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81. Effectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease : A Randomized Controlled Trial.
作者: Keren Ladin.;Hocine Tighiouart.;Olivia Bronzi.;Susan Koch-Weser.;John B Wong.;Sarah Levine.;Arushi Agarwal.;Lucy Ren.;Jack Degnan.;Lexi N Sewall.;Brianna Kuramitsu.;Patrick Fox.;Elisa J Gordon.;Tamara Isakova.;Dena Rifkin.;Ana Rossi.;Daniel E Weiner.
来源: Ann Intern Med. 2023年176卷1期29-38页
Older patients with advanced chronic kidney disease (CKD) face difficult decisions about managing kidney failure, frequently experiencing decisional conflict, regret, and treatment misaligned with preferences.
82. Effect of Calorie-Unrestricted Low-Carbohydrate, High-Fat Diet Versus High-Carbohydrate, Low-Fat Diet on Type 2 Diabetes and Nonalcoholic Fatty Liver Disease : A Randomized Controlled Trial.
作者: Camilla Dalby Hansen.;Eva-Marie Gram-Kampmann.;Johanne Kragh Hansen.;Mie Balle Hugger.;Bjørn Stæhr Madsen.;Jane Møller Jensen.;Sara Olesen.;Nikolaj Torp.;Ditlev Nytoft Rasmussen.;Maria Kjærgaard.;Stine Johansen.;Katrine Prier Lindvig.;Peter Andersen.;Katrine Holtz Thorhauge.;Jan Christian Brønd.;Pernille Hermann.;Henning Beck-Nielsen.;Sönke Detlefsen.;Torben Hansen.;Kurt Højlund.;Maja Sofie Thiele.;Mads Israelsen.;Aleksander Krag.
来源: Ann Intern Med. 2023年176卷1期10-21页
It remains unclear if a low-carbohydrate, high-fat (LCHF) diet is a possible treatment strategy for type 2 diabetes mellitus (T2DM), and the effect on nonalcoholic fatty liver disease (NAFLD) has not been investigated.
83. Comparative Effectiveness of Team-Based Care With and Without a Clinical Decision Support System for Diabetes Management : A Cluster Randomized Trial.
作者: Xiulin Shi.;Jiang He.;Mingzhu Lin.;Changqin Liu.;Bing Yan.;Haiqu Song.;Caihong Wang.;Fangsen Xiao.;Peiying Huang.;Liying Wang.;Zhibin Li.;Yinxiang Huang.;Mulin Zhang.;Chung-Shiuan Chen.;Katherine Obst.;Lizheng Shi.;Weihua Li.;Shuyu Yang.;Guanhua Yao.;Xuejun Li.
来源: Ann Intern Med. 2023年176卷1期49-58页
Uncontrolled hyperglycemia, hypercholesterolemia, and hypertension are common in persons with diabetes.
84. Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease : A Post Hoc Analysis of DAPA-CKD.
作者: Meir Schechter.;Niels Jongs.;Glenn M Chertow.;Ofri Mosenzon.;John J V McMurray.;Ricardo Correa-Rotter.;Peter Rossing.;Anna Maria Langkilde.;C David Sjöström.;Robert D Toto.;David C Wheeler.;Hiddo J L Heerspink.
来源: Ann Intern Med. 2023年176卷1期59-66页
Acute hospitalizations are common in patients with chronic kidney disease (CKD) and often lead to decreases in health-related quality of life and increased care costs.
85. Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers : A Randomized Trial.
作者: Mark Loeb.;Amy Bartholomew.;Madiha Hashmi.;Wadea Tarhuni.;Mohamed Hassany.;Ilan Youngster.;Ranjani Somayaji.;Oscar Larios.;Joseph Kim.;Bayan Missaghi.;Joseph V Vayalumkal.;Dominik Mertz.;Zain Chagla.;Maureen Cividino.;Karim Ali.;Sarah Mansour.;Lana A Castellucci.;Charles Frenette.;Leighanne Parkes.;Mark Downing.;Matthew Muller.;Verne Glavin.;Jennifer Newton.;Ravi Hookoom.;Jerome A Leis.;James Kinross.;Stephanie Smith.;Sayem Borhan.;Pardeep Singh.;Eleanor Pullenayegum.;John Conly.
来源: Ann Intern Med. 2022年175卷12期1629-1638页
It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators.
86. Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis: A Randomized Controlled Trial.
作者: Andrew J Goldberg.;Kashfia Chowdhury.;Ekaterina Bordea.;Iva Hauptmannova.;James Blackstone.;Deirdre Brooking.;Elizabeth L Deane.;Stephen Bendall.;Andrew Bing.;Chris Blundell.;Sunil Dhar.;Andrew Molloy.;Steve Milner.;Mike Karski.;Steve Hepple.;Malik Siddique.;David T Loveday.;Viren Mishra.;Paul Cooke.;Paul Halliwell.;David Townshend.;Simon S Skene.;Caroline J Doré.; .;Rick Brown.;Michael Butler.;Carolyn Chadwick.;Tim Clough.;Nick Cullen.;Mark Davies.;Howard Davies.;Bill Harries.;Michael Khoo.;Nilesh Makwana.;An Murty.;Ali Najefi.;Paul O'Donnell.;Martin Raglan.;Rhys Thomas.;Paulo Torres.;Matthew Welck.;Ian Winson.;Razi Zaidi.
来源: Ann Intern Med. 2022年175卷12期1648-1657页
End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF).
87. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial.
作者: Michael Camilleri.;Thyagarajan Subramanian.;Fernando Pagan.;Stuart Isaacson.;Ramon Gil.;Robert A Hauser.;Mary Feldman.;Mark Goldstein.;Rajeev Kumar.;Daniel Truong.;Nisha Chhabria.;Benjamin L Walter.;Jonathan Eskenazi.;Robert Riesenberg.;Daniel Burdick.;Winona Tse.;Eric Molho.;Bradley Robottom.;Perminder Bhatia.;Srinath Kadimi.;Kevin Klos.;David Shprecher.;Otto Marquez-Mendoza.;Gonzalo Hidalgo.;Stephen Grill.;George Li.;Howard Mandell.;Mary Hughes.;Sharisse Stephenson.;Joel Vandersluis.;Michael Pfeffer.;Andrew Duker.;Vikram Shivkumar.;William Kinney.;James MacDougall.;Michael Zasloff.;Denise Barbut.
来源: Ann Intern Med. 2022年175卷12期1666-1674页
Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with PD.
88. Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations : A Randomized, Multicenter Trial.
作者: Jeff S Healey.;Andrew D Krahn.;Jamil Bashir.;Guy Amit.;François Philippon.;William F McIntyre.;Bernice Tsang.;Jacqueline Joza.;Derek V Exner.;David H Birnie.;Mouhannad Sadek.;Darryl P Leong.;Markus Sikkel.;Victoria Korley.;John L Sapp.;Jean-Francois Roux.;Shun Fu Lee.;Gloria Wong.;Angie Djuric.;Danna Spears.;Sandra Carroll.;Eugene Crystal.;Tom Hruczkowski.;Stuart J Connolly.;Blandine Mondesert.; .
来源: Ann Intern Med. 2022年175卷12期1658-1665页
Implantable cardioverter defibrillators (ICDs) improve survival in patients at risk for cardiac arrest, but are associated with intravascular lead-related complications. The subcutaneous ICD (S-ICD), with no intravascular components, was developed to minimize lead-related complications.
89. Ticagrelor-Aspirin Versus Clopidogrel-Aspirin Among CYP2C19 Loss-of-Function Carriers With Minor Stroke or Transient Ischemic Attack in Relation to Renal Function: A Post Hoc Analysis of the CHANCE-2 Trial.
作者: Anxin Wang.;Xuewei Xie.;Xue Tian.;S Claiborne Johnston.;Hao Li.;Philip M Bath.;Yingting Zuo.;Jing Jing.;Jinxi Lin.;Yilong Wang.;Xingquan Zhao.;Zixiao Li.;Yong Jiang.;Liping Liu.;Xia Meng.;Yongjun Wang.
来源: Ann Intern Med. 2022年175卷11期1534-1542页
Evidence on the risk-benefit ratio of dual antiplatelet therapies among patients with stroke and impaired renal function is limited and inconsistent.
90. Effectiveness of an Unsupervised Online Yoga Program on Pain and Function in People With Knee Osteoarthritis : A Randomized Clinical Trial.
作者: Kim L Bennell.;Sarah Schwartz.;Pek Ling Teo.;Stephanie Hawkins.;Dave Mackenzie.;Fiona McManus.;Karen E Lamb.;Alexander J Kimp.;Ben Metcalf.;David J Hunter.;Rana S Hinman.
来源: Ann Intern Med. 2022年175卷10期1345-1355页
Yoga is a mind-body exercise typically done in groups in person, but this delivery method can be inconvenient, inaccessible, and costly. Effective online programs may increase access to exercise for knee osteoarthritis.
91. Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.
作者: .;Christina Barkauskas.;Eleftherios Mylonakis.;Garyfallia Poulakou.;Barnaby E Young.;David M Vock.;Lianne Siegel.;Nicole Engen.;Greg Grandits.;Nilima R Mosaly.;Andrew M Vekstein.;Ralph Rogers.;Fadi Shehadeh.;Matthew Kaczynski.;Evangelia K Mylona.;Konstantinos N Syrigos.;Vasiliki Rapti.;David C Lye.;Diong Shiau Hui.;Lindsay Leither.;Kirk U Knowlton.;Mamta K Jain.;Rubria Marines-Price.;Alice Osuji.;J Scott Overcash.;Ioannis Kalomenidis.;Zafeiria Barmparessou.;Michael Waters.;Karla Zepeda.;Peter Chen.;Sam Torbati.;Francis Kiweewa.;Nicholus Sebudde.;Eyad Almasri.;Alyssa Hughes.;Sanjay R Bhagani.;Alison Rodger.;Uriel Sandkovsky.;Robert L Gottlieb.;Eriobu Nnakelu.;Barbara Trautner.;Vidya Menon.;Joseph Lutaakome.;Michael Matthay.;Philip Robinson.;Konstantinos Protopapas.;Nikolaos Koulouris.;Ivan Kimuli.;Amiran Baduashvili.;Dominique L Braun.;Huldrych F Günthard.;Srikanth Ramachandruni.;Robert Kidega.;Kami Kim.;Timothy J Hatlen.;Andrew N Phillips.;Daniel D Murray.;Tomas O Jensen.;Maria L Padilla.;Evan X Accardi.;Katy Shaw-Saliba.;Robin L Dewar.;Marc Teitelbaum.;Ven Natarajan.;Sylvain Laverdure.;Helene C Highbarger.;M Tauseef Rehman.;Susan Vogel.;David Vallée.;Page Crew.;Negin Atri.;Adam J Schechner.;Sarah Pett.;Fleur Hudson.;Jonathan Badrock.;Giota Touloumi.;Samuel M Brown.;Wesley H Self.;Crystal M North.;Adit A Ginde.;Christina C Chang.;Anthony Kelleher.;Stephanie Nagy-Agren.;Shikha Vasudeva.;David Looney.;Hien H Nguyen.;Adriana Sánchez.;Amy C Weintrob.;Birgit Grund.;Shweta Sharma.;Cavan S Reilly.;Roger Paredes.;Agnieszka Bednarska.;Norman P Gerry.;Abdel G Babiker.;Victoria J Davey.;Annetine C Gelijns.;Elizabeth S Higgs.;Virginia Kan.;Gail Matthews.;B Taylor Thompson.;Philippe Legenne.;Richa Chandra.;H Clifford Lane.;James D Neaton.;Jens D Lundgren.
来源: Ann Intern Med. 2022年175卷9期1266-1274页
Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection.
92. Effect of Social Needs Case Management on Hospital Use Among Adult Medicaid Beneficiaries : A Randomized Study.
作者: Daniel M Brown.;Elizabeth A Hernandez.;Sara Levin.;Mathijs De Vaan.;Mi-Ok Kim.;Chris Lynch.;Anna Roth.;Amanda L Brewster.
来源: Ann Intern Med. 2022年175卷8期1109-1117页
Case management programs assisting patients with social needs may improve health and avoid unnecessary health care use, but little is known about their effectiveness.
93. Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial.
作者: Dean Follmann.;Holly E Janes.;Olive D Buhule.;Honghong Zhou.;Bethany Girard.;Kristen Marks.;Karen Kotloff.;Michaël Desjardins.;Lawrence Corey.;Kathleen M Neuzil.;Jacqueline M Miller.;Hana M El Sahly.;Lindsey R Baden.
来源: Ann Intern Med. 2022年175卷9期1258-1265页
Immunoassays for determining past SARS-CoV-2 infection have not been systematically evaluated in vaccinated persons in comparison with unvaccinated persons.
94. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial.
作者: Mark D Neuman.;Rui Feng.;Susan S Ellenberg.;Frederick Sieber.;Daniel I Sessler.;Jay Magaziner.;Nabil Elkassabany.;Eric S Schwenk.;Derek Dillane.;Edward R Marcantonio.;Diane Menio.;Sabry Ayad.;Manal Hassan.;Trevor Stone.;Steven Papp.;Derek Donegan.;Mitchell Marshall.;J Douglas Jaffe.;Charles Luke.;Balram Sharma.;Syed Azim.;Robert Hymes.;Ki-Jinn Chin.;Richard Sheppard.;Barry Perlman.;Joshua Sappenfield.;Ellen Hauck.;Mark A Hoeft.;Ann Tierney.;Lakisha J Gaskins.;Annamarie D Horan.;Trina Brown.;James Dattilo.;Jeffrey L Carson.; .;Thomas Looke.;Sandra Bent.;Ariana Franco-Mora.;Pamela Hedrick.;Matthew Newbern.;Rafik Tadros.;Karen Pealer.;Kamen Vlassakov.;Carolyn Buckley.;Lauren Gavin.;Svetlana Gorbatov.;James Gosnell.;Talora Steen.;Avery Vafai.;Jose Zeballos.;Jennifer Hruslinski.;Louis Cardenas.;Ashley Berry.;John Getchell.;Nicholas Quercetti.;Gauasan Bajracharya.;Damien Billow.;Michael Bloomfield.;Evis Cuko.;Mehrun K Elyaderani.;Robert Hampton.;Hooman Honar.;Dilara Khoshknabi.;Daniel Kim.;David Krahe.;Michael M Lew.;Conjeevram B Maheshwer.;Azfar Niazi.;Partha Saha.;Ahmed Salih.;Robert J de Swart.;Andrew Volio.;Kelly Bolkus.;Matthew DeAngelis.;Gregory Dodson.;Jeffrey Gerritsen.;Brian McEniry.;Ludmil Mitrev.;M Kwesi Kwofie.;Anne Belliveau.;Flynn Bonazza.;Vera Lloyd.;Izabela Panek.;Jared Dabiri.;Chris Chavez.;Jason Craig.;Todd Davidson.;Chad Dietrichs.;Cheryl Fleetwood.;Mike Foley.;Chris Getto.;Susie Hailes.;Sarah Hermes.;Andy Hooper.;Greg Koener.;Kate Kohls.;Leslie Law.;Adam Lipp.;Allison Losey.;William Nelson.;Mario Nieto.;Pam Rogers.;Steve Rutman.;Garrett Scales.;Barbara Sebastian.;Tom Stanciu.;Gregg Lobel.;Michelle Giampiccolo.;Dara Herman.;Margit Kaufman.;Bryan Murphy.;Clara Pau.;Thomas Puzio.;Marlene Veselsky.;Kelly Apostle.;Dory Boyer.;Brenda Chen Fan.;Susan Lee.;Mike Lemke.;Richard Merchant.;Farhad Moola.;Kyrsten Payne.;Bertrand Perey.;Darius Viskontas.;Mark Poler.;Patricia D'Antonio.;Greg O'Neill.;Amer Abdullah.;Jamie Fish-Fuhrmann.;Mark Giska.;Christina Fidkowski.;Stuart Trent Guthrie.;William Hakeos.;Lillian Hayes.;Joseph Hoegler.;Katherine Nowak.;Jeffery Beck.;Jaslynn Cuff.;Greg Gaski.;Sharon Haaser.;Michael Holzman.;A Stephen Malekzadeh.;Lolita Ramsey.;Jeff Schulman.;Cary Schwartzbach.;Tangwan Azefor.;Arman Davani.;Mahmood Jaberi.;Courtney Masear.;Syed Basit Haider.;Carolyn Chungu.;Ali Ebrahimi.;Karim Fikry.;Andrew Marcantonio.;Anitha Shelvan.;David Sanders.;Collin Clarke.;Abdel Lawendy.;Gary Schwartz.;Mohit Garg.;Joseph Kim.;Juan Caruci.;Ekow Commeh.;Randy Cuevas.;Germaine Cuff.;Lola Franco.;David Furgiuele.;Matthew Giuca.;Melissa Allman.;Omid Barzideh.;James Cossaro.;Armando D'Arduini.;Anita Farhi.;Jason Gould.;John Kafel.;Anuj Patel.;Abraham Peller.;Hadas Reshef.;Mohammed Safur.;Fiore Toscano.;Tiffany Tedore.;Michael Akerman.;Eric Brumberger.;Sunday Clark.;Rachel Friedlander.;Anita Jegarl.;Joseph Lane.;John P Lyden.;Nili Mehta.;Matthew T Murrell.;Nathan Painter.;William Ricci.;Kaitlyn Sbrollini.;Rahul Sharma.;Peter A D Steel.;Michele Steinkamp.;Roniel Weinberg.;David Stephenson Wellman.;Antoun Nader.;Paul Fitzgerald.;Michaela Ritz.;Greg Bryson.;Alexandra Craig.;Cassandra Farhat.;Braden Gammon.;Wade Gofton.;Nicole Harris.;Karl Lalonde.;Allan Liew.;Bradley Meulenkamp.;Kendra Sonnenburg.;Eugene Wai.;Geoffrey Wilkin.;Karen Troxell.;Mary Ellen Alderfer.;Jason Brannen.;Christopher Cupitt.;Stacy Gerhart.;Renee McLin.;Julie Sheidy.;Katherine Yurick.;Fei Chen.;Karen Dragert.;Geza Kiss.;Halina Malveaux.;Deborah McCloskey.;Scott Mellender.;Sagar S Mungekar.;Helaine Noveck.;Carlos Sagebien.;Luat Biby.;Gail McKelvy.;Anna Richards.;Ramon Abola.;Brittney Ayala.;Darcy Halper.;Ana Mavarez.;Sabeen Rizwan.;Stephen Choi.;Imad Awad.;Brendan Flynn.;Patrick Henry.;Richard Jenkinson.;Lilia Kaustov.;Elizabeth Lappin.;Paul McHardy.;Amara Singh.;Joanne Donnelly.;Meera Gonzalez.;Christopher Haydel.;Jon Livelsberger.;Theresa Pazionis.;Bridget Slattery.;Maritza Vazquez-Trejo.;Jaime Baratta.;Michael Cirullo.;Brittany Deiling.;Laura Deschamps.;Michael Glick.;Daniel Katz.;James Krieg.;Jennifer Lessin.;Jeffrey Mojica.;Marc Torjman.;Rongyu Jin.;Mary Jane Salpeter.;Mark Powell.;Jeffrey Simmons.;Prentiss Lawson.;Promil Kukreja.;Shanna Graves.;Adam Sturdivant.;Ayesha Bryant.;Sandra Joyce Crump.;Michelle Verrier.;James Green.;Matthew Menon.;Richard Applegate.;Ana Arias.;Natasha Pineiro.;Jeffrey Uppington.;Phillip Wolinsky.;Amy Gunnett.;Jennifer Hagen.;Sara Harris.;Kevin Hollen.;Brian Holloway.;Mary Beth Horodyski.;Trevor Pogue.;Ramachandran Ramani.;Cameron Smith.;Anna Woods.;Matthew Warrick.;Kelly Flynn.;Paul Mongan.;Yatish Ranganath.;Sean Fernholz.;Esperanza Ingersoll-Weng.;Anil Marian.;Melinda Seering.;Zita Sibenaller.;Lori Stout.;Allison Wagner.;Alicia Walter.;Cynthia Wong.;Denise Orwig.;Maithri Goud.;Chris Helker.;Lydia Mezenghie.;Brittany Montgomery.;Peter Preston.;J Sanford Schwartz.;Ramona Weber.;Lee A Fleisher.;Samir Mehta.;Alisa J Stephens-Shields.;Cassandra Dinh.;Jacques E Chelly.;Shiv Goel.;Wende Goncz.;Touichi Kawabe.;Sharad Khetarpal.;Amy Monroe.;Vladislav Shick.;Max Breidenstein.;Timothy Dominick.;Alexander Friend.;Donald Mathews.;Richard Lennertz.;Robert Sanders.;Helen Akere.;Tyler Balweg.;Amber Bo.;Christopher Doro.;David Goodspeed.;Gerald Lang.;Maggie Parker.;Amy Rettammel.;Mary Roth.;Marissa White.;Paul Whiting.;Brian F S Allen.;Tracie Baker.;Debra Craven.;Matt McEvoy.;Teresa Turnbo.;Stephen Kates.;Melanie Morgan.;Teresa Willoughby.;Wade Weigel.;David Auyong.;Ellie Fox.;Tina Welsh.;Bruce Cusson.;Sean Dobson.;Christopher Edwards.;Lynette Harris.;Daryl Henshaw.;Kathleen Johnson.;Glen McKinney.;Scott Miller.;Jon Reynolds.;B Scott Segal.;Jimmy Turner.;David VanEenenaam.;Robert Weller.;Jineli Lei.;Miriam Treggiari.;Shamsuddin Akhtar.;Marcelle Blessing.;Chanel Johnson.;Michael Kampp.;Kimberly Kunze.;Mary O'Connor.;Thomas Looke.;Rafik Tadros.;Kamen Vlassakov.;Louis Cardenas.;Kelly Bolkus.;Ludmil Mitrev.;M Kwesi Kwofie.;Jared Dabiri.;Gregg Lobel.;Mark Poler.;Mark Giska.;David Sanders.;Gary Schwartz.;Matthew Giuca.;Tiffany Tedore.;Antoun Nader.;Greg Bryson.;Karen Troxell.;Geza Kiss.;Stephen Choi.;Mark Powell.;Richard Applegate.;Matthew Warrick.;Yatish Ranganath.;Jacques E Chelly.;Richard Lennertz.;Robert Sanders.;Brian F S Allen.;Stephen Kates.;Wade Weigel.;Jinlei Li.;Duminda N Wijeysundera.;Sachin Kheterpal.;Reneé H Moore.;Alexander K Smith.;Laura L Tosi.;Thomas Looke.;Samir Mehta.;Lee Fleisher.;Jennifer Hruslinski.;Lolita Ramsey.;Christine Langlois.;Lydia Mezenghie.;Brittany Montgomery.;Samuel Oduwole.;Thomas Rose.; .
来源: Ann Intern Med. 2022年175卷7期952-960页
The REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) trial found similar ambulation and survival at 60 days with spinal versus general anesthesia for hip fracture surgery. Trial outcomes evaluating pain, prescription analgesic use, and patient satisfaction have not yet been reported.
95. Effect of Molnupiravir on Biomarkers, Respiratory Interventions, and Medical Services in COVID-19 : A Randomized, Placebo-Controlled Trial.
作者: Matthew G Johnson.;Amy Puenpatom.;Pablo Andrés Moncada.;Lesley Burgess.;Elizabeth R Duke.;Norio Ohmagari.;Timo Wolf.;Matteo Bassetti.;Sanjay Bhagani.;Jade Ghosn.;Ying Zhang.;Hong Wan.;Angela Williams-Diaz.;Michelle L Brown.;Amanda Paschke.;Carisa De Anda.
来源: Ann Intern Med. 2022年175卷8期1126-1134页
In the MOVe-OUT trial, molnupiravir showed a clinically meaningful reduction in the risk for hospitalization or death in adults with mild to moderate COVID-19 and risk factors for progression to severe disease.
96. Accuracy and Efficiency of Machine Learning-Assisted Risk-of-Bias Assessments in "Real-World" Systematic Reviews : A Noninferiority Randomized Controlled Trial.
作者: Anneliese Arno.;James Thomas.;Byron Wallace.;Iain J Marshall.;Joanne E McKenzie.;Julian H Elliott.
来源: Ann Intern Med. 2022年175卷7期1001-1009页
Automation is a proposed solution for the increasing difficulty of maintaining up-to-date, high-quality health evidence. Evidence assessing the effectiveness of semiautomated data synthesis, such as risk-of-bias (RoB) assessments, is lacking.
97. Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction : A Post Hoc Analysis of the DAPA-HF Trial.
作者: Jawad H Butt.;Pooja Dewan.;Béla Merkely.;Jan Belohlávek.;Jarosław Drożdż.;Masafumi Kitakaze.;Silvio E Inzucchi.;Mikhail N Kosiborod.;Felipe A Martinez.;Sergey Tereshchenko.;Piotr Ponikowski.;Olof Bengtsson.;Daniel Lindholm.;Anna Maria Langkilde.;Morten Schou.;Mikaela Sjöstrand.;Scott D Solomon.;Marc S Sabatine.;Chern-En Chiang.;Kieran F Docherty.;Pardeep S Jhund.;Lars Køber.;John J V McMurray.
来源: Ann Intern Med. 2022年175卷6期820-830页
Frailty may modify the risk-benefit profile of certain treatments, and frail patients may have reduced tolerance to treatments.
98. Mortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation.
作者: Mikkel Pretorius.;Karolina Lundstam.;Ansgar Heck.;Morten W Fagerland.;Kristin Godang.;Charlotte Mollerup.;Stine L Fougner.;Ylva Pernow.;Turid Aas.;Ola Hessman.;Thord Rosén.;Jörgen Nordenström.;Svante Jansson.;Mikael Hellström.;Jens Bollerslev.
来源: Ann Intern Med. 2022年175卷6期812-819页
Primary hyperparathyroidism (PHPT) is a common endocrine disorder associated with increased risk for fractures, cardiovascular disease, kidney disease, and cancer and increased mortality. In mild PHPT with modest hypercalcemia and without known morbidities, parathyroidectomy (PTX) is debated because no long-term randomized trials have been performed.
99. Safety of Ceasing Aspirin Used Without a Clinical Indication After Age 70 Years: A Subgroup Analysis of the ASPREE Randomized Trial.
作者: Mark R Nelson.;Galina Polekhina.;Robyn L Woods.;Christopher M Reid.;Andrew M Tonkin.;Rory Wolfe.;Anne M Murray.;Brenda Kirpach.;Michael E Ernst.;Jessica E Lockery.;Raj C Shah.;Nigel Stocks.;Suzanne G Orchard.;Zhen Zhou.
来源: Ann Intern Med. 2022年175卷5期761-764页 100. The Incidence of SARS-CoV-2 Reinfection in Persons With Naturally Acquired Immunity With and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine : A Retrospective Cohort Study.
作者: Sivan Gazit.;Roei Shlezinger.;Galit Perez.;Roni Lotan.;Asaf Peretz.;Amir Ben-Tov.;Esma Herzel.;Hillel Alapi.;Dani Cohen.;Khitam Muhsen.;Gabriel Chodick.;Tal Patalon.
来源: Ann Intern Med. 2022年175卷5期674-681页
There is insufficient evidence regarding the magnitude and durability of protection conferred by a combined effect of naturally acquired immunity after SARS-CoV-2 infection and vaccine-induced immunity.
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