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9801. Catheter-based endomyocardial injection with real-time magnetic resonance imaging.
作者: Robert J Lederman.;Michael A Guttman.;Dana C Peters.;Richard B Thompson.;Jonathan M Sorger.;Alexander J Dick.;Venkatesh K Raman.;Elliot R McVeigh.
来源: Circulation. 2002年105卷11期1282-4页
We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI).
9802. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.
Complex physiological interactions determine the functional consequences of gene abnormalities and make mechanistic interpretation of phenotypes extremely difficult. A recent example is a single mutation in the C terminus of the cardiac Na(+) channel, 1795insD. The mutation causes two distinct clinical syndromes, long QT (LQT) and Brugada, leading to life-threatening cardiac arrhythmias. Coexistence of these syndromes is seemingly paradoxical; LQT is associated with enhanced Na(+) channel function, and Brugada with reduced function.
9803. Validation of collateral fractional flow reserve by myocardial perfusion imaging.
作者: Hitoshi Matsuo.;Sachiro Watanabe.;Tohru Kadosaki.;Takahiko Yamaki.;Shinichiro Tanaka.;Shuusaku Miyata.;Tomonori Segawa.;Yukihiko Matsuno.;Masaaki Tomita.;Hisayoshi Fujiwara.
来源: Circulation. 2002年105卷9期1060-5页
Collateral fractional flow reserve (FFR(coll)) is an index to quantify collateral blood flow, derived from coronary pressure measurements. Although well defined theoretically, its direct validation by myocardial perfusion imaging has not been established so far. Validating this index by myocardial perfusion imaging is the main aim of this study.
9804. Targeting phospholamban by gene transfer in human heart failure.
作者: Federica del Monte.;Sian E Harding.;G William Dec.;Judith K Gwathmey.;Roger J Hajjar.
来源: Circulation. 2002年105卷8期904-7页
Myocardial cells from failing human hearts are characterized by abnormal calcium handling, a negative force-frequency relationship, and decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) activity. In this study, we tested whether contractile function can be improved by decreasing the inhibitory effects of phospholamban on SERCA2a with adenoviral gene transfer of antisense phospholamban (asPL).
9805. Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial.
作者: Daniel Skudicky.;Pinhas Sareli.;Elena Libhaber.;Geoffrey Candy.;Ivo Radevski.;Zdravska Valtchanova.;Elizabeth Tshele.;Lutgarde Thijs.;Ji-Guang Wang.;Jan A Staessen.
来源: Circulation. 2002年105卷7期830-6页
In a single-center study, we compared to what extent changes in conventional and ambulatory blood pressure (BP) predicted regression of left ventricular mass (LVM) index in response to antihypertensive treatment in previously untreated and treated patients with sustained hypertension.
9806. Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering.
作者: Stephanie H Wilson.;Joerg Herrmann.;Lilach O Lerman.;David R Holmes.;Claudio Napoli.;Erik L Ritman.;Amir Lerman.
来源: Circulation. 2002年105卷4期415-8页
Previous studies have demonstrated that experimental hypercholesterolemia leads to neovascularization in the coronary artery vasa vasorum (VV). Recent evidence suggests that HMG-CoA reductase inhibitors (statins) have beneficial effects independent of lipid lowering. We aimed to determine the effect of simvastatin on coronary VV neovascularization, in the absence of cholesterol lowering.
9807. Passage of inhaled particles into the blood circulation in humans.
作者: A Nemmar.;P H M Hoet.;B Vanquickenborne.;D Dinsdale.;M Thomeer.;M F Hoylaerts.;H Vanbilloen.;L Mortelmans.;B Nemery.
来源: Circulation. 2002年105卷4期411-4页
Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated.
9808. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
作者: Giovanni Esposito.;Antonio Rapacciuolo.;Sathyamangla V Naga Prasad.;Hideyuki Takaoka.;Steven A Thomas.;Walter J Koch.;Howard A Rockman.
来源: Circulation. 2002年105卷1期85-92页
A long-standing hypothesis has been that hypertrophy is compensatory and by normalizing wall stress acts to maintain normal cardiac function. Epidemiological data, however, have shown that cardiac hypertrophy is associated with increased mortality, thus casting doubt on the validity of this hypothesis.
9809. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.
作者: Sagar N Doshi.;Ian F W McDowell.;Stuart J Moat.;Nicola Payne.;Hilary J Durrant.;Malcolm J Lewis.;Jonathan Goodfellow.
来源: Circulation. 2002年105卷1期22-6页
Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact that plasma homocysteine can be safely and inexpensively reduced by 25% with folic acid. This reduction is maximally achieved by doses of 0.4 mg/d. High-dose folic acid (5 mg/d) improves endothelial function in CAD, although the mechanism is controversial. It has been proposed that improvement occurs through reduction in total (tHcy) or free (non-protein bound) homocysteine (fHcy). We investigated the effects of folic acid on endothelial function before a change in homocysteine in patients with CAD.
9810. Comparative efficacy of gamma-irradiation for treatment of in-stent restenosis in saphenous vein graft versus native coronary artery in-stent restenosis: An intravascular ultrasound study.
作者: M T Castagna.;G S Mintz.;R Waksman.;J M Ahmed.;A Maehara.;A E Ajani.;A B Bui.;L F Satler.;W O Suddath.;K M Kent.;A D Pichard.;N J Weissman.
来源: Circulation. 2001年104卷25期3020-2页
We used serial volumetric (post-irradiation and follow-up) intravascular ultrasound (IVUS) to compare the effectiveness of gamma-irradiation ((192)Ir) in saphenous vein graft (SVG) versus native coronary artery in-stent restenosis (ISR).
9811. Clinical and angiographic factors associated with asymptomatic restenosis after percutaneous coronary intervention.
作者: P N Ruygrok.;M W Webster.;V de Valk.;G A van Es.;J A Ormiston.;M A Morel.;P W Serruys.
来源: Circulation. 2001年104卷19期2289-94页
Angiographic restenosis after percutaneous coronary interventional procedures is more common than recurrent angina. Clinical and angiographic factors associated with asymptomatic versus symptomatic restenosis after percutaneous coronary intervention were compared.
9812. Vitamin C inhibits endothelial cell apoptosis in congestive heart failure.
作者: L Rössig.;J Hoffmann.;B Hugel.;Z Mallat.;A Haase.;J M Freyssinet.;A Tedgui.;A Aicher.;A M Zeiher.;S Dimmeler.
来源: Circulation. 2001年104卷18期2182-7页
Proinflammatory cytokines like tumor necrosis factor-alpha and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced EC apoptosis and the development of endothelial dysfunction. Therefore, we investigated the effects of antioxidative vitamin C therapy on EC apoptosis in CHF patients.
9813. Real-time quantification and display of skin radiation during coronary angiography and intervention.
Radiographically guided investigations may be associated with excessive radiation exposure, which may cause skin injuries. The purpose of this study was to develop and test a system that measures in real time the dose applied to each 1-cm(2) area of skin, taking into account the movement of the x-ray source and changes in the beam characteristics. The goal of such a system is to help prevent high doses that might cause skin injury.
9814. Influence of atrial fibrillation on outcome following mitral valve repair.
作者: E Lim.;C W Barlow.;A R Hosseinpour.;C Wisbey.;K Wilson.;W Pidgeon.;S Charman.;J B Barlow.;F C Wells.
来源: Circulation. 2001年104卷12 Suppl 1期I59-63页
To investigate the outcome of patients in atrial fibrillation (AF) following mitral valve repair, clinical and echocardiographic follow-up was undertaken in 400 consecutive patients who underwent mitral valvuloplasty from 1987 to 1999.
9815. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure.
作者: F del Monte.;E Williams.;D Lebeche.;U Schmidt.;A Rosenzweig.;J K Gwathmey.;E D Lewandowski.;R J Hajjar.
来源: Circulation. 2001年104卷12期1424-9页
In heart failure, sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling and contractile dysfunction. We have previously shown that increasing SERCA2a expression by gene transfer improves ventricular function in a rat model of heart failure created by ascending aortic constriction.
9817. Clinical and economic impact of diabetes mellitus on percutaneous and surgical treatment of multivessel coronary disease patients: insights from the Arterial Revascularization Therapy Study (ARTS) trial.
作者: A Abizaid.;M A Costa.;M Centemero.;A S Abizaid.;V M Legrand.;R V Limet.;G Schuler.;F W Mohr.;W Lindeboom.;A G Sousa.;J E Sousa.;B van Hout.;P G Hugenholtz.;F Unger.;P W Serruys.; .
来源: Circulation. 2001年104卷5期533-8页
Our aims were to compare coronary artery bypass grafting (CABG) and stenting for the treatment of diabetic patients with multivessel coronary disease enrolled in the Arterial Revascularization Therapy Study (ARTS) trial and to determine the costs of these 2 treatment strategies.
9819. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.
作者: R Patel.;S F Nagueh.;N Tsybouleva.;M Abdellatif.;S Lutucuta.;H A Kopelen.;M A Quinones.;W A Zoghbi.;M L Entman.;R Roberts.;A J Marian.
来源: Circulation. 2001年104卷3期317-24页
Hypertrophic cardiomyopathy is a genetic disease characterized by cardiac hypertrophy, myocyte disarray, interstitial fibrosis, and left ventricular (LV) dysfunction. We have proposed that hypertrophy and fibrosis, the major determinants of mortality and morbidity, are potentially reversible. We tested this hypothesis in beta-myosin heavy chain-Q(403) transgenic rabbits.
9820. Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function: the prospective P(2)C(2) HIV study.
作者: S E Lipshultz.;K A Easley.;E J Orav.;S Kaplan.;T J Starc.;J T Bricker.;W W Lai.;D S Moodie.;G Sopko.;M D Schluchter.;S D Colan.
来源: Circulation. 2001年104卷3期310-6页
To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility.
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