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9741. Randomized evaluation of polytetrafluoroethylene-covered stent in saphenous vein grafts: the Randomized Evaluation of polytetrafluoroethylene COVERed stent in Saphenous vein grafts (RECOVERS) Trial.
作者: Goran Stankovic.;Antonio Colombo.;Patrizia Presbitero.;Frank van den Branden.;Luigi Inglese.;Carmelo Cernigliaro.;Luigi Niccoli.;Antonio L Bartorelli.;Paolo Rubartelli.;Nicholaus Reifart.;Guy R Heyndrickx.;Kari Saunamäki.;Marie Claude Morice.;Fabio A Sgura.;Carlo Di Mario.; .
来源: Circulation. 2003年108卷1期37-42页
Treatment of lesions located in saphenous vein grafts (SVGs) is associated with increased procedural risk and a high rate of restenosis.
9742. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy.
作者: F Sennlaub.;F Valamanesh.;A Vazquez-Tello.;A M El-Asrar.;D Checchin.;S Brault.;F Gobeil.;M H Beauchamp.;B Mwaikambo.;Y Courtois.;K Geboes.;D R Varma.;P Lachapelle.;H Ong.;F Behar-Cohen.;S Chemtob.
来源: Circulation. 2003年108卷2期198-204页
Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy.
9743. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events.
作者: Paul V Targonski.;Piero O Bonetti.;Geralyn M Pumper.;Stuart T Higano.;David R Holmes.;Amir Lerman.
来源: Circulation. 2003年107卷22期2805-9页
Stroke, mainly attributable to atherothrombotic disease, represents a leading cause of disability and death in the Western world. Endothelial dysfunction, which is considered a key factor in atherogenesis, is associated with an increased risk of cardiovascular events. However, the magnitude of the association between coronary endothelial dysfunction (CED) and cerebrovascular events is unknown. This study was performed to investigate the association between CED and cerebrovascular events.
9744. In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction.
作者: Dara L Kraitchman.;Alan W Heldman.;Ergin Atalar.;Luciano C Amado.;Bradley J Martin.;Mark F Pittenger.;Joshua M Hare.;Jeff W M Bulte.
来源: Circulation. 2003年107卷18期2290-3页
We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model.
9745. Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation.
作者: Sander Verheule.;Emily Wilson.;Thomas Everett.;Sujata Shanbhag.;Catherine Golden.;Jeffrey Olgin.
来源: Circulation. 2003年107卷20期2615-22页
Clinically, chronic atrial dilatation is associated with an increased incidence of atrial fibrillation (AF), but the underlying mechanism is not clear. We have investigated atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation (MR).
9747. Human aortic valve calcification is associated with an osteoblast phenotype.
作者: Nalini M Rajamannan.;Malayannan Subramaniam.;David Rickard.;Stuart R Stock.;Janis Donovan.;Margaret Springett.;Thomas Orszulak.;David A Fullerton.;A J Tajik.;Robert O Bonow.;Thomas Spelsberg.
来源: Circulation. 2003年107卷17期2181-4页
Calcific aortic stenosis is the third most common cardiovascular disease in the United States. We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like phenotype.
9748. Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis.
作者: Giovanni Palladini.;Carlo Campana.;Catherine Klersy.;Alessandra Balduini.;Giovanbattista Vadacca.;Vittorio Perfetti.;Stefano Perlini.;Laura Obici.;Edoardo Ascari.;Gianvico Melzi d'Eril.;Remigio Moratti.;Giampaolo Merlini.
来源: Circulation. 2003年107卷19期2440-5页
Brain natriuretic peptide (BNP) is a marker of ventricular dysfunction and can be used to assess prognosis in heart failure and after myocardial infarction. Heart involvement is the most important prognostic factor and causes death in almost all patients with light-chain amyloidosis (AL). We investigated the prognostic value of NT-proBNP and its utility in monitoring amyloid heart dysfunction.
9749. Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging.
作者: Stefan D Anker.;Wolfram Doehner.;Mathias Rauchhaus.;Rakesh Sharma.;Darrel Francis.;Christoph Knosalla.;Constantinos H Davos.;Mariantonietta Cicoira.;Waqar Shamim.;Michel Kemp.;Robert Segal.;Karl Josef Osterziel.;Francisco Leyva.;Roland Hetzer.;Piotr Ponikowski.;Andrew J S Coats.
来源: Circulation. 2003年107卷15期1991-7页
Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF).
9750. Strain-rate imaging during dobutamine stress echocardiography provides objective evidence of inducible ischemia.
作者: Jens-Uwe Voigt.;Bert Exner.;Kristin Schmiedehausen.;Cord Huchzermeyer.;Udo Reulbach.;Uwe Nixdorff.;Günther Platsch.;Torsten Kuwert.;Werner G Daniel.;Frank A Flachskampf.
来源: Circulation. 2003年107卷16期2120-6页
Interpretation of dobutamine stress echocardiography (DSE) is subjective and strongly dependent on the skills of the reader. Strain-rate imaging (SRI) by tissue Doppler may objectively analyze regional myocardial function. This study investigated SRI markers of stress-induced ischemia and analyzed their applicability in a clinical setting.
9751. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling.
作者: Alexandra Aicher.;Winfried Brenner.;Maaz Zuhayra.;Cornel Badorff.;Schirin Massoudi.;Birgit Assmus.;Thomas Eckey.;Eberhard Henze.;Andreas M Zeiher.;Stefanie Dimmeler.
来源: Circulation. 2003年107卷16期2134-9页
Transplantation of endothelial progenitor cells (EPCs) improves vascularization and left ventricular function after experimental myocardial ischemia. However, tissue distribution of transplanted EPCs has not yet been monitored in living animals. Therefore, we tested whether radioactive labeling allows us to detect injected EPCs.
9752. Angiographic assessment of reperfusion in acute myocardial infarction by myocardial blush grade.
作者: Jose P S Henriques.;Felix Zijlstra.;Arnoud W J van 't Hof.;Menko-Jan de Boer.;Jan-Henk E Dambrink.;Marcel Gosselink.;Jan C A Hoorntje.;Harry Suryapranata.
来源: Circulation. 2003年107卷16期2115-9页
Angiographic successful reperfusion in acute myocardial infarction has been defined as TIMI 3 flow. However, TIMI 3 flow does not always result in effective myocardial reperfusion. Myocardial blush grade (MBG) is an angiographic measure of myocardial perfusion. We hypothesized that optimal angiographic reperfusion is defined by TIMI 3 flow and MBG 2 or 3.
9753. Left atrial volume: a powerful predictor of survival after acute myocardial infarction.
作者: Jacob E Moller.;Graham S Hillis.;Jae K Oh.;James B Seward.;Guy S Reeder.;R Scott Wright.;Seung W Park.;Kent R Bailey.;Patricia A Pellikka.
来源: Circulation. 2003年107卷17期2207-12页
After acute myocardial infarction (AMI), diastolic function assessed by Doppler echocardiography provides important prognostic information that is incremental to systolic function. However, Doppler variables are affected by multiple factors and may change rapidly. In contrast, left atrial (LA) volume is less influenced by acute changes and reflects subacute or chronic diastolic function. This may be of importance when one assesses risk in patients with AMI.
9754. Early detection of Fabry cardiomyopathy by tissue Doppler imaging.
作者: Maurizio Pieroni.;Cristina Chimenti.;Roberta Ricci.;Patrizio Sale.;Matteo Antonio Russo.;Andrea Frustaci.
来源: Circulation. 2003年107卷15期1978-84页
Fabry cardiomyopathy is diagnosed by detection of left ventricular hypertrophy (LVH) in patients with alpha-Galactosidase A deficiency. Conventional noninvasive tools are unable to provide a preclinical diagnosis allowing prompt institution of enzymatic therapy.
9755. Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping.
作者: Rishi Arora.;Sander Verheule.;Luis Scott.;Antonio Navarrete.;Vikram Katari.;Emily Wilson.;Dev Vaz.;Jeffrey E Olgin.
来源: Circulation. 2003年107卷13期1816-21页
It has recently been recognized that atrial fibrillation can originate from focal sources in the pulmonary veins (PVs). However, the mechanisms of focal atrial fibrillation have not been well characterized. We assessed the electrophysiological characteristics of the PVs using high-resolution optical mapping.
9756. Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis.
作者: Abderrahim Nemmar.;Peter H M Hoet.;David Dinsdale.;Jozef Vermylen.;Marc F Hoylaerts.;Benoit Nemery.
来源: Circulation. 2003年107卷8期1202-8页
Pollution by particulates has consistently been associated with increased cardiovascular morbidity and mortality, but a plausible biological basis for this association is lacking.
9757. Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia.
作者: Francesca I Arrigoni.;Patrick Vallance.;Sheila G Haworth.;James M Leiper.
来源: Circulation. 2003年107卷8期1195-201页
Nitric oxide (NO) plays an important part in lowering pulmonary vascular resistance after birth, and in persistent pulmonary hypertension of the newborn (PPHN), NO-mediated dilation is dysfunctional. The endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) circulates in plasma, and its concentrations are elevated in certain cardiovascular diseases, including pulmonary hypertension. ADMA is metabolized by the enzyme dimethylarginine dimethylaminohydrolase (DDAH), the activity of which regulates ADMA concentrations and provides a mechanism for modulating NO synthase in vivo. We investigated the changes in expression and activity of the 2 isoforms of DDAH in lungs from newborn piglets both during normal development and in PPHN.
9758. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
作者: Norihito Sasaki.;Mitsushige Murata.;Yiru Guo.;Su-Hyun Jo.;Andreas Ohler.;Masaharu Akao.;Brian O'Rourke.;Rui-Ping Xiao.;Roberto Bolli.;Eduardo Marbán.
来源: Circulation. 2003年107卷8期1183-8页
MCC-134 (1-[4-(H-imidazol-1-yl)benzoyl]-N-methylcyclobutane-carbothioamide), a newly developed analog of aprikalim, opens surface smooth muscle-type ATP-sensitive potassium (K(ATP)) channels but inhibits pancreatic K(ATP) channels. However, the effects of MCC-134 on cardiac surface K(ATP) channels and mitochondrial K(ATP) (mitoK(ATP)) channels are unknown. A mixed agonist/blocker with differential effects on the two channel types would help to clarify the role of K(ATP) channels in cardioprotection.
9759. Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes.
作者: Catherine Communal.;Fawzia Huq.;Djamel Lebeche.;Celine Mestel.;Judith K Gwathmey.;Roger J Hajjar.
来源: Circulation. 2003年107卷8期1170-5页
Aging is an independent risk factor for the development of cardiovascular disease. Clinical application of myocardial gene transfer may be best suited in the elderly. In vivo gene transfer by adenovirus is less efficient in aging myocardium.
9760. No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age.
We investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic predisposition to a prothrombotic state.
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