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81. Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer.
作者: Mario Campone.;Michelino De Laurentiis.;Komal Jhaveri.;Xichun Hu.;Sylvain Ladoire.;Anne Patsouris.;Claudio Zamagni.;Jiuwei Cui.;Marina Cazzaniga.;Timucin Cil.;Katarzyna J Jerzak.;Christian Fuentes.;Tetsuhiro Yoshinami.;Alvaro Rodriguez-Lescure.;Ahmet Sezer.;Andrea Fontana.;Valentina Guarneri.;Andrea Molckovsky.;Marie-Ange Mouret-Reynier.;Umut Demirci.;Yongqiang Zhang.;Olga Valota.;Dongrui R Lu.;Marcella Martignoni.;Janaki Parameswaran.;Xin Zhi.;Erika P Hamilton.; .
来源: N Engl J Med. 2025年
Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin-proteasome system.
83. Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer.
作者: Yelena Y Janjigian.;Salah-Eddin Al-Batran.;Zev A Wainberg.;Kei Muro.;Daniela Molena.;Eric Van Cutsem.;Woo Jin Hyung.;Lucjan Wyrwicz.;Do-Youn Oh.;Takeshi Omori.;Markus Moehler.;Marcelo Garrido.;Sulene C S Oliveira.;Moishe Liberman.;Victor Castro Oliden.;Elizabeth C Smyth.;Alexander Stein.;Mehmet Bilici.;Maria Lorena Alvarenga.;Vadim Kozlov.;Fernando Rivera.;Akihito Kawazoe.;Olivier Serrano.;Eric Heilbron.;Alejandra Negro.;John F Kurland.;Josep Tabernero.; .
来源: N Engl J Med. 2025年
Perioperative FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) is a standard therapy for resectable gastric and gastroesophageal junction adenocarcinomas, but recurrence rates remain high. Immunotherapy plus chemotherapy may improve outcomes.
84. Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer.
作者: Patrick M Forde.;Jonathan D Spicer.;Mariano Provencio.;Tetsuya Mitsudomi.;Mark M Awad.;Changli Wang.;Shun Lu.;Enriqueta Felip.;Scott J Swanson.;Julie R Brahmer.;Keith Kerr.;Janis M Taube.;Tudor-Eliade Ciuleanu.;Fumihiro Tanaka.;Gene B Saylors.;Ke-Neng Chen.;Hiroyuki Ito.;Moishe Liberman.;Claudio Martin.;Stephen Broderick.;Lily Wang.;Junliang Cai.;Quyen Duong.;Stephanie Meadows-Shropshire.;Joseph Fiore.;Sumeena Bhatia.;Nicolas Girard.; .
来源: N Engl J Med. 2025年
Neoadjuvant nivolumab plus chemotherapy significantly improved pathological complete response and event-free survival in patients with resectable non-small-cell lung cancer (NSCLC) in a phase 3 trial. Data are needed on overall survival.
85. Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer.
作者: Komal L Jhaveri.;Seock-Ah Im.;Cristina Saura.;Sibylle Loibl.;Kevin Kalinsky.;Peter Schmid.;Sherene Loi.;Eirini Thanopoulou.;Noopur Shankar.;Yanling Jin.;Thomas J Stout.;Tiffany D Clark.;Chunyan Song.;Dejan Juric.;Nicholas C Turner.
来源: N Engl J Med. 2025年
In the phase 3, double-blind, randomized INAVO120 trial, treatment with inavolisib plus palbociclib-fulvestrant led to a significant progression-free survival benefit, as compared with placebo plus palbociclib-fulvestrant, among patients with PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer who had had relapse during or within 12 months after completion of adjuvant endocrine therapy.
86. Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma.
作者: Danny Rischin.;Sandro Porceddu.;Fiona Day.;Daniel P Brungs.;Hayden Christie.;James E Jackson.;Brian N Stein.;Yungpo Bernard Su.;Rahul Ladwa.;Gerard Adams.;Samantha E Bowyer.;Zulfiquer Otty.;Naoya Yamazaki.;Paolo Bossi.;Amarnath Challapalli.;Axel Hauschild.;Annette M Lim.;Vishal A Patel.;Joanna L Walker.;Maite De Liz Vassen Schurmann.;Paola Queirolo.;Javier Cañueto.;Flavio Augusto Ferreira da Silva.;Alexander Stratigos.;Alexander Guminski.;Charles Lin.;Fernanda Damian.;Lukas Flatz.;Anne E Taylor.;David R Carr.;Samuel Harris.;Dmitry Kirtbaya.;Gaëlle Quereux.;Piotr Rutkowski.;Nicole Basset-Seguin.;Nikhil I Khushalani.;Caroline Robert.;Haisong Ju.;Camryn Joseph.;Shikha Bansal.;Chieh-I Chen.;Frank Seebach.;Suk-Young Yoo.;Israel Lowy.;Priscila Goncalves.;Matthew G Fury.; .
来源: N Engl J Med. 2025年
Patients who have cutaneous squamous-cell carcinoma with high-risk features are at risk for recurrence after definitive local therapy. The benefit of systemic adjuvant therapy options has not been well established in clinical trials.
87. First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer.
作者: François-Clément Bidard.;Erica L Mayer.;Yeon Hee Park.;Wolfgang Janni.;Cynthia Ma.;Massimo Cristofanilli.;Giampaolo Bianchini.;Kevin Kalinsky.;Hiroji Iwata.;Stephen Chia.;Peter A Fasching.;Adam Brufsky.;Zbigniew Nowecki.;Javier Pascual.;Lionel Moreau.;Shin-Cheh Chen.;Nuri Karadurmus.;Einav Nili Gal-Yam.;Kyung Hae Jung.;Sonia Pernas.;Sasha McClain.;Wei He.;Teresa Klinowska.;Cynthia Huang-Bartlett.;Nicholas C Turner.; .
来源: N Engl J Med. 2025年
Mutations in ESR1 are the most common mechanism of acquired resistance to treatment with an aromatase inhibitor plus a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor for advanced breast cancer. Camizestrant, a next-generation selective estrogen-receptor (ER) degrader and complete ER antagonist, has shown antitumor activity in ER-positive advanced breast cancer.
88. Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer.
作者: Fatima Cardoso.;Susanne Parke.;Donal J Brennan.;Paula Briggs.;Gilbert Donders.;Nick Panay.;Nazanin Haseli-Mashhadi.;Michael Block.;Cecilia Caetano.;Maja Francuski.;Claudia Haberland.;Kaisa Laapas.;Christian Seitz.;Lineke Zuurman.
来源: N Engl J Med. 2025年
Women receiving endocrine therapy for hormone receptor (HR)-positive breast cancer or its prevention among those at high risk for breast cancer commonly have vasomotor symptoms. Data are lacking on the effects of elinzanetant, a neurokinin-targeted therapy shown to be effective in treating vasomotor symptoms, in this population.
89. Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer.
作者: Kohei Shitara.;Eric Van Cutsem.;Mahmut Gümüş.;Sara Lonardi.;Christelle de la Fouchardière.;Clélia Coutzac.;Jeroen Dekervel.;Daniel Hochhauser.;Lin Shen.;Wasat Mansoor.;Bo Liu.;Lorenzo Fornaro.;Min-Hee Ryu.;Jeeyun Lee.;Cátia Faustino.;Jean-Philippe Metges.;Josep Tabernero.;Fábio Franke.;Yelena Y Janjigian.;Fabricio Souza.;Lori Jukofsky.;Yumin Zhao.;Takahiro Kamio.;Aziz Zaanan.;Filippo Pietrantonio.; .
来源: N Engl J Med. 2025年
On the basis of phase 2 studies, trastuzumab deruxtecan was approved for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic gastric cancer or gastroesophageal junction adenocarcinoma who had previously received trastuzumab-based therapy. Ramucirumab plus paclitaxel is also a standard second-line treatment option regardless of HER2 status.
91. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer.
作者: Kerry S Courneya.;Janette L Vardy.;Christopher J O'Callaghan.;Sharlene Gill.;Christine M Friedenreich.;Rebecca K S Wong.;Haryana M Dhillon.;Victoria Coyle.;Neil S Chua.;Derek J Jonker.;Philip J Beale.;Kamal Haider.;Patricia A Tang.;Tony Bonaventura.;Ralph Wong.;Howard J Lim.;Matthew E Burge.;Stacey Hubay.;Michael Sanatani.;Kristin L Campbell.;Fernanda Z Arthuso.;Jane Turner.;Ralph M Meyer.;Michael Brundage.;Patti O'Brien.;Dongsheng Tu.;Christopher M Booth.; .
来源: N Engl J Med. 2025年
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking.
92. Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer.
作者: Elena Elez.;Takayuki Yoshino.;Lin Shen.;Sara Lonardi.;Eric Van Cutsem.;Cathy Eng.;Tae Won Kim.;Harpreet Singh Wasan.;Jayesh Desai.;Fortunato Ciardiello.;Rona Yaeger.;Timothy S Maughan.;Van K Morris.;Christina Wu.;Tiziana Usari.;Robert Laliberte.;Samuel S Dychter.;Xiaosong Zhang.;Josep Tabernero.;Scott Kopetz.; .
来源: N Engl J Med. 2025年
First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E-mutated metastatic colorectal cancer, an aggressive subtype with a poor prognosis, was compared with standard care (chemotherapy with or without bevacizumab) in an open-label, phase 3 trial, which showed significance regarding one of the two primary end points, objective response according to blinded independent central review (odds ratio for EC+mFOLFOX6 vs. standard care, 2.44; one-sided P<0.001). This result led to accelerated Food and Drug Administration approval of this investigational combination therapy for BRAF V600E-mutated metastatic colorectal cancer, including as first-line therapy. Data on progression-free survival (the second primary end point) and an updated interim analysis of overall survival are now available.
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