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81. Comparison of Tc-99 m scintigraphic method and radiological method for colon transmit assessment in patients with functional constipation.
作者: Yuan Tian.;Yan Li.;Ting Yi.;Qiyue Wang.;Xuan Jiang.;Zuo-Xiang He.
来源: BMC Gastroenterol. 2025年25卷1期721页
The methods for assessing colonic transit in patients with functional constipation include the radiological method and Tc-99m scintigraphic method. This study aims to validate the practicality and accuracy of the Tc-99m scintigraphic method in evaluating colon transit, while also exploring the significance of the geometric center (GC).
82. Comparative efficacy of 200 mg versus 1200 mg of simethicone with 3 L polyethylene glycol electrolyte solution for afternoon colonoscopy: a randomized controlled trial.
作者: Xiaoyu Cai.;Peng Xue.;Yinpeng Li.;Yinhua Rao.;Xianrong Du.;Lin Zhong.;Ling Chen.;Shuangyan Liu.;Qian Yue.;Dingguo Zhang.
来源: BMC Gastroenterol. 2025年25卷1期722页
Simethicone (SIM) can enhance bowel preparation efficiency, but the optimal dose for patients undergoing afternoon colonoscopy is still unclear. This study compares bowel preparation efficiency and adenoma detection rate (ADR) between patients receiving 3 L of polyethylene glycol electrolyte solution (PEG-ELS) with 200 mg SIM or 1200 mg SIM for afternoon colonoscopy.
83. Predicting surgical NEC in neonates: risk factors and model development.
作者: Mingyun Tang.;Xiaofei Ma.;Yuan Gan.;Yanxing Lv.;Yunzhi Liu.;Yongjiang Jiang.;Xiaolan Li.;Yueju Cai.
来源: BMC Gastroenterol. 2025年25卷1期719页
Neonatal necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency associated with high morbidity and mortality in neonates. Early identification of cases requiring surgical intervention is critical to improving outcomes.
84. Ustekinumab trough concentrations predict clinical remission in perianal fistulizing crohn's disease: a real-world retrospective cohort study.
作者: Xiaoyu Liu.;Yuehua Yan.;Jiaqin Yi.;Dongmei Luo.;Jun Geng.;Huixian Huang.;Jingjing Wang.;Yunfei Gu.;Bolin Yang.;Yuxia Gong.;Hao Wang.
来源: BMC Gastroenterol. 2025年25卷1期718页
Limited evidence exists on the long-term efficacy of ustekinumab (UST) in perianal fistulizing Crohn's disease (PFCD), and the optimal UST trough level for predicting fistula remission remains uncertain. This study aimed to assess both short- and long-term effectiveness of UST in PFCD and to identify thresholds predicting fistula clinical remission.
85. Identification and tissue-level validation of ferroptosis-related genes in small intestinal neuroendocrine neoplasms based on machine learning.
作者: Chuang Lv.;Zhiqiang Liu.;Chengcheng Tong.;Le Liu.;Ziyue Dou.;Xi Chen.
来源: BMC Gastroenterol. 2025年25卷1期720页
Small intestinal neuroendocrine neoplasms (SI-NENs), a subgroup of neuroendocrine tumors originating from neuroendocrine cells in the small intestine, present significant therapeutic challenges, and their relationship with ferroptosis-a regulated form of cell death driven by iron-dependent lipid peroxidation-remains poorly understood. This study aimed to identify the ferroptosis-related genes in SI-NENs and evaluate their clinical relevance.
86. Early oral feeding after laparoscopic total gastrectomy in gastric cancer patients: a meta-analysis of randomized controlled trials and cohort studies.
作者: Leila Mohajeri.;Reza Daghayeghi.;Navid Rostami.;Yasamin Moeinipour.;Reza Hossein Zadeh.;Raoul Hossein Zadeh.;Reza Shah Hosseini.;Mohsen Jabbari.;Komeil Aghazadeh Habashi.;Niloofar Deravi.
来源: BMC Gastroenterol. 2025年25卷1期709页
Gastric cancer remains a leading cause of cancer-related morbidity and mortality worldwide, with surgery being central to treatment. However, postoperative malnutrition is common and significantly impairs recovery. Early oral feeding (EOF) has been proposed as a strategy to promote gastrointestinal recovery and reduce complications, but its clinical effectiveness following gastrectomy remains uncertain.
87. The burden of inflammatory bowel disease in five East Asian countries an analysis based on the global burden of disease study 1990-2021.
作者: Ya-Lin Liu.;Hai-Rui Shang.;Liang-Bi Xu.;Xiao-Wen Xu.;Yuan-Xue Ji.;Yi-Yang He.;Ye Wang.;Pai-Lan Peng.
来源: BMC Gastroenterol. 2025年25卷1期714页
Inflammatory bowel disease (IBD) is a chronic and relapsing gastrointestinal disorder whose global disease burden continues to rise, making it a significant public health issue. In recent years, rapid socioeconomic development in East Asia has led to notable changes in lifestyle and dietary patterns, accompanied by dynamic shifts in the epidemiological characteristics of IBD. However, there remains a lack of systematic comparison and analysis of the long-term disease burden and evolutionary trends of IBD across five East Asian countries and regions: China, Japan, South Korea, North Korea, and Mongolia. Based on data from The Global Burden of Disease Study 2021 (GBD 2021), this study aims to comprehensively describe the trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of IBD in The region from 1990 to 2021, thereby providing a basis for differentiated prevention and control strategies.
88. Clinical features, treatments and prognosis of COVID-19 (Omicron) and hemorrhagic colitis: a case series study.
This study aims to evaluate the gastrointestinal implications of the Omicron variant, focusing on intestinal injury.
89. Chronic PPI use after anti-reflux surgery: a retrospective observational pilot study.
作者: J W Van Dam.;L M Van den Dop.;G Van den Brink.;M W M De Waal.;J C Kiefte-de Jong.;M E Numans.;W E Hueting.
来源: BMC Gastroenterol. 2025年25卷1期710页
Chronic Proton Pump Inhibitor (PPI) use after anti-reflux surgery (ARS) remains common. Which patient factors contribute to chronic PPI use after surgery is unclear. The primary aim was to provide a long-term outcome of ARS by evaluating PPI use in the years after surgery and identify determinants of chronic PPI use after surgery.
90. Global burden of acute pancreatitis attributable to high alcohol intake from 1990 to 2021: findings and prevention potential based on GBD 2021.
Although recent studies have examined alcohol-attributable pancreatitis (AAP), the contributions of population growth, aging, and sociol demographic index (SDI)disparities remain insufficiently quantified.This study aimed to assess the global, regional, and national burden of alcohol-related AP from 1990 to 2021, evaluating trends across socioeconomic and demographic strata to inform policy making.
91. The role of peripheral blood cell analysis-derived inflammatory parameters in predicting malignant duodenal stenosis.
作者: Palidanguli Pata'er.;Shanshan Liu.;Jiawei Chen.;Qi He.;Guochen Shang.;Yu Jin.;Jun Liu.;Chaoqun Han.;Shi Liu.
来源: BMC Gastroenterol. 2025年25卷1期713页
The unique location and complex anatomical structure of the duodenum poses challenges for the application of endoscopic biopsy. Differentiating benign and malignant duodenal stenosis remains difficult for clinicians. Therefore, there is an urgent need for a new, reliable, and cost-effective biomarker to differentiate between benign and malignant duodenal stenosis.
92. Evaluation of the direct cost of chronic viral hepatitis B in patients monitored at the hepato-gastroenterology department of the Yalgado OUEDRAOGO University Hospital.
作者: Karim Ouedraogo.;Amadou Oury Toure.;Fadima Yaya Bocoum.;Djenabou Diallo.;Alexandre Delamou.;Seni Kouanda.
来源: BMC Gastroenterol. 2025年25卷1期717页
Chronic viral hepatitis B constitutes a public health problem due to its morbidity, mortality and economic consequences. To date, the direct costs incurred by patients for the treatment of this condition are not well documented. Our study aims to provide evidence on this cost in order to help facilitate patient care and optimize national hepatitis control policies.
93. Melatonin alleviates diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome by modulating of the TLR4/MyD88/NF-κB pathway.
作者: Zuohui Yuan.;Xiaoping Yang.;Xiaochun Wang.;Xinlong Shi.;Jia Chen.;Lijun Huang.;Jie Yang.;Yuping Shi.;Liping Zhang.;Ping Mai.
来源: BMC Gastroenterol. 2025年25卷1期715页
This study aimed to investigate the effects of melatonin on diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome (IBS-D) and to explore its potential mechanisms through modulation of the TLR4/MyD88/NF-κB pathway.
94. Elucidating the role of IgA plasma cells and PECAM1-CD38 interaction in intestinal fibrosis: a single-cell RNA sequencing analysis in Crohn's disease.
作者: Shuyang Sun.;Jiheng Wang.;Kai Li.;Hua Jin.;Shuwen Du.;Jingyan Feng.;Limin Zhang.;Lei Li.;Yuqi He.
来源: BMC Gastroenterol. 2025年25卷1期712页
Intestinal fibrosis-associated stricture is a frequent complication of inflammatory bowel disease (IBD), often necessitating endoscopic or surgical interventions. This study aims to investigate the pathogenesis of fibrosis in Crohn's disease (CD), a type of IBD, by analyzing single-cell RNA sequencing (scRNA-Seq) data from colon biopsies of both CD and ulcerative colitis (UC) patients.
95. ICD-10 code validation for gastrointestinal bleeding in patients receiving oral anticoagulation: nationwide cohort study.
作者: Arnar Bragi Ingason.;Jóhann Páll Hreinsson.;Arnar Snær Ágústsson.;Sigrún Helga Lund.;Edward Rumba.;Sigríður Kristjánsdóttir.;Einar Stefán Björnsson.
来源: BMC Gastroenterol. 2025年25卷1期706页
ICD-10 codes are commonly used to identify gastrointestinal bleeding (GIB) events in observational studies. However, most studies have neither used validated ICD-10 coding algorithms to identify GIB events nor manually confirmed the diagnosis of GIB, which raises concerns regarding the validity of their results. The aim of the study was to estimate the accuracy of ICD-10 codes for GIB in patients receiving oral anticoagulation and to develop new coding algorithm for identifying GIB events.
96. Associations of urinary iodine concentration (UIC) with Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) among non-diabetic population: analysis of the NHANES 2017-2020.
作者: Zhaoguang Chen.;Jianfeng Yu.;Yanbin Wang.;Donglei Zhang.;Jianyu Hao.;Xinjuan Liu.
来源: BMC Gastroenterol. 2025年25卷1期705页
Metabolic dysfunction-associated steatotic liver disease(MASLD) and diabetes are manifestations of metabolic syndrome. Urinary iodine concentration (UIC) is closely related to diabetes and glucose metabolism, but studies on the relationship between UIC and MASLD in non-diabetic individuals are limited. Our purpose was to explore the associations between UIC and MASLD as well as liver fibrosis in the non-diabetic population.
97. Upadacitinib induction therapy in Crohn' s disease: a retrospective real-world study in biologic-refractory patients.
作者: Xiaoyu Fu.;Lei Tu.;Yu Fu.;Huan Wang.;Yidong Chen.;Xiaopeng Zhang.;Qi Yu.;Fang Liu.;Yiyu Cheng.;Jiamin Li.;Qianxi Xia.;Rong Lin.;Liangru Zhu.
来源: BMC Gastroenterol. 2025年25卷1期707页
Upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy in clinical trials for Crohn's disease (CD) but real-world evidence remains limited. This study aimed to evaluate the effectiveness and safety of upadacitinib as induction therapy in a Chinese cohort with active CD.
98. Development and validation of a machine learning-based prediction model for prolonged length of stay after laparoscopic gastrointestinal surgery: a secondary analysis of the FDP-PONV trial.
作者: Jiankun Shi.;Yabin Huang.;Jiaxin Han.;Shimin Zhang.;Xingshan Cheng.;Tongfeng Luo.
来源: BMC Gastroenterol. 2025年25卷1期703页
Prolonged postoperative length of stay (PLOS) is associated with several clinical risks and increased medical costs. This study aimed to develop a prediction model for PLOS based on clinical features throughout pre-, intra-, and post-operative periods in patients undergoing laparoscopic gastrointestinal surgery.
99. Retrospective study: analysis of risk factors and construction of prediction model for pancreatic steatosis.
Pancreatic steatosis, closely related to various metabolic diseases has no unified standard for the diagnosis. The purpose of this study was to construct and validate a risk prediction model of pancreatic steatosis.
100. A Notch signal pathway related gene signature predicts overall survival in colorectal cancer.
作者: Mingyou Dong.;Zhihao Ding.;Xinyi Liang.;Meng Gao.;Mengqi Fan.;Xueying Peng.;Lusheng Liao.;Xiaodong Zhang.
来源: BMC Gastroenterol. 2025年25卷1期704页
Colorectal cancer (CRC) is a prevalent malignancy worldwide, characterized by high morbidity and mortality rates. The notch signaling pathway plays a dual role as both a tumor suppressor and promoter during embryonic development. However, the precise role and underlying mechanisms of notch signal pathway-related genes in CRC remain unclear.
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