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81. Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19.
作者: Felix Röttele.;Andreas Zollner.;Carolin Mogler.;Muhammed Yuksel.;Cigdem Arikan.;Vivien Karl.;Judith Helene Aberle.;Stephan W Aberle.;Hubert Kogler.;Andreas Vécsei.;Julia Vodopiutz.;Henrike Salié.;Anne Gräser.;Laurenz Krimmel.;Pius Martin.;Eberhard Lurz.;Felix Immanuel Maier.;Lena Woelfle.;Susana Nobre.;Isabel Goncalves.;Lisa Kern.;Martin Schwemmle.;Tobias Boettler.;Maike Hofmann.;Peter Hasselblatt.;Robert Thimme.;Herbert Tilg.;Thomas Müller.;Georg Friedrich Vogel.;Bertram Bengsch.
来源: Gut. 2025年
A rise in paediatric cases of acute hepatitis of unknown origin (AHUO) was observed in 2022, some requiring liver transplantation. A link to adeno-associated virus 2 infection and CD4+T-cell mediated disease was reported in cohorts in the UK and USA but does not explain all cases.
83. Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis.
作者: Emma C Robbins.;Kate Wooldrage.;Matthew D Rutter.;Andrew M Veitch.;Amanda J Cross.
来源: Gut. 2025年
Recommendations for the first postpolypectomy surveillance colonoscopy (SC1), based on stratifying postpolypectomy colorectal cancer (CRC) risk, are well established. Limited data inform recommendations for surveillance beyond SC1.
87. British Society of Gastroenterology guidelines for diagnosis and management of autoimmune hepatitis.
作者: Dermot Gleeson.;Rosemary Bornand.;Ann Brownlee.;Harpreet Dhaliwal.;Jessica K Dyson.;Janeane Hails.;Paul Henderson.;Deirdre Kelly.;George F Mells.;Rosa Miquel.;Ye H Oo.;Anthea Sutton.;Andrew Yeoman.;Michael A Heneghan.
来源: Gut. 2025年
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if untreated, often leads to cirrhosis, liver failure and death. The last British Society of Gastroenterology (BSG) guideline for the management of AIH was published in 2011. Since then, our understanding of AIH has advanced in many areas. This update to the previous guideline was commissioned by the BSG and developed by a multidisciplinary group. The aim of this guideline is to review and summarise the current evidence, in order to inform and guide diagnosis and management of patients with AIH and its variant syndromes. The main focus is on AIH in adults, but the guidelines should also be relevant to older children and adolescents.
88. Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression.
作者: Lars J S Kemp.;Jooske L Monster.;Colin S Wood.;Martijn Moers.;Marjolein J Vliem.;Antoine A Khalil.;Nigel B Jamieson.;Lodewijk A A Brosens.;Liudmila L Kodach.;Jolanda M van Dieren.;Tanya M Bisseling.;Rachel S van der Post.;Martijn Gloerich.
来源: Gut. 2025年
Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of differentiated, non-proliferative signet ring cells (SRCs). These indolent lesions can advance into highly proliferative and metastatic tumours, which requires suppression of DGC cell differentiation.
91. Endoscopic resection after downstaging of oesophageal carcinoma by neoadjuvant chemoimmunotherapy: - a new multimodal concept?
作者: Mingyan Cai.;Baohui Song.;Dongli He.;Chen Xu.;Rongkui Luo.;Yang Qian.;Sikei Kam.;Xucheng Huo.;Jian Wang.;Michael Vieth.;Yunshi Zhong.
来源: Gut. 2025年 92. Combining faecal haemoglobin, iron deficiency anaemia status and age can improve colorectal cancer risk prediction in patients attending primary care with bowel symptoms: a retrospective observational study.
作者: Jayne Digby.;Jennifer Nobes.;Judith A Strachan.;Rebecca McCann.;Christopher Hall.;Callum G Fraser.;Craig Mowat.
来源: Gut. 2025年
In primary care, National Institute for Health and Care Excellence suspected cancer guidelines recommend measuring faecal haemoglobin (f-Hb) if colorectal cancer (CRC) is suspected, with a referral threshold of ≥10 µg Hb/g faeces defining a 3% risk, but most have a normal colonoscopy.
94. Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2.
作者: Honghai Xu.;Zihao Wu.;Jiangfeng Qin.;Xutong Li.;Feng Xu.;Wei Wang.;Hui Zhang.;HeHe Yin.;Shiwei Zhu.;Wenzhe Zhang.;Yuanru Yang.;Yuanyuan Wei.;Long Gao.;Jiatao Liu.;Yufeng Gao.;Ming-Hua Zheng.;Haoxiong Zhou.;Tingting Qi.;Jinjun Chen.;Yanhang Gao.;Li Zuo.;Jiong Chen.;Suthat Liangpunsakul.;Jiabin Li.;Hua Wang.
来源: Gut. 2025年
Neutrophil infiltration and hepatocyte damage are indispensable hallmarks in alcohol-associated hepatitis (AH), yet the underlying crosstalk between neutrophils and hepatocytes and its role in AH pathogenesis remain unclear.
95. Dietary whey protein protects against Crohn's disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome.
作者: Runping Su.;Weijie Wen.;Yufeng Jin.;Zhirui Cao.;Zhiyang Feng.;Jie Chen.;Yu Lu.;Guicheng Zhou.;Chao Dong.;Shanshan Gao.;Xue Li.;Hu Zhang.;Kang Chao.;Ping Lan.;Xiaojian Wu.;Anna Philips.;Kun Li.;Xiang Gao.;Fen Zhang.;Tao Zuo.
来源: Gut. 2025年
The gut microbiome and diet are important factors in the pathogenesis and management of Crohn's disease (CD). However, the role of the gut phageome under dietary influences is unknown.
96. Endothelial-like cancer-associated fibroblasts facilitate pancreatic cancer metastasis via vasculogenic mimicry and paracrine signalling.
作者: Xugang Sun.;Wenrun Cai.;Haorui Li.;Chuntao Gao.;Xi Ma.;Yu Guo.;Danqi Fu.;Di Xiao.;Zhaoyu Zhang.;Yifei Wang.;Shengyu Yang.;Yukuan Feng.;Tiansuo Zhao.;Jihui Hao.
来源: Gut. 2025年
Cancer-associated fibroblasts (CAFs) are highly heterogeneous in the progression of pancreatic ductal adenocarcinoma (PDAC) and vasculogenic mimicry (VM) refers to a phenomenon in which cancer cells adopt endothelial-like characteristics.
97. Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence.
作者: Daniel Rodrigo-Torres.;Alastair M Kilpatrick.;Sofia Ferreira-Gonzalez.;Rhona E Aird.;Stephen Rahul Atkinson.;Victoria L Gadd.;Tak Yung Man.;Luke D Tyson.;Gopal Krishna R Dhondalay.;Nikhil Vergis.;Gavin E Arteel.;Mark R Thursz.;Laura Martinez-Gili.;Stuart J Forbes.
来源: Gut. 2025年
Alcohol-associated hepatitis (AH) is an acute form of alcohol-related liver disease (ALD) with high mortality rate. AH is histologically characterised by cellular processes, including steatosis, inflammation and cell death. Apoptosis is the most studied form of cell death in AH; however, the role of cellular senescence, another response to cellular injury, in AH is unknown. Here, we explore the mechanisms of ALD pathophysiology and describe the role of senescence in AH.
99. Diagnostic efficacy of an extracellular vesicle-derived lncRNA-based liquid biopsy signature for the early detection of early-onset gastric cancer.
作者: Xin Guo.;Weidong Wang.;Xin Cheng.;Qiying Song.;Xinxin Wang.;Jiangpeng Wei.;Shenhui Xu.;Xiaohui Lv.;Gang Ji.
来源: Gut. 2025年
Early-onset gastric cancer (EOGC) is a lethal malignancy. It differs from late-onset gastric cancer (LOGC) in clinical and molecular characteristics. The current strategies for EOGC detection have certain limitations in diagnostic performance due to the rising trend in EOGC.
100. Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial.
作者: Xiaoyu Kang.;Mingxing Xia.;Jun Wang.;Xiangping Wang.;Hui Luo.;Wenhao Qin.;Zirong Liang.;Gang Zhao.;Longbao Yang.;Hao Sun.;Jie Tao.;Bo Ning.;Li Zhong.;Rongchun Zhang.;Xuyuan Ma.;Jianghai Zhao.;Laifu Yue.;Haifeng Jin.;Chenxi Kang.;Gui Ren.;Shuhui Liang.;Haiying Wang.;Ling Wang.;Yongzhan Nie.;Kaichun Wu.;Dai-Ming Fan.;Yanglin Pan.
来源: Gut. 2025年74卷7期1094-1102页
Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was to compare the efficacy of 100 mg rectal indomethacin versus diclofenac on PEP incidences.
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