853. Lessons Learned: Risk Factors and Clinical Impact of Severe Pneumothorax After Endoscopic Lung Volume Reduction With Endobronchial Valves.
作者: Judith Maria Brock.;Susanne Annemarie Dittrich.;Florian Eichhorn.;Kai Schlamp.;Konstantina Kontogianni.;Felix J F Herth.
来源: Chest. 2025年167卷4期1012-1023页
Pneumothorax is a major complication after endoscopic lung volume reduction with valves, with a prevalence of up to 34%. Although some patients benefit from valve implantation despite pneumothorax, others are significantly impaired after lung collapse.
854. Trends in All-Cause Mortality Among US Veterans With Sarcoidosis, 2004-2022.
作者: Mohamed I Seedahmed.;Mohamed T Albirair.;Aaron D Baugh.;Walid F Gellad.;S Mehdi Nouraie.;Kevin F Gibson.;Mary A Whooley.;Charles E McCulloch.;Laura L Koth.;Mehrdad Arjomandi.
来源: Chest. 2025年167卷5期1416-1427页
Sarcoidosis is an idiopathic multiorgan disease with variable clinical outcomes. Comprehensive analysis of sarcoidosis mortality in US veterans is lacking.
855. The Dawn of Precision Medicine in Fibrotic Interstitial Lung Disease.
Interstitial lung diseases (ILDs) represent a broad group of heterogeneous parenchymal lung diseases. Some ILDs progress, causing architectural distortion and pulmonary fibrosis, and thus are called fibrotic ILDs. Recent studies have shown a beneficial effect of antifibrotic therapy in fibrotic ILDs other than idiopathic pulmonary fibrosis (IPF) that manifest progressive pulmonary fibrosis (PPF). However, it remains challenging to predict which patients with fibrotic ILDs will demonstrate PPF. Precision medicine approaches could identify patients at risk for progression and guide treatment in patients with IPF or PPF.
856. Parasitic Infections in Pulmonary and ICU Patients: Presentation, Diagnosis, and Treatment.
Parasitic infections in the United States are mostly seen in immigrants and travelers. In many cases, pulmonary and intensive care physicians fail to consider parasitic disease, which can result in delayed diagnosis and adverse outcomes. Almost 2,000 cases of imported malaria are diagnosed in the United States each year. Severe cases can be confused with bacterial sepsis (shock, lactic acidosis, pneumonia, renal failure, respiratory failure, and jaundice). In contrast to bacterial sepsis, survival is improved by restrictive fluid therapy. Parenteral artesunate is licensed to treat severe cases but may not be readily accessible. Strongyloidiasis is endemic in warm and most tropical regions. Chronic strongyloidiasis causes few symptoms and can persist for decades after the patient leaves the endemic region. Treatment with corticosteroids may lead to hyperinfection, which may present with bacteremia and meningitis caused by enteric organisms, pulmonary hemorrhage, and gastrointestinal pain, bleeding, or obstruction. Treatment with ivermectin can be curative if initiated early. Cystic echinococcosis can present as pulmonary mass. Paragonimus presents with hemoptysis, pulmonary nodules, or pleural effusions, and usually with eosinophilia. Endemic regions include not only East Asia but also Southeast Asia, West Africa, the Pacific coast of Latin America, and even North America. Other parasitic infections can involve the lungs. This article aims to provide awareness of the most clinically relevant parasitic infections seen in pulmonary and critical care medicine.
857. Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma: Population-Based Cohort.
Guidelines advise minimizing asthma exacerbation risk, which is achieved partially through good clinical practice activities, including scheduled asthma reviews, inhaler technique checks, and asthma management plans. We assessed how frequently these activities are provided and how effective they are in clinical practice.
858. Hypnotics and Mortality in Idiopathic Pulmonary Fibrosis: Hospital and National Data-Based Analysis.
作者: Hironao Hozumi.;Yoshinari Endo.;Masato Kono.;Hirotsugu Hasegawa.;Koichi Miyashita.;Hyogo Naoi.;Yuya Aono.;Yoichiro Aoshima.;Yusuke Inoue.;Kazutaka Mori.;Hideki Yasui.;Yuzo Suzuki.;Masato Karayama.;Kazuki Furuhashi.;Noriyuki Enomoto.;Tomoyuki Fujisawa.;Naoki Inui.;Koshi Yokomura.;Takafumi Suda.
来源: Chest. 2025年167卷4期1107-1119页
Patients with idiopathic pulmonary fibrosis (IPF) may experience insomnia and use hypnotics. However, the effect of the use of hypnotics on their clinical course remains unclear.
859. Estimation of Expiratory Function in Infants With Passive Expiration From Total Lung Capacity: A Retrospective Study.
作者: Avigdor Hevroni.;Yael Simpson Lavy.;Laurice Boursheh.;Ephraim Bar-Yishay.
来源: Chest. 2025年167卷4期1133-1141页
Evaluating expiratory airway function in infants is challenging because the criterion standard, the raised-volume rapid thoracoabdominal compression technique, is technically difficult and has a high failure rate.
860. Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020.
作者: Christine M Kava.;David A Siegel.;Jin Qin.;Susan A Sabatino.;Reda Wilson.;Manxia Wu.
来源: Chest. 2025年167卷4期1218-1231页
Treatment for lung cancer can improve prognosis, but 5-year survival remains low at 26%. An examination of treatment using data with higher population coverage, and among a broader number of treatment modalities and individual characteristics, would provide greater insight into differences in lung cancer treatment.
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