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81. Clinical challenges and patient experiences in early-onset colorectal cancer: insights from seven European countries.
作者: Marianna Vitaloni.;Katell Maguet.;Andi Carlan.;Patricia Stack.;Vincent de Jong.;Ross Williams.;Zorana Maravic.
来源: BMC Gastroenterol. 2025年25卷1期378页
The incidence of early-onset colorectal cancer (eoCRC), defined as CRC diagnosed in individuals under 50, is rising globally. Younger patients often face diagnostic delays and receive care pathways designed for older populations. These gaps highlight the need for tailored approaches to diagnosis, treatment, and support.
82. Clinical outcomes of endoscopic retrograde cholangiopancreatography after Billroth II anastomosis: a comparison of gastroscope and duodenoscope.
Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Billroth II anastomosis is challenging due to post-surgical anatomical alterations. This study aims to compare the clinical outcomes of using a duodenoscope and a cap-assisted gastroscope in these patients.
83. Changes in microbial and metabolic profiles of mice fed with long-term high salt diet.
作者: Huiying Tian.;Xiaotang Gao.;Hanlin Du.;Zhuofeng Lin.;Xianen Huang.
来源: BMC Gastroenterol. 2025年25卷1期375页
High salt diet (HSD) has been considered as a risk factor for the development of metabolic disorders. However, less is known about long-term implications of HSD. Therefore, the aim of this study was to conduct a preliminary investigation into the effects of mice feeding with long-term HSD on gut microbial and metabolic profiles.
84. Intravenous sedation during esophagogastroduodenoscopy is associated with a reduced risk of missed gastric cancer.
作者: Isabel Salvador.;Beatriz Arau.;Xavier Andújar.;Carme Ferrer.;Yamile Zabana.;Laura Ruiz.;Montserrat Aceituno.;Fernando Fernández-Bañares.;Maria Esteve.;Carme Loras.
来源: BMC Gastroenterol. 2025年25卷1期377页
Esophagogastroduodenoscopy (EGD) is an effective technique for diagnosing gastric cancer (GC). However, it is estimated that 10% of GCs are unnoticed, constituting missed gastric cancer (MGC). To analyse the incidence of MGC in our area, the characteristics of GC and factors related to MGC were evaluated.
85. Machine learning for predicting all-cause mortality of metabolic dysfunction-associated fatty liver disease: a longitudinal study based on NHANES.
The mortality burden of metabolic dysfunction-associated fatty liver disease (MAFLD) is rising, making it crucial to predict mortality and identify the factors influencing it. While advanced machine learning algorithms are gaining recognition as effective tools for clinical prediction, their ability to predict all-cause mortality of MAFLD individuals remains uncertain. This study aimed to develop different machine learning models to predict all-cause mortality of MAFLD individuals, compare the predictive performance of these models, and identify the risk factors contributing all-cause mortality, which is crucial for management of MAFLD individuals.
86. Impact of medical therapy on liver transplant eligibility in patients with portopulmonary hypertension: a systematic review.
作者: Matthew T Siuba.;Ahmed Abushamma.;Aman Qureshi.;Shelley Ivary.;Adriano R Tonelli.
来源: Minerva Gastroenterol (Torino). 2025年
Portopulmonary hypertension (PoPH) occurs in roughly 5% of patients evaluated for liver transplant and increases perioperative morbidity and mortality. PoPH patients often succumb to complications of the underlying liver disease, therefore liver transplantation can be a lifesaving intervention. Medical treatment of PoPH optimizes patients for transplantation, but the knowledge on the effect of PH specific therapy on transplant eligibility is limited.
87. Clinical characteristics of MASLD/MetALD/MAFLD/NAFLD and the relative risk analysis on metabolic disorders.
作者: Hong-Ye Peng.;Chun-Li Lu.;Mo Zhao.;Xiao-Qiang Huang.;Shu-Xia Huang.;Zi-Wen Zhuo.;Jing Liu.;Yan-Ping Lu.;Wen-Liang Lv.
来源: BMC Gastroenterol. 2025年25卷1期372页
Our objective was to compare the clinical features of Metabolic dysfunction-associated steatotic liver disease (MASLD) /metabolic alcohol-related liver disease (MetALD)/metabolic associated fatty liver disease (MAFLD)/nonalcoholic fatty liver disease (NAFLD) and the relative risk analysis of metabolic disorders.
88. The HbA1c/HDL-C ratio as a screening indicator of NAFLD in U.S. adults: a cross-sectional NHANES analysis (2017-2020).
作者: Ju Wu.;Wenjing Yu.;Linglong Huang.;Shuangshuang Hou.;Yanan Huang.;Zhihua Huang.;Zhiyuan Dai.;Jiajun Yin.;Zhequn Nie.
来源: BMC Gastroenterol. 2025年25卷1期369页
Non-alcoholic fatty liver disease (NAFLD), a metabolic liver disorder closely associated with obesity and diabetes, urgently requires early screening. This population-based study is the first to explore the relationship between glycemic control and a novel dyslipidemia composite index-the glycated hemoglobin/high-density lipoprotein cholesterol (HbA1c/HDL-C) ratio in individuals with NAFLD and liver fibrosis.
89. Surface area outcomes in EUS-guided liver biopsy: a comparative study of Franseen and Fork-tip needles.
作者: Kotaro Matsumoto.;Shinpei Doi.;Takako Adachi.;Ayako Watanabe.;Nobuhiro Katsukura.;Takayuki Tsujikawa.;Tatsuya Aso.;Mikiko Takahashi.;Kentaro Kikuchi.
来源: BMC Gastroenterol. 2025年25卷1期370页
The practice of endoscopic ultrasound-guided liver biopsy (EUS-LB) is becoming more common due to its proven safety and effectiveness. For accurate diagnosis, it is vital to secure ample tissue specimens. However, gauging the volume of tissue specimens accurately poses a challenge with existing methods. Additionally, determining the most suitable fine-needle biopsy (FNB) needle requires further study. Our aim was to contrast the tissue surface areas obtained using Franseen and Fork-tip needles and to identify factors affecting tissue volume.
90. Comparison of outcomes between surgery and non-surgery after conversion therapy for advanced gastric cancer with unresectable factors: a systematic review and meta-analysis.
Advanced gastric cancer (AGC) with unresectable factors presents a significant treatment challenge. Conventional treatments such as systemic chemotherapy, radiotherapy, and immunotherapy can delay disease progression but often yield limited outcomes. For stage III-IV gastric cancer with unresectable factors, conversion therapy based on chemotherapy can achieve tumor downstaging, providing a subset of patients with the opportunity for curative surgery. However, the efficacy of multimodal approaches combining chemotherapy, with or without immunotherapy, and conversion surgery compared to chemotherapy alone remains controversial.
91. Association of biological aging and the prevalence of nonalcoholic fatty liver disease: a population-based study.
作者: Gang Liu.;Qingsong Mao.;Xinling Tian.;Chenwei Zhang.;Yukai Zhang.;Jiarong He.;Yuzhe Kong.
来源: BMC Gastroenterol. 2025年25卷1期368页
To examine the relationship between biological aging and the prevalence of NAFLD.
92. Nonlinear association between AST/ALT ratio and 28-day all-cause mortality following ICU admission in critically ill cirrhotic patients: a retrospective cohort study.
The AST/ALT ratio is a biochemical marker associated with poor clinical outcomes in various patients, but its role in severe cirrhosis is unclear. This study investigated the relationship between the AST/ALT ratio and mortality in the intensive care unit (ICU) patients with cirrhosis.
93. Red cell distribution width as a potential new biomarker to predict the clinical severity of acute diverticulitis.
作者: Melek Yalcin Koc.;Mehmet Aykut Yildirim.;Suleyman Sakir Tavli.;Abdullah Gurhan Duyan.
来源: BMC Gastroenterol. 2025年25卷1期366页
To investigate the relationships between red cell distribution width (RDW), other inflammation-related markers and clinical features with the clinical and radiological severity of diverticulitis.
94. Investigation of the mechanism by which miR-223-3p inhibits reflux esophagitis through targeting the NLRP3 inflammasome.
作者: Shuying Lin.;Binbin Zheng.;Ruchen Wu.;Qiuli Wu.;Xiangbo Chen.
来源: BMC Gastroenterol. 2025年25卷1期365页
Reflux esophagitis is a common gastrointestinal disorder characterized by significant inflammatory responses. The NLRP3 inflammasome plays a crucial role in inflammation, and miR- 223 - 3p has been found to inhibit its expression by targeting NLRP3 mRNA. This study aims to further investigate the mechanism by which miR- 223 - 3p inhibits reflux esophagitis through targeting the NLRP3 inflammasome.
95. Eradication of Helicobacter pylori that contributes to hepatogenic ulcer is beneficial to the healing of hepatogenic ulcer.
作者: Guanen Qiao.;Le Feng.;Meng Wang.;Chaoyang Wang.;Changjuan Li.;Shuxiang Han.;Yanmei Wang.;Shubo Li.;Shuanli Xin.
来源: BMC Gastroenterol. 2025年25卷1期359页
This study aimed to explore the role of Helicobacter pylori (Hp) eradication in patients with hepatogenic ulcer (HU).
96. A network meta-analysis of different interventional treatment strategies for unresectable hepatocellular carcinoma.
作者: Xing-Yan Le.;Jun-Bang Feng.;Xiao-Li Yu.;Sui-Li Li.;Xiaocai Zhang.;Jiaqing Li.;Chuan-Ming Li.
来源: BMC Gastroenterol. 2025年25卷1期360页
The optimal clinical management of unresectable hepatocellular carcinoma (uHCC) is challenging for clinicians. Bayesian network meta-analysis was conducted to compare the efficacy and safety of different interventional strategies for uHCC.
97. Factors predicting conversion from colon capsule endoscopy to conventional optical endoscopy-findings from the CESCAIL study.
作者: Ian Io Lei.;Ioanna Parisi.;Anirudh Bhandare.;Francisco Porras Perez.;Thomas Lee.;Chander Shehkar.;Mary McStay.;Simon Anderson.;Angus Watson.;Abby Conlin.;Rawya Badreldin.;Kamran Malik.;John Jacob.;Andrew Dixon.;Jeffrey Butterworth.;Nicholas Parsons.;Anastasios Koulaouzidis.;Ramesh P Arasaradnam.; .
来源: BMC Gastroenterol. 2025年25卷1期363页
Colon capsule endoscopy (CCE) has become an alternative to traditional colonoscopy for low-risk patients. However, CCE's low completion rate and inability to take biopsies or remove polyps often result in a CCE-to-conventional colonoscopy conversion (CCC).
98. Efficient diagnosis for endoscopic remission in Crohn's diseases by the combination of three non-invasive markers.
作者: Kensuke Takei.;Toshihiro Inokuchi.;Sakiko Hiraoka.;Mikako Ishiguro.;Junki Toyosawa.;Yuki Aoyama.;Shoko Igawa.;Keiko Takeuchi.;Yasushi Yamasaki.;Hideaki Kinugasa.;Masahiro Takahara.;Seiji Kawano.;Toshiharu Mitsuhashi.;Motoyuki Otsuka.
来源: BMC Gastroenterol. 2025年25卷1期364页
Serum C-reactive protein (CRP), leucine-rich alpha-2 glycoprotein (LRG), and fecal calprotectin (Fcal) are non-invasive markers used to assess Crohn's disease (CD) severity. However, the accuracy of these markers alone is often limited, and most previous reports have evaluated the efficacy of each marker individually. We aimed to improve the diagnostic performance of endoscopic remission (ER) of CD by combining these 3 markers.
99. Evaluating the diagnostic significance of the R2* value on 3.0T MRI for assessing the severity of warm hepatic ischemia-reperfusion injury.
Magnetic resonance imaging (MRI) may be a non-invasive tool for managing warm hepatic ischemia-reperfusion injury (WHIRI).
100. ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions.
作者: Lu Xia.;Yiwen Pan.;Xianbin Wang.;Rong Hu.;Jie Gao.;Wei Chen.;Keke He.;Dongbin Cui.;Youbo Zhao.;Lu Liu.;Laijun Lai.;Min Su.
来源: BMC Gastroenterol. 2025年25卷1期362页
Both macrophages and T cells play a critical role in inflammatory bowel disease (IBD) development. Since our previous studies have shown that a novel immune checkpoint molecule erythrocyte membrane-associated protein (ERMAP) affects macrophage polarization and negatively regulates T cell responses, we investigated the effects of ERMAP on DSS-induced colitis progression in mice.
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