimed to detect microbial signatures that might predict response to the low FODMAP diet and assess whether microbiota compositional and functional shifts could provide insights into its mode of action.
998. Influence of timing of maternal antibiotic administration during caesarean section on infant microbial colonisation: a randomised controlled trial.
作者: Thomas Dierikx.;Daniel Berkhout.;Anat Eck.;Sebastian Tims.;Johan van Limbergen.;Douwe Visser.;Marjon de Boer.;Nanne de Boer.;Daan Touw.;Marc Benninga.;Nine Schierbeek.;Laura Visser.;Jan Knol.;Guus Roeselers.;Johanna de Vries.;Tim de Meij.
来源: Gut. 2022年71卷9期1803-1811页
Revised guidelines for caesarean section (CS) advise maternal antibiotic administration prior to skin incision instead of after umbilical cord clamping, unintentionally exposing the infant to antibiotics antenatally. We aimed to investigate if timing of intrapartum antibiotics contributes to the impairment of microbiota colonisation in CS born infants.
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