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863. In persons exposed to influenza, zanamivir, oseltamivir, laninamivir, and baloxavir reduce symptomatic seasonal influenza.
Zhao Y, Gao Y, Guyatt G, et al. Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis. Lancet. 2024;404:764-772. 39181596.
864. In hospitalized patients with influenza, oseltamivir or peramivir may reduce hospital length of stay (low-certainty evidence).
Gao Y, Guyatt G, Uyeki TM, et al. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials. Lancet. 2024;404:753-763. 39181595.
865. Adding naloxone to buprenorphine during pregnancy was not linked to increased adverse neonatal or maternal outcomes.
Straub L, Bateman BT, Hernández-Díaz S, et al. Comparative safety of in utero exposure to buprenorphine combined with naloxone vs buprenorphine alone. JAMA. 2024;332:805-816. 39133511.
866. The Past, Present, and Future of Restrictive Covenants in Medicine in the United States : A Narrative Review.
Restrictive covenants (RCs) are clauses placed into employment agreements across various industries, and they are frequently used in health care-specifically within physician contracts. Given the most recent guidance and rule determined by the Federal Trade Commission in April 2024, the relevancy of RCs in health care has come under even more scrutiny in the latter half of 2024. This review will focus on the history of RC law and review the value of these clauses from the perspectives of the employer, practicing physician, and patient. We also provide the stakeholder responses to both the ban and the subsequent blockage of enforcement by a Texas federal court in August of 2024.
867. In acute ischemic stroke and a large infarct, adding EVT to medical treatment improved functional outcome at 12 mo.
Thomalla G, Fiehler J, Subtil F, et al; TENSION Investigators. Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial. Lancet Neurol. 2024;23:883-892. 39074480.
868. A Framework for Considering the Value of Race and Ethnicity in Estimating Disease Risk.
作者: Madison Coots.;Soroush Saghafian.;David M Kent.;Sharad Goel.
来源: Ann Intern Med. 2025年178卷1期98-107页
Accounting for race and ethnicity in estimating disease risk may improve the accuracy of predictions but may also encourage a racialized view of medicine.
869. After COVID-19 diagnosis, risk for incident type 2 diabetes was elevated for up to 2 y.
Taylor K, Eastwood S, Walker V, et al. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people. Lancet Diabetes Endocrinol. 2024;12:558-568. 39054034.
871. Cost-Effectiveness of Extending Human Papillomavirus Vaccination to Population Subgroups Older Than 26 Years Who Are at Higher Risk for Human Papillomavirus Infection in the United States.
作者: Jean-François Laprise.;Harrell W Chesson.;Lauri E Markowitz.;Mélanie Drolet.;Marc Brisson.
来源: Ann Intern Med. 2025年178卷1期50-58页
In June 2019, the U.S. Advisory Committee on Immunization Practices recommended shared clinical decision making regarding potential human papillomavirus (HPV) vaccination of men and women aged 27 to 45 years ("mid-adults").
874. Association of Work Control With Burnout and Career Intentions Among U.S. Physicians : A Multi-institution Study.
作者: Christine A Sinsky.;Roger L Brown.;Lisa Rotenstein.;Lindsey E Carlasare.;Purva Shah.;Tait D Shanafelt.
来源: Ann Intern Med. 2025年178卷1期20-28页
Physician control over their clinical work is hypothesized to be associated with both burnout and career intentions.
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