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882. High-dose weekly intravenous immunoglobulin to prevent infections in patients undergoing autologous bone marrow transplantation or severe myelosuppressive therapy. A study of the American Bone Marrow Transplant Group.
作者: S N Wolff.;J W Fay.;R H Herzig.;J P Greer.;S Dummer.;R A Brown.;R H Collins.;D A Stevens.;G P Herzig.
来源: Ann Intern Med. 1993年118卷12期937-42页
To determine whether intravenous immunoglobulin (IVIG) prevents severe infections during autologous bone marrow transplantation or equivalent high-dose myelosuppressive therapy.
883. Efficacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia.
作者: R H Bradford.;M Downton.;A N Chremos.;A Langendörfer.;S Stinnett.;D T Nash.;G Mantell.;C L Shear.
来源: Ann Intern Med. 1993年118卷11期850-5页
To evaluate the efficacy and safety of lovastatin in women with moderate hypercholesterolemia.
884. Slowing the deterioration of asthma and chronic obstructive pulmonary disease observed during bronchodilator therapy by adding inhaled corticosteroids. A 4-year prospective study.
作者: E Dompeling.;C P van Schayck.;P M van Grunsven.;C L van Herwaarden.;R Akkermans.;J Molema.;H Folgering.;C van Weel.
来源: Ann Intern Med. 1993年118卷10期770-8页
To determine if deterioration in patients with asthma or chronic obstructive pulmonary disease (COPD) during bronchodilator therapy could be slowed by additional treatment with an inhaled corticosteroid.
885. Zalcitabine compared with zidovudine in patients with advanced HIV-1 infection who received previous zidovudine therapy.
作者: M A Fischl.;R M Olson.;S E Follansbee.;J P Lalezari.;D H Henry.;P T Frame.;S C Remick.;M P Salgo.;A H Lin.;C Nauss-Karol.;J Lieberman.;W Soo.
来源: Ann Intern Med. 1993年118卷10期762-9页
To evaluate the safety and efficacy of zalcitabine (also known as dideoxycytidine [ddC]) in patients with advanced human immunodeficiency virus (HIV) infection.
886. CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine.
To determine the extent to which lymphocytes, particularly those with the CD4 surface antigen, are a surrogate marker for the development of the acquired immunodeficiency syndrome (AIDS) in persons with asymptomatic human immunodeficiency virus (HIV) infection.
887. Ciprofloxacin and loperamide in the treatment of bacillary dysentery.
作者: G S Murphy.;L Bodhidatta.;P Echeverria.;S Tansuphaswadikul.;C W Hoge.;S Imlarp.;K Tamura.
来源: Ann Intern Med. 1993年118卷8期582-6页
To compare the safety and efficacy of loperamide plus ciprofloxacin with those of ciprofloxacin alone in the treatment of bacillary dysentery.
888. Long-term stabilizing effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients.
To evaluate the long-term effect of angiotensin-converting enzyme inhibition on proteinuria and on the rate of decline in kidney function in patients with type II diabetes mellitus and microalbuminuria.
889. Nurse-assisted counseling for smokers in primary care.
作者: J F Hollis.;E Lichtenstein.;T M Vogt.;V J Stevens.;A Biglan.
来源: Ann Intern Med. 1993年118卷7期521-5页
Physician-delivered advice to stop smoking is effective, but time demands often reduce the number of smokers who receive assistance. We evaluated three nurse-assisted interventions designed to minimize physician burden and increase counseling in primary care settings.
890. Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial.
作者: D J Winston.;P H Chandrasekar.;H M Lazarus.;J L Goodman.;J L Silber.;H Horowitz.;R K Shadduck.;C S Rosenfeld.;W G Ho.;M Z Islam.;D N Buell.
来源: Ann Intern Med. 1993年118卷7期495-503页
To evaluate the efficacy and safety of fluconazole for prevention of fungal infections.
891. Histamine-2 receptor antagonists do not alter serum ethanol levels in fed, nonalcoholic men.
作者: J P Raufman.;V Notar-Francesco.;R D Raffaniello.;E W Straus.
来源: Ann Intern Med. 1993年118卷7期488-94页
To determine whether the four histamine-2 receptor antagonists currently available for the treatment of acid-peptic disorders in the United States alter serum ethanol levels after moderate alcohol consumption.
892. Efficacy of oral ondansetron in the prevention of emesis in outpatients receiving cyclophosphamide-based chemotherapy. The Ondansetron Study Group.
作者: T M Beck.;A A Ciociola.;S E Jones.;W H Harvey.;N S Tchekmedyian.;A Chang.;D Galvin.;N E Hart.
来源: Ann Intern Med. 1993年118卷6期407-13页
To evaluate the efficacy and safety of oral ondansetron (Zofran) as an antiemetic in patients receiving cyclophosphamide-based chemotherapy.
893. Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex.
作者: G Skowron.;S A Bozzette.;L Lim.;C B Pettinelli.;H H Schaumburg.;J Arezzo.;M A Fischl.;W G Powderly.;D J Gocke.;D D Richman.;J C Pottage.;D Antoniskis.;G F McKinley.;N E Hyslop.;G Ray.;G Simon.;N Reed.;M L LoFaro.;R B Uttamchandani.;L D Gelb.;S J Sperber.;R L Murphy.;J M Leedom.;M H Grieco.;J Zachary.;M S Hirsch.;S A Spector.;J Bigley.;W Soo.;T C Merigan.
来源: Ann Intern Med. 1993年118卷5期321-30页
To determine whether alternating regimens consisting of zidovudine and 2',3'-dideoxycytidine (ddC) reduce the toxicity and maintain or increase the antiretroviral effect associated with each drug alone.
894. Improvement of lipid abnormalities associated with proteinuria using fosinopril, an angiotensin-converting enzyme inhibitor.
To examine whether reducing protein excretion in patients with proteinuric renal disease using an angiotensin-converting enzyme inhibitor, fosinopril sodium, would be accompanied by an amelioration of the associated hyperlipidemia.
895. Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial.
作者: J F Rooney.;S E Straus.;M L Mannix.;C R Wohlenberg.;D W Alling.;J A Dumois.;A L Notkins.
来源: Ann Intern Med. 1993年118卷4期268-72页
To determine whether oral acyclovir reduces the incidence of recurrent herpes labialis in otherwise healthy patients with proven frequently recurrent disease.
896. The risk of determining risk with multivariable models.
To review the principles of multivariable analysis and to examine the application of multivariable statistical methods in general medical literature.
897. What is the benefit of increasing the sulfonylurea dose?
To study the clinical benefit of increasing the dose of the sulfonylurea, glipizide, from 10 to 40 mg per day.
898. Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients. Results of a placebo-controlled, double-blind trial.
作者: D J Winston.;W G Ho.;K Bartoni.;C Du Mond.;D F Ebeling.;W C Buhles.;R E Champlin.
来源: Ann Intern Med. 1993年118卷3期179-84页
To evaluate the efficacy and safety of ganciclovir for prevention of cytomegalovirus (CMV) infection and disease.
899. Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant.
作者: J M Goodrich.;R A Bowden.;L Fisher.;C Keller.;G Schoch.;J D Meyers.
来源: Ann Intern Med. 1993年118卷3期173-8页
To study the efficacy and toxicity of ganciclovir prophylaxis given at engraftment to cytomegalovirus (CMV)-seropositive, allogeneic bone marrow transplant recipients.
900. Beta-blockers after myocardial infarction: influence of first-year clinical course on long-term effectiveness.
To develop a strategy for evaluating drug efficacy over time that accounts for heterogeneous clinical courses evolving after initiation of therapy and to demonstrate its use in assessing the long-term therapeutic benefit of propranolol after myocardial infarction.
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