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941. High antibody response in relation to immunosuppressive blood levels in liver transplant recipients after SARS-CoV-2 vaccination: an observational, cohort study.
作者: Midas B Mulder.;Annemiek A van der Eijk.;Corine H GeurtsvanKessel.;Nicole S Erler.;Brenda C M de Winter.;Wojciech G Polak.;Herold J Metselaar.;Caroline M den Hoed.
来源: Gut. 2022年71卷12期2605-2608页 942. Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT.
作者: Shaobo Tian.;Yanan Chu.;Jia Hu.;Xueliang Ding.;Zhibo Liu.;Daan Fu.;Ye Yuan.;Yan Deng.;Guobin Wang.;Lin Wang.;Zheng Wang.
来源: Gut. 2022年71卷12期2489-2501页
Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute to colorectal cancer (CRC) metastasis. We investigated the cellular source for secreted AGR2 in the TME and underlying mechanisms mediating secreted AGR2's effects.
943. Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome.
作者: Qin Liu.;Joyce Wing Yan Mak.;Qi Su.;Yun Kit Yeoh.;Grace Chung-Yan Lui.;Susanna So Shan Ng.;Fen Zhang.;Amy Y L Li.;Wenqi Lu.;David Shu-Cheong Hui.;Paul Ks Chan.;Francis K L Chan.;Siew C Ng.
来源: Gut. 2022年71卷3期544-552页
Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear.
944. Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model.
作者: Sumit Kumar.;Mark J A Schoonderwoerd.;Jessie S Kroonen.;Ilona J de Graaf.;Marjolein Sluijter.;Dina Ruano.;Román González-Prieto.;Matty Verlaan-de Vries.;Jasper Rip.;Ramon Arens.;Noel F C C de Miranda.;Lukas J A C Hawinkels.;Thorbald van Hall.;Alfred C O Vertegaal.
来源: Gut. 2022年71卷11期2266-2283页
Pancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density desmoplastic stroma, a distinctive immunosuppressive microenvironment and is profoundly resistant to all forms of chemotherapy and immunotherapy, leading to a 5-year survival rate of 9%. Our study aims to add novel small molecule therapeutics for the treatment of PDAC.
947. Clinical outcome of non-curative endoscopic submucosal dissection for early colorectal cancer.
作者: Marco Spadaccini.;Michael J Bourke.;Roberta Maselli.;Marhieu Pioche.;Pradeep Bhandari.;Jérémie Jacques.;Amyn Haji.;Dennis Yang.;Eduardo Albéniz.;Michal Filip Kaminski.;Helmut Messmann.;Alberto Herreros de Tejada.;Sandro Sferrazza.;Boris Pekarek.;Jerome Rivory.;Sophie Geyl.;Shraddha Gulati.;Peter Draganov.;Neal Shahidi.;Ejaz Hossain.;Carola Fleischmann.;Edoardo Vespa.;Andrea Iannone.;Asma Alkandari.;Cesare Hassan.;Alessandro Repici.; .
来源: Gut. 2022年71卷10期1998-2004页
Endoscopic submucosal dissection (ESD) in a curative intent for submucosa-invasive early (T1) colorectal cancers (T1-CRCs) often leads to subsequent surgical resection in case of histologic parameters indicating higher risk of nodal involvement. In some cases, however, the expected benefit may be offset by the surgical risks, suggesting a more conservative approach.
948. Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells.
作者: Martin J Lett.;Hema Mehta.;Adrian Keogh.;Tina Jaeger.;Maxime Jacquet.;Kate Powell.;Marie-Anne Meier.;Isabel Fofana.;Hassan Melhem.;Jürg Vosbeck.;Gieri Cathomas.;Andres Heigl.;Markus H Heim.;Emanuel Burri.;Kirsten D Mertz.;Jan Hendrik Niess.;Otto Kollmar.;Christoph J Zech.;Robert Ivanek.;Urs Duthaler.;Paul Klenerman.;Deborah Stroka.;Magdalena Filipowicz Sinnreich.
来源: Gut. 2022年71卷12期2526-2538页
Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert regulatory and antimicrobial functions and are implicated in liver fibrogenesis. It is not well understood which liver cells function as antigen (Ag)-presenting cells for MAIT cells, and under which conditions stimulatory Ags reach the circulation.
949. Host transcriptome signatures in human faecal-washes predict histological remission in patients with IBD.
作者: Bella Ungar.;Miri Yavzori.;Ella Fudim.;Orit Picard.;Uri Kopylov.;Rami Eliakim.;Dror Shouval.;Yishai Levin.;Alon Savidor.;Shani Ben-Moshe.;Rita Manco.;Stav Dan.;Adi Egozi.;Keren Bahar Halpern.;Chen Mayer.;Iris Barshack.;Shomron Ben-Horin.;Shalev Itzkovitz.
来源: Gut. 2022年71卷10期
Colonoscopy is the gold standard for evaluation of inflammation in inflammatory bowel diseases (IBDs), yet entails cumbersome preparations and risks of injury. Existing non-invasive prognostic tools are limited in their diagnostic power. Moreover, transcriptomics of colonic biopsies have been inconclusive in their association with clinical features.
951. Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage.
作者: Andrea Szentesi.;Nelli Farkas.;Zoltán Sipos.;Péter Mátrai.;Áron Vincze.;Ferenc Izbéki.;Andrea Párniczky.;Péter Hegyi.; .
来源: Gut. 2022年71卷12期2601-2602页 953. CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.
作者: Jonas Nørskov Søndergaard.;Christian Sommerauer.;Ionut Atanasoai.;Laura C Hinte.;Keyi Geng.;Giulia Guiducci.;Lars Bräutigam.;Myriam Aouadi.;Lovorka Stojic.;Isabel Barragan.;Claudia Kutter.
来源: Gut. 2022年71卷10期2081-92页
To better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs).
954. Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis.
作者: Gaia Bellomo.;Carolyn Rainer.;Valeria Quaranta.;Yuliana Astuti.;Meirion Raymant.;Elzbieta Boyd.;Ruth Stafferton.;Fiona Campbell.;Paula Ghaneh.;Christopher M Halloran.;Dean E Hammond.;Jennifer P Morton.;Daniel Palmer.;Dale Vimalachandran.;Robert Jones.;Ainhoa Mielgo.;Michael C Schmid.
来源: Gut. 2022年71卷11期2284-2299页
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood.
955. Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis.
作者: Alexander C Ford.;Evangelos Tsipotis.;Yuhong Yuan.;Grigorios I Leontiadis.;Paul Moayyedi.
来源: Gut. 2022年
Functional dyspepsia (FD) is a chronic disorder that is difficult to treat. Helicobacter pylori may contribute to its pathophysiology. A Cochrane review from 2006 suggested that eradication therapy was beneficial, but there have been numerous randomised controlled trials (RCTs) published since. We evaluated impact of eradication therapy on both cure and improvement of FD, as well as whether any benefit was likely to arise from eradication of H. pylori.
956. Establishment of a validated central reading system for ileocolonoscopy in an academic setting.
作者: Tim Raine.;Holly Pavey.;Wendi Qian.;Gordon W Moran.;Sreedhar Subramanian.;Lizzie Swaby.;Simon Pl Travis.;Shahida Din.;Peter M Irving.;James O Lindsay.;Miles Parkes.;Nicholas A Kennedy.
来源: Gut. 2022年71卷4期661-664页 958. Mapping the human gut mycobiome in middle-aged and elderly adults: multiomics insights and implications for host metabolic health.
作者: Menglei Shuai.;Yuanqing Fu.;Hai-Li Zhong.;Wanglong Gou.;Zengliang Jiang.;Yuhui Liang.;Zelei Miao.;Jin-Jian Xu.;Tien Huynh.;Mark L Wahlqvist.;Yu-Ming Chen.;Ju-Sheng Zheng.
来源: Gut. 2022年71卷9期1812-1820页
The human gut fungal community, known as the mycobiome, plays a fundamental role in the gut ecosystem and health. Here we aimed to investigate the determinants and long-term stability of gut mycobiome among middle-aged and elderly adults. We further explored the interplay between gut fungi and bacteria on metabolic health.
959. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
作者: Chun Chen.;Jianming Liao.;Yiyuan Xia.;Xia Liu.;Rheinallt Jones.;John Haran.;Beth McCormick.;Timothy Robert Sampson.;Ashfaqul Alam.;Keqiang Ye.
来源: Gut. 2022年71卷11期2233-2252页
This study is to investigate the role of gut dysbiosis in triggering inflammation in the brain and its contribution to Alzheimer's disease (AD) pathogenesis.
960. Risk of acute arterial events associated with treatment of inflammatory bowel diseases: a nationwide Danish cohort study.
作者: Daniel Ward.;Mikael Andersson.;Nynne Nyboe Andersen.;Kristine Højgaard Allin.;Laurent Beaugerie.;Tine Jess.;Julien Kirchgesner.
来源: Gut. 2022年71卷11期2373-2374页 |