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941. Controlled short-term trial of fluticasone propionate in ventilator-dependent patients with COPD.
There is no agreement about the efficacy of systemic corticosteroids in patients with COPD, but corticosteroids often are employed during exacerbations of the disease. The use of systemic or inhaled corticosteroids in patients in stable condition is even more controversial, even though the more severely affected patients seem to respond better. Unfortunately, in this subset of patients, the use of forced expiratory maneuvers frequently fails to detect significant functional response.
942. Geographic variations in prevalence and underdiagnosis of COPD: results of the IBERPOC multicentre epidemiological study.
作者: V S Peña.;M Miravitlles.;R Gabriel.;C A Jiménez-Ruiz.;C Villasante.;J F Masa.;J L Viejo.;L Fernández-Fau.
来源: Chest. 2000年118卷4期981-9页
To ascertain the prevalence, diagnostic level, and treatment of COPD in Spain through a multicenter study comprising seven different geographic areas.
943. Incidence, predictive factors, and prognostic significance of supraventricular tachyarrhythmias in congestive heart failure.
作者: J Mathew.;S Hunsberger.;J Fleg.;F Mc Sherry.;W Williford.;S Yusuf.
来源: Chest. 2000年118卷4期914-22页
The incidence, predictive factors, morbidity, and mortality associated with the development of supraventricular tachyarrhythmias (SVTs) in patients with congestive heart failure (CHF) are poorly defined.
944. Oxygen supplementation and cardiac-autonomic modulation in COPD.
Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients.
945. The cumulative effect of long-acting bronchodilators, exercise, and inspiratory muscle training on the perception of dyspnea in patients with advanced COPD.
Dyspnea is a common complaint during daily activities in patients with advanced COPD. The mechanisms underlying dyspnea and the appropriate treatment strategies to relieve it are still not totally understood. We hypothesized that the perception of dyspnea (POD) may be modified by the accumulative effect of bronchodilator therapy, exercise, and inspiratory muscle training (IMT).
946. Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study.
Results from several studies have described a relationship between pulmonary function and both all-cause and cause-specific mortality. The purpose of this study was to investigate the predictive value of pulmonary function by gender after 29 years of follow-up.
947. Combined lidocaine and salbutamol inhalation for airway anesthesia markedly protects against reflex bronchoconstriction.
Lidocaine inhalation, in subjects with bronchial hyperreactivity, attenuates evoked bronchoconstriction but also irritates airways. Whether salbutamol pretreatment can mitigate airway irritation and whether combined treatment offers more protection than treatment with either drug alone is unknown. Therefore, we evaluated the effects of the inhalation of lidocaine, salbutamol, lidocaine and salbutamol combined, and placebo on an inhalational histamine challenge.
948. Protocol weaning of mechanical ventilation in medical and surgical patients by respiratory care practitioners and nurses: effect on weaning time and incidence of ventilator-associated pneumonia.
作者: G P Marelich.;S Murin.;F Battistella.;J Inciardi.;T Vierra.;M Roby.
来源: Chest. 2000年118卷2期459-67页
(1) To determine the effect of a single ventilator management protocol (VMP) used in medical and surgical ICUs on the duration of mechanical ventilation. (2) To determine the effect of a VMP on the incidence of ventilator-associated pneumonia (VAP).
949. The clinical significance of reversed flow in the main pulmonary artery detected by doppler color flow imaging.
Using Doppler color flow imaging, abnormal flow patterns were reported to occur with pulmonary artery (PA) dilation. We have frequently observed red signals in the main PA, suggesting reversed flow (RF) in patients without overt pulmonary hypertension. The clinical implication of these signals has not been extensively studied.
950. Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 beta(2)-adrenoceptor polymorphism.
Formoterol and salmeterol differ in their relative intrinsic activity at airway beta(2)-adrenoceptors, with formoterol being a full agonist. The homozygous glycine-16 polymorphism of the beta(2)-adrenoceptor occurs in approximately 40% of patients and is known to predispose to agonist-induced downregulation and desensitization.
951. A randomized, placebo-controlled study to evaluate the role of salmeterol in the in-hospital management of asthma.
作者: J I Peters.;D C Shelledy.;A P Jones.;R W Lawson.;C P Davis.;T S LeGrand.
来源: Chest. 2000年118卷2期313-20页
To assess the safety and efficacy of salmeterol xinafoate as an adjunct to conventional therapy for the in-hospital management of acute asthma.
952. Long-term efficacy and safety of fluticasone propionate powder administered once or twice daily via inhaler to patients with moderate asthma.
作者: R ZuWallack.;J Adelglass.;D P Clifford.;S P Duke.;P D Wire.;M Faris.;S M Harding.
来源: Chest. 2000年118卷2期303-12页
To evaluate the efficacy and safety of fluticasone propionate administered as a once-daily or twice-daily regimen over a period of 1 year to patients with moderate asthma.
953. A dose-ranging study of fluticasone propionate administered once daily via multidose powder inhaler to patients with moderate asthma.
作者: R A Nathan.;J T Li.;A Finn.;R Jones.;J E Payne.;J P Wolford.;S M Harding.
来源: Chest. 2000年118卷2期296-302页
This dose-ranging study evaluated the clinical efficacy and safety of inhaled fluticasone propionate administered once daily via a multidose powder inhaler in patients with moderate asthma (FEV(1), 45 to 75% predicted).
954. Unpredictability of deception in compliance with physician-prescribed bronchodilator inhaler use in a clinical trial.
To identify subject characteristics that may be predictive of intentional dumping of metered-dose inhalers (MDIs) during a clinical trial.
955. The role of anticholinergics in bronchoscopy. A randomized clinical trial.
Anticholinergic medications have been utilized frequently prior to bronchoscopy and are thought to facilitate the drying of secretions to limit the amount of required topical anesthetic on the airway mucosa, prevent cardiac arrhythmias during the procedure, and increase patient comfort.
956. Results of a home-based training program for patients with COPD.
作者: M T Hernández.;T M Rubio.;F O Ruiz.;H S Riera.;R S Gil.;J C Gómez.
来源: Chest. 2000年118卷1期106-14页
To have a group of COPD patients undergo a simple program of home-based exercise training, using the shuttle walking test (SWT) to standardize the intensity of training.
957. Effect of a thromboxane A(2) antagonist on sputum production and its physicochemical properties in patients with mild to moderate asthma.
To determine the effects of a specific thromboxane A(2) (TxA(2)) receptor antagonist, seratrodast, on asthma control and airway secretions.
958. Role of respiratory function in exercise limitation in chronic heart failure.
作者: A Chauhan.;G Sridhar.;R Clemens.;B Krishnan.;D D Marciniuk.;C G Gallagher.
来源: Chest. 2000年118卷1期53-60页
To test the hypothesis that respiratory function contributes to limit maximal exercise performance in patients with chronic heart failure by using the technique of dead space loading during exercise.
959. Negative pressure ventilation vs external high-frequency oscillation during rigid bronchoscopy. A controlled randomized trial.
作者: G Natalini.;S Cavaliere.;V Seramondi.;P Foccoli.;M Vitacca.;N Ambrosino.;A Candiani.
来源: Chest. 2000年118卷1期18-23页
To compare the effectiveness of two modalities of external ventilation during rigid bronchoscopy: intermittent negative pressure ventilation (INPV) and external high-frequency oscillation (EHFO).
960. Prognostic value of hemodynamic vs big endothelin measurements during long-term IV therapy in advanced heart failure patients.
作者: B Frey.;R Pacher.;G Locker.;A Bojic.;E Hartter.;W Woloszczuk.;B Stanek.
来源: Chest. 2000年117卷6期1713-9页
To compare hemodynamics and plasma big endothelin levels in patients awaiting heart transplantation who are receiving continuous IV therapy, and to establish their respective potency for predicting future cardiac events.
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