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9761. Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes.
作者: Cornel Badorff.;Ralf P Brandes.;Rüdiger Popp.;Stefan Rupp.;Carmen Urbich.;Alexandra Aicher.;Ingrid Fleming.;Rudi Busse.;Andreas M Zeiher.;Stefanie Dimmeler.
来源: Circulation. 2003年107卷7期1024-32页
Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial progenitor cells (EPCs) is unknown.
9762. Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels.
作者: Ricardo Caballero.;Ignacio Moreno.;Teresa González.;Cristina Arias.;Carmen Valenzuela.;Eva Delpón.;Juan Tamargo.
来源: Circulation. 2003年107卷6期889-95页
It has been demonstrated that spironolactone (SP) decreases the QT dispersion in chronic heart failure. In this study, the effects of SP and its metabolite, canrenoic acid (CA), on human ether-a-go-go-related gene (HERG) currents were analyzed.
9763. Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?
作者: Victor A Medina-Ravell.;Ramarao S Lankipalli.;Gan-Xin Yan.;Charles Antzelevitch.;Napoleon A Medina-Malpica.;Otto A Medina-Malpica.;Christopher Droogan.;Peter R Kowey.
来源: Circulation. 2003年107卷5期740-6页
The present study examined pacing site-dependent changes in QT interval and transmural dispersion of repolarization (TDR) and their potential role in the development of torsade de pointes (TdP).
9765. Myocardial production of C-type natriuretic peptide in chronic heart failure.
作者: Paul R Kalra.;Jonathon R Clague.;Aidan P Bolger.;Stefan D Anker.;Phillip A Poole-Wilson.;Allan D Struthers.;Andrew J Coats.
来源: Circulation. 2003年107卷4期571-3页
C-type natriuretic peptide (CNP) is a vasodilator produced by the vascular endothelium. It shares structural and physiological properties with the cardiac hormones atrial natriuretic peptide and brain natriuretic peptide (BNP), but little is known about its pathophysiological role in chronic heart failure (CHF). We assessed the hypothesis that CNP is produced by the heart in patients with CHF.
9766. Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries.
作者: J Eduardo Sousa.;Marco A Costa.;Amanda G M R Sousa.;Alexandre C Abizaid.;Ana C Seixas.;Andrea S Abizaid.;Fausto Feres.;Luiz A Mattos.;Robert Falotico.;Judith Jaeger.;Jeffrey J Popma.;Patrick W Serruys.
来源: Circulation. 2003年107卷3期381-3页
The safety and efficacy of sirolimus-eluting stenting have been demonstrated, but the outcome of patients treated with this novel technology beyond the first year remains unknown. We sought to evaluate the angiographic, intravascular ultrasound (IVUS), and clinical outcomes of patients treated with sirolimus-eluting stents 2 years after implantation.
9767. Positron-emission tomography reporter gene expression imaging in rat myocardium.
作者: Masayuki Inubushi.;Joseph C Wu.;Sanjiv S Gambhir.;Gobalakrishnan Sundaresan.;Nagichettiar Satyamurthy.;Mohammad Namavari.;Simon Yee.;Jorge R Barrio.;David Stout.;Arion F Chatziioannou.;Lily Wu.;Heinrich R Schelbert.
来源: Circulation. 2003年107卷2期326-32页
This study examines the quantitative accuracy, detection sensitivity, and time course of imaging the expression of a mutant herpes simplex type-1 virus thymidine kinase (HSV1-sr39tk) PET reporter gene in rat myocardium by using the PET reporter probe 9-(4-[18F]-Fluoro-3-Hydroxymethylbutyl)-Guanine ([18F]-FHBG) and a small-animal PET (microPET).
9768. C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study.
作者: Mary S Beattie.;Michael G Shlipak.;Haiying Liu.;Warren S Browner.;Nelson B Schiller.;Mary A Whooley.
来源: Circulation. 2003年107卷2期245-50页
Elevated levels of C-reactive protein (CRP) are associated with an increased risk of coronary events, but whether inflammation is associated with inducible ischemia in patients with stable coronary disease is unknown.
9769. Sirolimus-eluting stent for the treatment of in-stent restenosis: a quantitative coronary angiography and three-dimensional intravascular ultrasound study.
作者: J Eduardo Sousa.;Marco A Costa.;Alexandre Abizaid.;Amanda G M R Sousa.;Fausto Feres.;Luiz A Mattos.;Marinella Centemero.;Galo Maldonado.;Andrea S Abizaid.;Ibraim Pinto.;Robert Falotico.;Judith Jaeger.;Jeffrey J Popma.;Patrick W Serruys.
来源: Circulation. 2003年107卷1期24-7页
We have previously reported the safety and effectiveness of sirolimus-eluting stents for the treatment of de novo coronary lesions. The present investigation explored the potential of this technology to treat in-stent restenosis.
9770. S-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty.
作者: Zoltan Kaposzta.;Andrew Clifton.;Jane Molloy.;John F Martin.;Hugh S Markus.
来源: Circulation. 2002年106卷24期3057-62页
The major complication of carotid angioplasty is embolic stroke, which may occur after balloon inflation and deflation or in the early postintervention period. Platelet adhesion and aggregation to the angioplasty site with subsequent embolization seems to plays a major role in early postangioplasty embolization and stroke. During this period, asymptomatic embolic signals can be detected in patients by transcranial Doppler ultrasound despite aspirin and heparin treatment. S-nitrosoglutathione (GSNO) is a nitric oxide donor that appears to have relative platelet specificity. We evaluated its effectiveness in reducing embolization after carotid angioplasty.
9771. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines.
作者: Hiroyasu Uzui.;Alice Harpf.;Ming Liu.;Terence M Doherty.;Arun Shukla.;Ning-Ning Chai.;Pinky V Tripathi.;Stefan Jovinge.;Douglas J Wilkin.;Kamlesh Asotra.;Prediman K Shah.;Tripathi B Rajavashisth.
来源: Circulation. 2002年106卷24期3024-30页
Matrix metalloproteinases (MMPs) are thought to play a prominent role in atherogenesis and destabilization of plaque. Pericellularly localized membrane-type (MT)-MMPs activate secreted MMPs. We investigated the hypothesis that MT3-MMP is expressed in human atherosclerotic plaques and is regulated by locally produced inflammatory cytokines and oxidized low-density lipoprotein (Ox-LDL).
9772. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI).
作者: Birgit Assmus.;Volker Schächinger.;Claudius Teupe.;Martina Britten.;Ralf Lehmann.;Natascha Döbert.;Frank Grünwald.;Alexandra Aicher.;Carmen Urbich.;Hans Martin.;Dieter Hoelzer.;Stefanie Dimmeler.;Andreas M Zeiher.
来源: Circulation. 2002年106卷24期3009-17页
Experimental studies suggest that transplantation of blood-derived or bone marrow-derived progenitor cells beneficially affects postinfarction remodeling. The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown.
9773. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction.
作者: Ellen O Weinberg.;Masahisa Shimpo.;Gilles W De Keulenaer.;Catherine MacGillivray.;Shin-ichi Tominaga.;Scott D Solomon.;Jean-Lucien Rouleau.;Richard T Lee.
来源: Circulation. 2002年106卷23期2961-6页
We identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized that ST2 participates in the acute myocardial response to stress and injury.
9774. Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting.
作者: Luisa Gregorini.;Jean Marco.;Bruno Farah.;Monique Bernies.;Carlo Palombo.;Michaela Kozàkovà.;Irene M Bossi.;Bernard Cassagneau.;Jean Fajadet.;Carlo Di Mario.;Remo Albiero.;Massimo Cugno.;Adalberto Grossi.;Gerd Heusch.
来源: Circulation. 2002年106卷23期2901-7页
Coronary flow reserve (CFR) is not normalized shortly after coronary stenting. We hypothesized that alpha-adrenergic coronary vasoconstriction acts to limit CFR.
9775. Transient limb ischemia induces remote ischemic preconditioning in vivo.
作者: R K Kharbanda.;U M Mortensen.;P A White.;S B Kristiansen.;M R Schmidt.;J A Hoschtitzky.;M Vogel.;K Sorensen.;A N Redington.;R MacAllister.
来源: Circulation. 2002年106卷23期2881-3页
Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size.
9776. Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall.
作者: Massimo Porqueddu.;Rita Spirito.;Alessandro Parolari.;Marco Zanobini.;Giulio Pompilio.;Gianluca Polvani.;Francesco Alamanni.;Davide Stangalini.;Elena Tremoli.;Paolo Biglioli.
来源: Circulation. 2002年106卷21期2647-8页
Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm.
9778. Beta2 integrin-dependent neutrophil adhesion induced by minimally modified low-density lipoproteins is mainly mediated by F2-isoprostanes.
作者: Luigi Fontana.;Cinzia Giagulli.;Luciano Cominacini.;Anna Fratta Pasini.;Pietro Minuz.;Alessandro Lechi.;Angelo Sala.;Carlo Laudanna.
来源: Circulation. 2002年106卷19期2434-41页
Oxidation of LDL produces a series of biologically active, oxidized lipids. Among them, isoprostanes, and in particular iPF(2alpha)-III, seem to be crucial in mediating some of the key cellular events seen in myocardial ischemia-reperfusion injury.
9780. Anatomic variability in coronary arterial distribution with regard to the arterial switch procedure.
作者: Parwis Massoudy.;Ahmet Baltalarli.;Marc R de Leval.;Andrew Cook.;Ulrich Neudorf.;Graham Derrick.;Karen P McCarthy.;Robert H Anderson.
来源: Circulation. 2002年106卷15期1980-4页
We investigated the coronary arterial origins and course and the position of the great arteries in hearts with discordant ventriculoarterial connections. At the same time, we sought to evaluate the practicality of alphanumeric classifications in accounting for surgically relevant features of the coronary arteries.
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