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921. Effectiveness and safety of salmeterol in nonspecialist practice settings.
作者: A D D'Urzo.;K R Chapman.;A Cartier.;F E Hargreave.;M Fitzgerald.;D Tesarowski.
来源: Chest. 2001年119卷3期714-9页
To evaluate the effectiveness and safety of inhaled salmeterol in patients managed in nonspecialist practice settings.
922. Filgrastim in patients with pneumonia and severe sepsis or septic shock.
作者: R Wunderink.;K Leeper.;R Schein.;S Nelson.;B DeBoisblanc.;N Fotheringham.;E Logan.
来源: Chest. 2001年119卷2期523-9页
Evaluate the safety of filgrastim (recombinant methionyl human granulocyte colony-stimulating factor) administration, combined with standard therapy, in patients with pneumonia and either septic shock or severe sepsis who were receiving mechanical ventilation.
923. Acute ventricular rate control in atrial fibrillation: IV combination of diltiazem and digoxin vs. IV diltiazem alone.
作者: N Wattanasuwan.;I A Khan.;N J Mehta.;P Arora.;N Singh.;B C Vasavada.;T J Sacchi.
来源: Chest. 2001年119卷2期502-6页
To analyze the efficacy of an IV combination of diltiazem and digoxin vs IV diltiazem alone for acute ventricular rate control in patients with atrial fibrillation.
924. Anti-inflammatory and lung function effects of montelukast in asthmatic volunteers exposed to sulfur dioxide.
Sulfur dioxide (SO(2)) gas may induce acute asthmatic responses when inhaled by individuals in the setting of community or occupational air pollution during exercise. Some asthma medications mitigate the SO(2) response, which is not fully understood but appears to involve multiple mechanisms.
925. Effects of levodopa on pulmonary function in Parkinson's disease.
Upper-airway obstruction (UAO) may be present in patients with Parkinson's disease (PD), and its reversibility after levodopa therapy has been suggested. To investigate the effects of oral intake of levodopa on pulmonary function and UAO criteria in patients with PD, we studied 22 patients with PD.
926. Regular inhaled salbutamol : effect on airway responsiveness to methacholine and adenosine 5'-monophosphate and tolerance to bronchoprotection.
Regular treatment with inhaled beta(2)-agonists increases airway responsiveness consistently to indirect bronchoconstrictors (allergen, exercise, hypertonic saline solution, etc) and inconsistently to direct bronchoconstrictors (histamine, methacholine). Studies demonstrating tolerance to beta(2)-agonist bronchoprotection against the indirect bronchoconstrictor adenosine 5'-monophosphate (AMP) have not examined changes in baseline AMP responsiveness. This study assessed the effect of regular salbutamol on AMP and methacholine responsiveness and on tolerance to bronchoprotection.
927. Impact of a hospital-based home-care program on the management of COPD patients receiving long-term oxygen therapy.
To analyze the influence of a hospital-based home-care program (HCP) on the management of patients with COPD receiving long-term oxygen therapy.
928. 4A randomized trial of prolonged prone positioning in children with acute respiratory failure.
To compare the effect of the prone position (PP) vs supine position (SP) on oxygenation in children with acute respiratory failure (ARF).
929. Oral moxifloxacin vs high-dosage amoxicillin in the treatment of mild-to-moderate, community-acquired, suspected pneumococcal pneumonia in adults.
Comparison of the efficacy and safety of moxifloxacin vs amoxicillin for treatment of mild-to-moderate, suspected pneumococcal community-acquired pneumonia (CAP) in adult patients.
930. Gender moderates the effects of exercise therapy on health-related quality of life among COPD patients.
To determine whether long-term treatment with exercise therapy results in more favorable, disease-specific, health-related quality of life (HRQL) compared with short-term treatment with exercise therapy; and to determine whether there are gender differences in disease-specific HRQL among individuals randomized into the two treatment groups.
931. Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients with severe COPD.
作者: C Casanova.;B R Celli.;L Tost.;E Soriano.;J Abreu.;V Velasco.;F Santolaria.
来源: Chest. 2000年118卷6期1582-90页
To determine the 1-year efficacy of noninvasive positive pressure ventilation (NPPV) added to long-term oxygen therapy (LTOT) in patients with stable severe COPD. PATIENT SELECTION AND METHODS: We prospectively randomized 52 patients with severe COPD (FEV(1) < 45%) to either NPPV plus "standard care" (96% patients with LTOT) or to standard care alone (93% patients with LTOT). The outcomes measured included the following: rate of acute COPD exacerbations; hospital admissions; intubations; and mortality at 3 months, 6 months, and 12 months. The patients were also evaluated at 3 months and 6 months for dyspnea using the Medical Research Council and Borg scales, gas exchange, hematocrit, pulmonary function, cardiac function with echocardiogram, and neuropsychological performance.
932. Additive effects of salmeterol and fluticasone or theophylline in COPD.
作者: M Cazzola.;G Di Lorenzo.;F Di Perna.;F Calderaro.;R Testi.;S Centanni.
来源: Chest. 2000年118卷6期1576-81页
ss(2)-Agonists and corticosteroids or theophylline can interact to produce beneficial effects on airway function in asthma, but this has not been established in COPD.
933. Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses.
To investigate the potential for mometasone furoate (MF) to exert systemic effects following administration by dry powder inhaler (DPI) or metered-dose inhaler (MDI).
934. Does an IV bolus of methylprednisolone relieve dyspnea in asthma exacerbations?
To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.
935. Different response to doubling and fourfold dose increases in methacholine provocation tests in healthy subjects.
In a modified methacholine provocation test that was used to study changes in airway responsiveness to occupational irritants or sensitizers in healthy subjects, two protocols were used: a long protocol (doubling methacholine concentrations between dose steps) or a short protocol (fourfold increases in concentration). This modified methacholine provocation allows measurements of the provocative dose causing 20% decrease in FEV(1) (PD(20)) in a high proportion of a normal population.
936. The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study Group.
作者: R Casaburi.;D D Briggs.;J F Donohue.;C W Serby.;S S Menjoge.;T J Witek.
来源: Chest. 2000年118卷5期1294-302页
To compare the bronchodilator efficacy and safety of tiotropium and placebo.
937. The appropriate setting of noninvasive pressure support ventilation in stable COPD patients.
作者: M Vitacca.;S Nava.;M Confalonieri.;L Bianchi.;R Porta.;E Clini.;N Ambrosino.
来源: Chest. 2000年118卷5期1286-93页
To evaluate the short-term physiologic effects of two settings of nasal pressure-support ventilation (NPSV) in stable COPD patients with chronic hypercapnia.
938. Targeting aerosol deposition in patients with cystic fibrosis: effects of alterations in particle size and inspiratory flow rate.
To determine if aerosolized medications can be targeted to deposit in the smaller, peripheral airways or the larger, central airways of adult cystic fibrosis (CF) patients by varying particle size and inspiratory flow rate.
939. Effects of once-daily formoterol and budesonide given alone or in combination on surrogate inflammatory markers in asthmatic adults.
We wished to evaluate the effects of once-daily combination therapy on surrogate inflammatory markers.
940. Constant vs. automatic continuous positive airway pressure therapy: home evaluation.
作者: M P d'Ortho.;V Grillier-Lanoir.;P Levy.;F Goldenberg.;E Corriger.;A Harf.;F Lofaso.
来源: Chest. 2000年118卷4期1010-7页
To compare the efficacy and patient tolerance, compliance, and preference between auto-continuous positive airway pressure (CPAP) and constant CPAP.
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