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83. Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease.
作者: Helen Griffin.;Lourdes Ceron-Gutierrez.;Nima Gharahdaghi.;Soraya Ebrahimi.;Sophie Davies.;Peh Sun Loo.;Andras Szabo.;Eleri Williams.;Anirban Mukhopadhyay.;Louise McLoughlin.;Steven Irwin.;Simon Travis.;Paul Klenerman.;Su Bunn.;Andrew J Cant.;Sophie Hambleton.;Holm H Uhlig.;Rainer Doffinger.
来源: N Engl J Med. 2024年391卷5期434-441页
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell-depletion therapy and an associated decrease in the anti-interleukin-10 titer, conventional IBD therapy could be withdrawn. A second child with neutralizing anti-interleukin-10 autoantibodies had a milder course of IBD and has been treated without B-cell depletion. We conclude that neutralizing anti-interleukin-10 autoantibodies may be a causative or modifying factor in IBD, with potential implications for therapy. (Funded by the National Institute for Health and Care Research and others.).
85. Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults.
作者: Mark R Litzow.;Zhuoxin Sun.;Ryan J Mattison.;Elisabeth M Paietta.;Kathryn G Roberts.;Yanming Zhang.;Janis Racevskis.;Hillard M Lazarus.;Jacob M Rowe.;Daniel A Arber.;Matthew J Wieduwilt.;Michaela Liedtke.;Julie Bergeron.;Brent L Wood.;Yaqi Zhao.;Gang Wu.;Ti-Cheng Chang.;Wenchao Zhang.;Keith W Pratz.;Shira N Dinner.;Noelle Frey.;Steven D Gore.;Bhavana Bhatnagar.;Ehab L Atallah.;Geoffrey L Uy.;Deepa Jeyakumar.;Tara L Lin.;Cheryl L Willman.;Daniel J DeAngelo.;Shejal B Patel.;Michelle A Elliott.;Anjali S Advani.;Dimitrios Tzachanis.;Pankit Vachhani.;Rupali R Bhave.;Elad Sharon.;Richard F Little.;Harry P Erba.;Richard M Stone.;Selina M Luger.;Charles G Mullighan.;Martin S Tallman.
来源: N Engl J Med. 2024年391卷4期320-333页
Many older adults with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) have a relapse despite having a measurable residual disease (MRD)-negative complete remission with combination chemotherapy. The addition of blinatumomab, a bispecific T-cell engager molecule that is approved for the treatment of relapsed, refractory, and MRD-positive BCP-ALL, may have efficacy in patients with MRD-negative remission.
86. Features of HIV Infection in the Context of Long-Acting Cabotegravir Preexposure Prophylaxis.
作者: Raphael J Landovitz.;Sinead Delany-Moretlwe.;Jessica M Fogel.;Mark A Marzinke.;Estelle Piwowar-Manning.;Paul Richardson.;Elias K Halvas.;John W Mellors.;Deborah Persaud.;Ryan Kofron.;Marybeth McCauley.;Scott Rose.;Alex R Rinehart.;James F Rooney.;Adeola Adeyeye.;Myron S Cohen.;Deborah Donnell.;Mina C Hosseinipour.;Beatriz Grinsztejn.;Susan H Eshleman.; .
来源: N Engl J Med. 2024年391卷13期1253-1256页 87. Sudan Virus Disease among Health Care Workers, Uganda, 2022.
作者: Abdullah Wailagala.;Paul W Blair.;Kenneth Kobba.;Kayiira Mubaraka.;Hellen Aanyu-Tumukahebwa.;Daniel Kiiza.;Musoke T Sekikongo.;John D Klena.;Peter Waitt.;Rony R Bahatungire.;Henry S Kyobe.;Diana Atwine.;Alex Adaku.;Bodo Bongomin.;Bruce Kirenga.;Amy Boore.;Danielle V Clark.;David Kaggwa.;Melissa Gregory.;Wilberforce Kabweru.;Willy Kayondo.;Stacy K Mbabazi.;Hannah Kibuuka.;Ivan Kimuli.;Sophie Mulei.;Michael Mutegeki.;Batibwe Emmanuel.;Henry Mwebesa.;Prossy Naluyima.;Stephen Okello.;Alex Tumusiime.;Joel Montgomery.;Vamsi Vasireddy.;Charles Olaro.;Misaki Wayengera.;Mohammed Lamorde.
来源: N Engl J Med. 2024年391卷3期285-287页 88. Case Series of Patients with Marburg Virus Disease, Equatorial Guinea, 2023.
作者: Luca Fontana.;Cándido O Ondo Avomo.;Ladislao E Ngomo Mikue.;Domitila Ñ Fuga Eyemam.;Micaela A Nguere.;Ilda E Mometolo.;Rosalia N Bibang Nzang.;Damaso M Nguema Maye.;Ruggero Giuliani.;Frédérique Jacquerioz.;Hans-Joerg Lang.;Richard Kojan.;Antoine Chaillon.;Stephanie Ngai.;Olivier le Polain de Waroux.;Anna Silenzi.;Michele Di Marco.;María E Negrón.;John D Klena.;Mary J Choi.;Oren Mayer.;Florine E M Scholte.;Stephen R Welch.;Emily Zielinski-Gutierrez.;Janet Diaz.
来源: N Engl J Med. 2024年391卷3期283-285页 89. Oral Nirmatrelvir-Ritonavir as Postexposure Prophylaxis for Covid-19.
作者: Jennifer Hammond.;Carla Yunis.;Robert J Fountaine.;Gerald Luscan.;Aimee M Burr.;Wuyan Zhang.;Wayne Wisemandle.;Holly Soares.;Mary Lynn Baniecki.;Victoria M Hendrick.;Veselin Kalfov.;Rienk Pypstra.;James M Rusnak.
来源: N Engl J Med. 2024年391卷3期224-234页
Clinical trials of treatments for coronavirus disease 2019 (Covid-19) have not shown a significant benefit of postexposure prophylaxis.
90. Postacute Sequelae of SARS-CoV-2 Infection in the Pre-Delta, Delta, and Omicron Eras.
Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) can affect many organ systems. However, temporal changes during the coronavirus disease 2019 (Covid-19) pandemic, including the evolution of SARS-CoV-2, may have affected the risk and burden of PASC. Whether the risk and burden of PASC have changed over the course of the pandemic is unclear.
92. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.
作者: Atul Malhotra.;Ronald R Grunstein.;Ingo Fietze.;Terri E Weaver.;Susan Redline.;Ali Azarbarzin.;Scott A Sands.;Richard J Schwab.;Julia P Dunn.;Sujatro Chakladar.;Mathijs C Bunck.;Josef Bednarik.; .
来源: N Engl J Med. 2024年391卷13期1193-1205页
Obstructive sleep apnea is characterized by disordered breathing during sleep and is associated with major cardiovascular complications; excess adiposity is an etiologic risk factor. Tirzepatide may be a potential treatment.
93. APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease.
作者: Yakeel T Quiroz.;David Aguillon.;Daniel C Aguirre-Acevedo.;Daniel Vasquez.;Yesica Zuluaga.;Ana Y Baena.;Lucia Madrigal.;Liliana Hincapié.;Justin S Sanchez.;Stephanie Langella.;Rafael Posada-Duque.;Jessica L Littau.;Nelson D Villalba-Moreno.;Clara Vila-Castelar.;Liliana Ramirez Gomez.;Gloria Garcia.;Elizabeth Kaplan.;Sofia Rassi Vargas.;J Alejandro Ossa.;Pablo Valderrama-Carmona.;Paula Perez-Corredor.;Susanne Krasemann.;Markus Glatzel.;Kenneth S Kosik.;Keith Johnson.;Reisa A Sperling.;Eric M Reiman.;Diego Sepulveda-Falla.;Francisco Lopera.;Joseph F Arboleda-Velasquez.
来源: N Engl J Med. 2024年390卷23期2156-2164页
Variants in APOE and PSEN1 (encoding apolipoprotein E and presenilin 1, respectively) alter the risk of Alzheimer's disease. We previously reported a delay of cognitive impairment in a person with autosomal dominant Alzheimer's disease caused by the PSEN1E280A variant who also had two copies of the apolipoprotein E3 Christchurch variant (APOE3Ch). Heterozygosity for the APOE3Ch variant may influence the age at which the onset of cognitive impairment occurs. We assessed this hypothesis in a population in which the PSEN1E280A variant is prevalent.
94. Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma.
作者: Christopher Melani.;Rahul Lakhotia.;Stefania Pittaluga.;James D Phelan.;Da Wei Huang.;George Wright.;Jillian Simard.;Jagan Muppidi.;Craig J Thomas.;Michele Ceribelli.;Frances A Tosto.;Yandan Yang.;Weihong Xu.;Theresa Davies-Hill.;Svetlana D Pack.;Cody J Peer.;Oluwatobi Arisa.;Esther Mena.;Liza Lindenberg.;Ethan Bergvall.;Craig A Portell.;Rafic J Farah.;Seung Tae Lee.;Amynah Pradhan.;Candis Morrison.;Atekelt Tadese.;Anna Marie Juanitez.;Crystal Lu.;Allison Jacob.;Heidi Simmons.;William D Figg.;Seth M Steinberg.;Elaine S Jaffe.;Mark Roschewski.;Louis M Staudt.;Wyndham H Wilson.
来源: N Engl J Med. 2024年390卷23期2143-2155页
The identification of oncogenic mutations in diffuse large B-cell lymphoma (DLBCL) has led to the development of drugs that target essential survival pathways, but whether targeting multiple survival pathways may be curative in DLBCL is unknown.
95. Inactivation of Avian Influenza A(H5N1) Virus in Raw Milk at 63°C and 72°C.
作者: Franziska Kaiser.;Dylan H Morris.;Arthur Wickenhagen.;Reshma Mukesh.;Shane Gallogly.;Kwe Claude Yinda.;Emmie de Wit.;James O Lloyd-Smith.;Vincent J Munster.
来源: N Engl J Med. 2024年391卷1期90-92页 96. Noninvasive Ventilation for Preoxygenation during Emergency Intubation.
作者: Kevin W Gibbs.;Matthew W Semler.;Brian E Driver.;Kevin P Seitz.;Susan B Stempek.;Caleb Taylor.;Daniel Resnick-Ault.;Heath D White.;Sheetal Gandotra.;Kevin C Doerschug.;Amira Mohamed.;Matthew E Prekker.;Akram Khan.;John P Gaillard.;Luke Andrea.;Neil R Aggarwal.;Jason C Brainard.;LuAnn H Barnett.;Stephen J Halliday.;Veronika Blinder.;Alon Dagan.;Micah R Whitson.;Steven G Schauer.;James E Walker.;Andrew B Barker.;Jessica A Palakshappa.;Amelia Muhs.;Joanne M Wozniak.;Patrick J Kramer.;Cori Withers.;Shekhar A Ghamande.;Derek W Russell.;Andrei Schwartz.;Ari Moskowitz.;Sydney J Hansen.;Gopal Allada.;Jordan K Goranson.;Daniel G Fein.;Peter D Sottile.;Nicholas Kelly.;Shannon M Alwood.;Micah T Long.;Rishi Malhotra.;Nathan I Shapiro.;David B Page.;Brit J Long.;Christopher B Thomas.;Stacy A Trent.;David R Janz.;Todd W Rice.;Wesley H Self.;Vikhyat S Bebarta.;Bradley D Lloyd.;Jillian Rhoads.;Kelsey Womack.;Brant Imhoff.;Adit A Ginde.;Jonathan D Casey.; .
来源: N Engl J Med. 2024年390卷23期2165-2177页
Among critically ill adults undergoing tracheal intubation, hypoxemia increases the risk of cardiac arrest and death. The effect of preoxygenation with noninvasive ventilation, as compared with preoxygenation with an oxygen mask, on the incidence of hypoxemia during tracheal intubation is uncertain.
97. Near-Universal Resistance to Macrolides of Treponema pallidum in North America.
作者: Nicole A P Lieberman.;Tara B Reid.;Chase A Cannon.;B Ethan Nunley.;Anna Berzkalns.;Stephanie E Cohen.;Lori M Newman.;Sol Aldrete.;Linda H Xu.;Clinton P Thornlund.;Kevin Pettus.;Stephanie Lundy.;Michael Kron.;Olusegun O Soge.;Kimberly Workowski.;Charlotte Perlowski.;Edward W Hook.;Jodie A Dionne.;Matthew R Golden.;Joshua A Lieberman.;Min-Kuang Lee.;Muhammad Morshed.;Prenilla Naidu.;Weiping Cao.;Allan Pillay.;Lorenzo Giacani.;Alexander L Greninger.
来源: N Engl J Med. 2024年390卷22期2127-2128页 98. Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy.
作者: Mark P Hamilton.;Takeshi Sugio.;Troy Noordenbos.;Shuyu Shi.;Philip L Bulterys.;Chih Long Liu.;Xiaoman Kang.;Mari N Olsen.;Zinaida Good.;Saurabh Dahiya.;Matthew J Frank.;Bita Sahaf.;Crystal L Mackall.;Dita Gratzinger.;Maximilian Diehn.;Ash A Alizadeh.;David B Miklos.
来源: N Engl J Med. 2024年390卷22期2047-2060页
The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy, especially the risk of T-cell neoplasms related to viral vector integration, is an emerging concern.
99. A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis.
作者: Arun J Sanyal.;Pierre Bedossa.;Mandy Fraessdorf.;Guy W Neff.;Eric Lawitz.;Elisabetta Bugianesi.;Quentin M Anstee.;Samina Ajaz Hussain.;Philip N Newsome.;Vlad Ratziu.;Azadeh Hosseini-Tabatabaei.;Jörn M Schattenberg.;Mazen Noureddin.;Naim Alkhouri.;Ramy Younes.; .
来源: N Engl J Med. 2024年391卷4期311-319页
Dual agonism of glucagon receptor and glucagon-like peptide-1 (GLP-1) receptor may be more effective than GLP-1 receptor agonism alone for treating metabolic dysfunction-associated steatohepatitis (MASH). The efficacy and safety of survodutide (a dual agonist of glucagon receptor and GLP-1 receptor) in persons with MASH and liver fibrosis are unclear.
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