8424. Amino acid decarboxylase enzymes--vital or irrelevant to gastric secretion?
The location and discovery of histidine decarboxylase and aromatic L-amino acid decarboxylase in the stomach are described. Feeding and gastrin-like agents stimulate increased gastric histidine decarboxylase (HD) acttvity in rats. Procedures which result in increased gastrin release - often by raising antral pH - also have this action in intact but not in antrectomised rats. Evidence for a histaminic feedback mechanism controlling HD levels is discussed. HD activity is reduced by protein synthesis inhibitors and by chronic pyridoxine deficiency. The effects of inhibitors of HD on gastric secretion in rat, dog and man are reviewed. The role of HD and histamine in gastric secretion is considered.
8425. Disruptions in enzyme regulation during aging.8427. Role of cyclic nucleotides in the induction of tyrosine hydroxylase.8433. [Research on the pathogenesis of manganese poisoning (a review of the literature)].8434. Rational use of psychotropic drugs. I. Hypnotics.8435. [Natural inhibitors of fibrinolysis and their physiological importance].8437. [Interaction of Na+, K+-ATPase with oubain].8439. Adaptive responses of the liver to foreign compounds, with special reference to microsomal drug-matabolizing enzymes. |